iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089506

Ensembl Protein ID

ENSOARP00000010582.1

UniProt Accession

W5PJG1; W5PJG1_SHEEP

Genbank Protein ID

ENSOARP00000010582

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01113632

Gene Name

TBL1Y

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000009866.1	ENSOART00000010739.1	ENSOARP00000010582.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-53	177.0	435	473
UBD/Beta-Prp	2.20e-64	217.7	306	507

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           H+++v+++af +d ++l+sGs D+ +++W++ +g l++s
   Q: 435  HQEPVYSVAFsPDgKYLASGSFDKCVHIWNTQSGSLVHS 473
           9**********999******************9999875 PP

UBD/Beta-Prp

   S: 14   tcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsf 102
            +v++ ++++ +a+ s+d +i v ++     +++++gh++ev+a+k++p+g +l+++s+D+t+k+w++++ +cvh l++h+++++++++
   Q: 306  LDVDW-QNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDTCVHDLQAHSKEIYTIKW 393
           33444.55555666666666666666666666666666666666666666666666666666666666666666666666666666555 PP
   S: 103  sp.........sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtds 182
           sp         s+  l+s+s d+t+r+wd+e g c++ tl++h++ v +v+++pdg++l+sGs D++v +W+ ++g+l++  +g  t+ 
   Q: 394  SPtgpatsnpnSSIMLASASFDSTVRLWDVERGVCIH-TLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGSLVHSYRG--TGG 479
           5544444433222455666666666666666666666.6666666666666666666666666666666666666666666665..666 PP
   S: 183  vyslsfdsngkelvsgsldgtvklwdlq 210
           +  + ++  g  + + + dg+v + dl+
   Q: 480  IFEVCWNARGDKVGASASDGSVCVLDLR 507
           6666666666666666666666555554 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MSITSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GTLVPPAALI SILQKGLQYV 60
EAEISINEDG TVFDGRPIES LSLIDAVMPD VVQTRQQAFR EKLAQQQAAP AAVSQQNPPK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTCTGGCAT CATAAAGCTT CACAAGGTGA CTCAGAGGAG GCTGATCACT GTGAACCCCC 60
GAGGAGAAGG AATCTCCGCC CCTGCCCTGC CCCGCCGGTA CACCGCACTG TGAAGAAAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005667--C:transcription factor complex
GO:0003682--F:chromatin binding
GO:0003714--F:transcription corepressor activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0045444--P:fat cell differentiation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043627--P:response to estrogen
GO:0048545--P:response to steroid hormone

KEGG

oas:101119116

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001450	Ailuropoda melanoleuca	97.24	0.00e+00	1002.00
IUUC-Apl-003232	Anas platyrhynchos	94.46	0.00e+00	999.00
IUUC-Aca-005035	Anolis carolinensis	93.17	0.00e+00	995.00
IUUC-Aly-005622	Arabidopsis lyrata	55.84	3.00e-119	422.00
IUUC-Ago-007869	Ashbya gossypii	26.24	5.00e-39	155.00
IUUC-Bta-013202	Bos taurus	95.64	0.00e+00	1013.00
IUUC-Bdi-014315	Brachypodium distachyon	60.92	4.00e-134	471.00
IUUC-Cja-019281	Callithrix jacchus	93.04	0.00e+00	978.00
IUUC-Cfa-020929	Canis familiaris	94.68	0.00e+00	1005.00
IUUC-Cre-022979	Chlamydomonas reinhardtii	61.71	8.00e-132	463.00
IUUC-Csa-023943	Chlorocebus sabaeus	92.32	0.00e+00	983.00
IUUC-Cin-025704	Ciona intestinalis	72.12	0.00e+00	790.00
IUUC-Csv-026257	Ciona savignyi	70.60	0.00e+00	763.00
IUUC-Cne-026946	Cryptococcus neoformans	38.01	1.00e-30	128.00
IUUC-Cme-027258	Cyanidioschyzon merolae	40.14	3.00e-107	382.00
IUUC-Dno-028926	Dasypus novemcinctus	93.55	0.00e+00	997.00
IUUC-Dme-031939	Drosophila melanogaster	81.74	2.00e-176	612.00
IUUC-Ete-032822	Echinops telfairi	84.56	0.00e+00	850.00
IUUC-Eca-033897	Equus caballus	95.06	0.00e+00	1010.00
IUUC-Fca-036462	Felis catus	94.50	0.00e+00	1007.00
IUUC-Fal-037388	Ficedula albicollis	95.41	0.00e+00	1003.00
IUUC-Gga-040671	Gallus gallus	95.41	0.00e+00	1003.00
IUUC-Gac-041851	Gasterosteus aculeatus	91.81	0.00e+00	941.00
IUUC-Ggo-045373	Gorilla gorilla	92.03	0.00e+00	985.00
IUUC-Hsa-045841	Homo sapiens	92.21	0.00e+00	985.00
IUUC-Itr-048236	Ictidomys tridecemlineatus	99.19	0.00e+00	775.00
IUUC-Kpa-049338	Komagataella pastoris	25.37	2.00e-38	154.00
IUUC-Lch-050535	Latimeria chalumnae	95.48	0.00e+00	989.00
IUUC-Laf-054071	Loxodonta africana	94.33	0.00e+00	1000.00
IUUC-Mcc-055233	Macaca mulatta	92.56	0.00e+00	968.00
IUUC-Mga-059895	Meleagris gallopavo	95.23	0.00e+00	1002.00
IUUC-Mmr-061286	Microcebus murinus	94.91	0.00e+00	1008.00
IUUC-Mmu-063447	Mus musculus	94.88	0.00e+00	1009.00
IUUC-Nle-069151	Nomascus leucogenys	92.37	0.00e+00	980.00
IUUC-Ont-072252	Oreochromis niloticus	91.81	0.00e+00	963.00
IUUC-Oan-073562	Ornithorhynchus anatinus	94.50	0.00e+00	1007.00
IUUC-Olu-087589	Ostreococcus lucimarinus	53.79	3.00e-157	548.00
IUUC-Ptr-090793	Pan troglodytes	91.60	0.00e+00	950.00
IUUC-Pan-091909	Papio anubis	93.14	0.00e+00	985.00
IUUC-Psi-093358	Pelodiscus sinensis	93.36	0.00e+00	962.00
IUUC-Pfo-097214	Poecilia formosa	89.86	0.00e+00	929.00
IUUC-Pab-098317	Pongo abelii	92.05	0.00e+00	962.00
IUUC-Pop-098989	Populus trichocarpa	57.89	3.00e-129	454.00
IUUC-Ppe-101572	Prunus persica	63.69	8.00e-128	450.00
IUUC-Rno-105857	Rattus norvegicus	94.88	0.00e+00	1009.00
IUUC-Sha-107326	Sarcophilus harrisii	97.27	0.00e+00	1014.00
IUUC-Sja-107844	Schizosaccharomyces japonicus	24.29	2.00e-29	123.00
IUUC-Sly-111042	Solanum lycopersicum	52.47	2.00e-152	532.00
IUUC-Stu-112786	Solanum tuberosum	50.00	2.00e-143	502.00
IUUC-Ssc-115646	Sus scrofa	95.27	0.00e+00	1010.00
IUUC-Tgu-116898	Taeniopygia guttata	94.65	0.00e+00	1001.00
IUUC-Tru-117862	Takifugu rubripes	91.81	0.00e+00	949.00
IUUC-Tni-119656	Tetraodon nigroviridis	92.98	0.00e+00	951.00
IUUC-Ttr-128826	Tursiops truncatus	95.01	0.00e+00	924.00
IUUC-Uma-129469	Ustilago maydis	43.53	1.00e-58	221.00
IUUC-Vvi-131193	Vitis vinifera	57.14	1.00e-129	456.00
IUUC-Xma-133591	Xiphophorus maculatus	90.25	0.00e+00	931.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence