iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Kpa-049225

Ensembl Protein ID

CAY70401

UniProt Accession

C4R4B5; C4R4B5_KOMPG

Genbank Protein ID

CAY70401.1

Protein Name

Ubiquitin-conjugating enzyme (E2)

Genbank Nucleotide ID

FN392321

Gene Name

PAS_chr3_0359

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
PAS_chr3_0359	CAY70401	CAY70401

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	4.10e-51	170.5	8	142

Active Site

Position(s)	Description	Evidence
88	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekWspalsvesv 101
           Rl++++k++++d p g+sa+p  + ++++w+++i+Gp+dtp+e+g+F+l i+f+e+YP kPP+vkf++ +fhPnvy++G++Cl+il+  ++W+p+++v+s+
   Q: 8    RLMRDFKRIQQDAPGGVSASPLPD-NVMTWNAVIVGPADTPFEDGTFRLVIQFDEQYPNKPPSVKFISDMFHPNVYASGDLCLDILQ--NRWTPTYDVSSI 105
           9***********************.9************************************************************9..************ PP
   S: 102  llsiqsllaepnpesplneeaaellkknreeykkkvr 138
           l+siqsll++pn++sp+n+eaa+l+k++r++y ++vr
   Q: 106  LTSIQSLLNDPNISSPANVEAANLYKDHRSQYIQRVR 142
           **********************************997 PP

Organism

Komagataella pastoris

Protein Sequence
(Fasta)

MSTPARRRLM RDFKRIQQDA PGGVSASPLP DNVMTWNAVI VGPADTPFED GTFRLVIQFD 60
EQYPNKPPSV KFISDMFHPN VYASGDLCLD ILQNRWTPTY DVSSILTSIQ SLLNDPNISS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTACTC CTGCAAGACG ACGATTGATG AGAGATTTCA AAGTAAGTGT TTTCCAAACG 60
TCTTATCAGT ATGCACTTTG AACTAACAAT TTATTTAGAG AATCCAACAG GATGCACCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0000781--C:chromosome, telomeric region
GO:0005829--C:cytosol
GO:0033503--C:HULC complex
GO:1990304--C:MUB1-RAD6-UBR2 ubiquitin ligase complex
GO:0000790--C:nuclear chromatin
GO:0000502--C:proteasome complex
GO:0097505--C:Rad6-Rad18 complex
GO:0005524--F:ATP binding
GO:0003697--F:single-stranded DNA binding
GO:0043142--F:single-stranded DNA-dependent ATPase activity
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0071455--P:cellular response to hyperoxia
GO:0031497--P:chromatin assembly
GO:0006348--P:chromatin silencing at telomere
GO:0006353--P:DNA-templated transcription, termination
GO:0000724--P:double-strand break repair via homologous recombination
GO:0042275--P:error-free postreplication DNA repair
GO:0070987--P:error-free translesion synthesis
GO:0042276--P:error-prone translesion synthesis
GO:0071894--P:histone H2B conserved C-terminal lysine ubiquitination
GO:0010390--P:histone monoubiquitination
GO:0042138--P:meiotic DNA double-strand break formation
GO:0031571--P:mitotic G1 DNA damage checkpoint
GO:0061186--P:negative regulation of chromatin silencing at silent mating-type cassette
GO:0031939--P:negative regulation of chromatin silencing at telomere
GO:1901487--P:negative regulation of SREBP signaling pathway by positive regulation of transcription factor catabolic process in response to increased oxygen levels
GO:0010620--P:negative regulation of transcription by transcription factor catabolism
GO:1990920--P:proteasome localization to nuclear periphery
GO:0070534--P:protein K63-linked ubiquitination
GO:1901044--P:protein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
GO:0090089--P:regulation of dipeptide transport
GO:0051569--P:regulation of histone H3-K4 methylation
GO:0000722--P:telomere maintenance via recombination
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0071629--P:ubiquitin-dependent catabolism of misfolded proteins by cytoplasm-associated proteasome
GO:0030433--P:ubiquitin-dependent ERAD pathway
GO:0071596--P:ubiquitin-dependent protein catabolic process via the N-end rule pathway

KEGG

ppa:PAS_chr3_0359

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001001	Aegilops tauschii	62.00	2.00e-58	215.00
IUUC-Aml-002120	Ailuropoda melanoleuca	69.33	3.00e-63	231.00
IUUC-Atr-002862	Amborella trichopoda	64.00	3.00e-59	218.00
IUUC-Apl-004063	Anas platyrhynchos	61.22	1.00e-51	193.00
IUUC-Aca-005001	Anolis carolinensis	68.67	5.00e-63	230.00
IUUC-Aly-005584	Arabidopsis lyrata	65.33	6.00e-60	220.00
IUUC-Ath-007149	Arabidopsis thaliana	65.33	6.00e-60	220.00
IUUC-Ago-007745	Ashbya gossypii	80.00	3.00e-75	271.00
IUUC-Acl-008139	Aspergillus clavatus	82.55	1.00e-74	269.00
IUUC-Afl-008551	Aspergillus flavus	82.55	1.00e-74	269.00
IUUC-Afu-008980	Aspergillus fumigatus	82.55	1.00e-74	269.00
IUUC-Ang-009554	Aspergillus niger	82.55	1.00e-74	269.00
IUUC-Aor-010242	Aspergillus oryzae	82.55	1.00e-74	269.00
IUUC-Ate-010390	Aspergillus terreus	82.55	1.00e-74	269.00
IUUC-Ame-010743	Astyanax mexicanus	70.47	1.00e-63	232.00
IUUC-Bgr-012039	Blumeria graminis	80.60	1.00e-65	239.00
IUUC-Bta-012840	Bos taurus	69.33	3.00e-63	231.00
IUUC-Bci-013919	Botrytis cinerea	80.54	3.00e-73	265.00
IUUC-Bdi-014308	Brachypodium distachyon	63.33	9.00e-59	216.00
IUUC-Bol-015726	Brassica oleracea	65.33	1.00e-59	222.00
IUUC-Bra-016809	Brassica rapa	65.33	5.00e-60	221.00
IUUC-Cel-018244	Caenorhabditis elegans	66.44	3.00e-62	228.00
IUUC-Cja-019737	Callithrix jacchus	69.33	3.00e-63	231.00
IUUC-Cfa-020244	Canis familiaris	69.33	3.00e-63	231.00
IUUC-Cpo-021323	Cavia porcellus	69.80	3.00e-63	231.00
IUUC-Cre-022822	Chlamydomonas reinhardtii	66.67	3.00e-51	191.00
IUUC-Csa-023430	Chlorocebus sabaeus	69.33	3.00e-63	231.00
IUUC-Cho-024773	Choloepus hoffmanni	54.00	1.00e-42	162.00
IUUC-Cin-025537	Ciona intestinalis	70.00	2.00e-54	202.00
IUUC-Csv-025846	Ciona savignyi	70.67	2.00e-57	212.00
IUUC-Cgl-026381	Colletotrichum gloeosporioides	82.55	1.00e-75	272.00
IUUC-Cne-026864	Cryptococcus neoformans	68.46	9.00e-63	230.00
IUUC-Cme-027284	Cyanidioschyzon merolae	60.00	3.00e-47	179.00
IUUC-Dre-028358	Danio rerio	69.13	4.00e-63	231.00
IUUC-Dno-029661	Dasypus novemcinctus	69.33	3.00e-63	231.00
IUUC-Dor-030452	Dipodomys ordii	65.93	1.00e-53	199.00
IUUC-Dse-031487	Dothistroma septosporum	81.21	5.00e-74	267.00
IUUC-Dme-031863	Drosophila melanogaster	69.80	7.00e-63	230.00
IUUC-Ete-032595	Echinops telfairi	68.00	3.00e-62	228.00
IUUC-Eca-033377	Equus caballus	69.33	3.00e-63	231.00
IUUC-Eeu-035191	Erinaceus europaeus	54.30	4.00e-42	161.00
IUUC-Fca-036336	Felis catus	69.33	3.00e-63	231.00
IUUC-Fal-037474	Ficedula albicollis	68.97	4.00e-48	180.00
IUUC-Fox-037808	Fusarium oxysporum	82.55	2.00e-75	271.00
IUUC-Fso-038232	Fusarium solani	82.55	1.00e-75	272.00
IUUC-Gmo-038517	Gadus morhua	69.13	4.00e-63	231.00
IUUC-Ggr-039875	Gaeumannomyces graminis	82.55	4.00e-75	271.00
IUUC-Gga-040494	Gallus gallus	69.33	3.00e-63	231.00
IUUC-Gac-042471	Gasterosteus aculeatus	68.46	2.00e-63	231.00
IUUC-Gma-043865	Glycine max	64.00	1.00e-59	219.00
IUUC-Ggo-044896	Gorilla gorilla	69.13	4.00e-63	231.00
IUUC-Hsa-046239	Homo sapiens	69.33	3.00e-63	231.00
IUUC-Hvu-047054	Hordeum vulgare	62.00	2.00e-58	215.00
IUUC-Itr-048960	Ictidomys tridecemlineatus	69.33	3.00e-63	231.00
IUUC-Lch-049964	Latimeria chalumnae	69.13	4.00e-63	231.00
IUUC-Lpe-051301	Leersia perrieri	64.00	3.00e-59	218.00
IUUC-Loc-051962	Lepisosteus oculatus	70.00	7.00e-64	233.00
IUUC-Laf-053380	Loxodonta africana	69.33	3.00e-63	231.00
IUUC-Mcc-054819	Macaca mulatta	69.33	2.00e-63	232.00
IUUC-Meu-056231	Macropus eugenii	69.13	4.00e-63	231.00
IUUC-Mor-057087	Magnaporthe oryzae	82.09	6.00e-67	243.00
IUUC-Mpo-057498	Magnaporthe poae	82.55	2.00e-75	272.00
IUUC-Mtr-058305	Medicago truncatula	64.00	2.00e-59	219.00
IUUC-Mla-058876	Melampsora laricipopulina	73.15	1.00e-60	223.00
IUUC-Mga-059863	Meleagris gallopavo	66.18	2.00e-54	202.00
IUUC-Mvi-060330	Microbotryum violaceum	72.48	1.00e-59	219.00
IUUC-Mmr-060630	Microcebus murinus	69.33	3.00e-63	231.00
IUUC-Mdo-062676	Monodelphis domestica	69.33	3.00e-63	231.00
IUUC-Mmu-063491	Mus musculus	69.33	3.00e-63	231.00
IUUC-Mac-064774	Musa acuminata	64.00	4.00e-59	218.00
IUUC-Mpu-065803	Mustela putorius furo	69.33	3.00e-63	231.00
IUUC-Mlu-067147	Myotis lucifugus	69.33	3.00e-63	231.00
IUUC-Nfi-068580	Neosartorya fischeri	82.55	1.00e-74	269.00
IUUC-Ncr-068913	Neurospora crassa	82.55	3.00e-75	271.00
IUUC-Nle-070105	Nomascus leucogenys	69.33	3.00e-63	231.00
IUUC-Opr-070935	Ochotona princeps	69.33	3.00e-63	231.00
IUUC-Ont-071335	Oreochromis niloticus	68.46	3.00e-63	231.00
IUUC-Oan-072706	Ornithorhynchus anatinus	63.27	6.00e-56	207.00
IUUC-Ocu-074130	Oryctolagus cuniculus	69.33	3.00e-63	231.00
IUUC-Oba-075896	Oryza barthii	64.00	7.00e-59	216.00
IUUC-Obr-076770	Oryza brachyantha	64.67	3.00e-59	218.00
IUUC-Ogl-077116	Oryza glaberrima	64.00	3.00e-59	218.00
IUUC-Ogu-078696	Oryza glumaepatula	64.00	3.00e-59	218.00
IUUC-Oin-079099	Oryza indica	64.00	3.00e-59	218.00
IUUC-Olo-081018	Oryza longistaminata	54.55	1.00e-49	186.00
IUUC-Ome-081285	Oryza meridionalis	64.00	3.00e-59	218.00
IUUC-Oni-082088	Oryza nivara	64.00	3.00e-59	218.00
IUUC-Opu-083310	Oryza punctata	64.00	3.00e-59	218.00
IUUC-Oru-084449	Oryza rufipogon	64.00	3.00e-59	218.00
IUUC-Osa-085923	Oryza sativa	64.00	3.00e-59	218.00
IUUC-Ola-087448	Oryzias latipes	69.33	3.00e-63	231.00
IUUC-Olu-087830	Ostreococcus lucimarinus	63.76	2.00e-50	188.00
IUUC-Oga-088836	Otolemur garnettii	69.33	3.00e-63	231.00
IUUC-Oar-090141	Ovis aries	69.33	3.00e-63	231.00
IUUC-Ptr-091453	Pan troglodytes	69.33	3.00e-63	231.00
IUUC-Pan-092511	Papio anubis	69.33	3.00e-63	231.00
IUUC-Psi-094094	Pelodiscus sinensis	69.13	4.00e-63	231.00
IUUC-Pma-094376	Petromyzon marinus	68.46	2.00e-62	228.00
IUUC-Pno-094935	Phaeosphaeria nodorum	80.54	2.00e-73	265.00
IUUC-Ppa-095689	Physcomitrella patens	67.72	7.00e-52	193.00
IUUC-Pfo-096784	Poecilia formosa	69.13	5.00e-63	230.00
IUUC-Pab-098121	Pongo abelii	69.33	3.00e-63	231.00
IUUC-Pop-099712	Populus trichocarpa	64.00	3.00e-54	201.00
IUUC-Pca-100906	Procavia capensis	63.76	3.00e-56	208.00
IUUC-Ppe-101594	Prunus persica	64.00	2.00e-59	218.00
IUUC-Pva-102380	Pteropus vampyrus	68.46	5.00e-61	224.00
IUUC-Pgr-103611	Puccinia graminis	73.15	6.00e-61	224.00
IUUC-Ptt-103971	Puccinia triticina	75.00	2.00e-46	175.00
IUUC-Pte-104378	Pyrenophora teres	81.21	9.00e-74	266.00
IUUC-Pyt-104757	Pyrenophora triticirepentis	81.21	9.00e-74	266.00
IUUC-Rno-105772	Rattus norvegicus	69.33	2.00e-63	232.00
IUUC-Sce-106283	Saccharomyces cerevisiae	80.00	3.00e-75	271.00
IUUC-Sha-107650	Sarcophilus harrisii	68.67	8.00e-62	226.00
IUUC-Sja-107790	Schizosaccharomyces japonicus	77.85	1.00e-62	229.00
IUUC-Spo-108073	Schizosaccharomyces pombe	77.18	3.00e-62	228.00
IUUC-Ssl-108432	Sclerotinia sclerotiorum	80.54	3.00e-73	265.00
IUUC-Smo-109036	Selaginella moellendorffii	64.67	7.00e-60	220.00
IUUC-Sit-110731	Setaria italica	64.00	3.00e-59	218.00
IUUC-Sly-111506	Solanum lycopersicum	64.00	2.00e-59	219.00
IUUC-Stu-112080	Solanum tuberosum	64.00	2.00e-59	219.00
IUUC-Sar-113429	Sorex araneus	69.33	3.00e-63	231.00
IUUC-Sbi-114289	Sorghum bicolor	64.00	3.00e-59	218.00
IUUC-Sre-115106	Sporisorium reilianum	70.47	2.00e-59	219.00
IUUC-Ssc-116265	Sus scrofa	69.13	4.00e-63	231.00
IUUC-Tgu-117383	Taeniopygia guttata	69.13	4.00e-63	231.00
IUUC-Tru-118576	Takifugu rubripes	69.13	7.00e-63	230.00
IUUC-Tsy-119000	Tarsius syrichta	69.33	3.00e-63	231.00
IUUC-Tni-119745	Tetraodon nigroviridis	68.67	5.00e-63	230.00
IUUC-Tca-121827	Theobroma cacao	64.67	1.00e-59	219.00
IUUC-Tre-122002	Trichoderma reesei	81.88	5.00e-75	270.00
IUUC-Tvi-122331	Trichoderma virens	81.88	5.00e-75	270.00
IUUC-Tae-124461	Triticum aestivum	63.33	5.00e-59	218.00
IUUC-Tur-126866	Triticum urartu	62.00	4.00e-58	214.00
IUUC-Tme-127148	Tuber melanosporum	81.88	1.00e-74	269.00
IUUC-Tbe-127921	Tupaia belangeri	67.33	1.00e-58	216.00
IUUC-Ttr-129121	Tursiops truncatus	69.33	3.00e-63	231.00
IUUC-Uma-129561	Ustilago maydis	70.47	1.00e-59	219.00
IUUC-Vda-129711	Verticillium dahliae	82.55	1.00e-75	272.00
IUUC-Vpa-130570	Vicugna pacos	60.74	7.00e-48	180.00
IUUC-Vvi-131108	Vitis vinifera	64.00	6.00e-60	220.00
IUUC-Xtr-131824	Xenopus tropicalis	69.33	2.00e-63	231.00
IUUC-Xma-133937	Xiphophorus maculatus	69.13	4.00e-63	231.00
IUUC-Yli-134660	Yarrowia lipolytica	81.33	1.00e-74	269.00
IUUC-Zma-135584	Zea mays	62.67	5.00e-59	218.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence