iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Cel-018629

Ensembl Protein ID

F22B7.6a

UniProt Accession

P34409; A8WFE8; A8WFE9; POLK_CAEEL

Genbank Protein ID

CCD62142.1; CCD62143.1

Protein Name

DNA polymerase kappa

Genbank Nucleotide ID

FO080222; FO080222

Gene Name

polk-1; F22B7.6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
WBGene00017696	F22B7.6a	F22B7.6a

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
IID
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/ZnF/UBZ	43.05	1.00e-99	361.00	IUUC-Hsa-046294
UBD/ZnF/UBZ	41.62	3.00e-98	356.00	IUUC-Mmu-063675

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Caenorhabditis elegans

Functional Description
(View)

DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity (By similarity).

Protein Sequence
(Fasta)

MLTFNDNKAG MNGLDKEKIT KVIEENTSAS YSSFSKKQQS RIEEKVLEIK NRLQTATREE 60
RQKSEILMEN LEMKLESSRD LSRDCVCIDM DAYFAAVEMR DNPALRTVPM AVGSSAMLST 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TACGCGCATT TGCACACTCA CAATCAGTGG AGTTTCTCCG CGAATTTCAA AATCCGGCTC 60
TTTTTCGTGA AAAATGCTGA CTTTCAACGA TAATAAAGCT GGAATGAATG GACTGGATAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0235--DNA replication
KW-0237--DNA synthesis
KW-0239--DNA-directed DNA polymerase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0515--Mutator protein
KW-0548--Nucleotidyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0704--Schiff base
KW-0808--Transferase

Interpro

IPR017961--DNA_pol_Y-fam_little_finger
IPR022880--DNApol_IV
IPR024728--PolY_HhH_motif
IPR001126--UmuC

PROSITE

PS50173--UMUC

Pfam

PF00817--IMS
PF11799--IMS_C
PF11798--IMS_HHH

Gene Ontology

GO:0005634--C:nucleus
GO:0003684--F:damaged DNA binding
GO:0003887--F:DNA-directed DNA polymerase activity
GO:0046872--F:metal ion binding
GO:0006260--P:DNA replication
GO:0009792--P:embryo development ending in birth or egg hatching
GO:0042276--P:error-prone translesion synthesis
GO:0000003--P:reproduction
GO:0019985--P:translesion synthesis

KEGG

cel:CELE_F22B7.6

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001908	Ailuropoda melanoleuca	43.30	4.00e-103	367.00
IUUC-Apl-003228	Anas platyrhynchos	42.97	6.00e-92	330.00
IUUC-Aca-005080	Anolis carolinensis	43.07	2.00e-102	365.00
IUUC-Afl-008688	Aspergillus flavus	41.13	8.00e-29	120.00
IUUC-Afu-008792	Aspergillus fumigatus	35.89	7.00e-72	263.00
IUUC-Aor-010225	Aspergillus oryzae	41.13	9.00e-29	120.00
IUUC-Ame-011889	Astyanax mexicanus	43.08	4.00e-93	334.00
IUUC-Bta-013127	Bos taurus	43.22	2.00e-104	372.00
IUUC-Bra-017144	Brassica rapa	36.17	2.00e-77	281.00
IUUC-Cja-019598	Callithrix jacchus	43.50	3.00e-100	358.00
IUUC-Cfa-020661	Canis familiaris	42.86	2.00e-102	365.00
IUUC-Cpo-022040	Cavia porcellus	41.17	7.00e-93	333.00
IUUC-Csa-023669	Chlorocebus sabaeus	43.11	3.00e-104	371.00
IUUC-Cho-024910	Choloepus hoffmanni	44.21	7.00e-42	164.00
IUUC-Csv-026293	Ciona savignyi	41.51	2.00e-93	335.00
IUUC-Dre-028317	Danio rerio	42.50	1.00e-95	342.00
IUUC-Dno-029973	Dasypus novemcinctus	41.97	6.00e-103	367.00
IUUC-Dor-030667	Dipodomys ordii	42.03	1.00e-105	376.00
IUUC-Dse-031339	Dothistroma septosporum	34.16	2.00e-66	245.00
IUUC-Ete-033030	Echinops telfairi	43.05	6.00e-103	367.00
IUUC-Eca-033959	Equus caballus	43.00	2.00e-106	379.00
IUUC-Fca-036160	Felis catus	43.52	3.00e-102	365.00
IUUC-Fal-037116	Ficedula albicollis	43.05	6.00e-97	347.00
IUUC-Gmo-039003	Gadus morhua	41.92	1.00e-98	353.00
IUUC-Gga-040431	Gallus gallus	42.75	4.00e-97	348.00
IUUC-Gac-042455	Gasterosteus aculeatus	40.58	2.00e-92	332.00
IUUC-Gma-043303	Glycine max	37.15	5.00e-54	204.00
IUUC-Ggo-045024	Gorilla gorilla	43.08	8.00e-100	357.00
IUUC-Hsa-046294	Homo sapiens	43.05	2.00e-103	369.00
IUUC-Itr-048670	Ictidomys tridecemlineatus	43.11	2.00e-103	369.00
IUUC-Lch-050251	Latimeria chalumnae	36.99	3.00e-82	298.00
IUUC-Loc-051939	Lepisosteus oculatus	40.16	1.00e-94	340.00
IUUC-Laf-054562	Loxodonta africana	40.23	1.00e-95	343.00
IUUC-Mcc-055653	Macaca mulatta	42.91	1.00e-103	369.00
IUUC-Meu-055994	Macropus eugenii	40.87	1.00e-62	233.00
IUUC-Mga-059228	Meleagris gallopavo	36.70	2.00e-66	246.00
IUUC-Mvi-060383	Microbotryum violaceum	30.40	3.00e-47	182.00
IUUC-Mmr-061202	Microcebus murinus	42.72	3.00e-103	368.00
IUUC-Mdo-062829	Monodelphis domestica	42.26	3.00e-103	368.00
IUUC-Mmu-063675	Mus musculus	42.00	2.00e-104	372.00
IUUC-Mpu-066825	Mustela putorius furo	42.50	2.00e-103	369.00
IUUC-Mlu-067316	Myotis lucifugus	43.69	3.00e-106	378.00
IUUC-Nle-069272	Nomascus leucogenys	42.88	6.00e-104	370.00
IUUC-Opr-070616	Ochotona princeps	41.94	1.00e-103	369.00
IUUC-Ont-072011	Oreochromis niloticus	40.08	2.00e-92	332.00
IUUC-Oan-073343	Ornithorhynchus anatinus	40.69	2.00e-98	352.00
IUUC-Ocu-073766	Oryctolagus cuniculus	44.39	7.00e-94	337.00
IUUC-Ogl-077190	Oryza glaberrima	36.14	3.00e-72	265.00
IUUC-Ogu-078415	Oryza glumaepatula	36.68	3.00e-78	285.00
IUUC-Osa-085963	Oryza sativa	36.14	2.00e-72	265.00
IUUC-Ola-087034	Oryzias latipes	42.75	2.00e-98	352.00
IUUC-Oga-088157	Otolemur garnettii	40.59	4.00e-99	354.00
IUUC-Oar-089218	Ovis aries	42.86	2.00e-105	375.00
IUUC-Ptr-091552	Pan troglodytes	43.05	1.00e-103	369.00
IUUC-Pan-092646	Papio anubis	42.94	4.00e-100	358.00
IUUC-Psi-093608	Pelodiscus sinensis	42.59	9.00e-101	360.00
IUUC-Pma-094381	Petromyzon marinus	42.31	6.00e-98	350.00
IUUC-Pno-095081	Phaeosphaeria nodorum	39.57	1.00e-38	152.00
IUUC-Pfo-096545	Poecilia formosa	43.51	9.00e-103	366.00
IUUC-Pab-097613	Pongo abelii	39.67	5.00e-94	337.00
IUUC-Pca-101071	Procavia capensis	43.21	3.00e-33	135.00
IUUC-Pva-102252	Pteropus vampyrus	43.00	1.00e-108	386.00
IUUC-Pgr-103567	Puccinia graminis	29.27	3.00e-43	168.00
IUUC-Ptt-103934	Puccinia triticina	29.75	1.00e-27	116.00
IUUC-Rno-105793	Rattus norvegicus	42.20	4.00e-101	361.00
IUUC-Sha-107230	Sarcophilus harrisii	43.10	3.00e-105	375.00
IUUC-Spo-108028	Schizosaccharomyces pombe	30.78	2.00e-65	242.00
IUUC-Smo-109490	Selaginella moellendorffii	29.75	5.00e-27	113.00
IUUC-Sly-111390	Solanum lycopersicum	38.49	3.00e-84	305.00
IUUC-Stu-112284	Solanum tuberosum	38.70	4.00e-86	311.00
IUUC-Sar-113594	Sorex araneus	37.79	5.00e-79	288.00
IUUC-Sre-115078	Sporisorium reilianum	29.22	4.00e-34	138.00
IUUC-Ssc-116013	Sus scrofa	43.08	2.00e-104	372.00
IUUC-Tgu-117442	Taeniopygia guttata	43.02	3.00e-97	348.00
IUUC-Tru-117935	Takifugu rubripes	39.43	1.00e-93	335.00
IUUC-Tsy-119489	Tarsius syrichta	46.04	5.00e-47	181.00
IUUC-Tni-120543	Tetraodon nigroviridis	39.77	2.00e-91	328.00
IUUC-Tbe-128112	Tupaia belangeri	46.92	2.00e-55	209.00
IUUC-Ttr-128371	Tursiops truncatus	35.80	8.00e-72	264.00
IUUC-Uma-129377	Ustilago maydis	30.52	2.00e-49	189.00
IUUC-Vpa-130243	Vicugna pacos	43.58	3.00e-106	378.00
IUUC-Xtr-132453	Xenopus tropicalis	44.89	6.00e-106	377.00
IUUC-Xma-133255	Xiphophorus maculatus	41.73	1.00e-102	366.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence