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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046002
Ensembl Protein ID ENSP00000448054.1
UniProt Accession Q8NFH4; Q9H644; NUP37_HUMAN
Genbank Protein ID AAM76705.1; AAH00861.2; BAB15422.1
Protein Name Nucleoporin Nup37; Nup107-160 subcomplex subunit Nup37
Genbank Nucleotide ID AF514994; BC000861; AK026271
Gene Name NUP37
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000075188.8 ENST00000552283.5 ENSP00000448054.1
ENSG00000075188.8 ENST00000547269.1 ENSP00000447284.1
ENSG00000075188.8 ENST00000551744.2 ENSP00000448086.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDB
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDBioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.80e-06 29.1 122 154
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDl 30
           gHtd +++l f   +   ++s sdD+t+++W+l
   Q: 122  GHTDFINGLVFdpKEgQEIASVSDDHTCRIWNL 154
           8**********9644688**************7 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.
 Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.
Protein Sequence
(Fasta)
MKQDASRNAA YTVDCEDYVH VVEFNPFENG DSGNLIAYGG NNYVVIGTCT FQEEEADVEG 60
IQYKTLRTFH HGVRVDGIAW SPETRLDSLP PVIKFCTSAA DMKIRLFTSD LQDKNEYKVL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046002|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAGCAGAGCC ACAGCGCGTC GCGGCAGCCC CCAAGGAAGA CCAGCCTGCC TCTGGTCGGT 60
TCCTGGCGCT CTGCGGTGCG TATCGAGCTG GGAGCCCGAG AGGCCGGGAT GCTTTTCTGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046002|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0131--Cell cycle
KW-0132--Cell division
KW-0137--Centromere
KW-0158--Chromosome
KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-0995--Kinetochore
KW-0498--Mitosis
KW-0509--mRNA transport
KW-0906--Nuclear pore complex
KW-0539--Nucleus
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0811--Translocation
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0000777--C:condensed chromosome kinetochore
GO:0005829--C:cytosol
GO:0005635--C:nuclear envelope
GO:0031080--C:nuclear pore outer ring
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0051301--P:cell division
GO:0031047--P:gene silencing by RNA
GO:0075733--P:intracellular transport of virus
GO:0007067--P:mitotic nuclear division
GO:0007077--P:mitotic nuclear envelope disassembly
GO:0006406--P:mRNA export from nucleus
GO:0016925--P:protein sumoylation
GO:1900034--P:regulation of cellular response to heat
GO:0010827--P:regulation of glucose transport
GO:0007062--P:sister chromatid cohesion
GO:0006409--P:tRNA export from nucleus
GO:0016032--P:viral process
GO:0019083--P:viral transcription
KEGG hsa:79023
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002109 Ailuropoda melanoleuca 93.56 0.00e+00 634.00
IUUC-Aca-004272 Anolis carolinensis 75.46 2.00e-156 545.00
IUUC-Bta-012525 Bos taurus 94.79 0.00e+00 663.00
IUUC-Cfa-020623 Canis familiaris 94.17 0.00e+00 657.00
IUUC-Cpo-021545 Cavia porcellus 89.57 0.00e+00 631.00
IUUC-Csa-023698 Chlorocebus sabaeus 99.69 0.00e+00 685.00
IUUC-Cho-024401 Choloepus hoffmanni 89.76 8.00e-140 489.00
IUUC-Cin-025648 Ciona intestinalis 33.95 9.00e-40 157.00
IUUC-Csv-025913 Ciona savignyi 32.31 6.00e-38 150.00
IUUC-Dre-027990 Danio rerio 69.02 9.00e-142 496.00
IUUC-Dor-031077 Dipodomys ordii 89.91 2.00e-179 620.00
IUUC-Dme-031831 Drosophila melanogaster 31.44 4.00e-38 151.00
IUUC-Ete-032819 Echinops telfairi 89.88 0.00e+00 635.00
IUUC-Eca-033212 Equus caballus 95.40 0.00e+00 667.00
IUUC-Fca-036071 Felis catus 91.84 0.00e+00 649.00
IUUC-Fal-036718 Ficedula albicollis 79.14 3.00e-166 577.00
IUUC-Gmo-039710 Gadus morhua 66.87 7.00e-141 493.00
IUUC-Gga-041026 Gallus gallus 78.22 5.00e-165 573.00
IUUC-Gac-041726 Gasterosteus aculeatus 68.71 4.00e-144 504.00
IUUC-Ggo-045372 Gorilla gorilla 99.69 0.00e+00 684.00
IUUC-Itr-048542 Ictidomys tridecemlineatus 92.02 0.00e+00 644.00
IUUC-Lch-049456 Latimeria chalumnae 76.99 4.00e-148 517.00
IUUC-Loc-052159 Lepisosteus oculatus 56.85 7.00e-117 413.00
IUUC-Laf-053514 Loxodonta africana 91.72 0.00e+00 644.00
IUUC-Mcc-055148 Macaca mulatta 100.00 0.00e+00 686.00
IUUC-Meu-056644 Macropus eugenii 69.02 2.00e-131 461.00
IUUC-Mga-060061 Meleagris gallopavo 78.22 2.00e-164 571.00
IUUC-Mmr-061448 Microcebus murinus 95.71 0.00e+00 665.00
IUUC-Mdo-063006 Monodelphis domestica 85.58 1.00e-174 605.00
IUUC-Mmu-063269 Mus musculus 91.10 0.00e+00 641.00
IUUC-Mpu-066663 Mustela putorius furo 93.56 0.00e+00 654.00
IUUC-Nle-069989 Nomascus leucogenys 100.00 0.00e+00 686.00
IUUC-Ont-072544 Oreochromis niloticus 68.40 5.00e-141 493.00
IUUC-Oan-073360 Ornithorhynchus anatinus 83.38 1.00e-171 595.00
IUUC-Ola-087370 Oryzias latipes 64.11 1.00e-131 462.00
IUUC-Oar-089696 Ovis aries 95.40 0.00e+00 664.00
IUUC-Ptr-091333 Pan troglodytes 100.00 0.00e+00 686.00
IUUC-Pan-091814 Papio anubis 100.00 0.00e+00 686.00
IUUC-Psi-093497 Pelodiscus sinensis 81.90 3.00e-170 590.00
IUUC-Pfo-096789 Poecilia formosa 68.81 6.00e-142 496.00
IUUC-Pab-098451 Pongo abelii 99.69 0.00e+00 685.00
IUUC-Pca-101057 Procavia capensis 73.72 3.00e-116 411.00
IUUC-Pva-102866 Pteropus vampyrus 93.87 0.00e+00 656.00
IUUC-Pgr-103570 Puccinia graminis 25.40 3.00e-09 56.20
IUUC-Rno-106000 Rattus norvegicus 89.26 0.00e+00 626.00
IUUC-Sha-106639 Sarcophilus harrisii 86.50 4.00e-176 610.00
IUUC-Sja-108011 Schizosaccharomyces japonicus 28.95 1.00e-07 50.80
IUUC-Spo-108334 Schizosaccharomyces pombe 28.87 1.00e-08 54.30
IUUC-Ssc-115982 Sus scrofa 90.51 8.00e-151 525.00
IUUC-Tgu-116575 Taeniopygia guttata 78.53 1.00e-164 572.00
IUUC-Tru-117729 Takifugu rubripes 68.71 7.00e-142 496.00
IUUC-Tsy-118870 Tarsius syrichta 78.83 3.00e-153 534.00
IUUC-Tni-120524 Tetraodon nigroviridis 68.69 2.00e-141 495.00
IUUC-Ttr-128693 Tursiops truncatus 89.57 7.00e-170 589.00
IUUC-Vpa-130328 Vicugna pacos 91.05 4.00e-173 600.00
IUUC-Xtr-132017 Xenopus tropicalis 70.55 5.00e-145 506.00
Created Date 25-Jun-2017

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