iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pma-094380

UUCD1 version

UUC-PeM-00502

Ensembl Protein ID

ENSPMAP00000008275.1

UniProt Accession

S4RST5; S4RST5_PETMA

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPMAG00000007476.1	ENSPMAT00000008313.1	ENSPMAP00000008275.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.70e-95	319.9	13	500

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvn 89
           YDRQ+rlwG+++q++l++a+v+l++a ++G+E+lKnLvl G+g +t++D+++v+ ++++++F+++++++g s+A++a++ ++eln+dv+
   Q: 13   YDRQLRLWGDHGQQALENAHVCLINASATGTEILKNLVLPGIGAFTILDGNKVSGEDIGNNFFLDKSSIGESRAKTAMNLIQELNSDVS 101
           ***************************************************************************************** PP
   S: 90   veaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfc 174
           + ++ee +++  e+++ Ff kf+vV++++ + ++ ++++ ++++a vpl+ ++++G+ G++rv ++++t+ +s++d   ++++++ Pf+
   Q: 102  GNFVEEAVEKVLEKEPtFFHKFTVVITTQLPQSTLLRLAAALWEAGVPLLACRAYGMTGYMRVALREHTVVESHPDnalEDLRLDRPFP 190
           **************99************************************************************************* PP
   S: 175  tlketpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkafakt 248
            l ++ +         +++++++w v+++k+l+ ++++++++ +++++ek ++k+++++++ +        eenfeeai+++++a+++t
   Q: 191  ALVKHLAscdlalldkKEHSHTPWLVVVAKYLDVWRSQHDGSLPKNYKEKDQFKELIRQGMIKnehgasSVEENFEEAIKNTTTALNPT 279
           *****77788888888**********************************************999999999****************** PP
   S: 249  tins.ikqllksfecdivtkskspfwv.............................................................. 274
            i++ ++ql+++++c+ ++ ++++fwv                                                              
   Q: 280  RIPDvVRQLFSDPSCQSLSAKSADFWVlvralrdfveaeggegalplrgsipdmiadsdkfvrlqnvyrekakqdadavgkltasllhs 368
           ***************************************************************************************** PP
   S: 275  ..............sfcsnaealqvp.............ekvekdeevvkasap................lylllralerfekkkgrkp 320
                          fc+ a+ l+v                                             l ++lra++rf +++gr+p
   Q: 369  lgrpadgisegdvrLFCKHAAFLRVVrcrslaeeydaktA-------------LtadigsqlesaegeavLNIMLRAVDRFYQQYGRYP 444
           **************99999999996655544444444332.............12222233333346788******************* PP
   S: 321  gelsfekdddsavdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgG 378
           g+   ++d d + +l + +a l  ++ g+   ++d++++e++++++++ +t+++++gG
   Q: 445  GVRAEDVDRD-VAELRACVAGLL-HEWGLHCTVKDEYLHEFCRYGAAEPHTVASFIGG 500
           8888888888.888888888777.999*9999*************************9 PP

Organism

Petromyzon marinus

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

Protein Sequence
(Fasta)

KSQTLAKEKE RRYDRQLRLW GDHGQQALEN AHVCLINASA TGTEILKNLV LPGIGAFTIL 60
DGNKVSGEDI GNNFFLDKSS IGESRAKTAM NLIQELNSDV SGNFVEEAVE KVLEKEPTFF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGAGCCAGA CGCTCGCCAA GGAGAAAGAG AGGAGATACG ACCGACAGCT GAGGTGAATG 60
CCGCCCCTTG CGACGCCTGG CGGCCTCGCG CGCTCGCCGT TTTGTTTTTG AGGGAGGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	40.52	1.00e-110	391.00
IUUC-Aml-002333	Ailuropoda melanoleuca	61.62	0.00e+00	676.00
IUUC-Atr-002644	Amborella trichopoda	39.47	4.00e-100	357.00
IUUC-Apl-003446	Anas platyrhynchos	62.89	0.00e+00	658.00
IUUC-Aca-004450	Anolis carolinensis	59.55	0.00e+00	657.00
IUUC-Aly-006187	Arabidopsis lyrata	40.28	3.00e-113	400.00
IUUC-Ath-007600	Arabidopsis thaliana	40.73	1.00e-115	408.00
IUUC-Ago-007900	Ashbya gossypii	28.79	7.00e-33	133.00
IUUC-Acl-008333	Aspergillus clavatus	37.72	2.00e-76	278.00
IUUC-Afl-008529	Aspergillus flavus	34.49	1.00e-79	288.00
IUUC-Afu-009071	Aspergillus fumigatus	38.88	7.00e-76	276.00
IUUC-Ani-009443	Aspergillus nidulans	38.93	2.00e-73	268.00
IUUC-Ang-009669	Aspergillus niger	38.50	4.00e-77	280.00
IUUC-Aor-009914	Aspergillus oryzae	34.16	3.00e-77	281.00
IUUC-Ate-010450	Aspergillus terreus	35.19	9.00e-78	283.00
IUUC-Ame-011183	Astyanax mexicanus	63.29	0.00e+00	684.00
IUUC-Bgr-012111	Blumeria graminis	36.57	9.00e-58	216.00
IUUC-Bta-012583	Bos taurus	61.46	0.00e+00	674.00
IUUC-Bci-013892	Botrytis cinerea	37.78	7.00e-60	223.00
IUUC-Bdi-014592	Brachypodium distachyon	41.85	4.00e-112	396.00
IUUC-Bol-016399	Brassica oleracea	39.92	2.00e-112	397.00
IUUC-Bra-017506	Brassica rapa	39.20	1.00e-108	385.00
IUUC-Cel-018456	Caenorhabditis elegans	32.34	5.00e-77	280.00
IUUC-Cja-020007	Callithrix jacchus	61.49	0.00e+00	674.00
IUUC-Cfa-020324	Canis familiaris	62.07	0.00e+00	683.00
IUUC-Cpo-022248	Cavia porcellus	53.56	4.00e-113	399.00
IUUC-Csa-023149	Chlorocebus sabaeus	57.08	2.00e-157	547.00
IUUC-Cho-024537	Choloepus hoffmanni	49.30	2.00e-130	457.00
IUUC-Cin-025763	Ciona intestinalis	50.50	3.00e-149	520.00
IUUC-Csv-026113	Ciona savignyi	47.39	9.00e-144	501.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	34.22	2.00e-59	221.00
IUUC-Cne-026884	Cryptococcus neoformans	30.69	9.00e-66	243.00
IUUC-Cme-027210	Cyanidioschyzon merolae	26.58	7.00e-19	87.40
IUUC-Dre-028140	Danio rerio	62.07	0.00e+00	676.00
IUUC-Dno-030033	Dasypus novemcinctus	61.12	0.00e+00	625.00
IUUC-Dor-030513	Dipodomys ordii	41.46	1.00e-102	365.00
IUUC-Dse-031536	Dothistroma septosporum	34.27	8.00e-77	279.00
IUUC-Dme-031683	Drosophila melanogaster	46.17	2.00e-121	427.00
IUUC-Ete-032420	Echinops telfairi	52.80	5.00e-160	555.00
IUUC-Eca-033992	Equus caballus	58.25	7.00e-155	538.00
IUUC-Eeu-034713	Erinaceus europaeus	43.89	2.00e-54	205.00
IUUC-Fca-036548	Felis catus	61.66	0.00e+00	679.00
IUUC-Fal-037600	Ficedula albicollis	62.92	0.00e+00	659.00
IUUC-Fox-038037	Fusarium oxysporum	36.32	2.00e-68	251.00
IUUC-Fso-038387	Fusarium solani	36.32	3.00e-65	241.00
IUUC-Gmo-038562	Gadus morhua	60.04	0.00e+00	667.00
IUUC-Ggr-040005	Gaeumannomyces graminis	35.12	4.00e-65	240.00
IUUC-Gga-041129	Gallus gallus	62.01	0.00e+00	663.00
IUUC-Gac-042558	Gasterosteus aculeatus	60.40	0.00e+00	663.00
IUUC-Gma-043610	Glycine max	40.49	3.00e-110	390.00
IUUC-Ggo-045611	Gorilla gorilla	61.69	0.00e+00	674.00
IUUC-Hsa-046563	Homo sapiens	62.07	0.00e+00	679.00
IUUC-Hvu-047790	Hordeum vulgare	36.49	2.00e-63	234.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	61.87	0.00e+00	672.00
IUUC-Kpa-049309	Komagataella pastoris	33.40	9.00e-71	259.00
IUUC-Lch-050038	Latimeria chalumnae	62.15	0.00e+00	673.00
IUUC-Lpe-051535	Leersia perrieri	38.91	3.00e-99	353.00
IUUC-Loc-051917	Lepisosteus oculatus	58.42	4.00e-177	612.00
IUUC-Lma-053112	Leptosphaeria maculans	33.72	2.00e-75	275.00
IUUC-Laf-053690	Loxodonta africana	61.87	0.00e+00	680.00
IUUC-Mcc-055117	Macaca mulatta	60.36	0.00e+00	659.00
IUUC-Meu-056761	Macropus eugenii	50.00	2.00e-146	510.00
IUUC-Mor-057230	Magnaporthe oryzae	33.98	6.00e-68	250.00
IUUC-Mpo-057514	Magnaporthe poae	35.85	3.00e-66	244.00
IUUC-Mtr-058551	Medicago truncatula	40.20	3.00e-106	377.00
IUUC-Mla-059183	Melampsora laricipopulina	39.88	6.00e-98	349.00
IUUC-Mga-060144	Meleagris gallopavo	61.20	0.00e+00	647.00
IUUC-Mvi-060221	Microbotryum violaceum	39.08	2.00e-77	281.00
IUUC-Mmr-061325	Microcebus murinus	60.28	0.00e+00	661.00
IUUC-Mdo-062532	Monodelphis domestica	62.27	0.00e+00	679.00
IUUC-Mmu-063956	Mus musculus	62.07	0.00e+00	678.00
IUUC-Mac-064521	Musa acuminata	40.24	4.00e-112	396.00
IUUC-Mpu-066716	Mustela putorius furo	61.51	0.00e+00	674.00
IUUC-Mlu-067459	Myotis lucifugus	61.45	0.00e+00	679.00
IUUC-Nfi-068245	Neosartorya fischeri	37.39	4.00e-75	274.00
IUUC-Ncr-068910	Neurospora crassa	36.91	1.00e-67	249.00
IUUC-Nle-070034	Nomascus leucogenys	60.74	0.00e+00	647.00
IUUC-Opr-070552	Ochotona princeps	56.88	2.00e-168	583.00
IUUC-Ont-071426	Oreochromis niloticus	62.68	0.00e+00	686.00
IUUC-Oan-073389	Ornithorhynchus anatinus	55.80	4.00e-146	509.00
IUUC-Ocu-074911	Oryctolagus cuniculus	62.68	0.00e+00	682.00
IUUC-Oba-075437	Oryza barthii	40.64	8.00e-102	362.00
IUUC-Obr-076684	Oryza brachyantha	40.53	2.00e-94	338.00
IUUC-Ogl-077170	Oryza glaberrima	40.64	8.00e-102	362.00
IUUC-Ogu-078844	Oryza glumaepatula	40.85	1.00e-101	361.00
IUUC-Oin-079105	Oryza indica	40.64	3.00e-101	360.00
IUUC-Olo-080943	Oryza longistaminata	37.90	5.00e-95	339.00
IUUC-Oni-082891	Oryza nivara	37.63	8.00e-94	335.00
IUUC-Opu-083457	Oryza punctata	40.64	2.00e-101	360.00
IUUC-Oru-084960	Oryza rufipogon	37.90	5.00e-95	340.00
IUUC-Osa-085358	Oryza sativa	41.01	1.00e-101	362.00
IUUC-Ola-086420	Oryzias latipes	57.35	5.00e-124	436.00
IUUC-Olu-087625	Ostreococcus lucimarinus	30.02	8.00e-48	183.00
IUUC-Oga-088810	Otolemur garnettii	61.05	0.00e+00	676.00
IUUC-Oar-089196	Ovis aries	61.29	0.00e+00	671.00
IUUC-Ptr-090617	Pan troglodytes	62.07	0.00e+00	679.00
IUUC-Pan-092761	Papio anubis	62.27	0.00e+00	681.00
IUUC-Psi-093191	Pelodiscus sinensis	61.16	0.00e+00	662.00
IUUC-Pno-095084	Phaeosphaeria nodorum	32.55	9.00e-66	244.00
IUUC-Ppa-095798	Physcomitrella patens	39.41	1.00e-108	385.00
IUUC-Pfo-096467	Poecilia formosa	61.49	0.00e+00	671.00
IUUC-Pab-098255	Pongo abelii	62.93	1.00e-174	603.00
IUUC-Pop-099722	Populus trichocarpa	40.93	1.00e-116	411.00
IUUC-Pca-100807	Procavia capensis	55.47	4.00e-84	303.00
IUUC-Ppe-101280	Prunus persica	40.28	5.00e-112	396.00
IUUC-Pva-102333	Pteropus vampyrus	60.89	0.00e+00	648.00
IUUC-Pgr-103401	Puccinia graminis	29.84	2.00e-66	245.00
IUUC-Ptt-103889	Puccinia triticina	29.19	1.00e-55	209.00
IUUC-Pte-104355	Pyrenophora teres	33.52	3.00e-73	268.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	33.71	2.00e-74	271.00
IUUC-Rno-105810	Rattus norvegicus	61.87	0.00e+00	675.00
IUUC-Sce-106397	Saccharomyces cerevisiae	27.68	2.00e-31	128.00
IUUC-Sha-106770	Sarcophilus harrisii	68.13	2.00e-116	410.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	31.64	3.00e-63	234.00
IUUC-Spo-108276	Schizosaccharomyces pombe	30.32	1.00e-64	238.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	38.65	9.00e-63	233.00
IUUC-Smo-109296	Selaginella moellendorffii	40.88	3.00e-107	380.00
IUUC-Sit-110157	Setaria italica	41.94	1.00e-117	415.00
IUUC-Sly-111105	Solanum lycopersicum	39.88	3.00e-113	400.00
IUUC-Stu-112469	Solanum tuberosum	39.49	4.00e-114	403.00
IUUC-Sar-113083	Sorex araneus	45.76	3.00e-132	463.00
IUUC-Sbi-113813	Sorghum bicolor	41.45	2.00e-116	410.00
IUUC-Sre-115058	Sporisorium reilianum	38.27	1.00e-80	292.00
IUUC-Tgu-116772	Taeniopygia guttata	62.68	0.00e+00	662.00
IUUC-Tru-118686	Takifugu rubripes	59.43	0.00e+00	664.00
IUUC-Tsy-119111	Tarsius syrichta	62.55	9.00e-104	369.00
IUUC-Tni-120231	Tetraodon nigroviridis	55.04	5.00e-174	602.00
IUUC-Tca-121491	Theobroma cacao	39.88	3.00e-105	374.00
IUUC-Tre-122103	Trichoderma reesei	36.91	6.00e-68	250.00
IUUC-Tvi-122672	Trichoderma virens	37.30	9.00e-68	249.00
IUUC-Tae-125679	Triticum aestivum	41.13	3.00e-112	397.00
IUUC-Tur-126487	Triticum urartu	39.63	5.00e-106	376.00
IUUC-Tme-127097	Tuber melanosporum	35.60	1.00e-82	298.00
IUUC-Ttr-128465	Tursiops truncatus	58.06	3.00e-179	620.00
IUUC-Uma-129645	Ustilago maydis	37.99	3.00e-82	297.00
IUUC-Vda-129989	Verticillium dahliae	32.67	1.00e-50	192.00
IUUC-Vpa-130529	Vicugna pacos	58.47	0.00e+00	629.00
IUUC-Vvi-131059	Vitis vinifera	40.73	2.00e-111	394.00
IUUC-Xtr-132002	Xenopus tropicalis	64.10	0.00e+00	701.00
IUUC-Xma-133930	Xiphophorus maculatus	62.47	0.00e+00	681.00
IUUC-Yli-134505	Yarrowia lipolytica	31.23	4.00e-68	250.00
IUUC-Zma-135895	Zea mays	41.45	5.00e-115	406.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence