iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-004071

Ensembl Protein ID

ENSAPLP00000001472.1

UniProt Accession

U3I2K2; U3I2K2_ANAPL

Genbank Protein ID

ENSAPLP00000001472

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADON01084899

Gene Name

AREL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000001964.1	ENSAPLT00000002046.1	ENSAPLP00000001472.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.00e-100	334.6	485	822

Active Site

Position(s)	Description	Evidence
790	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdg..... 85
           sd++k++ev f++Ee+ld+gG+ re+++l++k+l++++ +lf ++s+n+++ ++pnp + +  + +lkl+ef+Grl+gk+l+++     
   Q: 485  SDWSKNFEVVFQDEEALDWGGPRREWFELICKALFDTSSQLFtRFSDNNQALVHPNPVRPT--CVRLKLYEFAGRLVGKCLYESslgga 571
           7999**************************************888999**********996..58******************999999 PP
   S: 86   ..rlldlplsksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNke 171
             +l+++++++sf+ +++g +++++ +e+ dpe+yks + +i++n   d++e++l ++ ++ ++  +  k++eL++gG+++pVtneNk 
   Q: 572  ykQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSkVCFILNN---DVSEMDLVFAEEKYSKTGQLEKVVELVTGGAQVPVTNENKI 657
           99***********************************99****99...9*********9999999999********************* PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkket.kykggytedspaiqwFwevleefsse 259
            Y +l+++yrl ++++e+v++f +G+ne++p++ll++F+e+elell+cG+ +i+v d+k+++    g ++ ++++++wFw v+++f++e
   Q: 658  FYLNLLAQYRLANQVREEVDHFLKGLNELVPENLLAIFDENELELLMCGTGDISVCDFKAHAvVVGGSWHFREKVMRWFWTVVSSFTQE 746
           **************************************************************555788999****************** PP
   S: 260  erkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           e   +LqF+Tgss+lP+gGfa+l+p++ +i    +++ lP+++TCfn+L+LP+Y+s+e+++++L++Ai+e+ +gF++
   Q: 747  ELGWLLQFTTGSSQLPPGGFAALSPSFQIIAA-PTHSTLPTAHTCFNQLCLPTYDSYEEVHKMLQLAISEGcEGFGM 822
           ************************99555555.**************************************9***97 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

MFYIIGGITV FVVAFFFTIK FLFELAARIV SFLQHEDRER RGERTIYDYV RGNYLDPRSC 60
KISWDWKDPH EVGHSMAFRV HLFYKNGQPF PAHRPLGLRV HICHVELAID IPVTQEVLQE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTTTACA TTATTGGTAA GTGAAGGAAA GGCTGCCACT GTATTTGTTG ACCTCTCCAT 60
AGGCTTTAGA GGAATTTCTT GAAAGCCCCG GCTTTCACGT TAGCTTAGAG TCTACCTAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR017868--Filamin/ABP280_repeat-like
IPR000569--HECT_dom
IPR013783--Ig-like_fold
IPR014756--Ig_E-set

PROSITE

PS50194--FILAMIN_REPEAT
PS50237--HECT

Pfam

PF00630--Filamin
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0016021--C:integral component of membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043066--P:negative regulation of apoptotic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001308	Ailuropoda melanoleuca	91.61	0.00e+00	1545.00
IUUC-Aca-005218	Anolis carolinensis	94.17	0.00e+00	1524.00
IUUC-Ame-011871	Astyanax mexicanus	78.98	0.00e+00	1379.00
IUUC-Bta-012978	Bos taurus	91.01	0.00e+00	1537.00
IUUC-Cja-019081	Callithrix jacchus	90.89	0.00e+00	1540.00
IUUC-Cfa-020736	Canis familiaris	89.51	0.00e+00	1459.00
IUUC-Cpo-021581	Cavia porcellus	90.89	0.00e+00	1537.00
IUUC-Csa-024189	Chlorocebus sabaeus	88.94	0.00e+00	860.00
IUUC-Cho-024751	Choloepus hoffmanni	90.77	0.00e+00	1475.00
IUUC-Cin-025773	Ciona intestinalis	42.71	8.00e-148	516.00
IUUC-Csv-026090	Ciona savignyi	40.32	2.00e-171	595.00
IUUC-Dre-027788	Danio rerio	79.22	0.00e+00	1379.00
IUUC-Dno-030022	Dasypus novemcinctus	90.64	0.00e+00	1534.00
IUUC-Dme-031577	Drosophila melanogaster	47.19	0.00e+00	716.00
IUUC-Ete-032402	Echinops telfairi	89.01	0.00e+00	1460.00
IUUC-Eca-033908	Equus caballus	91.62	0.00e+00	1548.00
IUUC-Eeu-034869	Erinaceus europaeus	92.87	0.00e+00	878.00
IUUC-Fca-036023	Felis catus	91.86	0.00e+00	1548.00
IUUC-Fal-037477	Ficedula albicollis	96.60	0.00e+00	1588.00
IUUC-Gmo-039197	Gadus morhua	79.71	0.00e+00	1360.00
IUUC-Gga-040704	Gallus gallus	98.91	0.00e+00	1604.00
IUUC-Gac-041511	Gasterosteus aculeatus	78.37	0.00e+00	1364.00
IUUC-Ggo-044527	Gorilla gorilla	87.62	0.00e+00	1468.00
IUUC-Hsa-046082	Homo sapiens	90.89	0.00e+00	1540.00
IUUC-Itr-048168	Ictidomys tridecemlineatus	91.62	0.00e+00	1546.00
IUUC-Lch-049772	Latimeria chalumnae	76.79	0.00e+00	1241.00
IUUC-Loc-052541	Lepisosteus oculatus	81.45	0.00e+00	1396.00
IUUC-Laf-053852	Loxodonta africana	90.64	0.00e+00	1529.00
IUUC-Mcc-054759	Macaca mulatta	88.91	0.00e+00	776.00
IUUC-Meu-056247	Macropus eugenii	75.67	0.00e+00	812.00
IUUC-Mga-060161	Meleagris gallopavo	97.57	0.00e+00	1582.00
IUUC-Mmr-061447	Microcebus murinus	91.13	0.00e+00	1541.00
IUUC-Mdo-062110	Monodelphis domestica	90.52	0.00e+00	1479.00
IUUC-Mmu-064349	Mus musculus	90.77	0.00e+00	1540.00
IUUC-Mpu-065824	Mustela putorius furo	91.74	0.00e+00	1539.00
IUUC-Mlu-067729	Myotis lucifugus	91.49	0.00e+00	1515.00
IUUC-Nle-069721	Nomascus leucogenys	90.77	0.00e+00	1530.00
IUUC-Opr-070189	Ochotona princeps	91.55	0.00e+00	1536.00
IUUC-Ont-072122	Oreochromis niloticus	79.59	0.00e+00	1357.00
IUUC-Oan-072700	Ornithorhynchus anatinus	82.55	0.00e+00	1194.00
IUUC-Ocu-074057	Oryctolagus cuniculus	91.13	0.00e+00	1541.00
IUUC-Ola-087492	Oryzias latipes	78.74	0.00e+00	1366.00
IUUC-Oga-088084	Otolemur garnettii	91.13	0.00e+00	1536.00
IUUC-Oar-090354	Ovis aries	90.66	0.00e+00	1514.00
IUUC-Ptr-091456	Pan troglodytes	90.89	0.00e+00	1539.00
IUUC-Pan-092596	Papio anubis	89.68	0.00e+00	1509.00
IUUC-Psi-092942	Pelodiscus sinensis	94.41	0.00e+00	1553.00
IUUC-Pma-094662	Petromyzon marinus	63.21	0.00e+00	762.00
IUUC-Pfo-096838	Poecilia formosa	80.07	0.00e+00	1342.00
IUUC-Pab-097849	Pongo abelii	90.40	0.00e+00	1533.00
IUUC-Pca-100498	Procavia capensis	89.58	0.00e+00	885.00
IUUC-Pva-102599	Pteropus vampyrus	91.74	0.00e+00	1528.00
IUUC-Rno-105776	Rattus norvegicus	91.37	0.00e+00	1541.00
IUUC-Sha-106699	Sarcophilus harrisii	90.89	0.00e+00	1486.00
IUUC-Sar-113621	Sorex araneus	89.78	0.00e+00	1488.00
IUUC-Ssc-115742	Sus scrofa	91.13	0.00e+00	1542.00
IUUC-Tgu-116490	Taeniopygia guttata	96.35	0.00e+00	1588.00
IUUC-Tru-117679	Takifugu rubripes	79.22	0.00e+00	1352.00
IUUC-Tsy-119607	Tarsius syrichta	87.62	0.00e+00	1062.00
IUUC-Tni-120376	Tetraodon nigroviridis	75.49	0.00e+00	1270.00
IUUC-Tbe-127348	Tupaia belangeri	62.57	1.00e-169	589.00
IUUC-Ttr-128786	Tursiops truncatus	87.85	0.00e+00	1473.00
IUUC-Vpa-130180	Vicugna pacos	90.38	0.00e+00	1220.00
IUUC-Xtr-132631	Xenopus tropicalis	68.48	0.00e+00	1148.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence