iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-092596

Ensembl Protein ID

ENSPANP00000007680.1

UniProt Accession

A0A096N5G7; A0A096N5G7_PAPAN

Genbank Protein ID

ENSPANP00000007680

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHZZ01004447

Gene Name

AREL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000018774.1	ENSPANT00000004884.1	ENSPANP00000007680.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.80e-102	342.6	484	821

Active Site

Position(s)	Description	Evidence
789	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdg..... 85
           sd++k++ev f++Ee+ld+gG+ re+++l++k+l++++++lf ++s+n+++ ++pnp++  +   +lk++ef+Grl+gk+l+++     
   Q: 484  SDWSKNFEVVFQDEEALDWGGPRREWFELICKALFDTTNQLFtRFSDNNQALVHPNPNRPAH--LRLKMYEFAGRLVGKCLYESslgga 570
           7999**************************************888999***********975..9******************999999 PP
   S: 86   ..rlldlplsksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNke 171
             +l+++++++sf+ +++g +++++ +e+ dpe+yks + +i++n   d++e++l ++ ++ +++++  k++eL++gG+++pVtn+Nk 
   Q: 571  ykQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSkVCFILNN---DMSEMELVFAEEKYNKSVEIEKVVELMTGGAQTPVTNANKI 656
           99***********************************99****99...9**************************************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkket.kykggytedspaiqwFwevleefsse 259
            Y +l+++yrl +++ke+ve+f +G+ne++p++ll++F+e+elell+cG+ +i+v+d+k+++    g ++ ++++++wFw v++++++e
   Q: 657  FYLNLLAQYRLASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAvVVGGSWHFREKVMRWFWTVVSSLTQE 745
           **************************************************************555788999****************** PP
   S: 260  erkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           e +++LqF+Tgss+lP+gGfa+l p++ +i    +++ lP+++TCfn+L+LP+Y+s+e+++++L++Ai+e+ +gF++
   Q: 746  ELARLLQFTTGSSQLPPGGFAALCPSFQIIAA-PTHSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGcEGFGM 821
           ************************99555555.**************************************9***97 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MFYVIGGITV SVVAFFFTIK FLFELAARVV SFLQNEDRER RGDRTIYDYV RGNYLDPRSC 60
KVSWDWKDPY EVGHSMAFRV HLFYKNGQPF PAHRPVGLRV HISHVELAVE IPVTQEVLQE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATCCTGGGG CATCCTTTGG CAGCCGATTG TACCCTGCAC TAGAGAGAAG TCCAGGAATG 60
AGATATTCTT GGGCTGTATT TCTCTACCCT GGAATTCATC CAGTTCATCC CAGAAACACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR017868--Filamin/ABP280_repeat-like
IPR000569--HECT_dom
IPR013783--Ig-like_fold
IPR014756--Ig_E-set

PROSITE

PS50194--FILAMIN_REPEAT
PS50237--HECT

Pfam

PF00630--Filamin
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043066--P:negative regulation of apoptotic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001308	Ailuropoda melanoleuca	96.48	0.00e+00	1616.00
IUUC-Apl-004071	Anas platyrhynchos	89.68	0.00e+00	1443.00
IUUC-Aca-005218	Anolis carolinensis	90.18	0.00e+00	1473.00
IUUC-Ame-011871	Astyanax mexicanus	78.88	0.00e+00	1362.00
IUUC-Bta-012978	Bos taurus	95.87	0.00e+00	1608.00
IUUC-Cja-019081	Callithrix jacchus	98.18	0.00e+00	1640.00
IUUC-Cfa-020736	Canis familiaris	93.91	0.00e+00	1515.00
IUUC-Cpo-021581	Cavia porcellus	96.00	0.00e+00	1607.00
IUUC-Csa-024189	Chlorocebus sabaeus	97.50	0.00e+00	924.00
IUUC-Cho-024751	Choloepus hoffmanni	95.15	0.00e+00	1527.00
IUUC-Cin-025773	Ciona intestinalis	42.04	1.00e-145	510.00
IUUC-Csv-026090	Ciona savignyi	40.15	5.00e-171	594.00
IUUC-Dre-027788	Danio rerio	79.49	0.00e+00	1368.00
IUUC-Dno-030022	Dasypus novemcinctus	96.36	0.00e+00	1610.00
IUUC-Dme-031577	Drosophila melanogaster	46.62	0.00e+00	706.00
IUUC-Ete-032402	Echinops telfairi	93.78	0.00e+00	1527.00
IUUC-Eca-033908	Equus caballus	97.45	0.00e+00	1629.00
IUUC-Eeu-034869	Erinaceus europaeus	96.11	0.00e+00	900.00
IUUC-Fca-036023	Felis catus	96.48	0.00e+00	1616.00
IUUC-Fal-037477	Ficedula albicollis	90.41	0.00e+00	1504.00
IUUC-Gmo-039197	Gadus morhua	79.37	0.00e+00	1340.00
IUUC-Gga-040704	Gallus gallus	90.17	0.00e+00	1494.00
IUUC-Gac-041511	Gasterosteus aculeatus	78.03	0.00e+00	1346.00
IUUC-Ggo-044527	Gorilla gorilla	95.27	0.00e+00	1581.00
IUUC-Hsa-046082	Homo sapiens	98.54	0.00e+00	1644.00
IUUC-Itr-048168	Ictidomys tridecemlineatus	96.48	0.00e+00	1616.00
IUUC-Lch-049772	Latimeria chalumnae	75.73	0.00e+00	1217.00
IUUC-Loc-052541	Lepisosteus oculatus	80.75	0.00e+00	1376.00
IUUC-Laf-053852	Loxodonta africana	96.24	0.00e+00	1605.00
IUUC-Mcc-054759	Macaca mulatta	99.77	0.00e+00	859.00
IUUC-Meu-056247	Macropus eugenii	78.06	0.00e+00	838.00
IUUC-Mga-060161	Meleagris gallopavo	89.33	0.00e+00	1474.00
IUUC-Mmr-061447	Microcebus murinus	96.84	0.00e+00	1618.00
IUUC-Mdo-062110	Monodelphis domestica	93.33	0.00e+00	1511.00
IUUC-Mmu-064349	Mus musculus	95.75	0.00e+00	1608.00
IUUC-Mpu-065824	Mustela putorius furo	96.72	0.00e+00	1610.00
IUUC-Mlu-067729	Myotis lucifugus	96.36	0.00e+00	1583.00
IUUC-Nle-069721	Nomascus leucogenys	97.82	0.00e+00	1621.00
IUUC-Opr-070189	Ochotona princeps	96.45	0.00e+00	1600.00
IUUC-Ont-072122	Oreochromis niloticus	79.85	0.00e+00	1343.00
IUUC-Oan-072700	Ornithorhynchus anatinus	82.84	0.00e+00	1200.00
IUUC-Ocu-074057	Oryctolagus cuniculus	96.48	0.00e+00	1613.00
IUUC-Ola-087492	Oryzias latipes	78.30	0.00e+00	1348.00
IUUC-Oga-088084	Otolemur garnettii	96.97	0.00e+00	1615.00
IUUC-Oar-090354	Ovis aries	96.20	0.00e+00	1590.00
IUUC-Ptr-091456	Pan troglodytes	98.30	0.00e+00	1640.00
IUUC-Psi-092942	Pelodiscus sinensis	91.38	0.00e+00	1505.00
IUUC-Pma-094662	Petromyzon marinus	59.64	0.00e+00	733.00
IUUC-Pfo-096838	Poecilia formosa	79.61	0.00e+00	1326.00
IUUC-Pab-097849	Pongo abelii	98.06	0.00e+00	1638.00
IUUC-Pca-100498	Procavia capensis	94.20	0.00e+00	916.00
IUUC-Pva-102599	Pteropus vampyrus	96.48	0.00e+00	1595.00
IUUC-Rno-105776	Rattus norvegicus	96.24	0.00e+00	1601.00
IUUC-Sha-106699	Sarcophilus harrisii	93.20	0.00e+00	1514.00
IUUC-Sar-113621	Sorex araneus	94.59	0.00e+00	1557.00
IUUC-Ssc-115742	Sus scrofa	96.48	0.00e+00	1618.00
IUUC-Tgu-116490	Taeniopygia guttata	89.93	0.00e+00	1501.00
IUUC-Tru-117679	Takifugu rubripes	78.88	0.00e+00	1333.00
IUUC-Tsy-119607	Tarsius syrichta	92.57	0.00e+00	1118.00
IUUC-Tni-120376	Tetraodon nigroviridis	75.60	0.00e+00	1261.00
IUUC-Tbe-127348	Tupaia belangeri	77.40	6.00e-140	490.00
IUUC-Ttr-128786	Tursiops truncatus	92.84	0.00e+00	1544.00
IUUC-Vpa-130180	Vicugna pacos	95.50	0.00e+00	1277.00
IUUC-Xtr-132631	Xenopus tropicalis	67.07	0.00e+00	1125.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence