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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046271
UUCD1 version UUC-HoS-00335
Ensembl Protein ID ENSP00000233630.6
UniProt Accession Q9BSM1; Q7Z506; PCGF1_HUMAN
Genbank Protein ID AAP97183.1; AAH04952.1
Protein Name Polycomb group RING finger protein 1; Nervous system Polycomb-1; RING finger protein 68
Genbank Nucleotide ID AF087884; AC005041
Gene Name PCGF1; NSPC1; RNF68
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000115289.13 ENST00000233630.10 ENSP00000233630.6
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18650381
ULD/UDP/UFD/RAWUL RAWUL 21282530; 23523425
Classification
Family E-value Score Start End
E3 activity/RING/RING 4.20e-05 25.6 47 86
ULD/UDP/UFD/RAWUL 6.50e-25 89.1 170 253
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++C   f d + ++ C H+f+++C+ k+       +++ +CP C+
   Q: 47   CCLCAGYFVDATTITECLHTFCKSCIVKY------LQTSKYCPMCN 86
           ********998999***************......**********7 PP
   

   ULD/UDP/UFD/RAWUL
   S: 2    slsLeplesnkakddsklkkkylrcsarltVkhlkkflaeklklsssyevdllcedevLednetLeeikyifiwk.kegpLvLqYr 86
           +l+Le+l+s k+k++s+l++ky+rcs r++V+hl+++l+++l+l+++ +v+ll+++evL d++t+++i +  +w  k +pL+LqY+
   Q: 170  NLCLERLSSGKDKNKSVLQNKYVRCSVRAEVRHLRRVLCHRLMLNPQ-HVQLLFDNEVLPDHMTMKQI-WLSRWFgKPSPLLLQYS 253
           89*********************************************.********************.*****9999*******5 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells (PubMed:26687479).
 Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells (PubMed:26687479).
Protein Sequence
(Fasta)
MASPQGGQIA IAMRLRNQLQ SVYKMDPLRN EEEVRVKIKD LNEHIVCCLC AGYFVDATTI 60
TECLHTFCKS CIVKYLQTSK YCPMCNIKIH ETQPLLNLKL DRVMQDIVYK LVPGLQDSEE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046271|E3,RING;ULD,RAWUL|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGAGGTCTCC ATTGGAATCT CTCCCTTCTC GTATCTCCAG TTGCATTTGA TGTTAATACC 60
TCATAGCAAA TTTATCCCTT TTTAAGTACC CAGAGCCGGC GGTGTAGAGC TCTCGAGCGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046271|E3,RING;ULD,RAWUL|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR032443--RAWUL
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF16207--RAWUL
SMART

SM00184--RING
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0008022--F:protein C-terminus binding
GO:0008270--F:zinc ion binding
GO:0035518--P:histone H2A monoubiquitination
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG hsa:84759
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002099 Ailuropoda melanoleuca 98.84 6.00e-144 503.00
IUUC-Atr-002463 Amborella trichopoda 41.46 4.00e-12 65.90
IUUC-Aca-004475 Anolis carolinensis 69.63 9.00e-72 262.00
IUUC-Ame-011787 Astyanax mexicanus 78.60 1.00e-122 432.00
IUUC-Bta-012404 Bos taurus 98.46 3.00e-143 500.00
IUUC-Cja-019959 Callithrix jacchus 98.46 1.00e-143 501.00
IUUC-Cfa-021067 Canis familiaris 98.84 6.00e-144 503.00
IUUC-Cpo-021935 Cavia porcellus 98.46 3.00e-143 500.00
IUUC-Csa-023876 Chlorocebus sabaeus 99.61 2.00e-144 504.00
IUUC-Cin-025434 Ciona intestinalis 44.44 2.00e-52 199.00
IUUC-Csv-026203 Ciona savignyi 46.26 9.00e-50 189.00
IUUC-Dre-027690 Danio rerio 78.60 2.00e-123 434.00
IUUC-Dno-029852 Dasypus novemcinctus 99.23 5.00e-144 503.00
IUUC-Dor-030923 Dipodomys ordii 98.07 4.00e-152 530.00
IUUC-Eca-033830 Equus caballus 98.79 9.00e-136 475.00
IUUC-Eeu-034879 Erinaceus europaeus 74.90 6.00e-102 363.00
IUUC-Fca-036120 Felis catus 98.84 6.00e-144 503.00
IUUC-Fal-036629 Ficedula albicollis 82.06 3.00e-101 360.00
IUUC-Gmo-039075 Gadus morhua 74.90 2.00e-116 411.00
IUUC-Gga-040955 Gallus gallus 82.38 2.00e-130 458.00
IUUC-Gac-042588 Gasterosteus aculeatus 78.52 1.00e-111 395.00
IUUC-Ggo-045205 Gorilla gorilla 100.00 6.00e-145 506.00
IUUC-Itr-048922 Ictidomys tridecemlineatus 99.23 5.00e-144 503.00
IUUC-Lpe-051490 Leersia perrieri 44.29 1.00e-11 64.70
IUUC-Loc-052395 Lepisosteus oculatus 81.50 2.00e-115 408.00
IUUC-Laf-054374 Loxodonta africana 97.98 2.00e-135 474.00
IUUC-Mcc-055839 Macaca mulatta 99.61 2.00e-144 504.00
IUUC-Meu-056254 Macropus eugenii 81.56 1.00e-105 375.00
IUUC-Mmr-061131 Microcebus murinus 98.84 6.00e-144 503.00
IUUC-Mdo-062849 Monodelphis domestica 93.63 7.00e-133 466.00
IUUC-Mmu-064195 Mus musculus 98.07 8.00e-143 499.00
IUUC-Mac-065443 Musa acuminata 41.46 1.00e-11 63.90
IUUC-Mpu-066111 Mustela putorius furo 98.84 5.00e-144 503.00
IUUC-Mlu-067503 Myotis lucifugus 97.70 6.00e-141 493.00
IUUC-Nle-069996 Nomascus leucogenys 99.61 2.00e-144 504.00
IUUC-Ont-071986 Oreochromis niloticus 76.74 2.00e-114 405.00
IUUC-Ocu-073943 Oryctolagus cuniculus 99.23 5.00e-144 503.00
IUUC-Oba-075928 Oryza barthii 43.66 2.00e-11 63.50
IUUC-Ogl-077158 Oryza glaberrima 43.66 3.00e-11 63.20
IUUC-Ogu-078857 Oryza glumaepatula 43.66 3.00e-11 63.50
IUUC-Oin-080071 Oryza indica 43.66 3.00e-11 63.20
IUUC-Olo-080821 Oryza longistaminata 43.66 3.00e-11 63.50
IUUC-Ome-081413 Oryza meridionalis 43.66 4.00e-11 62.80
IUUC-Oni-082240 Oryza nivara 43.66 3.00e-11 63.20
IUUC-Oru-084344 Oryza rufipogon 43.66 3.00e-11 63.20
IUUC-Ola-086932 Oryzias latipes 74.75 1.00e-87 315.00
IUUC-Oga-089144 Otolemur garnettii 98.46 3.00e-143 500.00
IUUC-Oar-089550 Ovis aries 98.46 3.00e-143 500.00
IUUC-Ptr-091118 Pan troglodytes 100.00 6.00e-145 506.00
IUUC-Pan-092208 Papio anubis 99.61 2.00e-144 504.00
IUUC-Pma-094218 Petromyzon marinus 69.02 2.00e-95 342.00
IUUC-Ppa-095811 Physcomitrella patens 48.33 6.00e-10 59.30
IUUC-Pfo-096815 Poecilia formosa 75.88 6.00e-115 406.00
IUUC-Pab-098575 Pongo abelii 99.61 2.00e-144 504.00
IUUC-Pca-100587 Procavia capensis 96.72 2.00e-130 458.00
IUUC-Ppe-102026 Prunus persica 41.46 4.00e-13 68.90
IUUC-Pva-102656 Pteropus vampyrus 93.44 2.00e-132 464.00
IUUC-Rno-105780 Rattus norvegicus 98.07 8.00e-143 499.00
IUUC-Sha-106983 Sarcophilus harrisii 89.45 3.00e-93 333.00
IUUC-Sit-110796 Setaria italica 42.25 1.00e-10 60.80
IUUC-Sly-111519 Solanum lycopersicum 46.34 3.00e-13 70.10
IUUC-Stu-112366 Solanum tuberosum 46.34 2.00e-13 70.10
IUUC-Sar-113694 Sorex araneus 98.45 2.00e-73 266.00
IUUC-Sbi-114697 Sorghum bicolor 43.66 1.00e-10 61.20
IUUC-Ssc-115319 Sus scrofa 96.14 3.00e-149 520.00
IUUC-Tru-118337 Takifugu rubripes 78.29 4.00e-120 424.00
IUUC-Tsy-119461 Tarsius syrichta 94.52 2.00e-69 254.00
IUUC-Tni-120608 Tetraodon nigroviridis 77.11 9.00e-116 409.00
IUUC-Tca-121851 Theobroma cacao 40.23 1.00e-11 64.30
IUUC-Ttr-129127 Tursiops truncatus 98.84 6.00e-144 503.00
IUUC-Vpa-130033 Vicugna pacos 67.54 2.00e-79 288.00
Created Date 25-Jun-2017

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