iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-027577

UUCD1 version

UUC-DaR-01458

Ensembl Protein ID

ENSDARP00000036071.4

UniProt Accession

Q1MTK1; Q1MTK1_DANRE

Genbank Protein ID

AAI71546.1; AAI71548.1

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AL645789; BC171548

Gene Name

usp49; LOC559473

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000000229.8	ENSDART00000037069.4	ENSDARP00000036071.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.90e-96	324.1	265	647

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle....kkkeklneenp................................kepkgellksl 53
           tGl+NlgNtCYmNS+LQ+Ls+++++re++l+    +++e l+++n+                                + ++ +l+++l
   Q: 265  TGLRNLGNTCYMNSILQVLSHLQKFRECFLTldlcETEELLAKSNHpqvgalsaggggggggvpsslqsaeqkeprssSRQQVSLCHEL 353
           7******************************9997555555555558889999999999999999998888888887777777****** PP
   S: 54   qklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknksli 142
           ++lf+ +w+++++ vsp ++l++++++ + f+gy+qqDaqEfl+ lld++++el+  ++ p+++        l  + ++k  k+  +++
   Q: 354  HTLFRVMWSGRWSLVSPFAMLHSVWNLIPAFRGYDQQDAQEFLCELLDKVQQELE--SDAPRKH-------FLIPITQRKLSKQVLKVL 433
           ******************************************************3..3444444.......47788999********** PP
   S: 143  sdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke..........slqdcLesftkeeelegenkyycekckkkqe..... 216
           +++F+gql sq++cl+c+++s++ epf+dlsl++p++ ++ ++          sl+++L++ft++e leg   y c+ c++k++     
   Q: 434  NTIFHGQLLSQVTCLSCKRKSNTVEPFWDLSLEFPERYHRMEKpsaaacqrscSLSEMLAKFTETEALEGC-IYACNFCNRKRRksshk 521
           *************************************9987779*************************95.5*******888888899 PP
   S: 217  ......aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvay 298
                 a k+l + +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c+ ++ +  e ++Y+L+avv+H+G +++sGHY+ay
   Q: 522  plslseACKQLLICRLPQVLRLHLKRFRWSGR-NHREKIGVHVAFDQVLNIQPYCSCSDAAAREAYTYDLSAVVMHHGkGFGSGHYTAY 609
           999999***********************997.8889**************************************************** PP
   S: 299  vknekgk.WllfdDskVtevkeeevleetgstaYvlfYkrr 338
           ++n++g+ W++++Ds+ ++++ eev++   ++aY+lfY++r
   Q: 610  CYNTEGGfWVHCNDSEMNVCSVEEVCS---TQAYILFYTQR 647
           ***9999********************...********985 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MDRCKHVVRF RLGHGHSILN PQMWRCVDCD TTESVWACLK CTHVACGRYM EEHSRSHYQQ 60
TQHPLAMDVR ELDVFCFACG DYVLNDNVEG DLKLLRGALS TVRSPGQRSL RSSVTDGGLR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTGATCCG CACGATGACG ACCTATATTC TGAATAGCAG CAGGACGCGT CCGCTCTGAT 60
GCTACAACGC ACCATTTCTC ACAGTAAGTT CTTCAACCAA TAATATCCAG CCGCAGACCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

dre:559473

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011403	Astyanax mexicanus	76.80	0.00e+00	861.00
IUUC-Cho-025051	Choloepus hoffmanni	73.81	1.00e-123	437.00
IUUC-Eca-033851	Equus caballus	57.53	0.00e+00	674.00
IUUC-Gmo-039249	Gadus morhua	82.91	5.00e-153	534.00
IUUC-Gga-040383	Gallus gallus	63.59	1.00e-173	602.00
IUUC-Gac-042595	Gasterosteus aculeatus	69.84	0.00e+00	861.00
IUUC-Loc-051961	Lepisosteus oculatus	71.77	0.00e+00	647.00
IUUC-Mga-059720	Meleagris gallopavo	66.80	5.00e-173	600.00
IUUC-Mlu-067090	Myotis lucifugus	69.88	9.00e-167	580.00
IUUC-Ont-072103	Oreochromis niloticus	73.41	0.00e+00	908.00
IUUC-Ocu-074851	Oryctolagus cuniculus	69.18	2.00e-124	439.00
IUUC-Ola-086413	Oryzias latipes	66.72	0.00e+00	824.00
IUUC-Pma-094155	Petromyzon marinus	57.59	7.00e-82	296.00
IUUC-Pfo-096413	Poecilia formosa	71.64	0.00e+00	888.00
IUUC-Pva-102868	Pteropus vampyrus	71.15	5.00e-166	578.00
IUUC-Sar-113561	Sorex araneus	80.43	6.00e-64	238.00
IUUC-Ssc-115727	Sus scrofa	72.75	1.00e-164	573.00
IUUC-Tru-117585	Takifugu rubripes	72.44	0.00e+00	874.00
IUUC-Tni-120600	Tetraodon nigroviridis	72.70	0.00e+00	847.00
IUUC-Xtr-132090	Xenopus tropicalis	66.47	0.00e+00	811.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence