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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046104
UUCD1 version UUC-HoS-00371
Ensembl Protein ID ENSP00000320893.3
UniProt Accession Q9H765; A8K1P2; Q547Q2; ASB8_HUMAN
Genbank Protein ID AAQ04830.1; BAB15033.1; BAF82646.1; AAH01321.1
Protein Name Ankyrin repeat and SOCS box protein 8
Genbank Nucleotide ID AF464877; AK024908; AK289957; BC001321
Gene Name ASB8; PP14212
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000177981.10 ENST00000317697.7 ENSP00000320893.3
ENSG00000177981.10 ENST00000536953.5 ENSP00000438498.1
ENSG00000177981.10 ENST00000539865.5 ENSP00000438434.1
ENSG00000177981.10 ENST00000536071.5 ENSP00000442737.1
ENSG00000177981.10 ENST00000540143.5 ENSP00000443835.1
ENSG00000177981.10 ENST00000540782.1 ENSP00000437530.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlus
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box SOCS 12559969
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 3.00e-14 54.3 238 286
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box
   S: 2    sklwllrseprSLqhLCRlaIrrclgsqrl.kaidkLPLPksLkdYLly 49
           +kl++l+s p +L++L R+a+rr+lg q l +a+++LPLP sLk+YLl 
   Q: 238  EKLTVLCSAPGTLKTLARYAVRRSLGLQYLpDAVKGLPLPASLKEYLLL 286
           7899*******************************************96 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
 May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Sequence
(Fasta)
MSSSMWYIMQ SIQSKYSLSE RLIRTIAAIR SFPHDNVEDL IRGGADVNCT HGTLKPLHCA 60
CMVSDADCVE LLLEKGAEVN ALDGYNRTAL HYAAEKDEAC VEVLLEYGAN PNALDGNRDT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046104|E3,SOCS|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAAATTATTG GAGAAGCACA AAAGGCCATG GGAAACATGT GCAGAGATCA AGCAGTTTGG 60
CTGGTCCAGT CAAGTTCCAG GTCAAACATT TGAGAGCCAA GGGTAGGTGG GAACTGGGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046104|E3,SOCS|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001496--SOCS_box
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50225--SOCS
Pfam

PF12796--Ank_2
PF07525--SOCS_box
SMART

SM00248--ANK
SM00969--SOCS_box
Gene Ontology

GO:0005737--C:cytoplasm
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination
KEGG hsa:140461
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001601 Ailuropoda melanoleuca 98.61 5.00e-168 583.00
IUUC-Apl-003898 Anas platyrhynchos 84.02 4.00e-123 433.00
IUUC-Aca-005321 Anolis carolinensis 90.21 6.00e-156 543.00
IUUC-Ame-010739 Astyanax mexicanus 79.79 5.00e-129 453.00
IUUC-Bta-013314 Bos taurus 98.26 1.00e-167 582.00
IUUC-Cja-018726 Callithrix jacchus 98.96 2.00e-168 584.00
IUUC-Cfa-020084 Canis familiaris 98.61 5.00e-168 583.00
IUUC-Cpo-022509 Cavia porcellus 97.92 2.00e-167 580.00
IUUC-Csa-023640 Chlorocebus sabaeus 100.00 3.00e-170 590.00
IUUC-Cho-024844 Choloepus hoffmanni 98.61 5.00e-168 583.00
IUUC-Cin-025183 Ciona intestinalis 37.42 1.00e-19 91.70
IUUC-Dre-027663 Danio rerio 79.44 4.00e-133 467.00
IUUC-Dno-029623 Dasypus novemcinctus 98.26 1.00e-167 581.00
IUUC-Dor-030857 Dipodomys ordii 97.22 5.00e-166 576.00
IUUC-Eca-033273 Equus caballus 98.26 1.00e-167 582.00
IUUC-Eeu-034981 Erinaceus europaeus 97.57 2.00e-166 578.00
IUUC-Fca-035934 Felis catus 98.61 5.00e-168 583.00
IUUC-Fal-037472 Ficedula albicollis 83.22 2.00e-137 481.00
IUUC-Gmo-038873 Gadus morhua 77.51 3.00e-131 460.00
IUUC-Gga-041086 Gallus gallus 86.22 2.00e-147 514.00
IUUC-Gac-041583 Gasterosteus aculeatus 79.09 7.00e-134 469.00
IUUC-Ggo-044756 Gorilla gorilla 100.00 3.00e-170 590.00
IUUC-Itr-048325 Ictidomys tridecemlineatus 97.92 5.00e-167 579.00
IUUC-Lch-050156 Latimeria chalumnae 83.97 2.00e-147 514.00
IUUC-Laf-053574 Loxodonta africana 98.26 4.00e-167 580.00
IUUC-Mcc-054710 Macaca mulatta 97.30 7.00e-168 582.00
IUUC-Meu-056561 Macropus eugenii 95.83 2.00e-163 567.00
IUUC-Mga-059733 Meleagris gallopavo 85.25 3.00e-125 440.00
IUUC-Mmr-060632 Microcebus murinus 98.26 1.00e-167 582.00
IUUC-Mmu-064371 Mus musculus 97.22 2.00e-165 574.00
IUUC-Mpu-066066 Mustela putorius furo 98.26 2.00e-167 581.00
IUUC-Mlu-067200 Myotis lucifugus 98.61 5.00e-168 583.00
IUUC-Nle-069782 Nomascus leucogenys 100.00 3.00e-170 590.00
IUUC-Opr-070962 Ochotona princeps 95.14 4.00e-163 566.00
IUUC-Ont-071639 Oreochromis niloticus 79.79 8.00e-130 456.00
IUUC-Oan-072927 Ornithorhynchus anatinus 79.21 3.00e-73 267.00
IUUC-Ocu-074106 Oryctolagus cuniculus 95.45 1.00e-162 565.00
IUUC-Ola-086720 Oryzias latipes 79.09 1.00e-128 452.00
IUUC-Oga-088635 Otolemur garnettii 98.61 5.00e-168 583.00
IUUC-Oar-090018 Ovis aries 98.26 1.00e-167 582.00
IUUC-Ptr-091388 Pan troglodytes 99.65 8.00e-170 589.00
IUUC-Pan-092014 Papio anubis 100.00 3.00e-170 590.00
IUUC-Psi-093909 Pelodiscus sinensis 86.76 4.00e-150 523.00
IUUC-Pfo-096383 Poecilia formosa 78.40 2.00e-128 451.00
IUUC-Pab-097714 Pongo abelii 97.87 7.00e-162 562.00
IUUC-Pva-103230 Pteropus vampyrus 97.96 9.00e-141 492.00
IUUC-Rno-104942 Rattus norvegicus 97.92 2.00e-166 577.00
IUUC-Sha-106733 Sarcophilus harrisii 97.22 1.00e-165 575.00
IUUC-Ssc-116033 Sus scrofa 98.26 1.00e-167 582.00
IUUC-Tgu-117411 Taeniopygia guttata 86.36 3.00e-143 500.00
IUUC-Tru-118207 Takifugu rubripes 77.70 7.00e-127 446.00
IUUC-Tsy-119535 Tarsius syrichta 73.96 3.00e-111 394.00
IUUC-Tni-120699 Tetraodon nigroviridis 78.05 5.00e-127 446.00
IUUC-Tbe-127600 Tupaia belangeri 97.96 3.00e-140 490.00
IUUC-Ttr-128818 Tursiops truncatus 97.57 5.00e-167 579.00
IUUC-Vpa-130323 Vicugna pacos 98.26 1.00e-167 582.00
IUUC-Xtr-132195 Xenopus tropicalis 64.77 3.00e-91 328.00
Created Date 25-Jun-2017

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