iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000004132.10	ENSDART00000147778.1	ENSDARP00000116060.1
ENSDARG00000004132.10	ENSDART00000112840.3	ENSDARP00000100933.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.50e-107	359.4	638	1355

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl NlgNtC+mNSv+Q+Lsn++elr+++++  +++++n +np ++ g+l+  ++ l+++lwk++++a++p++l+++++++a++f+g
   Q: 638  TGLVNLGNTCFMNSVIQSLSNTRELRDYFHDrGFESEINCNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTG 724
           7******************************889***************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           y+q+DaqEf+aflld+l+e+l++ +nkp++e+ ++d   ++de     a++++k++n+s+i+dlFqgq+ks+++       s +++p
   Q: 725  YAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSD--GRQDEvvaeeAWQRHKMRNDSFIVDLFQGQYKSKLV-------SITFDP 802
           ********************************9998..5555556777**********************9885.......79**** PP
   S: 169  fldlslpvpgkeetkke...................................................................... 185
           fl+l++p+p+k++  +                                                                       
   Q: 803  FLYLPVPLPQKQKVLTVfyfakephkkpvkflvsvskessstaevlesisrsvrikpenlrltevvkgrfhrifspsqsldtvsssd 889
           ************87555********************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 890  llfcfemlskdlikervvllkvqqrpqipsipitkcagclkppasddeklkrctrcyrvgycnqtcqknhwpshktmcrsnvenigq 976
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 977  pflisvpesrlsytrltqllegysrysvnvfqppfqsgrtspesslsrvdltsmassvpecqekdlpsagdpenpaeqdesvtasqt 1063
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 1064 esaadggdtlsthttdsgccelassshdslleketscekavkpeavvtgyqqpsesasggasqfyitildssqkedkkleekgdavl 1150
           *************************************************************************************** PP
   S: 186  ...............................................slqdcLesftkeeelegenkyycekckkkqeaekklklkk 225
                                                          +l++cL+ ftk+e l  e+++yc+kc++++ea+k+l l++
   Q: 1151 elpdectlelvwknnerqkeyvlvrskdlefdedpgsatetsraghfTLEQCLNLFTKPEVLAPEEAWYCPKCQQHREASKQLLLWR 1237
           *************************************************************************************** PP
   S: 226  lPevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk...... 305
           lP+vLi++LkRfsf++  +++ kin+ v+fp + Ldls+fc+  + + +++ +Y+L+av++H+G++ +GHY+ay++  ++k      
   Q: 1238 LPNVLIIQLKRFSFRSFIWRD-KINDMVDFPVRnLDLSKFCIGHKGDIQQPPIYDLYAVINHYGGMIGGHYTAYARLPSDKnsqlsd 1323
           *****************8886.**********9*******************************************95444456777 PP
   S: 306  ..WllfdDskVtevkeeevleetgstaYvlfYkrr 338
             W lfdDs+Vt+v+e++v++   + aYvlfY+rr
   Q: 1324 vgWRLFDDSTVTTVEESQVVT---RYAYVLFYRRR 1355
           78*******************...********996 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MASSSTGSSE SGRRRGQRGP DDTVSTSKKK QKDRANQESK EAKRVATSTE TKKDLFLDWK 60
QNAYEVIVRL NCGGAGELRV EDIEYDFSNS ACHIRLPDGR EWSCHLHEEI EASCSKLNYK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTTTGGGCA GGCAGGCAGG TTGGCGTGAT CTCCGTCTCT ACCCGGTTTG TTTTGTTCTC 60
TAACAAAGTG CGAGTGACGG AGCGGCGCTC GGCTCATCGG GTAGAGCACG GACAGCGTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR007052--CS_dom
IPR008978--HSP20-like_chaperone
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS51203--CS
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF04969--CS
PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0046872--F:metal ion binding
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0021551--P:central nervous system morphogenesis
GO:0016579--P:protein deubiquitination
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001999	Ailuropoda melanoleuca	68.93	0.00e+00	1360.00
IUUC-Apl-003368	Anas platyrhynchos	70.69	0.00e+00	1379.00
IUUC-Aca-004267	Anolis carolinensis	71.27	0.00e+00	1387.00
IUUC-Ame-010970	Astyanax mexicanus	72.22	0.00e+00	1906.00
IUUC-Bta-012905	Bos taurus	68.92	0.00e+00	1342.00
IUUC-Cel-018257	Caenorhabditis elegans	42.48	5.00e-91	329.00
IUUC-Cja-018789	Callithrix jacchus	68.42	0.00e+00	1357.00
IUUC-Cfa-021004	Canis familiaris	68.82	0.00e+00	1340.00
IUUC-Cpo-021529	Cavia porcellus	69.62	0.00e+00	1322.00
IUUC-Csa-024035	Chlorocebus sabaeus	69.49	0.00e+00	1373.00
IUUC-Cho-025036	Choloepus hoffmanni	70.56	0.00e+00	634.00
IUUC-Cin-025451	Ciona intestinalis	38.66	6.00e-81	296.00
IUUC-Csv-025931	Ciona savignyi	42.15	5.00e-54	206.00
IUUC-Dno-029240	Dasypus novemcinctus	66.44	0.00e+00	1280.00
IUUC-Dor-030495	Dipodomys ordii	68.42	0.00e+00	828.00
IUUC-Ete-032741	Echinops telfairi	68.62	0.00e+00	1326.00
IUUC-Eca-033661	Equus caballus	68.82	0.00e+00	1361.00
IUUC-Eeu-034648	Erinaceus europaeus	74.63	5.00e-171	595.00
IUUC-Fca-035646	Felis catus	68.69	0.00e+00	1345.00
IUUC-Fal-037094	Ficedula albicollis	67.81	0.00e+00	1462.00
IUUC-Gmo-038869	Gadus morhua	72.24	0.00e+00	1434.00
IUUC-Gga-041170	Gallus gallus	68.08	0.00e+00	1427.00
IUUC-Gac-041901	Gasterosteus aculeatus	72.91	0.00e+00	1519.00
IUUC-Ggo-044708	Gorilla gorilla	70.04	0.00e+00	1355.00
IUUC-Hsa-046791	Homo sapiens	70.04	0.00e+00	1351.00
IUUC-Itr-048892	Ictidomys tridecemlineatus	69.60	0.00e+00	1288.00
IUUC-Lch-050456	Latimeria chalumnae	62.87	0.00e+00	1118.00
IUUC-Loc-052861	Lepisosteus oculatus	58.84	0.00e+00	1452.00
IUUC-Laf-053788	Loxodonta africana	69.78	0.00e+00	1342.00
IUUC-Mcc-055693	Macaca mulatta	69.32	0.00e+00	1366.00
IUUC-Meu-055921	Macropus eugenii	70.70	0.00e+00	1164.00
IUUC-Mga-059879	Meleagris gallopavo	67.57	0.00e+00	1417.00
IUUC-Mmr-060802	Microcebus murinus	67.66	0.00e+00	1365.00
IUUC-Mdo-061856	Monodelphis domestica	66.82	0.00e+00	1341.00
IUUC-Mmu-063874	Mus musculus	64.22	0.00e+00	1355.00
IUUC-Mpu-066166	Mustela putorius furo	67.94	0.00e+00	1336.00
IUUC-Nle-070161	Nomascus leucogenys	69.26	0.00e+00	1356.00
IUUC-Opr-071015	Ochotona princeps	68.98	0.00e+00	1320.00
IUUC-Ont-072308	Oreochromis niloticus	64.60	0.00e+00	1736.00
IUUC-Oan-072723	Ornithorhynchus anatinus	64.99	0.00e+00	1335.00
IUUC-Ocu-073938	Oryctolagus cuniculus	70.23	0.00e+00	1338.00
IUUC-Ola-086375	Oryzias latipes	76.97	0.00e+00	1537.00
IUUC-Oga-088297	Otolemur garnettii	67.40	0.00e+00	1350.00
IUUC-Oar-089675	Ovis aries	69.22	0.00e+00	1191.00
IUUC-Ptr-091621	Pan troglodytes	69.83	0.00e+00	1349.00
IUUC-Pan-092118	Papio anubis	69.49	0.00e+00	1373.00
IUUC-Pfo-097246	Poecilia formosa	68.31	0.00e+00	1533.00
IUUC-Pab-098551	Pongo abelii	69.11	0.00e+00	1333.00
IUUC-Pca-100158	Procavia capensis	63.09	0.00e+00	1294.00
IUUC-Pva-103160	Pteropus vampyrus	68.74	0.00e+00	1325.00
IUUC-Rno-105355	Rattus norvegicus	65.02	0.00e+00	1343.00
IUUC-Sha-107057	Sarcophilus harrisii	71.30	0.00e+00	1346.00
IUUC-Sar-113011	Sorex araneus	64.34	0.00e+00	972.00
IUUC-Ssc-115761	Sus scrofa	67.72	0.00e+00	1348.00
IUUC-Tgu-116956	Taeniopygia guttata	56.74	0.00e+00	775.00
IUUC-Tru-118739	Takifugu rubripes	74.06	0.00e+00	1509.00
IUUC-Tsy-118827	Tarsius syrichta	76.96	0.00e+00	681.00
IUUC-Tni-119921	Tetraodon nigroviridis	71.79	0.00e+00	1484.00
IUUC-Tbe-128017	Tupaia belangeri	66.93	0.00e+00	1306.00
IUUC-Ttr-128869	Tursiops truncatus	65.71	0.00e+00	1346.00
IUUC-Vpa-130427	Vicugna pacos	62.08	1.00e-174	607.00
IUUC-Xtr-132734	Xenopus tropicalis	73.28	0.00e+00	1399.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence