iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-098551

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABGA01324618

Gene Name

USP19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000013881.2	ENSPPYT00000016146.2	ENSPPYP00000015528.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.60e-115	384.8	497	1209

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl NlgNtC+mNSv+Q+Lsn++elr+++++ +++ ++n +np ++ g+l+  ++ l+++lwk++++a++p++l+++++++a++f+g
   Q: 497  TGLVNLGNTCFMNSVIQSLSNTRELRDFFHDrSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTG 583
           7*****************************999****************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           y+q+DaqEf+aflld+l+e+l++ +nkp++e+ ++d   ++de     a++++k++n+s+i+dlFqgq+ks+++c+ c++vs +++p
   Q: 584  YAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSD--GRPDEvvaeeAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDP 668
           ********************************9999..6666666777*************************************** PP
   S: 169  fldlslpvpgkeetkke...................................................................... 185
           fl+l++p+p+k++  +                                                                       
   Q: 669  FLYLPVPLPQKQKVLPVfyfarephskpikflvsiskenstasevldslsqnvhvkpenlrlaeviknrfhrvflpshsldtvspsd 755
           ************87666********************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 756  mllcfellsselakervvvlevqqrpqvpsvpiskcaacqrkqqsedeklkrctrcyrvgycnqlcqkthwpdhkglcrpenigypf 842
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 843  lvsvpasrltyarlaqflkgyavfqppfqpgrmalesqspgcttllstgsleagdserdpiqppelqlvtpmaegdtglprvwaapd 929
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 930  rgpvpstsgissemlasgpievgslpagervsrpeaavpgyqhpseamnahtpqffiykidssnreqrledkgdtplelgddcslal 1016
           *************************************************************************************** PP
   S: 186  .....................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLk 235
                                                +l++cL+ ft++e l  e+++yc++ck+++ea+k+l l++lP+vLi++Lk
   Q: 1017 vwrnnerlqefvlvaskelecaedpgsageaaraghfTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLK 1103
           *************************************************************************************** PP
   S: 236  Rfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk........WllfdDsk 313
           Rfsf++  +++ kin+ vefp + Ldls+fc+ ++e+q    +Y+L+av++H+G++ +GHY+a+++  +++        W lfdDs+
   Q: 1104 RFSFRSFIWRD-KINDLVEFPVRnLDLSKFCIGQKEEQ--LPSYDLYAVINHYGGMIGGHYTACARLPNDRssqrsdvgWRLFDDST 1187
           *******8886.**********9**********99888..9**************************544445566777******** PP
   S: 314  VtevkeeevleetgstaYvlfYkrr 338
           Vt+v+e++v++   + aYvlfY+rr
   Q: 1188 VTTVDESQVVT---RYAYVLFYRRR 1209
           ***********...********996 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MSGGASATGP RRGPPGLEDA TSKKKQKDRA NQESKDGDPR KETGSRSVAQ AGLELLASGD 60
PSASASHAAG ITGSRHRTRL FFPSSSGSAS TPQEEQTKEG ACEDPHDLLA TPPPELLLDW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCTCCGAGC CCATTCCCGC CGGAAGTGCG TCACCAGCTT GGCGCTCCGC CTCCCTCGGC 60
CTTAGCTAGA AGTCGAAACA AAACAAGCCG CTAAGGCGGT GGCGGCGGCG CCGGGACGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR007052--CS_dom
IPR008978--HSP20-like_chaperone
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS51203--CS
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF04969--CS
PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0048642--P:negative regulation of skeletal muscle tissue development
GO:0050821--P:protein stabilization
GO:1900037--P:regulation of cellular response to hypoxia
GO:1904292--P:regulation of ERAD pathway
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001999	Ailuropoda melanoleuca	94.36	0.00e+00	1954.00
IUUC-Apl-003368	Anas platyrhynchos	73.07	0.00e+00	1477.00
IUUC-Aca-004267	Anolis carolinensis	76.21	0.00e+00	1458.00
IUUC-Ame-010970	Astyanax mexicanus	70.09	0.00e+00	1312.00
IUUC-Bta-012905	Bos taurus	92.23	0.00e+00	1932.00
IUUC-Cel-018257	Caenorhabditis elegans	42.79	1.00e-90	328.00
IUUC-Cja-018789	Callithrix jacchus	96.77	0.00e+00	2128.00
IUUC-Cfa-021004	Canis familiaris	93.59	0.00e+00	1955.00
IUUC-Cpo-021529	Cavia porcellus	89.61	0.00e+00	1966.00
IUUC-Csa-024035	Chlorocebus sabaeus	96.73	0.00e+00	2031.00
IUUC-Cho-025036	Choloepus hoffmanni	85.63	0.00e+00	833.00
IUUC-Cin-025451	Ciona intestinalis	42.78	2.00e-83	303.00
IUUC-Csv-025931	Ciona savignyi	36.57	1.00e-109	390.00
IUUC-Dre-028556	Danio rerio	66.54	0.00e+00	1292.00
IUUC-Dno-029240	Dasypus novemcinctus	88.38	0.00e+00	1892.00
IUUC-Dor-030495	Dipodomys ordii	94.54	0.00e+00	1258.00
IUUC-Ete-032741	Echinops telfairi	91.14	0.00e+00	1831.00
IUUC-Eca-033661	Equus caballus	94.77	0.00e+00	2045.00
IUUC-Eeu-034648	Erinaceus europaeus	82.30	0.00e+00	1028.00
IUUC-Fca-035646	Felis catus	93.39	0.00e+00	1935.00
IUUC-Fal-037094	Ficedula albicollis	72.28	0.00e+00	1570.00
IUUC-Gmo-038869	Gadus morhua	61.90	0.00e+00	878.00
IUUC-Gga-041170	Gallus gallus	70.01	0.00e+00	1536.00
IUUC-Gac-041901	Gasterosteus aculeatus	60.18	0.00e+00	1405.00
IUUC-Ggo-044708	Gorilla gorilla	98.30	0.00e+00	2166.00
IUUC-Hsa-046791	Homo sapiens	98.48	0.00e+00	2534.00
IUUC-Itr-048892	Ictidomys tridecemlineatus	91.84	0.00e+00	1977.00
IUUC-Lch-050456	Latimeria chalumnae	62.82	0.00e+00	1108.00
IUUC-Loc-052861	Lepisosteus oculatus	61.06	0.00e+00	1112.00
IUUC-Laf-053788	Loxodonta africana	91.66	0.00e+00	1989.00
IUUC-Mcc-055693	Macaca mulatta	96.93	0.00e+00	2048.00
IUUC-Meu-055921	Macropus eugenii	77.86	0.00e+00	1490.00
IUUC-Mga-059879	Meleagris gallopavo	71.10	0.00e+00	1522.00
IUUC-Mmr-060802	Microcebus murinus	94.67	0.00e+00	2056.00
IUUC-Mdo-061856	Monodelphis domestica	73.12	0.00e+00	1754.00
IUUC-Mmu-063874	Mus musculus	91.43	0.00e+00	1980.00
IUUC-Mpu-066166	Mustela putorius furo	93.49	0.00e+00	1932.00
IUUC-Nle-070161	Nomascus leucogenys	97.42	0.00e+00	2159.00
IUUC-Opr-071015	Ochotona princeps	86.88	0.00e+00	2086.00
IUUC-Ont-072308	Oreochromis niloticus	67.41	0.00e+00	1342.00
IUUC-Oan-072723	Ornithorhynchus anatinus	71.40	0.00e+00	1501.00
IUUC-Ocu-073938	Oryctolagus cuniculus	93.43	0.00e+00	1897.00
IUUC-Ola-086375	Oryzias latipes	69.77	0.00e+00	1317.00
IUUC-Oga-088297	Otolemur garnettii	94.38	0.00e+00	2031.00
IUUC-Oar-089675	Ovis aries	85.32	0.00e+00	1645.00
IUUC-Ptr-091621	Pan troglodytes	98.33	0.00e+00	2534.00
IUUC-Pan-092118	Papio anubis	97.11	0.00e+00	2037.00
IUUC-Pfo-097246	Poecilia formosa	67.54	0.00e+00	1315.00
IUUC-Pca-100158	Procavia capensis	87.31	0.00e+00	1905.00
IUUC-Pva-103160	Pteropus vampyrus	94.14	0.00e+00	2008.00
IUUC-Rno-105355	Rattus norvegicus	91.94	0.00e+00	1986.00
IUUC-Sha-107057	Sarcophilus harrisii	79.33	0.00e+00	1559.00
IUUC-Sar-113011	Sorex araneus	89.10	0.00e+00	1556.00
IUUC-Ssc-115761	Sus scrofa	93.06	0.00e+00	1959.00
IUUC-Tgu-116956	Taeniopygia guttata	62.30	0.00e+00	816.00
IUUC-Tru-118739	Takifugu rubripes	68.74	0.00e+00	1332.00
IUUC-Tsy-118827	Tarsius syrichta	91.92	0.00e+00	941.00
IUUC-Tni-119921	Tetraodon nigroviridis	66.29	0.00e+00	1298.00
IUUC-Tbe-128017	Tupaia belangeri	91.22	0.00e+00	1969.00
IUUC-Ttr-128869	Tursiops truncatus	93.17	0.00e+00	1993.00
IUUC-Vpa-130427	Vicugna pacos	94.23	0.00e+00	911.00
IUUC-Xtr-132734	Xenopus tropicalis	70.27	0.00e+00	1419.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence