iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000015132.1	ENSONIT00000019060.1	ENSONIP00000019043.1
ENSONIG00000015132.1	ENSONIT00000019061.1	ENSONIP00000019044.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.50e-119	399.7	1316	1648

Active Site

Position(s)	Description	Evidence
1616	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+f+gEegld++G++ref++lls+el+np++glf+ys+nd++t+q++p s +  ++hl++F+f Gr+lg+al ++ lld
   Q: 1316 ELQRNKLYVTFLGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLALIHQYLLD 1401
           567899****************************************************985.6************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+   +l+dle +d+e+++sl+++k+n   di+++ ldltf+v+ee++g+++e+eLk+gG+n +Vt++Nk++Y+++
   Q: 1402 AFFTRPFYKALLRLATDLSDLEYLDEEFHQSLQWMKDN---DITDI-LDLTFTVNEEVFGQVTERELKSGGANLQVTEKNKKDYIER 1484
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           ++++r+++g+ +q+ea+ +Gf+ev++ +l+s+F+++elel+i G+ eid+ d++++t+y+ggy++ + +++wFw ++e+f++e+r +
   Q: 1485 MAKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTVEIDLGDWRNNTEYRGGYHDGHIVMRWFWAAVERFNNEQRLR 1571
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+     r+f+i+k+++ ++lP+++TCfn+L+LP+Y+s++ l+ekLl+A+eet+ F+l+
   Q: 1572 LLQFVTGTSSVPYEGFAALRgsngLRRFCIEKWGKVTSLPRAHTCFNRLDLPPYPSYTMLYEKLLIAVEETSTFGLE 1648
           ************************999***********************************************985 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MLMQLCSFKN LYQNRFLGLA AMASPTRSSQ TRQRCKDAVR HSYGPESFAV NGLNQDAFML 60
GLSRSTSDTD LVSPDARSTL TISSSHYTIG QSEDLVITWD IKEEVDAGDW IGMYLVDETL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTTGGTCT GCTTTGGGTT GACTGGTCAT TATGCTGATG CAGCTCTGTA GTTTCAAGGT 60
CAGTGCCCCC TCCTTCCTCC AATCACTCTC CAGCTTCTTT GTATGTGTAC CTCCACCCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001636	Ailuropoda melanoleuca	77.59	0.00e+00	1301.00
IUUC-Apl-003299	Anas platyrhynchos	77.54	0.00e+00	1344.00
IUUC-Aca-005024	Anolis carolinensis	71.15	0.00e+00	1409.00
IUUC-Bta-012604	Bos taurus	78.54	0.00e+00	1341.00
IUUC-Cja-019880	Callithrix jacchus	72.57	0.00e+00	1256.00
IUUC-Cfa-021216	Canis familiaris	77.99	0.00e+00	1342.00
IUUC-Cpo-021466	Cavia porcellus	78.28	0.00e+00	1346.00
IUUC-Csa-023080	Chlorocebus sabaeus	78.48	0.00e+00	1347.00
IUUC-Cho-024740	Choloepus hoffmanni	83.39	0.00e+00	1029.00
IUUC-Dre-028750	Danio rerio	76.20	0.00e+00	1387.00
IUUC-Dno-030019	Dasypus novemcinctus	78.06	0.00e+00	1350.00
IUUC-Ete-032352	Echinops telfairi	84.09	0.00e+00	1138.00
IUUC-Eca-033948	Equus caballus	78.12	0.00e+00	1347.00
IUUC-Eeu-034474	Erinaceus europaeus	63.01	0.00e+00	747.00
IUUC-Fca-036148	Felis catus	78.48	0.00e+00	1342.00
IUUC-Fal-036957	Ficedula albicollis	76.92	0.00e+00	1348.00
IUUC-Gmo-038714	Gadus morhua	67.04	0.00e+00	1088.00
IUUC-Gga-041194	Gallus gallus	77.30	0.00e+00	1355.00
IUUC-Gac-041366	Gasterosteus aculeatus	79.14	0.00e+00	1693.00
IUUC-Ggo-045442	Gorilla gorilla	71.44	0.00e+00	1259.00
IUUC-Hsa-045730	Homo sapiens	78.59	0.00e+00	1347.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	78.44	0.00e+00	1354.00
IUUC-Lch-050185	Latimeria chalumnae	65.09	0.00e+00	1182.00
IUUC-Loc-052744	Lepisosteus oculatus	74.77	0.00e+00	1463.00
IUUC-Laf-054368	Loxodonta africana	83.95	0.00e+00	1293.00
IUUC-Mcc-055487	Macaca mulatta	78.59	0.00e+00	1347.00
IUUC-Mga-059545	Meleagris gallopavo	77.22	0.00e+00	1350.00
IUUC-Mmr-061078	Microcebus murinus	76.61	0.00e+00	1290.00
IUUC-Mdo-062176	Monodelphis domestica	75.98	0.00e+00	1293.00
IUUC-Mmu-063513	Mus musculus	77.03	0.00e+00	1334.00
IUUC-Mpu-065786	Mustela putorius furo	77.52	0.00e+00	1340.00
IUUC-Mlu-067780	Myotis lucifugus	70.74	0.00e+00	1170.00
IUUC-Nle-069213	Nomascus leucogenys	78.48	0.00e+00	1346.00
IUUC-Opr-070208	Ochotona princeps	83.59	0.00e+00	1287.00
IUUC-Oan-072807	Ornithorhynchus anatinus	78.55	0.00e+00	1346.00
IUUC-Ocu-074745	Oryctolagus cuniculus	77.86	0.00e+00	1343.00
IUUC-Ola-086981	Oryzias latipes	77.77	0.00e+00	2370.00
IUUC-Oga-087965	Otolemur garnettii	77.92	0.00e+00	1320.00
IUUC-Oar-089749	Ovis aries	78.43	0.00e+00	1337.00
IUUC-Ptr-091243	Pan troglodytes	78.48	0.00e+00	1347.00
IUUC-Pan-092201	Papio anubis	78.48	0.00e+00	1346.00
IUUC-Psi-093511	Pelodiscus sinensis	77.63	0.00e+00	1326.00
IUUC-Pfo-097001	Poecilia formosa	73.67	0.00e+00	1874.00
IUUC-Pab-098728	Pongo abelii	73.54	0.00e+00	1256.00
IUUC-Pca-100129	Procavia capensis	67.24	0.00e+00	1002.00
IUUC-Pva-102250	Pteropus vampyrus	74.48	0.00e+00	1256.00
IUUC-Rno-105031	Rattus norvegicus	77.23	0.00e+00	1337.00
IUUC-Tgu-117515	Taeniopygia guttata	77.65	0.00e+00	1346.00
IUUC-Tru-117914	Takifugu rubripes	86.27	0.00e+00	1561.00
IUUC-Tni-120178	Tetraodon nigroviridis	86.46	0.00e+00	1558.00
IUUC-Tbe-127762	Tupaia belangeri	73.18	0.00e+00	1228.00
IUUC-Ttr-128806	Tursiops truncatus	77.15	0.00e+00	1340.00
IUUC-Xtr-132903	Xenopus tropicalis	77.22	0.00e+00	1357.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence