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Tag Content
UUCD2 ID IUUC-Bta-012505
UUCD1 version UUC-BoT-01064
Ensembl Protein ID ENSBTAP00000015041.5
UniProt Accession A6QQJ8; ZC12A_BOVIN
Genbank Protein ID AAI49868.1
Protein Name Ribonuclease ZC3H12A; Zinc finger CCCH domain-containing protein 12A
Genbank Nucleotide ID BC149867
Gene Name ZC3H12A
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000011316.5 ENSBTAT00000015041.5 ENSBTAP00000015041.5
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
DUB/Other 86.79 0.00e+00 873.00 IUUC-Hsa-046924
UBD/Other/Other 86.79 0.00e+00 873.00 IUUC-Hsa-046924
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Bos taurus
Functional Description
(View)

Functional Description



     Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response and inflammation by regulating the decay of specific mRNA molecules. Recognizes the 3'-untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA. Triggers apoptosis and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19 (By similarity).
Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response and inflammation by regulating the decay of specific mRNA molecules. Recognizes the 3'-untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA. Triggers apoptosis and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19 (By similarity).
Protein Sequence
(Fasta)
MSLWELEDRR SCQGTPRPAQ EPTAEEATTA ELQMKVDFFR KLGYSSAEIH SVLQKLGIQA 60
DTNTVLGELV KHGSAAERER QASPDPCPQL PLVPRGGGTP KAPTVETYPP EEDKEGSDLR 120
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Protein Fasta Sequence



>IUUC-Bta-012505|DUB,DUB/Other;UBD,UBD/Other/Other|Bos taurus
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Nucleotide Sequence
(Fasta)
GGAGACGCCG CCGGCCGCTG CTGGCGTACG GCAGGGTGAG GCGCTCGCGG CTGGGAAGGG 60
GAGCAGGCCT CCGGGGCGGG AGGAGGAGGG GGTGGGAAGG GCTGGAGCTG AGACCGACCG 120
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Nucleotide Fasta Sequence



>IUUC-Bta-012505|DUB,DUB/Other;UBD,UBD/Other/Other|Bos taurus
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Sequence Source Ensembl
Keyword

KW-0037--Angiogenesis
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0255--Endonuclease
KW-0378--Hydrolase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0540--Nuclease
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR021869--RNase_Zc3h12_NYN
IPR000571--Znf_CCCH

PROSITE

PS50103--ZF_C3H1

Pfam

PF11977--RNase_Zc3h12a

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0042406--C:extrinsic component of endoplasmic reticulum membrane
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0043234--C:protein complex
GO:0005791--C:rough endoplasmic reticulum
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0004521--F:endoribonuclease activity
GO:0004532--F:exoribonuclease activity
GO:0046872--F:metal ion binding
GO:0035198--F:miRNA binding
GO:0035925--F:mRNA 3'-UTR AU-rich region binding
GO:0003730--F:mRNA 3'-UTR binding
GO:0003729--F:mRNA binding
GO:0043022--F:ribosome binding
GO:0035613--F:RNA stem-loop binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0061158--P:3'-UTR-mediated mRNA destabilization
GO:0001525--P:angiogenesis
GO:0006915--P:apoptotic process
GO:0030154--P:cell differentiation
GO:1990869--P:cellular response to chemokine
GO:0006974--P:cellular response to DNA damage stimulus
GO:0042149--P:cellular response to glucose starvation
GO:0071347--P:cellular response to interleukin-1
GO:1904637--P:cellular response to ionomycin
GO:0071222--P:cellular response to lipopolysaccharide
GO:0034599--P:cellular response to oxidative stress
GO:1904628--P:cellular response to phorbol 13-acetate 12-myristate
GO:1903936--P:cellular response to sodium arsenite
GO:0071356--P:cellular response to tumor necrosis factor
GO:0098586--P:cellular response to virus
GO:0044828--P:negative regulation by host of viral genome replication
GO:0055118--P:negative regulation of cardiac muscle contraction
GO:1900016--P:negative regulation of cytokine production involved in inflammatory response
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:1902714--P:negative regulation of interferon-gamma secretion
GO:0050713--P:negative regulation of interleukin-1 beta secretion
GO:1900165--P:negative regulation of interleukin-6 secretion
GO:0010656--P:negative regulation of muscle cell apoptotic process
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045019--P:negative regulation of nitric oxide biosynthetic process
GO:1903799--P:negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:0001933--P:negative regulation of protein phosphorylation
GO:1904468--P:negative regulation of tumor necrosis factor secretion
GO:0000294--P:nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay
GO:0045766--P:positive regulation of angiogenesis
GO:0010508--P:positive regulation of autophagy
GO:0010942--P:positive regulation of cell death
GO:0002230--P:positive regulation of defense response to virus by host
GO:0010595--P:positive regulation of endothelial cell migration
GO:1900119--P:positive regulation of execution phase of apoptosis
GO:0045600--P:positive regulation of fat cell differentiation
GO:0010884--P:positive regulation of lipid storage
GO:2000627--P:positive regulation of miRNA catabolic process
GO:0061014--P:positive regulation of mRNA catabolic process
GO:1900745--P:positive regulation of p38MAPK cascade
GO:1903003--P:positive regulation of protein deubiquitination
GO:0042307--P:positive regulation of protein import into nucleus
GO:2000379--P:positive regulation of reactive oxygen species metabolic process
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0016579--P:protein deubiquitination
GO:0051259--P:protein oligomerization
GO:0090501--P:RNA phosphodiester bond hydrolysis
GO:0090502--P:RNA phosphodiester bond hydrolysis, endonucleolytic

KEGG bta:535344
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002223 Ailuropoda melanoleuca 87.65 0.00e+00 815.00
IUUC-Apl-003631 Anas platyrhynchos 67.07 6.00e-154 536.00
IUUC-Aca-005301 Anolis carolinensis 52.89 1.00e-150 526.00
IUUC-Ate-010342 Aspergillus terreus 29.17 1.10e+00 27.30
IUUC-Ame-010867 Astyanax mexicanus 68.51 2.00e-120 426.00
IUUC-Cja-019490 Callithrix jacchus 85.29 0.00e+00 833.00
IUUC-Cfa-021149 Canis familiaris 78.63 0.00e+00 781.00
IUUC-Cpo-021301 Cavia porcellus 84.42 0.00e+00 811.00
IUUC-Csa-023367 Chlorocebus sabaeus 86.32 0.00e+00 860.00
IUUC-Cin-025756 Ciona intestinalis 64.38 2.00e-16 78.60
IUUC-Dre-027579 Danio rerio 69.23 5.00e-119 420.00
IUUC-Dno-030064 Dasypus novemcinctus 83.85 0.00e+00 748.00
IUUC-Dor-031093 Dipodomys ordii 75.47 0.00e+00 741.00
IUUC-Ete-032302 Echinops telfairi 75.11 4.00e-171 594.00
IUUC-Eca-033237 Equus caballus 89.71 0.00e+00 924.00
IUUC-Eeu-035130 Erinaceus europaeus 82.73 0.00e+00 689.00
IUUC-Fca-035416 Felis catus 88.34 0.00e+00 837.00
IUUC-Fal-037281 Ficedula albicollis 55.83 2.00e-166 579.00
IUUC-Fso-038424 Fusarium solani 32.88 3.00e-03 35.40
IUUC-Gmo-039204 Gadus morhua 46.15 3.00e-114 405.00
IUUC-Gac-041980 Gasterosteus aculeatus 54.52 7.00e-121 427.00
IUUC-Ggo-044933 Gorilla gorilla 86.62 0.00e+00 854.00
IUUC-Hsa-046924 Homo sapiens 86.79 0.00e+00 864.00
IUUC-Itr-048614 Ictidomys tridecemlineatus 84.56 0.00e+00 818.00
IUUC-Lch-050063 Latimeria chalumnae 56.36 2.00e-167 582.00
IUUC-Loc-051993 Lepisosteus oculatus 51.88 1.00e-148 520.00
IUUC-Laf-053400 Loxodonta africana 85.40 0.00e+00 838.00
IUUC-Mcc-054768 Macaca mulatta 86.84 0.00e+00 853.00
IUUC-Meu-056059 Macropus eugenii 56.17 1.00e-134 473.00
IUUC-Mga-059707 Meleagris gallopavo 59.08 3.00e-178 618.00
IUUC-Mvi-060339 Microbotryum violaceum 34.62 2.50e-01 28.10
IUUC-Mmr-061391 Microcebus murinus 85.76 0.00e+00 852.00
IUUC-Mdo-062040 Monodelphis domestica 67.83 0.00e+00 654.00
IUUC-Mmu-064420 Mus musculus 81.48 0.00e+00 787.00
IUUC-Mpu-066099 Mustela putorius furo 85.76 0.00e+00 844.00
IUUC-Mlu-067979 Myotis lucifugus 86.52 0.00e+00 860.00
IUUC-Nle-069830 Nomascus leucogenys 83.70 0.00e+00 802.00
IUUC-Opr-071005 Ochotona princeps 82.93 2.00e-171 595.00
IUUC-Ont-072306 Oreochromis niloticus 47.64 1.00e-127 450.00
IUUC-Oan-073138 Ornithorhynchus anatinus 64.17 9.00e-169 586.00
IUUC-Ocu-073908 Oryctolagus cuniculus 89.27 0.00e+00 650.00
IUUC-Ola-087280 Oryzias latipes 46.56 6.00e-123 434.00
IUUC-Oga-088418 Otolemur garnettii 85.42 0.00e+00 842.00
IUUC-Oar-090414 Ovis aries 93.79 0.00e+00 736.00
IUUC-Ptr-091275 Pan troglodytes 86.62 0.00e+00 855.00
IUUC-Pan-092541 Papio anubis 86.84 0.00e+00 835.00
IUUC-Psi-094002 Pelodiscus sinensis 60.80 0.00e+00 627.00
IUUC-Pab-098538 Pongo abelii 87.48 0.00e+00 847.00
IUUC-Pca-100137 Procavia capensis 81.57 0.00e+00 662.00
IUUC-Pva-102367 Pteropus vampyrus 87.14 0.00e+00 685.00
IUUC-Rno-105133 Rattus norvegicus 81.82 0.00e+00 863.00
IUUC-Sha-106603 Sarcophilus harrisii 63.21 2.00e-148 518.00
IUUC-Tgu-117358 Taeniopygia guttata 59.87 3.00e-143 501.00
IUUC-Tru-118112 Takifugu rubripes 47.15 8.00e-122 430.00
IUUC-Tsy-119005 Tarsius syrichta 78.01 3.00e-152 531.00
IUUC-Ttr-129314 Tursiops truncatus 91.77 0.00e+00 945.00
Created Date 25-Jun-2017

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