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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106398
UUCD1 version UUC-SaC-00072
Ensembl Protein ID YOR156C
UniProt Accession Q12216; D6W2L3; SIZ2_YEAST
Genbank Protein ID AAA86121.1; AAC49642.1; CAA99362.1; DAA10929.1
Protein Name E3 SUMO-protein ligase SIZ2; SAP and Miz-finger domain-containing protein 2
Genbank Nucleotide ID U33152; U55020; Z75064; BK006948
Gene Name NFI1; SIZ2; YOR156C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YOR156C YOR156C YOR156C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMPHOSIDA
BioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 20195513; 14623866; 20592809
Classification
Family E-value Score Start End
E3 activity/RING/RING 6.30e-06 25.1 338 381
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+i ++++k++ ++ +C+H+ ++d l  w+++++s+ ++++CP+C+
   Q: 338  CPISCTRMKYPAKTDQCKHIQCFDAL--WFLHSQSQVPTWQCPICQ 381
           **********888788**********..*****************7 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     May act as an E3 ligase mediating SUMO/Smt3 attachment to septins. May be involved in chromosome maintenance.
 May act as an E3 ligase mediating SUMO/Smt3 attachment to septins. May be involved in chromosome maintenance.
Protein Sequence
(Fasta)
MASVMSNNNN NNNNNNASYM FTNPLSNTGG GLINEIKDAI NEMEQLKVLE LKQICKSLDL 60
SITGKKAVLQ DRIKQFLRKS CDIGHIDPWR PKAIKILIAK VRINSSLPKY STLWETLKTG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106398|E3,RING|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGCAAGTG TCATGTCAAA TAATAATAAT AATAATAATA ATAATAATGC CAGTTATATG 60
TTTACGAACC CTTTGTCCAA CACAGGTGGT GGACTCATAA ATGAAATAAA AGATGCAATA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106398|E3,RING|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR023321--PINIT
IPR003034--SAP_dom
IPR027229--SIZ1/SIZ2/Pli1/Gei17
IPR004181--Znf_MIZ
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51466--PINIT
PS50800--SAP
PS51044--ZF_SP_RING
Pfam

PF14324--PINIT
PF02037--SAP
PF02891--zf-MIZ
SMART

SM00513--SAP
Gene Ontology

GO:0000790--C:nuclear chromatin
GO:0003690--F:double-stranded DNA binding
GO:0016874--F:ligase activity
GO:0019789--F:SUMO transferase activity
GO:0008270--F:zinc ion binding
GO:0007059--P:chromosome segregation
GO:1990683--P:DNA double-strand break attachment to nuclear envelope
GO:0060969--P:negative regulation of gene silencing
GO:0016925--P:protein sumoylation
KEGG sce:YOR156C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000121 Aegilops tauschii 34.69 6.00e-16 77.40
IUUC-Aml-001745 Ailuropoda melanoleuca 27.60 4.00e-29 120.00
IUUC-Atr-002447 Amborella trichopoda 38.58 1.00e-19 90.10
IUUC-Apl-003765 Anas platyrhynchos 28.72 1.00e-29 121.00
IUUC-Aca-004464 Anolis carolinensis 29.94 1.00e-23 102.00
IUUC-Aly-006247 Arabidopsis lyrata 28.79 1.00e-18 86.30
IUUC-Ath-006888 Arabidopsis thaliana 27.59 9.00e-19 86.70
IUUC-Ame-010763 Astyanax mexicanus 33.93 2.00e-29 121.00
IUUC-Bta-012369 Bos taurus 27.42 2.00e-29 121.00
IUUC-Bdi-014054 Brachypodium distachyon 34.69 1.00e-15 77.00
IUUC-Bol-015380 Brassica oleracea 29.35 9.00e-21 93.20
IUUC-Bra-017443 Brassica rapa 28.86 5.00e-21 94.00
IUUC-Cja-019450 Callithrix jacchus 34.10 2.00e-29 121.00
IUUC-Cfa-020933 Canis familiaris 27.54 8.00e-30 122.00
IUUC-Cpo-022112 Cavia porcellus 27.54 3.00e-29 120.00
IUUC-Csa-023988 Chlorocebus sabaeus 26.20 5.00e-24 103.00
IUUC-Cho-024816 Choloepus hoffmanni 26.41 5.00e-24 103.00
IUUC-Cin-025791 Ciona intestinalis 33.04 3.00e-25 107.00
IUUC-Cme-027209 Cyanidioschyzon merolae 26.57 3.00e-12 65.10
IUUC-Dre-027609 Danio rerio 33.92 8.00e-30 122.00
IUUC-Dno-028983 Dasypus novemcinctus 26.41 9.00e-24 102.00
IUUC-Dor-030842 Dipodomys ordii 27.60 2.00e-20 92.00
IUUC-Dme-032018 Drosophila melanogaster 30.98 3.00e-21 95.10
IUUC-Ete-032543 Echinops telfairi 31.91 8.00e-21 93.20
IUUC-Eca-034430 Equus caballus 27.21 2.00e-29 121.00
IUUC-Eeu-034994 Erinaceus europaeus 30.51 4.00e-22 97.10
IUUC-Fca-035422 Felis catus 29.38 2.00e-23 101.00
IUUC-Fal-037449 Ficedula albicollis 27.41 1.00e-29 122.00
IUUC-Fox-038010 Fusarium oxysporum 29.63 4.00e-11 60.50
IUUC-Gmo-038925 Gadus morhua 33.33 5.00e-30 123.00
IUUC-Gga-040362 Gallus gallus 25.66 3.00e-30 124.00
IUUC-Gac-042353 Gasterosteus aculeatus 32.74 2.00e-27 115.00
IUUC-Ggo-044810 Gorilla gorilla 34.10 2.00e-29 121.00
IUUC-Hsa-045784 Homo sapiens 27.42 1.00e-29 122.00
IUUC-Hvu-047061 Hordeum vulgare 28.89 6.00e-19 87.40
IUUC-Itr-048486 Ictidomys tridecemlineatus 33.91 4.00e-29 120.00
IUUC-Lch-050424 Latimeria chalumnae 30.50 1.00e-23 102.00
IUUC-Lpe-050926 Leersia perrieri 38.30 1.00e-17 83.60
IUUC-Loc-052354 Lepisosteus oculatus 34.52 3.00e-30 124.00
IUUC-Laf-054261 Loxodonta africana 33.53 5.00e-29 120.00
IUUC-Mcc-054931 Macaca mulatta 34.10 2.00e-29 121.00
IUUC-Meu-056468 Macropus eugenii 34.10 2.00e-29 121.00
IUUC-Mpo-057405 Magnaporthe poae 28.16 2.00e-43 167.00
IUUC-Mtr-058267 Medicago truncatula 24.15 5.00e-20 90.90
IUUC-Mla-058882 Melampsora laricipopulina 29.97 2.00e-31 128.00
IUUC-Mga-059790 Meleagris gallopavo 29.95 2.00e-22 98.20
IUUC-Mvi-060421 Microbotryum violaceum 30.80 1.00e-37 149.00
IUUC-Mmr-061181 Microcebus murinus 34.10 3.00e-29 121.00
IUUC-Mdo-062345 Monodelphis domestica 25.97 1.00e-29 122.00
IUUC-Mmu-063197 Mus musculus 32.37 2.00e-28 118.00
IUUC-Mac-064907 Musa acuminata 29.22 9.00e-20 90.10
IUUC-Mpu-066275 Mustela putorius furo 33.53 6.00e-29 120.00
IUUC-Mlu-067194 Myotis lucifugus 34.10 2.00e-29 121.00
IUUC-Nle-070060 Nomascus leucogenys 29.94 6.00e-24 103.00
IUUC-Opr-070251 Ochotona princeps 29.94 6.00e-24 103.00
IUUC-Ont-072227 Oreochromis niloticus 32.74 2.00e-29 121.00
IUUC-Oan-073028 Ornithorhynchus anatinus 29.94 1.00e-23 102.00
IUUC-Ocu-074400 Oryctolagus cuniculus 28.08 7.00e-24 103.00
IUUC-Oba-075731 Oryza barthii 38.32 3.00e-19 88.60
IUUC-Obr-076179 Oryza brachyantha 41.24 3.00e-19 88.60
IUUC-Ogl-077808 Oryza glaberrima 38.32 3.00e-19 88.60
IUUC-Ogu-078271 Oryza glumaepatula 41.24 3.00e-19 88.60
IUUC-Oin-079070 Oryza indica 41.24 2.00e-19 89.00
IUUC-Olo-080754 Oryza longistaminata 32.20 2.00e-16 79.30
IUUC-Ome-081404 Oryza meridionalis 38.32 2.00e-19 89.00
IUUC-Oni-082630 Oryza nivara 32.20 2.00e-16 79.30
IUUC-Opu-083841 Oryza punctata 37.38 7.00e-19 87.40
IUUC-Oru-084716 Oryza rufipogon 41.24 2.00e-19 89.00
IUUC-Osa-085685 Oryza sativa 41.24 3.00e-19 88.60
IUUC-Ola-086865 Oryzias latipes 31.76 6.00e-29 120.00
IUUC-Olu-087742 Ostreococcus lucimarinus 25.42 5.00e-15 73.20
IUUC-Oga-088945 Otolemur garnettii 27.42 6.00e-30 123.00
IUUC-Oar-089412 Ovis aries 27.42 3.00e-29 120.00
IUUC-Ptr-090464 Pan troglodytes 29.94 1.00e-23 102.00
IUUC-Pan-092183 Papio anubis 27.42 2.00e-29 121.00
IUUC-Psi-093003 Pelodiscus sinensis 28.82 1.00e-29 122.00
IUUC-Pma-094693 Petromyzon marinus 32.95 2.00e-25 108.00
IUUC-Ppa-095583 Physcomitrella patens 26.05 5.00e-21 94.40
IUUC-Pfo-096704 Poecilia formosa 32.74 2.00e-29 121.00
IUUC-Pab-097699 Pongo abelii 29.94 1.00e-23 102.00
IUUC-Pop-099745 Populus trichocarpa 33.02 1.00e-14 73.60
IUUC-Pca-101088 Procavia capensis 29.94 7.00e-24 103.00
IUUC-Ppe-101666 Prunus persica 22.98 3.00e-16 78.60
IUUC-Pva-102562 Pteropus vampyrus 34.30 3.00e-29 120.00
IUUC-Pgr-103580 Puccinia graminis 32.21 1.00e-30 126.00
IUUC-Ptt-103870 Puccinia triticina 29.81 2.00e-28 117.00
IUUC-Rno-105762 Rattus norvegicus 26.77 2.00e-29 121.00
IUUC-Sha-107253 Sarcophilus harrisii 34.10 2.00e-29 121.00
IUUC-Smo-109174 Selaginella moellendorffii 33.71 5.00e-14 71.20
IUUC-Sit-110527 Setaria italica 39.13 8.00e-19 87.00
IUUC-Sly-111180 Solanum lycopersicum 41.00 2.00e-19 89.00
IUUC-Stu-112120 Solanum tuberosum 31.63 2.00e-15 75.50
IUUC-Sar-113273 Sorex araneus 29.94 9.00e-24 103.00
IUUC-Sbi-114516 Sorghum bicolor 34.69 6.00e-17 80.50
IUUC-Ssc-115241 Sus scrofa 27.42 1.00e-29 122.00
IUUC-Tgu-116884 Taeniopygia guttata 28.37 3.00e-29 120.00
IUUC-Tru-118031 Takifugu rubripes 32.74 1.00e-29 122.00
IUUC-Tsy-119019 Tarsius syrichta 29.38 2.00e-23 102.00
IUUC-Tni-119766 Tetraodon nigroviridis 32.74 6.00e-30 123.00
IUUC-Tca-121811 Theobroma cacao 39.00 4.00e-16 78.20
IUUC-Tae-124127 Triticum aestivum 29.31 5.00e-19 87.80
IUUC-Tur-126304 Triticum urartu 31.63 3.00e-15 75.10
IUUC-Tbe-127942 Tupaia belangeri 28.81 3.00e-21 94.70
IUUC-Ttr-128556 Tursiops truncatus 34.10 2.00e-29 120.00
IUUC-Vpa-130725 Vicugna pacos 26.72 3.00e-24 103.00
IUUC-Vvi-131541 Vitis vinifera 24.66 6.00e-22 97.40
IUUC-Xtr-131866 Xenopus tropicalis 31.98 1.00e-26 112.00
IUUC-Xma-133963 Xiphophorus maculatus 32.74 2.00e-29 121.00
Created Date 25-Jun-2017

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