iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cpo-021779

Ensembl Protein ID

ENSCPOP00000004688.2

UniProt Accession

H0V4Y0; H0V4Y0_CAVPO

Genbank Protein ID

ENSCPOP00000004688

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AAKN02003333

Gene Name

BLK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000005215.3	ENSCPOT00000005270.2	ENSCPOP00000004688.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	7.60e-15	54.6	53	111

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++++v +lydy a+nd +L++ kG++++v+   ++ ++W+ +++  +g++G +P+nFv+ +e
   Q: 53   EDHYVVALYDYAAVNDRDLQMCKGEKLQVL---KETGDWWLAKSLITGREGYVPSNFVAPVE 111
           5799**************************...88899********************9986 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MGLLSSKRQV PEKGKAWSPV KAGSRSQAPP PLPPLVVFNH LPPPPPNEHP DQEDHYVVAL 60
YDYAAVNDRD LQMCKGEKLQ VLKETGDWWL AKSLITGREG YVPSNFVAPV ETLEVEKWFF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGACTGC TAAGCAGCAA GAGGCAGGTC CCCGAGAAGG GCAAGGCCTG GAGCCCTGTG 60
AAGGCTGGTT CCCGGAGCCA GGCTCCCCCA CCGCTGCCGC CCCTGGTGAG TGAGTGGTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0050853--P:B cell receptor signaling pathway
GO:0032024--P:positive regulation of insulin secretion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002133	Ailuropoda melanoleuca	87.37	0.00e+00	876.00
IUUC-Apl-003307	Anas platyrhynchos	76.79	0.00e+00	748.00
IUUC-Aca-004357	Anolis carolinensis	69.66	0.00e+00	677.00
IUUC-Ame-010642	Astyanax mexicanus	70.89	0.00e+00	697.00
IUUC-Bta-012400	Bos taurus	86.23	0.00e+00	887.00
IUUC-Cfa-021056	Canis familiaris	86.00	0.00e+00	880.00
IUUC-Csa-023557	Chlorocebus sabaeus	88.61	0.00e+00	882.00
IUUC-Dre-027517	Danio rerio	69.26	0.00e+00	706.00
IUUC-Eca-034218	Equus caballus	87.78	0.00e+00	873.00
IUUC-Eeu-035095	Erinaceus europaeus	66.20	0.00e+00	636.00
IUUC-Fca-036015	Felis catus	86.20	0.00e+00	886.00
IUUC-Fal-036946	Ficedula albicollis	76.63	0.00e+00	739.00
IUUC-Gmo-038861	Gadus morhua	67.34	0.00e+00	633.00
IUUC-Gga-040822	Gallus gallus	71.60	0.00e+00	751.00
IUUC-Gac-041860	Gasterosteus aculeatus	69.37	0.00e+00	661.00
IUUC-Ggo-044608	Gorilla gorilla	89.20	0.00e+00	811.00
IUUC-Hsa-046719	Homo sapiens	87.99	0.00e+00	872.00
IUUC-Itr-048323	Ictidomys tridecemlineatus	88.98	0.00e+00	891.00
IUUC-Lch-050114	Latimeria chalumnae	73.36	0.00e+00	702.00
IUUC-Loc-052326	Lepisosteus oculatus	72.49	0.00e+00	716.00
IUUC-Laf-053387	Loxodonta africana	84.20	0.00e+00	863.00
IUUC-Mcc-055026	Macaca mulatta	88.82	0.00e+00	884.00
IUUC-Mga-059427	Meleagris gallopavo	75.28	0.00e+00	736.00
IUUC-Mmr-061660	Microcebus murinus	88.60	0.00e+00	885.00
IUUC-Mdo-062318	Monodelphis domestica	75.35	0.00e+00	794.00
IUUC-Mmu-063325	Mus musculus	87.58	0.00e+00	905.00
IUUC-Mpu-066582	Mustela putorius furo	87.58	0.00e+00	878.00
IUUC-Nle-069624	Nomascus leucogenys	88.17	0.00e+00	867.00
IUUC-Opr-070656	Ochotona princeps	82.57	0.00e+00	817.00
IUUC-Ont-072266	Oreochromis niloticus	67.14	0.00e+00	697.00
IUUC-Ocu-073907	Oryctolagus cuniculus	86.00	0.00e+00	875.00
IUUC-Ola-086668	Oryzias latipes	70.05	0.00e+00	665.00
IUUC-Oga-088057	Otolemur garnettii	85.63	0.00e+00	877.00
IUUC-Oar-089332	Ovis aries	82.63	0.00e+00	839.00
IUUC-Ptr-091551	Pan troglodytes	86.42	0.00e+00	831.00
IUUC-Pan-092173	Papio anubis	89.23	0.00e+00	874.00
IUUC-Psi-093895	Pelodiscus sinensis	75.67	0.00e+00	742.00
IUUC-Pfo-096608	Poecilia formosa	70.04	0.00e+00	695.00
IUUC-Pab-097598	Pongo abelii	88.61	0.00e+00	858.00
IUUC-Pva-102135	Pteropus vampyrus	89.18	0.00e+00	868.00
IUUC-Rno-104891	Rattus norvegicus	88.38	0.00e+00	902.00
IUUC-Sha-107192	Sarcophilus harrisii	76.63	0.00e+00	810.00
IUUC-Ssc-115696	Sus scrofa	88.02	0.00e+00	900.00
IUUC-Tgu-117056	Taeniopygia guttata	75.68	0.00e+00	734.00
IUUC-Tru-117621	Takifugu rubripes	69.27	0.00e+00	666.00
IUUC-Tbe-127520	Tupaia belangeri	88.39	0.00e+00	666.00
IUUC-Ttr-128457	Tursiops truncatus	86.43	0.00e+00	884.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence