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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Rno-104891
Ensembl Protein ID ENSRNOP00000015021.4
UniProt Accession Q4KM97; Q4KM97_RAT
Genbank Protein ID AAH98683.1; EDL85321.1
Protein Name Tyrosine-protein kinase
Genbank Nucleotide ID AABR07018198; CH474023
Gene Name Blk; rCG_52180
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000010798.6 ENSRNOT00000015021.6 ENSRNOP00000015021.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACRAID2
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 6.60e-13 48.8 55 111
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3

   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
    + v +l+dy a+nd +L+ kG++++v+ + ++W+ + + +g++G +P+nFv+ +e
   Q: 55 RFVVALFDYAAVNDRDLQVLKGEKLQVL---KSTGDWWLARSLVTGREGYVPSNFVAPVE 111
    6789************************...8999*********************9986 PP
   

Organism Rattus norvegicus
Protein Sequence
(Fasta)
MGLLSSKRQI SEKSKSWSPV KARAQGKVPP PLPPLVVFNH LPPPSPNQHP DEEERFVVAL 60
FDYAAVNDRD LQVLKGEKLQ VLKSTGDWWL ARSLVTGREG YVPSNFVAPV ETLEVEKWFF 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Rno-104891|UBD,SH3|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CAACAAACCA ATGGAGGGAA AACACCAGCC ACGTGGTAAA CCAAAACCCA TGAGAAAACT 60
CTGGGGTACC AGAGGGGCAA TATGACCAGC ATGGCTGAAC GTCAGGTGCC CACGGAACTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Rno-104891|UBD,SH3|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0050853--P:B cell receptor signaling pathway
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0032024--P:positive regulation of insulin secretion
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG rno:364403
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002133 Ailuropoda melanoleuca 88.41 0.00e+00 884.00
IUUC-Apl-003307 Anas platyrhynchos 75.45 0.00e+00 738.00
IUUC-Aca-004357 Anolis carolinensis 69.30 0.00e+00 669.00
IUUC-Ame-010642 Astyanax mexicanus 70.44 0.00e+00 688.00
IUUC-Bta-012400 Bos taurus 85.23 0.00e+00 870.00
IUUC-Cja-019717 Callithrix jacchus 84.83 0.00e+00 688.00
IUUC-Cfa-021056 Canis familiaris 87.40 0.00e+00 897.00
IUUC-Cpo-021779 Cavia porcellus 88.38 0.00e+00 891.00
IUUC-Csa-023557 Chlorocebus sabaeus 86.93 0.00e+00 891.00
IUUC-Dre-027517 Danio rerio 69.48 0.00e+00 701.00
IUUC-Eca-034218 Equus caballus 87.37 0.00e+00 871.00
IUUC-Eeu-035095 Erinaceus europaeus 65.40 0.00e+00 634.00
IUUC-Fca-036015 Felis catus 86.40 0.00e+00 894.00
IUUC-Fal-036946 Ficedula albicollis 70.72 0.00e+00 733.00
IUUC-Gga-040822 Gallus gallus 70.38 0.00e+00 747.00
IUUC-Ggo-044608 Gorilla gorilla 90.14 0.00e+00 818.00
IUUC-Hsa-046719 Homo sapiens 86.53 0.00e+00 888.00
IUUC-Itr-048323 Ictidomys tridecemlineatus 89.38 0.00e+00 896.00
IUUC-Lch-050114 Latimeria chalumnae 74.27 0.00e+00 706.00
IUUC-Loc-052326 Lepisosteus oculatus 71.49 0.00e+00 711.00
IUUC-Laf-053387 Loxodonta africana 84.00 0.00e+00 863.00
IUUC-Mcc-055026 Macaca mulatta 87.13 0.00e+00 894.00
IUUC-Mga-059427 Meleagris gallopavo 74.83 0.00e+00 732.00
IUUC-Mmr-061660 Microcebus murinus 88.00 0.00e+00 882.00
IUUC-Mdo-062318 Monodelphis domestica 75.90 0.00e+00 788.00
IUUC-Mmu-063325 Mus musculus 96.39 0.00e+00 980.00
IUUC-Mpu-066582 Mustela putorius furo 88.82 0.00e+00 885.00
IUUC-Nle-069624 Nomascus leucogenys 88.59 0.00e+00 864.00
IUUC-Opr-070656 Ochotona princeps 81.76 0.00e+00 805.00
IUUC-Ont-072266 Oreochromis niloticus 68.83 0.00e+00 681.00
IUUC-Ocu-073907 Oryctolagus cuniculus 85.60 0.00e+00 863.00
IUUC-Oga-088057 Otolemur garnettii 85.43 0.00e+00 868.00
IUUC-Oar-089332 Ovis aries 81.24 0.00e+00 828.00
IUUC-Ptr-091551 Pan troglodytes 85.19 0.00e+00 847.00
IUUC-Pan-092173 Papio anubis 87.33 0.00e+00 875.00
IUUC-Psi-093895 Pelodiscus sinensis 73.66 0.00e+00 725.00
IUUC-Pab-097598 Pongo abelii 86.73 0.00e+00 862.00
IUUC-Pva-102135 Pteropus vampyrus 88.53 0.00e+00 869.00
IUUC-Sha-107192 Sarcophilus harrisii 77.34 0.00e+00 811.00
IUUC-Ssc-115696 Sus scrofa 86.83 0.00e+00 890.00
IUUC-Tgu-117056 Taeniopygia guttata 74.77 0.00e+00 725.00
IUUC-Tru-117621 Takifugu rubripes 68.37 0.00e+00 654.00
IUUC-Tbe-127520 Tupaia belangeri 87.07 0.00e+00 666.00
Created Date 25-Jun-2017

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