• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Cel-018509
Ensembl Protein ID T04D1.3d
UniProt Accession B1V8A0; A5A8Q9; A5A8R0; O61843; Q6TM46; SH3GH_CAEEL
Genbank Protein ID AAQ96373.1; CCD61260.1; CCD61261.1; CCD61262.1; CCD61263.1
Protein Name Endophilin-A homolog; Endophilin-1 homolog; Uncoordinated protein 57
Genbank Nucleotide ID AY394006; BX284601; BX284601; BX284601; BX284601
Gene Name unc-57; T04D1.3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00006791 T04D1.3a T04D1.3a
WBGene00006791 T04D1.3c T04D1.3c
WBGene00006791 T04D1.3d T04D1.3d
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNARAID2
Post-translational Modifications (PTMs)
PHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 8.40e-13 48.4 321 377
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +k ++++l+d++aq+++eL +k+G  ++++   + de+W +g    +gk GlfP  +v+ l
   Q: 321  QKPQCRALFDFDAQSEGELDFKEGTLIELV--SQIDENWYEG--RVNGKTGLFPVTYVQVL 377
           6779**************************..999*******..8************9865 PP
   
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Involved in synaptic vesicle (SV) recycling in neurons probably by regulating clathrin-mediated endocytosis (PubMed:14622579, PubMed:21029864). By controlling SV endocytosis, regulates the rate of excitatory postsynaptic currents (EPSCs) at neuromuscular junctions and thus locomotion (PubMed:21029864). In a similar manner, involved in necrotic neuronal cell death induced by abnormal hyperactivation of ion channels (PubMed:22157748). Plays a minor role in responses to mechanical stimuli (PubMed:17928447). Plays a minor role in unc-26/synaptojanin localization to synapses (PubMed:14622579).
 Involved in synaptic vesicle (SV) recycling in neurons probably by regulating clathrin-mediated endocytosis (PubMed:14622579, PubMed:21029864). By controlling SV endocytosis, regulates the rate of excitatory postsynaptic currents (EPSCs) at neuromuscular junctions and thus locomotion (PubMed:21029864). In a similar manner, involved in necrotic neuronal cell death induced by abnormal hyperactivation of ion channels (PubMed:22157748). Plays a minor role in responses to mechanical stimuli (PubMed:17928447). Plays a minor role in unc-26/synaptojanin localization to synapses (PubMed:14622579).
Protein Sequence
(Fasta)
MSLSGLRKQF NKANQYLSET MGAAEPTKLD DVFNEMEKNV DTTYNLITDL VAGTNEYLQP 60
NPATRAKMAT QVALSKVRGT TKTSPYPQTE GMLADVMQKY GQQLGDNSDL GKSLNDAAET 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018509|UBD,SH3|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAAAATGTCG TTGTCGGGGT TACGTAAGCA ATTCAACAAG GCGAATCAAT ACCTTTCGGA 60
GACGATGGGC GCCGCAGAGC CAACAAAACT TGACGATGTG TTCAATGAAA TGGAGAAAAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018509|UBD,SH3|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0965--Cell junction
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0254--Endocytosis
KW-0472--Membrane
KW-1210--Necrosis
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0770--Synapse
Interpro

IPR027267--AH/BAR-dom
IPR004148--BAR_dom
IPR028501--Endophilin-A
IPR001452--SH3_domain
PROSITE

PS51021--BAR
PS50002--SH3
Pfam

PF03114--BAR
PF00018--SH3_1
PRINTS

PR00452--SH3DOMAIN
SMART

SM00721--BAR
SM00326--SH3
Gene Ontology

GO:0030054--C:cell junction
GO:0016020--C:membrane
GO:0031594--C:neuromuscular junction
GO:0008021--C:synaptic vesicle
GO:0072583--P:clathrin-dependent endocytosis
GO:0010940--P:positive regulation of necrotic cell death
GO:0012501--P:programmed cell death
KEGG cel:CELE_T04D1.3
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001598 Ailuropoda melanoleuca 45.26 2.00e-89 320.00
IUUC-Apl-004209 Anas platyrhynchos 44.35 3.00e-84 303.00
IUUC-Aca-004816 Anolis carolinensis 45.55 1.00e-95 342.00
IUUC-Ame-011714 Astyanax mexicanus 45.29 3.00e-98 350.00
IUUC-Bgr-012305 Blumeria graminis 37.74 3.00e-09 56.60
IUUC-Bta-012875 Bos taurus 45.31 4.00e-95 340.00
IUUC-Bci-013864 Botrytis cinerea 39.62 5.00e-10 59.30
IUUC-Bdi-014394 Brachypodium distachyon 47.83 6.00e-07 47.40
IUUC-Cja-019400 Callithrix jacchus 45.55 4.00e-92 329.00
IUUC-Cfa-020979 Canis familiaris 43.60 2.00e-83 301.00
IUUC-Cpo-021364 Cavia porcellus 44.99 1.00e-84 305.00
IUUC-Csa-023447 Chlorocebus sabaeus 44.76 1.00e-89 322.00
IUUC-Cho-024348 Choloepus hoffmanni 43.72 1.00e-93 335.00
IUUC-Cin-025799 Ciona intestinalis 44.39 1.00e-86 311.00
IUUC-Csv-026266 Ciona savignyi 42.06 1.00e-80 291.00
IUUC-Cne-026909 Cryptococcus neoformans 51.92 3.00e-12 65.10
IUUC-Dre-028063 Danio rerio 45.81 3.00e-97 347.00
IUUC-Dno-029219 Dasypus novemcinctus 45.81 6.00e-91 326.00
IUUC-Dor-030288 Dipodomys ordii 38.85 4.00e-76 276.00
IUUC-Dse-031521 Dothistroma septosporum 45.90 1.00e-11 63.50
IUUC-Dme-031633 Drosophila melanogaster 45.14 8.00e-94 335.00
IUUC-Ete-032686 Echinops telfairi 40.60 9.00e-76 275.00
IUUC-Eca-033209 Equus caballus 44.27 3.00e-87 313.00
IUUC-Eeu-034924 Erinaceus europaeus 44.24 1.00e-93 335.00
IUUC-Fca-036354 Felis catus 42.31 3.00e-85 306.00
IUUC-Fal-036965 Ficedula albicollis 45.43 4.00e-91 326.00
IUUC-Gmo-038951 Gadus morhua 42.15 2.00e-76 278.00
IUUC-Gga-041064 Gallus gallus 46.60 4.00e-95 340.00
IUUC-Gac-042642 Gasterosteus aculeatus 44.53 3.00e-88 317.00
IUUC-Ggo-045448 Gorilla gorilla 44.50 2.00e-91 328.00
IUUC-Hsa-046112 Homo sapiens 44.50 3.00e-91 327.00
IUUC-Itr-048752 Ictidomys tridecemlineatus 44.76 3.00e-92 330.00
IUUC-Kpa-049352 Komagataella pastoris 47.17 3.00e-11 62.00
IUUC-Lch-050556 Latimeria chalumnae 46.79 7.00e-97 345.00
IUUC-Loc-052711 Lepisosteus oculatus 48.04 2.00e-102 363.00
IUUC-Laf-053698 Loxodonta africana 46.09 4.00e-97 346.00
IUUC-Mcc-055620 Macaca mulatta 42.97 3.00e-82 297.00
IUUC-Meu-056119 Macropus eugenii 43.72 2.00e-93 333.00
IUUC-Mga-059193 Meleagris gallopavo 45.90 9.00e-89 318.00
IUUC-Mvi-060542 Microbotryum violaceum 50.00 9.00e-11 58.90
IUUC-Mmr-061056 Microcebus murinus 42.86 2.00e-91 327.00
IUUC-Mdo-062217 Monodelphis domestica 43.72 6.00e-94 335.00
IUUC-Mmu-063596 Mus musculus 45.36 1.00e-92 332.00
IUUC-Mpu-066681 Mustela putorius furo 43.36 1.00e-92 331.00
IUUC-Mlu-067212 Myotis lucifugus 41.36 2.00e-87 314.00
IUUC-Nle-069316 Nomascus leucogenys 45.14 3.00e-86 310.00
IUUC-Opr-070661 Ochotona princeps 45.97 1.00e-92 332.00
IUUC-Ont-072622 Oreochromis niloticus 45.55 6.00e-97 345.00
IUUC-Oan-073674 Ornithorhynchus anatinus 43.17 9.00e-87 312.00
IUUC-Ocu-074005 Oryctolagus cuniculus 43.81 5.00e-93 332.00
IUUC-Ola-086645 Oryzias latipes 44.50 2.00e-95 340.00
IUUC-Oga-088627 Otolemur garnettii 44.57 2.00e-90 324.00
IUUC-Oar-089220 Ovis aries 45.38 3.00e-85 307.00
IUUC-Ptr-090943 Pan troglodytes 44.65 2.00e-93 333.00
IUUC-Pan-092153 Papio anubis 44.76 1.00e-89 322.00
IUUC-Psi-093052 Pelodiscus sinensis 45.55 1.00e-96 345.00
IUUC-Pma-094657 Petromyzon marinus 43.28 3.00e-81 293.00
IUUC-Pfo-096876 Poecilia formosa 44.39 4.00e-88 316.00
IUUC-Pab-097667 Pongo abelii 37.98 1.00e-64 238.00
IUUC-Pca-100102 Procavia capensis 42.97 1.00e-86 311.00
IUUC-Pva-102745 Pteropus vampyrus 43.46 2.00e-92 331.00
IUUC-Rno-105425 Rattus norvegicus 44.87 7.00e-91 325.00
IUUC-Sha-106675 Sarcophilus harrisii 44.36 2.00e-92 330.00
IUUC-Sar-113540 Sorex araneus 42.35 1.00e-81 294.00
IUUC-Ssc-115548 Sus scrofa 45.03 9.00e-92 328.00
IUUC-Tgu-117366 Taeniopygia guttata 44.50 7.00e-95 338.00
IUUC-Tru-118509 Takifugu rubripes 45.03 7.00e-96 342.00
IUUC-Tsy-119366 Tarsius syrichta 44.81 1.00e-84 305.00
IUUC-Tni-120585 Tetraodon nigroviridis 43.46 9.00e-89 318.00
IUUC-Tbe-127252 Tupaia belangeri 39.08 2.00e-29 122.00
IUUC-Ttr-128449 Tursiops truncatus 44.26 2.00e-85 307.00
IUUC-Vpa-130032 Vicugna pacos 38.19 2.00e-62 231.00
IUUC-Xtr-131935 Xenopus tropicalis 46.13 8.00e-89 318.00
IUUC-Xma-132985 Xiphophorus maculatus 44.65 5.00e-88 316.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved