iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-007696

UUCD1 version

UUC-ArT-01403

Ensembl Protein ID

AT2G33340.1

UniProt Accession

O22785; C1KE07; Q3EBP5; PR19B_ARATH

Genbank Protein ID

ACO38702.1; AAB80652.1; AEC08817.1; AEC08818.1; AT2G33340.1

Protein Name

Pre-mRNA-processing factor 19 homolog 2; MOS4-associated complex protein 3B; Plant U-box protein 60; RING-type E3 ubiquitin transferase PRP19 2; U-box domain-containing protein 60

Genbank Nucleotide ID

FJ820118; AC002332; CP002685; CP002685; AY080868

Gene Name

PRP19B; MAC3B; PUB60; At2g33340; F4P9.11

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT2G33340	AT2G33340.3	AT2G33340.3
AT2G33340	AT2G33340.1	AT2G33340.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
PINA	HINT
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/U-box	U-box	18393940; 19629177
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	19629177

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	1.00e-15	58.4	2	68
E3 adaptor/Cullin RING/DCX/DWD	5.20e-27	93.6	262	292
UBD/Beta-Prp	1.90e-46	159.5	217	432

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 7    lCpIslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawceens 73
           +C+Is+e++ +Pvv+  sG  ++r+ Ie++++++gk cPvt++plt +d+vP +t   +  + +++ s
   Q: 2    NCAISGEVPVEPVVSTkSGLLFERRLIERHISDYGK-CPVTGEPLTIDDIVPIKTGEIIKPKTLHTAS 68
           7*************999*******************.******************9999998888766 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gH+ +vt+++f  d +l++++s D+t+++W+
   Q: 262  GHSKKVTSVKFvGDsDLVLTASADKTVRIWR 292
           8***********666***************8 PP

UBD/Beta-Prp

   S: 48   l.sgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdle...tgqcleetlsghdgvvn 141
           l + +++++ ++++ +++++++tg+ D+t+ ++d  +g++++tl+gh+++v+s++f  ++d ++++s+d+t+r+w  +   ++ c + tl+ h++ v+
   Q: 217  LhKTNKPGICSMDILHSKDVIATGGVDATAVLFDRPSGQILSTLTGHSKKVTSVKFVGDSDLVLTASADKTVRIWRNPgdgNYACGY-TLNDHSAEVR 313
           44678899*******************************************************************886222555555.********** PP
   S: 142  cvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysls..fdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderl 237
            v+vhp+++++vs+slD+t  ++dl++g++l + +  + + v  ++  f+++g  l +g   + vk+wd++++  v ++ ght  v+ + fs+n+ +l
   Q: 314  AVTVHPTNKYFVSASLDGTWCFYDLSSGSCLAQVSD-DSKNVDYTAaaFHPDGLILGTGTSQSVVKIWDVKSQANVAKFDGHTGEVTAISFSENGYFL 410
           **********************************87.88888777778********************************************999888 PP
   S: 238  vsgssDgsiriWdlrsgdllktl 260
           +++++D  +r+Wdlr+  + k++
   Q: 411  ATAAED-GVRLWDLRKLRNFKSF 432
           888866.58*****998777765 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Probable ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair (By similarity). Component of the MAC complex that probably regulates defense responses through transcriptional control and thereby is essential for plant innate immunity.

Protein Sequence
(Fasta)

MNCAISGEVP VEPVVSTKSG LLFERRLIER HISDYGKCPV TGEPLTIDDI VPIKTGEIIK 60
PKTLHTASIP GLLGTFQNEW DGLMLSNFAL EQQLHTARQE LSHALYQHDS ACRVIARLKK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAAATATAAG AAGGTGATCG TTAAAGGCCC AATTAAATTG AATCCCTAAT ATATCAAGTG 60
AGAGTGTTAA TCGTCGTCTC TCTCTTCAAC CATTTCCCGG CTTCCGCGTT TTTGCTTTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0391--Immunity
KW-0399--Innate immunity
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0611--Plant defense
KW-1185--Reference proteome
KW-0677--Repeat
KW-0747--Spliceosome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR013915--Pre-mRNA_splic_Prp19
IPR003613--Ubox_domain
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51698--U_BOX
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08606--Prp19
PF00400--WD40

SMART

SM00504--Ubox
SM00320--WD40

Gene Ontology

GO:0005618--C:cell wall
GO:0009507--C:chloroplast
GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005634--C:nucleus
GO:0000974--C:Prp19 complex
GO:0071006--C:U2-type catalytic step 1 spliceosome
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0042742--P:defense response to bacterium
GO:0006281--P:DNA repair
GO:0000349--P:generation of catalytic spliceosome for first transesterification step
GO:0045087--P:innate immune response
GO:0070534--P:protein K63-linked ubiquitination

KEGG

ath:AT2G33340

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001230	Ailuropoda melanoleuca	43.64	5.00e-105	374.00
IUUC-Aca-005272	Anolis carolinensis	44.00	5.00e-112	397.00
IUUC-Aly-006002	Arabidopsis lyrata	97.74	0.00e+00	963.00
IUUC-Ago-007879	Ashbya gossypii	26.92	2.00e-34	139.00
IUUC-Acl-008335	Aspergillus clavatus	32.52	1.00e-59	223.00
IUUC-Afl-008527	Aspergillus flavus	34.17	4.00e-67	248.00
IUUC-Afu-008957	Aspergillus fumigatus	34.26	3.00e-69	254.00
IUUC-Ani-009280	Aspergillus nidulans	33.85	1.00e-62	233.00
IUUC-Ang-009746	Aspergillus niger	35.23	1.00e-65	243.00
IUUC-Aor-009905	Aspergillus oryzae	33.98	3.00e-69	254.00
IUUC-Ate-010412	Aspergillus terreus	34.88	3.00e-59	221.00
IUUC-Ame-011561	Astyanax mexicanus	40.46	4.00e-41	160.00
IUUC-Bgr-012283	Blumeria graminis	31.90	6.00e-50	191.00
IUUC-Bta-013242	Bos taurus	44.04	6.00e-111	393.00
IUUC-Bci-013901	Botrytis cinerea	33.66	1.00e-66	246.00
IUUC-Bol-016207	Brassica oleracea	93.90	0.00e+00	1004.00
IUUC-Bra-017650	Brassica rapa	92.76	0.00e+00	1012.00
IUUC-Cel-018271	Caenorhabditis elegans	38.95	2.00e-100	358.00
IUUC-Cja-019879	Callithrix jacchus	44.15	2.00e-110	392.00
IUUC-Cfa-020175	Canis familiaris	43.99	8.00e-111	393.00
IUUC-Cpo-022379	Cavia porcellus	44.04	8.00e-111	393.00
IUUC-Cre-022993	Chlamydomonas reinhardtii	45.26	2.00e-128	451.00
IUUC-Csa-023500	Chlorocebus sabaeus	44.23	2.00e-111	395.00
IUUC-Cgl-026507	Colletotrichum gloeosporioides	32.95	8.00e-62	230.00
IUUC-Dre-028187	Danio rerio	43.50	1.00e-109	389.00
IUUC-Dno-029453	Dasypus novemcinctus	44.23	3.00e-111	394.00
IUUC-Dse-031220	Dothistroma septosporum	35.37	6.00e-65	241.00
IUUC-Dme-031906	Drosophila melanogaster	45.56	4.00e-110	390.00
IUUC-Ete-033035	Echinops telfairi	43.70	1.00e-53	203.00
IUUC-Eca-033478	Equus caballus	44.04	8.00e-111	393.00
IUUC-Eeu-034974	Erinaceus europaeus	43.66	1.00e-73	269.00
IUUC-Fca-036194	Felis catus	43.77	1.00e-109	389.00
IUUC-Fal-037417	Ficedula albicollis	44.62	7.00e-112	396.00
IUUC-Fso-038256	Fusarium solani	31.65	3.00e-64	238.00
IUUC-Gmo-038713	Gadus morhua	43.50	1.00e-111	396.00
IUUC-Ggr-039854	Gaeumannomyces graminis	32.95	3.00e-54	205.00
IUUC-Gga-041143	Gallus gallus	44.81	1.00e-112	399.00
IUUC-Gac-042129	Gasterosteus aculeatus	43.99	6.00e-112	397.00
IUUC-Gma-043635	Glycine max	75.58	0.00e+00	826.00
IUUC-Ggo-045262	Gorilla gorilla	44.23	2.00e-111	395.00
IUUC-Hsa-046036	Homo sapiens	44.23	2.00e-111	395.00
IUUC-Itr-048169	Ictidomys tridecemlineatus	43.71	4.00e-110	390.00
IUUC-Kpa-049195	Komagataella pastoris	43.07	2.00e-20	93.20
IUUC-Lch-050105	Latimeria chalumnae	43.95	2.00e-111	395.00
IUUC-Loc-052042	Lepisosteus oculatus	39.34	2.00e-76	279.00
IUUC-Lma-053143	Leptosphaeria maculans	34.39	2.00e-65	244.00
IUUC-Laf-053451	Loxodonta africana	42.83	3.00e-108	385.00
IUUC-Mcc-055786	Macaca mulatta	44.23	2.00e-111	395.00
IUUC-Meu-056161	Macropus eugenii	43.53	3.00e-50	192.00
IUUC-Mor-057215	Magnaporthe oryzae	33.33	1.00e-56	213.00
IUUC-Mpo-057419	Magnaporthe poae	32.31	4.00e-50	191.00
IUUC-Mtr-057756	Medicago truncatula	73.98	0.00e+00	800.00
IUUC-Mla-059085	Melampsora laricipopulina	35.51	3.00e-80	291.00
IUUC-Mga-060158	Meleagris gallopavo	44.12	4.00e-99	354.00
IUUC-Mvi-060441	Microbotryum violaceum	35.16	4.00e-77	281.00
IUUC-Mmr-061085	Microcebus murinus	44.23	2.00e-111	395.00
IUUC-Mdo-061804	Monodelphis domestica	44.23	3.00e-111	394.00
IUUC-Mmu-063608	Mus musculus	42.30	4.00e-107	381.00
IUUC-Mac-064972	Musa acuminata	73.36	0.00e+00	778.00
IUUC-Mpu-065700	Mustela putorius furo	43.99	6.00e-111	393.00
IUUC-Mlu-068223	Myotis lucifugus	42.99	1.00e-107	382.00
IUUC-Nfi-068504	Neosartorya fischeri	34.52	2.00e-70	258.00
IUUC-Ncr-068729	Neurospora crassa	32.54	6.00e-61	227.00
IUUC-Nle-069754	Nomascus leucogenys	44.23	2.00e-111	395.00
IUUC-Opr-070621	Ochotona princeps	45.61	4.00e-104	370.00
IUUC-Ont-071377	Oreochromis niloticus	43.69	7.00e-110	390.00
IUUC-Ocu-074182	Oryctolagus cuniculus	42.51	9.00e-108	383.00
IUUC-Oba-075509	Oryza barthii	71.18	0.00e+00	774.00
IUUC-Ogl-077052	Oryza glaberrima	71.18	0.00e+00	774.00
IUUC-Ogu-078919	Oryza glumaepatula	71.37	0.00e+00	775.00
IUUC-Oin-079357	Oryza indica	68.28	0.00e+00	726.00
IUUC-Ome-081973	Oryza meridionalis	70.45	0.00e+00	720.00
IUUC-Oni-082849	Oryza nivara	70.99	0.00e+00	771.00
IUUC-Oru-084613	Oryza rufipogon	71.18	0.00e+00	773.00
IUUC-Osa-085407	Oryza sativa	70.99	0.00e+00	771.00
IUUC-Ola-086566	Oryzias latipes	43.05	7.00e-109	387.00
IUUC-Olu-087757	Ostreococcus lucimarinus	46.06	2.00e-119	421.00
IUUC-Oga-089010	Otolemur garnettii	42.53	1.00e-105	376.00
IUUC-Oar-089638	Ovis aries	44.04	6.00e-111	393.00
IUUC-Ptr-091141	Pan troglodytes	44.23	2.00e-111	395.00
IUUC-Pan-092662	Papio anubis	44.23	2.00e-111	395.00
IUUC-Pno-095115	Phaeosphaeria nodorum	34.06	4.00e-67	248.00
IUUC-Pfo-096390	Poecilia formosa	44.19	2.00e-110	392.00
IUUC-Pab-098250	Pongo abelii	44.58	8.00e-107	380.00
IUUC-Pop-099854	Populus trichocarpa	76.49	0.00e+00	830.00
IUUC-Pca-100553	Procavia capensis	43.91	2.00e-109	388.00
IUUC-Pva-102189	Pteropus vampyrus	44.04	4.00e-111	394.00
IUUC-Pgr-103304	Puccinia graminis	33.52	3.00e-78	285.00
IUUC-Ptt-103984	Puccinia triticina	33.40	4.00e-80	291.00
IUUC-Pte-104385	Pyrenophora teres	31.44	6.00e-61	227.00
IUUC-Pyt-104697	Pyrenophora triticirepentis	30.92	1.00e-59	223.00
IUUC-Rno-105581	Rattus norvegicus	43.85	9.00e-111	393.00
IUUC-Sce-106147	Saccharomyces cerevisiae	43.18	2.00e-24	106.00
IUUC-Sha-107071	Sarcophilus harrisii	42.44	2.00e-107	382.00
IUUC-Ssl-108628	Sclerotinia sclerotiorum	33.07	4.00e-63	234.00
IUUC-Smo-109648	Selaginella moellendorffii	64.66	0.00e+00	691.00
IUUC-Sit-109873	Setaria italica	70.59	0.00e+00	769.00
IUUC-Sbi-114696	Sorghum bicolor	64.81	0.00e+00	678.00
IUUC-Sre-115134	Sporisorium reilianum	34.97	6.00e-83	300.00
IUUC-Ssc-116260	Sus scrofa	44.04	4.00e-111	394.00
IUUC-Tgu-116533	Taeniopygia guttata	44.81	2.00e-112	398.00
IUUC-Tru-117800	Takifugu rubripes	42.97	6.00e-111	393.00
IUUC-Tsy-118980	Tarsius syrichta	42.16	5.00e-98	350.00
IUUC-Tni-120334	Tetraodon nigroviridis	34.17	3.00e-73	268.00
IUUC-Tre-121920	Trichoderma reesei	32.67	1.00e-60	226.00
IUUC-Tvi-122294	Trichoderma virens	32.34	1.00e-52	200.00
IUUC-Tme-127026	Tuber melanosporum	33.91	3.00e-69	255.00
IUUC-Tbe-127582	Tupaia belangeri	43.95	2.00e-74	272.00
IUUC-Ttr-128313	Tursiops truncatus	44.04	7.00e-110	390.00
IUUC-Uma-129626	Ustilago maydis	35.70	8.00e-85	306.00
IUUC-Vda-129699	Verticillium dahliae	32.69	2.00e-58	219.00
IUUC-Vpa-130593	Vicugna pacos	45.40	3.00e-103	367.00
IUUC-Vvi-131668	Vitis vinifera	77.84	0.00e+00	837.00
IUUC-Xtr-132186	Xenopus tropicalis	46.35	7.00e-100	357.00
IUUC-Xma-133212	Xiphophorus maculatus	43.41	2.00e-110	392.00
IUUC-Yli-134607	Yarrowia lipolytica	50.74	5.00e-35	139.00
IUUC-Zma-135662	Zea mays	71.24	0.00e+00	769.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence