iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Csv-026131

UUCD1 version

UUC-CiS-00382

Ensembl Protein ID

ENSCSAVP00000001769.1

UniProt Accession

H2Y8X1; H2Y8X1_CIOSA

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAVG00000001032.1	ENSCSAVT00000001800.1	ENSCSAVP00000001769.1
ENSCSAVG00000001032.1	ENSCSAVT00000001801.1	ENSCSAVP00000001770.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.00e-66	223.7	608	895

Active Site

Position(s)	Description	Evidence
865	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 54   lqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklllgkklsledleevdpelykslkei.kena..esdieelgld 138
           + p ++  + n+ +l+ ++ +Grllg++l +++l++lpl ++++k +lg+k++++dl+ +dp+ly+sl ++ ++ +  +  + + +l+
   Q: 608  YAPTSWGEM-NEARLNAYRNVGRLLGLCLLQNELCPLPLCRHVLKVILGRKVNWHDLAFFDPNLYESLRQLvLDGEqeDGGVLD-ALE 693
           445566665.669******************************************************66651555432224444.5** PP
   S: 139  ltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidv 226
           ltf v+ +  +  +++ L+p+G+  pVt++N ++Yv++++  r+    k+ +e++r+G ++vip + l+++t+e+l+ll +G+ ++ v
   Q: 694  LTFVVDLQPEEGGQQVPLVPDGDALPVTKANVRDYVRKYALQRMLICCKKPLEKIRQGVYDVIPRSALQSLTAEDLRLLANGCGHVGV 781
           **************************************************************************************** PP
   S: 227  edlkketky.....kggytedspai....qwFwevleefsseerkafLqFvTgssrlPl..gGfaelkprlfvirkdasddrlPssnT 303
           ++l + t +     k g+++++  +    +wFw+v+ +fss er+++L F+Tgs+ lP+   Gf++++   ++ir   +d++lP++nT
   Q: 782  HTLISYTLFndesgKTGTSAEK--LtqfrRWFWSVVDRFSSVERQELLYFWTGSPALPAseDGFQPMP--TITIRP-PDDHHLPTANT 864
           *******997765544443333..233579*****************************999******..789998.999******** PP
   S: 304  CfnyLkLPeYsskeilkekLlyAieetkgFel 335
           C+++L +P Yss +ilk+kL +Ai++ k+F++
   Q: 865  CISRLYVPLYSSRKILKQKLSIAIKT-KNFGF 895
           *************************9.99875 PP

Organism

Ciona savignyi

Protein Sequence
(Fasta)

DFLSYALSLM RSHTSEHSDL LPIVDVSALK HIAYVLDAYI FFARGLSYKN GDGKKVNESS 60
RHSISLDIGY DNSENEDDDD DLLSFTDELY SVAVLSDTSI TKTSEDPGSI LSQPPHSFFR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACTTTCTAT CCTATGCATT GTCGCTGATG CGGTCACATA CCAGTGAGCA CTCAGATTTG 60
CTTCCCATTG TGGATGTGAG TGCGCTGAAG CATATCGCTT ATGTGCTAGA CGCATACATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR002004--PABP_HYD

PROSITE

PS50237--HECT
PS51309--PABC

Pfam

PF00632--HECT
PF00658--PABP

SMART

SM00119--HECTc
SM00517--PolyA

Gene Ontology

GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-010702	Astyanax mexicanus	65.78	7.00e-110	391.00
IUUC-Cel-018165	Caenorhabditis elegans	44.52	8.00e-63	235.00
IUUC-Cpo-022065	Cavia porcellus	66.45	2.00e-113	401.00
IUUC-Cho-025034	Choloepus hoffmanni	66.45	6.00e-113	402.00
IUUC-Cin-025715	Ciona intestinalis	75.79	0.00e+00	1202.00
IUUC-Dre-027730	Danio rerio	65.45	5.00e-110	392.00
IUUC-Dor-030757	Dipodomys ordii	66.45	6.00e-113	402.00
IUUC-Dme-032192	Drosophila melanogaster	48.45	6.00e-146	511.00
IUUC-Gmo-039589	Gadus morhua	45.61	0.00e+00	659.00
IUUC-Gac-042538	Gasterosteus aculeatus	46.91	0.00e+00	665.00
IUUC-Loc-052664	Lepisosteus oculatus	65.78	3.00e-110	392.00
IUUC-Laf-053960	Loxodonta africana	66.45	2.00e-113	402.00
IUUC-Meu-056431	Macropus eugenii	64.17	1.00e-82	301.00
IUUC-Mga-059289	Meleagris gallopavo	46.84	0.00e+00	661.00
IUUC-Ont-071951	Oreochromis niloticus	65.12	4.00e-109	389.00
IUUC-Ola-086757	Oryzias latipes	65.45	1.00e-109	390.00
IUUC-Pfo-096173	Poecilia formosa	65.45	9.00e-110	391.00
IUUC-Sar-113517	Sorex araneus	66.79	2.00e-99	357.00
IUUC-Ssc-115470	Sus scrofa	66.45	2.00e-113	403.00
IUUC-Tru-117682	Takifugu rubripes	65.68	1.00e-108	387.00
IUUC-Tsy-119417	Tarsius syrichta	64.78	8.00e-108	384.00
IUUC-Tni-120442	Tetraodon nigroviridis	65.45	2.00e-109	390.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence