iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-131929

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAMC01001399

Gene Name

UBR5; ubr5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000031995.1	ENSXETT00000046601.3	ENSXETP00000046601.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.70e-79	267.1	2467	2789

Active Site

Position(s)	Description	Evidence
2759	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 17   egldlgGvtreflallskelqnpd..lglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfykll 100
           e+ + +G++r ++++ + ++ + d  ++lf +  +++ ++ +p +++      +l++F+ +Gr+lg++l +++l++++ls+ ++k l
   Q: 2467 ENRKRHGSSRSVVDMELTDTDDGDdnAPLFyQPGKRGFYSPRPGKNTE----ARLNCFRNIGRILGLCLLQNELCPITLSRQVIKVL 2549
           556677999999999888888888777888233333666666666554....89********************************* PP
   S: 101  lgkklsledleevdpelyks.lkeikena..esdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlke 184
           lg+k++++d++ +d  +y+s  + i++++  ++d   +++dl+f ++ ++ ++  ++eL+p+G nipVt +N +eYv++++e+r+ +
   Q: 2550 LGRKVNWHDFAFFDHVMYESlRQLILASQspDADAVFASMDLAFAIDLCKEESGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLT 2636
           ********************445566555667799999************************************************* PP
   S: 185  gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspai....qwFwevleefsseerkafLqF 267
             ++ ++a+r+G+ +v+p++ l+ +t+e+++ll++G+ e++v++l ++t+++++  e+ +++    +wFw+++e++s++er++++ F
   Q: 2637 VAEQPLNAMRKGLLDVLPKNALEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLlqfkRWFWSIVEKMSMTERQDLVYF 2723
           ***************************************************9999999999989999******************** PP
   S: 268  vTgssrlPl..gGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +T+s++lP+  +Gf++++  +++ir   +d++lP++nTC+++L +P Yssk+ilk+kLl+Ai++ k+F++
   Q: 2724 WTSSPSLPAseEGFQPMP--SITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKT-KNFGF 2789
           *********999******..799999.99**********************************9.99875 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MTSIHFVVHP LPGTEDQLND RLREVSEKLN KYNLSSCSHP PLNVLEQTTI KQCVVGPNHA 60
AFLLEDGRIC RIGFSVQPDR LELSKPENND GSKLSSGSGA GRTSRPGRTS DSPWFLSGSE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACTTCCA TTCACTTTGT GGTACACCCG CTGCCCGGCA CGGAGGATCA GCTGAACGAT 60
CGGTAATGAG AGGGCGAGGG GAGGAGAAAT AGGCAAAACC TTGGCGCTCC AGCTGTTCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR024725--E3_UbLigase_EDD_UBA
IPR000569--HECT_dom
IPR002004--PABP_HYD
IPR009091--RCC1/BLIP-II
IPR003126--Znf_UBR

PROSITE

PS50237--HECT
PS51309--PABC
PS51157--ZF_UBR

Pfam

PF11547--E3_UbLigase_EDD
PF00632--HECT
PF00658--PABP

SMART

SM00119--HECTc
SM00517--PolyA
SM00396--ZnF_UBR1

Gene Ontology

GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002217	Ailuropoda melanoleuca	94.46	0.00e+00	4411.00
IUUC-Apl-004165	Anas platyrhynchos	94.71	0.00e+00	4381.00
IUUC-Aca-004577	Anolis carolinensis	93.77	0.00e+00	3834.00
IUUC-Ame-010702	Astyanax mexicanus	83.54	0.00e+00	2435.00
IUUC-Bta-012313	Bos taurus	94.01	0.00e+00	4453.00
IUUC-Cel-018165	Caenorhabditis elegans	35.65	2.00e-69	259.00
IUUC-Cja-019858	Callithrix jacchus	93.86	0.00e+00	4422.00
IUUC-Cfa-020973	Canis familiaris	94.11	0.00e+00	4459.00
IUUC-Cpo-022108	Cavia porcellus	95.21	0.00e+00	1890.00
IUUC-Csa-023985	Chlorocebus sabaeus	94.89	0.00e+00	4485.00
IUUC-Cho-025034	Choloepus hoffmanni	83.52	0.00e+00	958.00
IUUC-Cin-025715	Ciona intestinalis	40.37	0.00e+00	935.00
IUUC-Csv-026131	Ciona savignyi	47.24	0.00e+00	682.00
IUUC-Dre-027730	Danio rerio	85.70	0.00e+00	3957.00
IUUC-Dno-029123	Dasypus novemcinctus	91.20	0.00e+00	4260.00
IUUC-Dor-030757	Dipodomys ordii	89.42	0.00e+00	2781.00
IUUC-Dme-032192	Drosophila melanogaster	50.56	5.00e-171	596.00
IUUC-Ete-032292	Echinops telfairi	91.47	0.00e+00	2095.00
IUUC-Eca-034347	Equus caballus	93.68	0.00e+00	4361.00
IUUC-Eeu-034873	Erinaceus europaeus	89.65	0.00e+00	4188.00
IUUC-Fca-036485	Felis catus	92.65	0.00e+00	4299.00
IUUC-Fal-037071	Ficedula albicollis	95.32	0.00e+00	4395.00
IUUC-Gmo-039589	Gadus morhua	87.51	0.00e+00	3950.00
IUUC-Gga-041195	Gallus gallus	92.72	0.00e+00	4318.00
IUUC-Gac-042538	Gasterosteus aculeatus	87.21	0.00e+00	3954.00
IUUC-Ggo-045351	Gorilla gorilla	93.22	0.00e+00	4460.00
IUUC-Hsa-045941	Homo sapiens	93.94	0.00e+00	4492.00
IUUC-Itr-048635	Ictidomys tridecemlineatus	93.93	0.00e+00	4415.00
IUUC-Lch-050480	Latimeria chalumnae	91.37	0.00e+00	4236.00
IUUC-Loc-052664	Lepisosteus oculatus	87.45	0.00e+00	4075.00
IUUC-Laf-053935	Loxodonta africana	95.41	0.00e+00	1555.00
IUUC-Mcc-054703	Macaca mulatta	94.89	0.00e+00	4486.00
IUUC-Meu-056431	Macropus eugenii	84.41	0.00e+00	776.00
IUUC-Mga-059289	Meleagris gallopavo	94.66	0.00e+00	3510.00
IUUC-Mmr-061737	Microcebus murinus	93.61	0.00e+00	4340.00
IUUC-Mdo-062499	Monodelphis domestica	93.82	0.00e+00	4374.00
IUUC-Mmu-063273	Mus musculus	93.19	0.00e+00	4361.00
IUUC-Mpu-066907	Mustela putorius furo	94.74	0.00e+00	4071.00
IUUC-Mlu-067942	Myotis lucifugus	94.54	0.00e+00	4422.00
IUUC-Nle-069527	Nomascus leucogenys	93.89	0.00e+00	4454.00
IUUC-Opr-070626	Ochotona princeps	83.92	0.00e+00	1398.00
IUUC-Ont-071951	Oreochromis niloticus	86.18	0.00e+00	3920.00
IUUC-Oan-072958	Ornithorhynchus anatinus	95.01	0.00e+00	4053.00
IUUC-Ocu-074503	Oryctolagus cuniculus	92.68	0.00e+00	4355.00
IUUC-Ola-086757	Oryzias latipes	86.88	0.00e+00	4008.00
IUUC-Oga-088781	Otolemur garnettii	94.01	0.00e+00	4442.00
IUUC-Oar-089274	Ovis aries	94.74	0.00e+00	4393.00
IUUC-Ptr-090669	Pan troglodytes	94.50	0.00e+00	3878.00
IUUC-Pan-092226	Papio anubis	93.87	0.00e+00	4460.00
IUUC-Psi-093502	Pelodiscus sinensis	94.19	0.00e+00	4376.00
IUUC-Pma-094454	Petromyzon marinus	83.00	0.00e+00	731.00
IUUC-Pfo-096173	Poecilia formosa	86.04	0.00e+00	3684.00
IUUC-Pab-098355	Pongo abelii	94.13	0.00e+00	3085.00
IUUC-Pca-100570	Procavia capensis	95.82	0.00e+00	1139.00
IUUC-Pva-102572	Pteropus vampyrus	90.60	0.00e+00	1306.00
IUUC-Rno-104916	Rattus norvegicus	92.12	0.00e+00	3820.00
IUUC-Sha-106653	Sarcophilus harrisii	94.01	0.00e+00	4428.00
IUUC-Sar-113517	Sorex araneus	85.11	0.00e+00	1231.00
IUUC-Ssc-115470	Sus scrofa	93.73	0.00e+00	2447.00
IUUC-Tgu-116932	Taeniopygia guttata	95.03	0.00e+00	4378.00
IUUC-Tru-117682	Takifugu rubripes	86.86	0.00e+00	2534.00
IUUC-Tsy-119417	Tarsius syrichta	89.30	0.00e+00	2388.00
IUUC-Tni-120442	Tetraodon nigroviridis	81.60	0.00e+00	3541.00
IUUC-Tbe-127456	Tupaia belangeri	82.99	0.00e+00	2042.00
IUUC-Ttr-128606	Tursiops truncatus	89.06	0.00e+00	1528.00
IUUC-Vpa-130112	Vicugna pacos	91.91	0.00e+00	3604.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence