iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-097654

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin-conjugating enzyme E2 L3

Genbank Nucleotide ID

ABGA01056874

Gene Name

UBE2L3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000011602.2	ENSPPYT00000013471.2	ENSPPYP00000012943.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	8.80e-44	148.7	6	141

Active Site

Position(s)	Description	Evidence
86	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkee 89
           Rl+kel+e++k  +++++  +vde++l +w+ li+ p++ pY++g+F++ei+fp +YPfkPPk++f tki+hPn++e+G+vCl ++ ++
   Q: 6    RLMKELEEIRKCGMKNFRNIQVDEANLLTWQGLIV-PDNPPYDKGAFRIEINFPAEYPFKPPKITFKTKIYHPNIDEKGQVCLPVI-SA 92
           9**********************************.**************************************************.5* PP
   S: 90   ekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           e+W+pa++  +v+ s+++l+++p+pe+pl+++ ae+++k+r+++ k+++
   Q: 93   ENWKPATKTDQVIQSLIALVNDPQPEHPLRADLAEEYSKDRKKFCKNAE 141
           *********************************************9986 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MAASRRLMKE LEEIRKCGMK NFRNIQVDEA NLLTWQGLIV PDNPPYDKGA FRIEINFPAE 60
YPFKPPKITF KTKIYHPNID EKGQVCLPVI SAENWKPATK TDQVIQSLIA LVNDPQPEHP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCAGGAAGTG CGGGGGCTCC AGCCGCCCGG CCGGCCGCAA TGCATTCTGG GGAAGGAGCA 60
GCACCAAATC CAAGATGGCG GCCAGCAGGA GGCTGATGAA GGTAAAAGCC ATTCTCTGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0003723--F:RNA binding
GO:0003713--F:transcription coactivator activity
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0044770--P:cell cycle phase transition
GO:0008283--P:cell proliferation
GO:0071385--P:cellular response to glucocorticoid stimulus
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0070979--P:protein K11-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006355--P:regulation of transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001446	Ailuropoda melanoleuca	100.00	7.00e-53	198.00
IUUC-Apl-003318	Anas platyrhynchos	94.81	4.00e-73	266.00
IUUC-Aca-005234	Anolis carolinensis	98.65	9.00e-74	268.00
IUUC-Ame-011452	Astyanax mexicanus	93.92	7.00e-69	252.00
IUUC-Bta-012693	Bos taurus	99.32	1.00e-72	264.00
IUUC-Cel-018332	Caenorhabditis elegans	59.21	3.00e-58	217.00
IUUC-Cja-019062	Callithrix jacchus	100.00	3.00e-78	283.00
IUUC-Cfa-020027	Canis familiaris	100.00	3.00e-78	283.00
IUUC-Cpo-022341	Cavia porcellus	100.00	3.00e-78	283.00
IUUC-Cho-024916	Choloepus hoffmanni	93.14	6.00e-43	164.00
IUUC-Csv-026183	Ciona savignyi	65.56	2.00e-47	181.00
IUUC-Dre-027710	Danio rerio	94.81	1.00e-73	268.00
IUUC-Dno-029371	Dasypus novemcinctus	100.00	8.00e-55	204.00
IUUC-Dor-031017	Dipodomys ordii	94.81	3.00e-71	259.00
IUUC-Dme-031814	Drosophila melanogaster	74.03	1.00e-68	251.00
IUUC-Ete-032754	Echinops telfairi	100.00	3.00e-78	283.00
IUUC-Eca-034056	Equus caballus	96.75	7.00e-76	275.00
IUUC-Eeu-034942	Erinaceus europaeus	98.70	3.00e-77	280.00
IUUC-Fca-036173	Felis catus	100.00	3.00e-78	283.00
IUUC-Fal-036820	Ficedula albicollis	100.00	5.00e-73	266.00
IUUC-Gmo-038480	Gadus morhua	91.03	3.00e-65	239.00
IUUC-Gga-041039	Gallus gallus	100.00	3.00e-78	283.00
IUUC-Gac-041571	Gasterosteus aculeatus	77.48	1.00e-56	211.00
IUUC-Ggo-044482	Gorilla gorilla	100.00	8.00e-74	268.00
IUUC-Hsa-046287	Homo sapiens	100.00	3.00e-78	283.00
IUUC-Itr-049057	Ictidomys tridecemlineatus	100.00	4.00e-67	246.00
IUUC-Lch-049699	Latimeria chalumnae	81.90	1.00e-43	168.00
IUUC-Loc-052000	Lepisosteus oculatus	92.95	2.00e-71	261.00
IUUC-Laf-053833	Loxodonta africana	99.32	2.00e-72	264.00
IUUC-Meu-056738	Macropus eugenii	100.00	9.00e-48	181.00
IUUC-Mga-060134	Meleagris gallopavo	97.37	2.00e-73	267.00
IUUC-Mmr-060627	Microcebus murinus	96.10	6.00e-84	302.00
IUUC-Mdo-062043	Monodelphis domestica	82.35	3.00e-73	267.00
IUUC-Mmu-063615	Mus musculus	100.00	3.00e-78	283.00
IUUC-Mlu-067987	Myotis lucifugus	98.05	2.00e-87	313.00
IUUC-Opr-070315	Ochotona princeps	100.00	3.00e-78	283.00
IUUC-Ont-072036	Oreochromis niloticus	92.86	2.00e-71	261.00
IUUC-Ocu-074565	Oryctolagus cuniculus	96.15	5.00e-74	269.00
IUUC-Ola-086994	Oryzias latipes	82.47	4.00e-73	266.00
IUUC-Oga-088085	Otolemur garnettii	94.16	1.00e-83	301.00
IUUC-Oar-089520	Ovis aries	99.32	9.00e-73	265.00
IUUC-Ptr-090890	Pan troglodytes	99.35	3.00e-88	316.00
IUUC-Pan-092445	Papio anubis	100.00	8.00e-74	268.00
IUUC-Psi-093376	Pelodiscus sinensis	96.05	6.00e-73	265.00
IUUC-Pma-094445	Petromyzon marinus	79.86	6.00e-55	205.00
IUUC-Pfo-096258	Poecilia formosa	92.86	4.00e-71	260.00
IUUC-Pca-100712	Procavia capensis	79.22	2.00e-55	207.00
IUUC-Pva-103113	Pteropus vampyrus	100.00	2.00e-72	264.00
IUUC-Sha-106823	Sarcophilus harrisii	100.00	3.00e-70	256.00
IUUC-Sar-113240	Sorex araneus	100.00	2.00e-72	264.00
IUUC-Ssc-115442	Sus scrofa	100.00	3.00e-78	283.00
IUUC-Tgu-117352	Taeniopygia guttata	99.32	1.00e-72	264.00
IUUC-Tru-117653	Takifugu rubripes	92.86	6.00e-72	262.00
IUUC-Tsy-119345	Tarsius syrichta	79.22	4.00e-54	203.00
IUUC-Tni-119709	Tetraodon nigroviridis	92.86	6.00e-72	262.00
IUUC-Tbe-127451	Tupaia belangeri	94.16	2.00e-83	300.00
IUUC-Ttr-128840	Tursiops truncatus	100.00	3.00e-78	283.00
IUUC-Xtr-132650	Xenopus tropicalis	97.40	5.00e-76	276.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence