iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-027594

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Autocrine motility factor receptor, E3 ubiquitin protein ligase a

Genbank Nucleotide ID

CU855766

Gene Name

amfr

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000020218.8	ENSDART00000122559.3	ENSDARP00000106624.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.00e-08	36.5	334	372
UBD/Alpha-Helix/CUE	5.10e-11	43.2	452	490

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiC++++ +  + lpCgH+fh +Cl  w        +  +CP+Cr
   Q: 334  CAICWDSMTT-ARKLPCGHLFHNSCLRSW------LEQDTSCPTCR 372
           ********99.9*****************......9*********8 PP

UBD/Alpha-Helix/CUE

   S: 4    taleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
            +++q++e+FP+++y +i ++L ++t s+e +++n+Leg 
   Q: 452  GMAHQIQEMFPQVPYHLILQDL-QLTRSVEVTTDNILEGR 490
           599*******************.***************95 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MPLLFLERFP WPSLQTYTAL SALLLAGTVL SAYSTVRDSE FSSALSEGPQ NEELKLENLG 60
NVATGVLLHL ITDSLFVWVM VNTACCILML IGKVIQCIVF GPLRVSEKQH LKDKFWNFIF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAGAAGTTT GAATTGTGAA GGACTCAGAC TGTCACCATC AGTAAAAGGA CATCATCAGG 60
TTTCTCCTGG AGCAGAGTTC AGAAGACTGC TGTACGTGTG GACTGTGGAT CTGAGCTGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR003892--CUE
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51140--CUE
PS50089--ZF_RING_2

Pfam

PF02845--CUE
PF13639--zf-RING_2

SMART

SM00546--CUE
SM00184--RING

Gene Ontology

GO:0016021--C:integral component of membrane
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:1990381--F:ubiquitin-specific protease binding
GO:0008270--F:zinc ion binding
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001300	Ailuropoda melanoleuca	71.77	0.00e+00	746.00
IUUC-Apl-003404	Anas platyrhynchos	75.79	0.00e+00	759.00
IUUC-Aca-004559	Anolis carolinensis	75.25	0.00e+00	711.00
IUUC-Ame-011640	Astyanax mexicanus	80.76	0.00e+00	895.00
IUUC-Bta-012980	Bos taurus	67.50	0.00e+00	773.00
IUUC-Cel-018598	Caenorhabditis elegans	24.72	2.00e-33	137.00
IUUC-Cja-019577	Callithrix jacchus	68.99	0.00e+00	826.00
IUUC-Cfa-020793	Canis familiaris	75.15	0.00e+00	753.00
IUUC-Cpo-022387	Cavia porcellus	69.10	0.00e+00	818.00
IUUC-Csa-023168	Chlorocebus sabaeus	69.46	0.00e+00	830.00
IUUC-Cho-024433	Choloepus hoffmanni	73.38	1.00e-176	612.00
IUUC-Cin-025215	Ciona intestinalis	43.81	1.00e-137	483.00
IUUC-Csv-026133	Ciona savignyi	47.36	1.00e-127	450.00
IUUC-Dno-029407	Dasypus novemcinctus	73.08	0.00e+00	736.00
IUUC-Dor-030961	Dipodomys ordii	73.32	0.00e+00	750.00
IUUC-Ete-032962	Echinops telfairi	66.12	7.00e-178	617.00
IUUC-Eca-033683	Equus caballus	65.82	0.00e+00	769.00
IUUC-Eeu-034515	Erinaceus europaeus	80.00	1.00e-56	214.00
IUUC-Fca-035398	Felis catus	75.45	0.00e+00	742.00
IUUC-Fal-036758	Ficedula albicollis	68.32	0.00e+00	695.00
IUUC-Gmo-039014	Gadus morhua	73.42	0.00e+00	805.00
IUUC-Gga-040575	Gallus gallus	71.65	0.00e+00	794.00
IUUC-Gac-041414	Gasterosteus aculeatus	75.71	0.00e+00	778.00
IUUC-Hsa-046272	Homo sapiens	69.10	0.00e+00	824.00
IUUC-Itr-047956	Ictidomys tridecemlineatus	72.00	0.00e+00	750.00
IUUC-Lch-050491	Latimeria chalumnae	71.89	0.00e+00	774.00
IUUC-Loc-052758	Lepisosteus oculatus	74.17	0.00e+00	810.00
IUUC-Laf-053452	Loxodonta africana	75.05	0.00e+00	746.00
IUUC-Mcc-055820	Macaca mulatta	72.76	0.00e+00	744.00
IUUC-Meu-056726	Macropus eugenii	68.32	0.00e+00	668.00
IUUC-Mga-059937	Meleagris gallopavo	75.84	0.00e+00	744.00
IUUC-Mmr-060730	Microcebus murinus	68.75	0.00e+00	806.00
IUUC-Mdo-062771	Monodelphis domestica	69.11	0.00e+00	813.00
IUUC-Mmu-064219	Mus musculus	70.33	0.00e+00	833.00
IUUC-Mpu-066796	Mustela putorius furo	73.19	0.00e+00	740.00
IUUC-Mlu-068189	Myotis lucifugus	72.99	0.00e+00	746.00
IUUC-Nle-069239	Nomascus leucogenys	68.86	0.00e+00	786.00
IUUC-Opr-070702	Ochotona princeps	79.46	7.00e-84	304.00
IUUC-Ont-072033	Oreochromis niloticus	70.95	0.00e+00	811.00
IUUC-Oan-073717	Ornithorhynchus anatinus	79.20	0.00e+00	714.00
IUUC-Ocu-074145	Oryctolagus cuniculus	70.06	0.00e+00	822.00
IUUC-Ogl-077929	Oryza glaberrima	40.30	1.00e-11	62.80
IUUC-Ola-087152	Oryzias latipes	70.47	0.00e+00	791.00
IUUC-Oga-088486	Otolemur garnettii	72.05	0.00e+00	750.00
IUUC-Oar-089310	Ovis aries	73.61	0.00e+00	759.00
IUUC-Ptr-090649	Pan troglodytes	72.89	0.00e+00	764.00
IUUC-Pan-091692	Papio anubis	65.13	0.00e+00	760.00
IUUC-Psi-093064	Pelodiscus sinensis	83.17	0.00e+00	663.00
IUUC-Pma-094763	Petromyzon marinus	74.59	2.00e-95	342.00
IUUC-Ppa-095969	Physcomitrella patens	31.19	4.00e-37	149.00
IUUC-Pfo-096810	Poecilia formosa	72.55	0.00e+00	811.00
IUUC-Pab-097859	Pongo abelii	73.95	0.00e+00	744.00
IUUC-Pca-100344	Procavia capensis	70.02	0.00e+00	791.00
IUUC-Pva-103114	Pteropus vampyrus	47.95	2.00e-129	456.00
IUUC-Rno-105880	Rattus norvegicus	68.14	0.00e+00	774.00
IUUC-Sha-107015	Sarcophilus harrisii	74.76	0.00e+00	771.00
IUUC-Sar-113397	Sorex araneus	82.21	1.00e-180	625.00
IUUC-Ssc-115988	Sus scrofa	63.10	2.00e-77	282.00
IUUC-Tgu-116717	Taeniopygia guttata	74.52	0.00e+00	748.00
IUUC-Tru-117805	Takifugu rubripes	69.19	0.00e+00	798.00
IUUC-Tsy-119442	Tarsius syrichta	67.58	0.00e+00	658.00
IUUC-Tni-119777	Tetraodon nigroviridis	70.72	1.00e-165	576.00
IUUC-Tbe-127322	Tupaia belangeri	52.71	2.00e-78	286.00
IUUC-Ttr-128181	Tursiops truncatus	73.26	0.00e+00	758.00
IUUC-Vpa-130483	Vicugna pacos	70.95	4.00e-152	531.00
IUUC-Xtr-132614	Xenopus tropicalis	69.26	0.00e+00	666.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence