iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gga-041269

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

NEDD8-conjugating enzyme UBE2F; NEDD8 carrier protein UBE2F; NEDD8 protein ligase UBE2F; NEDD8-conjugating enzyme 2; RING-type E3 NEDD8 transferase UBE2F; Ubiquitin-conjugating enzyme E2 F

Genbank Nucleotide ID

AJ719958

Gene Name

UBE2F; RCJMB04_8m10

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000003812.6	ENSGALT00000054996.1	ENSGALP00000053500.1
ENSGALG00000003812.6	ENSGALT00000056310.1	ENSGALP00000052225.1
ENSGALG00000003812.6	ENSGALT00000006045.5	ENSGALP00000006035.5
ENSGALG00000003812.6	ENSGALT00000075219.1	ENSGALP00000045869.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	6.80e-34	117.0	52	178

Active Site

Position(s)	Description	Evidence
116	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 16   gisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilk....eeekWspalsves 100
           ++++++ d ++l+ ++++++ p++ +Y+gg+F++eie+p+ Y++ PPkvk+lt+i+hPn++e+G++Cls+l+    + + W p+ ++++
   Q: 52   TCKVNFPDPNKLHYFQLTVI-PDEGYYQGGKFQFEIEVPDAYNMVPPKVKCLTRIWHPNITETGEICLSLLRehsiDGTGWAPTRTLKD 139
           78999999999*********.**************************************************77788899********** PP
   S: 101  vllsiqsllae.pnpesplneeaaellkknreeykkkvr 138
           v+++++sl+++  n+++pln eaae++ +++e++++kv+
   Q: 140  VVWGLNSLFTDlLNFDDPLNIEAAEHHLRDKEDFRNKVE 178
           *********8879***********************996 PP

Organism

Gallus gallus

Functional Description
(View)

Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5.

Protein Sequence
(Fasta)

MLTLASKLKR DDGVRGPRAS NPASDSTRRV SVRDKLLVKG ERNLHLNFVF CTCKVNFPDP 60
NKLHYFQLTV IPDEGYYQGG KFQFEIEVPD AYNMVPPKVK CLTRIWHPNI TETGEICLSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGGCGGGC GGCTGAGGGA GGAGGAGGAG CTGCGCCGCC GCCCCTGCCC CGGGCTAGCC 60
CCGGGATGGT GTTGGCTGCG GGAGCCGGGC CCTGACACCG CGCTCAGGTA GGTGCGGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0019788--F:NEDD8 transferase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0045116--P:protein neddylation

KEGG

gga:424015

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001473	Ailuropoda melanoleuca	88.71	5.00e-83	299.00
IUUC-Apl-003569	Anas platyrhynchos	82.86	4.00e-49	185.00
IUUC-Aca-005152	Anolis carolinensis	88.71	5.00e-95	339.00
IUUC-Ame-011839	Astyanax mexicanus	76.88	2.00e-83	301.00
IUUC-Bta-013524	Bos taurus	89.78	1.00e-83	301.00
IUUC-Cel-018579	Caenorhabditis elegans	57.03	2.00e-35	141.00
IUUC-Cja-019211	Callithrix jacchus	88.17	4.00e-85	306.00
IUUC-Cfa-020014	Canis familiaris	88.71	5.00e-83	299.00
IUUC-Cpo-022479	Cavia porcellus	87.63	4.00e-85	306.00
IUUC-Cho-024583	Choloepus hoffmanni	63.44	6.00e-59	219.00
IUUC-Cin-025378	Ciona intestinalis	47.57	1.00e-49	188.00
IUUC-Csv-026195	Ciona savignyi	48.63	1.00e-48	184.00
IUUC-Dre-028671	Danio rerio	78.49	3.00e-84	303.00
IUUC-Dno-029004	Dasypus novemcinctus	89.25	2.00e-95	340.00
IUUC-Dor-030940	Dipodomys ordii	87.63	3.00e-85	306.00
IUUC-Eca-034345	Equus caballus	89.25	1.00e-83	301.00
IUUC-Fca-036125	Felis catus	88.71	5.00e-83	299.00
IUUC-Fal-036808	Ficedula albicollis	93.01	1.00e-100	357.00
IUUC-Gmo-039394	Gadus morhua	92.04	2.00e-61	226.00
IUUC-Gac-041480	Gasterosteus aculeatus	79.26	6.00e-84	302.00
IUUC-Ggo-045010	Gorilla gorilla	88.17	1.00e-94	338.00
IUUC-Hsa-046664	Homo sapiens	88.17	1.00e-94	338.00
IUUC-Itr-048522	Ictidomys tridecemlineatus	89.25	5.00e-86	309.00
IUUC-Loc-052137	Lepisosteus oculatus	81.18	3.00e-87	313.00
IUUC-Laf-053694	Loxodonta africana	89.78	2.00e-88	317.00
IUUC-Mcc-055638	Macaca mulatta	88.17	1.00e-94	338.00
IUUC-Meu-056568	Macropus eugenii	74.73	2.00e-75	274.00
IUUC-Mga-059437	Meleagris gallopavo	94.62	1.00e-101	361.00
IUUC-Mmr-060651	Microcebus murinus	85.16	5.00e-80	290.00
IUUC-Mdo-061993	Monodelphis domestica	91.40	1.00e-97	348.00
IUUC-Mmu-064372	Mus musculus	87.10	5.00e-84	302.00
IUUC-Mpu-066423	Mustela putorius furo	88.17	7.00e-83	298.00
IUUC-Mlu-067910	Myotis lucifugus	88.71	5.00e-83	299.00
IUUC-Nle-069032	Nomascus leucogenys	88.17	4.00e-85	306.00
IUUC-Opr-070798	Ochotona princeps	87.10	2.00e-93	334.00
IUUC-Ont-071232	Oreochromis niloticus	79.57	1.00e-84	304.00
IUUC-Oan-072779	Ornithorhynchus anatinus	93.39	5.00e-66	241.00
IUUC-Ocu-074366	Oryctolagus cuniculus	84.95	2.00e-91	327.00
IUUC-Ola-087548	Oryzias latipes	89.83	7.00e-63	231.00
IUUC-Oga-089149	Otolemur garnettii	88.71	3.00e-87	313.00
IUUC-Oar-089662	Ovis aries	89.78	1.00e-83	301.00
IUUC-Ptr-090895	Pan troglodytes	88.17	1.00e-94	338.00
IUUC-Pan-092771	Papio anubis	87.70	3.00e-93	333.00
IUUC-Psi-093582	Pelodiscus sinensis	93.01	3.00e-100	356.00
IUUC-Pma-094321	Petromyzon marinus	89.92	6.00e-64	235.00
IUUC-Pfo-096040	Poecilia formosa	80.65	1.00e-85	308.00
IUUC-Pab-097931	Pongo abelii	88.17	1.00e-94	338.00
IUUC-Pca-100697	Procavia capensis	94.85	2.00e-76	277.00
IUUC-Pva-102609	Pteropus vampyrus	87.63	2.00e-83	301.00
IUUC-Rno-105622	Rattus norvegicus	87.63	5.00e-84	302.00
IUUC-Sha-107614	Sarcophilus harrisii	89.30	1.00e-94	338.00
IUUC-Ssc-115597	Sus scrofa	88.71	2.00e-85	307.00
IUUC-Tgu-117397	Taeniopygia guttata	93.55	6.00e-101	358.00
IUUC-Tru-118496	Takifugu rubripes	77.42	5.00e-82	296.00
IUUC-Tsy-119592	Tarsius syrichta	89.25	2.00e-87	314.00
IUUC-Tni-119759	Tetraodon nigroviridis	77.42	3.00e-82	296.00
IUUC-Tbe-128085	Tupaia belangeri	77.78	1.00e-57	214.00
IUUC-Ttr-129228	Tursiops truncatus	89.25	7.00e-83	299.00
IUUC-Xtr-131773	Xenopus tropicalis	85.51	5.00e-57	212.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence