iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-061809

UUCD1 version

UUC-MoD-01147

Ensembl Protein ID

ENSMODP00000026841.2

UniProt Accession

F7G2Y7; F7G2Y7_MONDO

Protein Name

Uncharacterized protein

Gene Name

USP14

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000021483.2	ENSMODT00000027322.2	ENSMODP00000026841.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.50e-64	218.5	105	482
ULD/UDP/UBQ/UBQ_Other	2.40e-08	33.9	6	74

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.... 85
           +Gl+NlgNtCYmN+++Qc+ ++pel+e+l++ +  +l+++ +  + + ++ +l++lf ++ +++++++ p  ll+ l+++ ++f     
   Q: 105  CGLTNLGNTCYMNATVQCIRSVPELKEALKR-YGGALRASGEMASAQYITAALRDLFDSM-DKTSSSIPPIILLQFLHMAFPQFAekgd 191
           7******************************.****************************.99999******************99*** PP
   S: 86   ..gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
             +y qqDa+E++ +++  l+++l+  +  +++e+ +e+       a    ++k+ksli++ F++++++++kc e +++  ++ + ++l
   Q: 192  qgQYLQQDANECWVQMMRVLQQKLEALEGDSIMETDGES-----PAAAAPAPSKKKSLIDQFFGVEFETTMKCTEAEEEEATKGKENQL 275
           999*********************665555555554444.....66788999****************************999988888 PP
   S: 173  slpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdl 261
           +l+   ++e   + l   L+   +ee  +     ++++ +++    k+ k+++lP +L++++ Rf ++e+++++ k+ k v+fpl+Ld+
   Q: 276  QLSCFINQEV--KYLFTGLKLRLQEEITK-----QSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDV 357
           8888877754..58999999999999998.....58899999999******************************************** PP
   S: 262  spfcts........................peekqke...........................kkkYeLiavvvHsG.slssGHYvay 298
            + ct                         p     +                           +  Y+L av+ H+G s+ssGHYv++
   Q: 358  YELCTPelqekmvsfrskfkdledkkvnqqP-----KtsskssgaqkeakyepfsfpddigsnnCGYYDLQAVLTHQGrSSSSGHYVSW 441
           ******6666666666666666555555551.....0555556666667777777777777777************************* PP
   S: 299  vknekgkWllfdDskVtevkeeevleetg....staYvlfY 335
           vk ++++W++fdD+kV+ v+ e++l+ +g    + aYvl+Y
   Q: 442  VKRKQDEWIKFDDDKVSIVTPEDILRLSGggdwHIAYVLLY 482
           **************************988************ PP

ULD/UDP/UBQ/UBQ_Other

   S: 3    vtvksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllek 72
           v vk+ + +  ++++n +++  ++K +++ ++g++p++q+ ++kG  L+dd ++++ ++k g+t++++ +
   Q: 6    VNVKWGKEKFDGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDD-DWGNIKIKSGMTLLMMGS 74
           7899999999999***********************************999.9**************965 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MPLFSVNVKW GKEKFDGVEL NTDEPPMVFK AQLFALTGVQ PARQKVMVKG GTLKDDDWGN 60
IKIKSGMTLL MMGSADALPE EPTAKTVFVE DMTEEQLASA MELPCGLTNL GNTCYMNATV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCGCTCT TCTCAGGTGA GCTCCCTCCG GGCCCCTTAC CTTCTTTCGC GTCCTCCCCC 60
AGGCGGCTCC CCGGAGCACT AGGCCTCCCT CGGGCGGAGG CGCCGGCCAA GCCTGGGCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

SMART

SM00213--UBQ

Gene Ontology

GO:0009986--C:cell surface
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0045202--C:synapse
GO:0004866--F:endopeptidase inhibitor activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007268--P:chemical synaptic transmission
GO:1903070--P:negative regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0050920--P:regulation of chemotaxis
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mdo:100013535

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000893	Aegilops tauschii	43.96	5.00e-38	152.00
IUUC-Aml-002053	Ailuropoda melanoleuca	93.31	0.00e+00	895.00
IUUC-Atr-002725	Amborella trichopoda	41.57	2.00e-101	362.00
IUUC-Apl-004031	Anas platyrhynchos	93.12	0.00e+00	904.00
IUUC-Aca-004361	Anolis carolinensis	91.53	0.00e+00	911.00
IUUC-Aly-006078	Arabidopsis lyrata	42.23	9.00e-111	393.00
IUUC-Ath-007623	Arabidopsis thaliana	42.41	9.00e-111	393.00
IUUC-Ago-007796	Ashbya gossypii	32.64	2.00e-57	216.00
IUUC-Acl-008258	Aspergillus clavatus	37.40	1.00e-63	237.00
IUUC-Afl-008732	Aspergillus flavus	33.33	1.00e-75	277.00
IUUC-Afu-008755	Aspergillus fumigatus	35.51	4.00e-80	291.00
IUUC-Ani-009148	Aspergillus nidulans	35.92	7.00e-84	304.00
IUUC-Ang-009878	Aspergillus niger	34.13	1.00e-74	273.00
IUUC-Aor-010239	Aspergillus oryzae	33.33	1.00e-75	277.00
IUUC-Ate-010243	Aspergillus terreus	34.88	4.00e-77	282.00
IUUC-Ame-011327	Astyanax mexicanus	52.00	1.00e-125	443.00
IUUC-Bgr-012231	Blumeria graminis	34.42	7.00e-77	281.00
IUUC-Bta-012553	Bos taurus	92.14	0.00e+00	893.00
IUUC-Bci-013606	Botrytis cinerea	39.49	2.00e-67	250.00
IUUC-Bdi-014567	Brachypodium distachyon	43.37	3.00e-111	395.00
IUUC-Bol-015565	Brassica oleracea	42.43	3.00e-114	405.00
IUUC-Bra-017501	Brassica rapa	42.23	2.00e-111	395.00
IUUC-Cel-018140	Caenorhabditis elegans	42.28	2.00e-102	365.00
IUUC-Cja-019516	Callithrix jacchus	92.35	0.00e+00	908.00
IUUC-Cfa-020808	Canis familiaris	93.15	0.00e+00	904.00
IUUC-Cpo-021688	Cavia porcellus	92.34	0.00e+00	892.00
IUUC-Cre-022663	Chlamydomonas reinhardtii	37.75	9.00e-83	300.00
IUUC-Csa-023429	Chlorocebus sabaeus	93.12	0.00e+00	895.00
IUUC-Cho-024347	Choloepus hoffmanni	93.52	0.00e+00	901.00
IUUC-Cin-025198	Ciona intestinalis	53.55	8.00e-147	513.00
IUUC-Csv-026007	Ciona savignyi	52.59	1.00e-148	520.00
IUUC-Cgl-026757	Colletotrichum gloeosporioides	38.65	1.00e-62	234.00
IUUC-Cne-026963	Cryptococcus neoformans	34.96	2.00e-74	272.00
IUUC-Cme-027240	Cyanidioschyzon merolae	29.92	3.00e-57	216.00
IUUC-Dre-027647	Danio rerio	83.94	0.00e+00	832.00
IUUC-Dno-029967	Dasypus novemcinctus	93.35	0.00e+00	898.00
IUUC-Dor-030886	Dipodomys ordii	87.10	0.00e+00	728.00
IUUC-Dse-031466	Dothistroma septosporum	36.17	1.00e-54	207.00
IUUC-Dme-032079	Drosophila melanogaster	54.71	9.00e-155	540.00
IUUC-Ete-032351	Echinops telfairi	78.83	0.00e+00	758.00
IUUC-Eca-033461	Equus caballus	91.94	0.00e+00	919.00
IUUC-Eeu-035220	Erinaceus europaeus	70.08	0.00e+00	639.00
IUUC-Fca-036210	Felis catus	93.35	0.00e+00	906.00
IUUC-Fal-037528	Ficedula albicollis	92.73	0.00e+00	895.00
IUUC-Fox-037805	Fusarium oxysporum	39.69	5.00e-68	251.00
IUUC-Fso-038177	Fusarium solani	37.89	1.00e-64	240.00
IUUC-Gmo-038953	Gadus morhua	78.30	0.00e+00	748.00
IUUC-Ggr-039972	Gaeumannomyces graminis	37.73	1.00e-62	234.00
IUUC-Gga-040462	Gallus gallus	92.14	0.00e+00	897.00
IUUC-Gac-041312	Gasterosteus aculeatus	80.98	0.00e+00	800.00
IUUC-Gma-043255	Glycine max	42.66	1.00e-107	383.00
IUUC-Ggo-045458	Gorilla gorilla	76.81	0.00e+00	726.00
IUUC-Hsa-045706	Homo sapiens	93.15	0.00e+00	899.00
IUUC-Hvu-047821	Hordeum vulgare	46.76	7.00e-57	213.00
IUUC-Itr-048654	Ictidomys tridecemlineatus	91.53	0.00e+00	903.00
IUUC-Lch-050464	Latimeria chalumnae	83.13	0.00e+00	823.00
IUUC-Lpe-051419	Leersia perrieri	42.54	7.00e-106	377.00
IUUC-Loc-052732	Lepisosteus oculatus	82.79	0.00e+00	833.00
IUUC-Lma-053177	Leptosphaeria maculans	40.53	4.00e-67	248.00
IUUC-Laf-053822	Loxodonta africana	93.32	0.00e+00	897.00
IUUC-Mcc-055893	Macaca mulatta	93.32	0.00e+00	897.00
IUUC-Meu-056307	Macropus eugenii	85.51	0.00e+00	814.00
IUUC-Mor-057171	Magnaporthe oryzae	39.02	7.00e-66	244.00
IUUC-Mpo-057415	Magnaporthe poae	39.95	1.00e-67	250.00
IUUC-Mtr-057901	Medicago truncatula	43.54	9.00e-111	394.00
IUUC-Mla-058897	Melampsora laricipopulina	40.48	1.00e-74	274.00
IUUC-Mga-060016	Meleagris gallopavo	92.31	0.00e+00	899.00
IUUC-Mvi-060562	Microbotryum violaceum	39.84	2.00e-64	239.00
IUUC-Mmr-060624	Microcebus murinus	92.54	0.00e+00	925.00
IUUC-Mmu-063869	Mus musculus	91.53	0.00e+00	883.00
IUUC-Mac-064876	Musa acuminata	39.52	1.00e-95	343.00
IUUC-Mpu-066480	Mustela putorius furo	93.15	0.00e+00	902.00
IUUC-Mlu-067866	Myotis lucifugus	91.73	0.00e+00	902.00
IUUC-Nfi-068393	Neosartorya fischeri	35.22	2.00e-74	273.00
IUUC-Ncr-068815	Neurospora crassa	36.25	6.00e-82	298.00
IUUC-Nle-070121	Nomascus leucogenys	92.16	6.00e-133	466.00
IUUC-Opr-070712	Ochotona princeps	72.85	2.00e-163	568.00
IUUC-Ont-071544	Oreochromis niloticus	82.15	0.00e+00	768.00
IUUC-Oan-073635	Ornithorhynchus anatinus	93.02	0.00e+00	747.00
IUUC-Ocu-074926	Oryctolagus cuniculus	92.34	0.00e+00	890.00
IUUC-Oba-075633	Oryza barthii	42.01	7.00e-105	374.00
IUUC-Obr-076423	Oryza brachyantha	42.45	6.00e-107	380.00
IUUC-Ogl-077913	Oryza glaberrima	42.05	3.00e-107	381.00
IUUC-Ogu-078435	Oryza glumaepatula	42.01	7.00e-105	374.00
IUUC-Oin-080072	Oryza indica	41.98	4.00e-105	375.00
IUUC-Olo-080535	Oryza longistaminata	39.56	1.00e-89	323.00
IUUC-Ome-081309	Oryza meridionalis	42.01	7.00e-105	374.00
IUUC-Oni-083113	Oryza nivara	42.01	7.00e-105	374.00
IUUC-Opu-083168	Oryza punctata	41.07	2.00e-99	355.00
IUUC-Oru-084253	Oryza rufipogon	42.01	7.00e-105	374.00
IUUC-Osa-085554	Oryza sativa	42.05	3.00e-107	382.00
IUUC-Ola-086998	Oryzias latipes	81.62	0.00e+00	795.00
IUUC-Olu-087818	Ostreococcus lucimarinus	35.94	8.00e-69	254.00
IUUC-Oga-088571	Otolemur garnettii	92.54	0.00e+00	897.00
IUUC-Oar-089526	Ovis aries	92.31	0.00e+00	890.00
IUUC-Ptr-091433	Pan troglodytes	93.32	0.00e+00	897.00
IUUC-Pan-091966	Papio anubis	93.12	0.00e+00	895.00
IUUC-Psi-093458	Pelodiscus sinensis	90.77	0.00e+00	850.00
IUUC-Pma-094343	Petromyzon marinus	68.51	2.00e-112	398.00
IUUC-Pno-095109	Phaeosphaeria nodorum	39.07	1.00e-63	237.00
IUUC-Ppa-095756	Physcomitrella patens	43.53	2.00e-110	392.00
IUUC-Pfo-096514	Poecilia formosa	82.76	0.00e+00	787.00
IUUC-Pab-098477	Pongo abelii	81.74	0.00e+00	707.00
IUUC-Pop-099221	Populus trichocarpa	41.39	8.00e-105	374.00
IUUC-Pca-100791	Procavia capensis	74.71	1.00e-163	569.00
IUUC-Ppe-101812	Prunus persica	41.48	4.00e-108	385.00
IUUC-Pva-102462	Pteropus vampyrus	87.47	0.00e+00	720.00
IUUC-Pgr-103623	Puccinia graminis	42.17	5.00e-74	271.00
IUUC-Ptt-103767	Puccinia triticina	40.36	6.00e-66	244.00
IUUC-Pte-104109	Pyrenophora teres	38.86	6.00e-67	248.00
IUUC-Pyt-104766	Pyrenophora triticirepentis	39.21	2.00e-66	246.00
IUUC-Rno-105351	Rattus norvegicus	90.73	0.00e+00	867.00
IUUC-Sce-106168	Saccharomyces cerevisiae	32.56	1.00e-62	234.00
IUUC-Sha-107491	Sarcophilus harrisii	96.37	0.00e+00	928.00
IUUC-Sja-107769	Schizosaccharomyces japonicus	34.51	2.00e-77	283.00
IUUC-Spo-108174	Schizosaccharomyces pombe	37.15	7.00e-78	284.00
IUUC-Ssl-108659	Sclerotinia sclerotiorum	35.02	7.00e-81	295.00
IUUC-Smo-108805	Selaginella moellendorffii	43.85	1.00e-110	393.00
IUUC-Sit-110361	Setaria italica	42.43	3.00e-110	392.00
IUUC-Sly-110965	Solanum lycopersicum	41.01	9.00e-108	384.00
IUUC-Sar-113355	Sorex araneus	80.74	0.00e+00	637.00
IUUC-Sbi-114778	Sorghum bicolor	43.06	5.00e-111	394.00
IUUC-Sre-115011	Sporisorium reilianum	37.54	4.00e-60	225.00
IUUC-Ssc-116273	Sus scrofa	92.07	0.00e+00	880.00
IUUC-Tgu-117063	Taeniopygia guttata	92.51	0.00e+00	894.00
IUUC-Tru-118381	Takifugu rubripes	80.32	0.00e+00	783.00
IUUC-Tsy-119076	Tarsius syrichta	77.87	8.00e-113	400.00
IUUC-Tni-119941	Tetraodon nigroviridis	81.10	0.00e+00	771.00
IUUC-Tca-121246	Theobroma cacao	41.87	2.00e-109	389.00
IUUC-Tre-121969	Trichoderma reesei	37.50	4.00e-64	239.00
IUUC-Tvi-122543	Trichoderma virens	32.86	1.00e-64	240.00
IUUC-Tae-125484	Triticum aestivum	41.85	7.00e-108	384.00
IUUC-Tur-126128	Triticum urartu	41.87	1.00e-38	154.00
IUUC-Tbe-128030	Tupaia belangeri	85.51	0.00e+00	797.00
IUUC-Ttr-128701	Tursiops truncatus	90.85	0.00e+00	726.00
IUUC-Uma-129657	Ustilago maydis	37.43	2.00e-63	236.00
IUUC-Vda-129723	Verticillium dahliae	35.58	1.00e-56	214.00
IUUC-Vpa-130284	Vicugna pacos	65.31	1.00e-166	579.00
IUUC-Vvi-131037	Vitis vinifera	42.91	3.00e-109	389.00
IUUC-Xtr-132235	Xenopus tropicalis	85.94	0.00e+00	860.00
IUUC-Xma-133840	Xiphophorus maculatus	82.76	0.00e+00	811.00
IUUC-Yli-134453	Yarrowia lipolytica	37.03	1.00e-81	297.00
IUUC-Zma-135669	Zea mays	35.55	5.00e-92	331.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence