iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-036693

Ensembl Protein ID

ENSFALP00000002992.1

UniProt Accession

U3JJN8; U3JJN8_FICAL

Genbank Protein ID

ENSFALP00000002992

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

AGTO01011009

Gene Name

UCHL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000002871.1	ENSFALT00000003005.1	ENSFALP00000002992.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	2.40e-56	191.1	31	237

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/UCH

   S: 21   lvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvigNsCatyAllsvll 109
           +++++gv   +++ ++ + + e l+ ++ p ++llllF+++e++e++rk+q++    +++d++i ++++f+kq+++NsC+t++l+++++
   Q: 31   VLSRLGVGPGWRFVDVLGFEDEALRAVPSPACALLLLFPLTEQHENFRKQQTE----KIKDQEISSKVYFLKQTVSNSCGTIGLIHAVA 115
           7899***********************************************98....88****************************** PP
   S: 110  ncedkl.ldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsyvningrlyeldglk 197
           n++dkl l+ G+ l++++++t   spe++a++l n+++++ +hns+a++++++ + +           +fhf+++vn++g+lyeldg++
   Q: 116  NNKDKLkLEEGSALKKFLDETADLSPEERAKHLANNKAIQEVHNSVAQEGQCRVEDN---------SVNFHFILFVNVDGHLYELDGRM 195
           ****************************************************99843.........489******************** PP
   S: 198  pfPldlgkkketeelkdklkvvraflerikllesdeirfnllaiva 243
           pfP+++g ++++  lkd +k +r+f+er    e++e+rf+++a ++
   Q: 196  PFPVNHGTSSDDLLLKDSAKICRQFTER----EKGEVRFSAVAFCK 237
           ****************************....99*******99876 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

GGGGGGGGGG GAPRGRACRG RATRSLCPVQ VLSRLGVGPG WRFVDVLGFE DEALRAVPSP 60
ACALLLLFPL TEQHENFRKQ QTEKIKDQEI SSKVYFLKQT VSNSCGTIGL IHAVANNKDK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGGGGGGG GGGGGGGGGG GGGGGGGGGG GGGGCTCCCC GGGGACGGGC GTGTCGCGGC 60
CGGGCCACCC GCTCTCTGTG CCCCGTGCAG GTGCTGTCCC GCCTCGGGGT GGGTCCTGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR030297--UCHL1

PROSITE

PS00140--UCH_1

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:1904115--C:axon cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0043209--C:myelin sheath
GO:0044306--C:neuron projection terminus
GO:0043025--C:neuronal cell body
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0004197--F:cysteine-type endopeptidase activity
GO:0016874--F:ligase activity
GO:0008242--F:omega peptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007628--P:adult walking behavior
GO:0007412--P:axon target recognition
GO:0019896--P:axonal transport of mitochondrion
GO:0008283--P:cell proliferation
GO:0042755--P:eating behavior
GO:0048747--P:muscle fiber development
GO:0043407--P:negative regulation of MAP kinase activity
GO:0050905--P:neuromuscular process
GO:0016579--P:protein deubiquitination
GO:0002931--P:response to ischemia
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001376	Ailuropoda melanoleuca	60.25	5.00e-77	280.00
IUUC-Apl-003693	Anas platyrhynchos	89.52	3.00e-109	387.00
IUUC-Aca-004716	Anolis carolinensis	78.57	2.00e-100	357.00
IUUC-Ame-011806	Astyanax mexicanus	63.16	5.00e-77	280.00
IUUC-Bta-013521	Bos taurus	61.09	8.00e-79	286.00
IUUC-Cel-018302	Caenorhabditis elegans	37.75	1.00e-30	125.00
IUUC-Cja-018752	Callithrix jacchus	74.41	4.00e-82	296.00
IUUC-Cfa-020442	Canis familiaris	75.24	6.00e-84	302.00
IUUC-Cpo-021723	Cavia porcellus	74.25	7.00e-73	265.00
IUUC-Csa-023626	Chlorocebus sabaeus	73.33	1.00e-81	295.00
IUUC-Cho-024548	Choloepus hoffmanni	76.92	3.00e-29	120.00
IUUC-Cgl-026409	Colletotrichum gloeosporioides	30.94	2.00e-24	105.00
IUUC-Dre-027854	Danio rerio	64.29	2.00e-77	281.00
IUUC-Dno-029325	Dasypus novemcinctus	73.33	3.00e-82	297.00
IUUC-Dor-030114	Dipodomys ordii	72.38	2.00e-90	324.00
IUUC-Ete-033092	Echinops telfairi	72.29	4.00e-70	257.00
IUUC-Eeu-034493	Erinaceus europaeus	74.87	1.00e-79	288.00
IUUC-Gmo-038848	Gadus morhua	60.10	3.00e-68	250.00
IUUC-Gga-041078	Gallus gallus	95.24	3.00e-117	413.00
IUUC-Gac-042064	Gasterosteus aculeatus	64.11	5.00e-78	283.00
IUUC-Ggo-044827	Gorilla gorilla	74.29	6.00e-83	299.00
IUUC-Hsa-045820	Homo sapiens	74.29	6.00e-83	299.00
IUUC-Itr-048496	Ictidomys tridecemlineatus	72.86	2.00e-81	294.00
IUUC-Lch-050121	Latimeria chalumnae	66.83	2.00e-86	311.00
IUUC-Loc-052342	Lepisosteus oculatus	66.98	2.00e-84	304.00
IUUC-Laf-053916	Loxodonta africana	72.04	3.00e-80	290.00
IUUC-Mcc-054838	Macaca mulatta	73.33	1.00e-81	295.00
IUUC-Meu-056478	Macropus eugenii	73.81	2.00e-92	330.00
IUUC-Mtr-057713	Medicago truncatula	43.59	8.00e-40	156.00
IUUC-Mga-059878	Meleagris gallopavo	95.24	3.00e-117	413.00
IUUC-Mdo-062544	Monodelphis domestica	72.38	1.00e-80	291.00
IUUC-Mmu-063300	Mus musculus	73.81	8.00e-92	329.00
IUUC-Mpu-066128	Mustela putorius furo	72.19	6.00e-69	253.00
IUUC-Mlu-067778	Myotis lucifugus	72.86	2.00e-91	328.00
IUUC-Nle-069686	Nomascus leucogenys	73.81	1.00e-82	298.00
IUUC-Opr-070535	Ochotona princeps	72.89	2.00e-71	261.00
IUUC-Ont-071510	Oreochromis niloticus	61.24	1.00e-76	278.00
IUUC-Ocu-074590	Oryctolagus cuniculus	72.38	6.00e-81	293.00
IUUC-Ola-087552	Oryzias latipes	59.81	4.00e-73	266.00
IUUC-Oga-089013	Otolemur garnettii	60.25	2.00e-77	281.00
IUUC-Oar-089861	Ovis aries	61.09	8.00e-79	286.00
IUUC-Ptr-091536	Pan troglodytes	74.29	7.00e-83	299.00
IUUC-Pan-092909	Papio anubis	73.33	1.00e-81	295.00
IUUC-Psi-093818	Pelodiscus sinensis	82.86	5.00e-103	366.00
IUUC-Pfo-097335	Poecilia formosa	63.51	6.00e-78	283.00
IUUC-Pab-098048	Pongo abelii	74.29	6.00e-83	299.00
IUUC-Pca-100818	Procavia capensis	57.69	3.00e-44	171.00
IUUC-Pva-102954	Pteropus vampyrus	74.29	8.00e-81	292.00
IUUC-Pyt-104587	Pyrenophora triticirepentis	35.38	1.00e-30	125.00
IUUC-Rno-105966	Rattus norvegicus	73.81	8.00e-92	329.00
IUUC-Sha-107111	Sarcophilus harrisii	72.89	4.00e-71	259.00
IUUC-Sly-111832	Solanum lycopersicum	44.08	2.00e-44	172.00
IUUC-Stu-112526	Solanum tuberosum	44.08	4.00e-45	174.00
IUUC-Sar-113190	Sorex araneus	56.52	3.00e-26	109.00
IUUC-Tgu-117465	Taeniopygia guttata	95.26	2.00e-116	410.00
IUUC-Tru-118565	Takifugu rubripes	63.24	1.00e-75	275.00
IUUC-Tsy-119561	Tarsius syrichta	72.29	8.00e-70	256.00
IUUC-Tbe-128048	Tupaia belangeri	74.10	2.00e-72	263.00
IUUC-Ttr-128494	Tursiops truncatus	73.08	4.00e-80	290.00
IUUC-Xtr-132286	Xenopus tropicalis	67.62	3.00e-83	300.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence