iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-034283

UUCD1 version

UUC-EqC-01034

Ensembl Protein ID

ENSECAP00000007122.1

UniProt Accession

F6WTG5; F6WTG5_HORSE

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP20

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000008342.1	ENSECAT00000009369.1	ENSECAP00000007122.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.20e-99	333.9	146	686

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tG+kNlgN+CYmN++LQ+Lsn+p+l++++le     +    ++++k +l+ks+qkl++e+w  ++ ++v p++l + +k ++++f+gy+
   Q: 146  TGMKNLGNSCYMNAALQALSNCPPLTQFFLE-----CGGLVRTDKKPALCKSYQKLVSEVWhRKRPSYVVPTSLSHGIKLVNPMFRGYA 229
           7******************************.....999999*******************889999********************** PP
   S: 89   qqDaqEflaflldqleeelkk..............eknkpkeeeeeedkselsde.................................. 129
           qqD+qEfl++l+dql+eelk+              +           d+s+++++                                  
   Q: 230  QQDTQEFLRCLMDQLHEELKEpvvaaaaalteardS-----------DSSDSDEKregdrspsedeflscdsssdrgegdgqgrgggss 307
           *******************99887444444443333...........4433333366666666677*********************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 308  qaetellipdeagraisekermkdrkfswgqqrtnseqvdedadvdtamtaldhqptdaqapsprsaspcrtpepdneahmrsasrpcs 396
           ***************************************************************************************** PP
   S: 130  ......................................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgke 180
                                                 ++++k+++++s+isd+F+g++ s ++cl+cd+vs++ e+f+dlslp+pgke
   Q: 397  pvhhheghaklassppraspvrmgpsyvlkkaqvlsagSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKE 485
           ***************************************************************************************** PP
   S: 181  etkke.................................................slqdcLesftkeeelegenkyycekckkkqeaekk 220
           + +k+                                                 +l+dcL++f++++el+g+n+y+ce+ckk+++ +k 
   Q: 486  DLAKLhsaiyqnvpakpgacgdsyaaqgwlafimeyirrfvvsctpswfwgpvvTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKY 574
           99888************************************************************************************ PP
   S: 221  lklkklPevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWl 307
           +k+ +lPev    L     ++++    +i+++v+fple Ldl+pf+++++++q   ++Y+L++v++H+G+++sGHY+ay++n  +g+W+
   Q: 575  CKVLRLPEVSGRPLAAA--TRQGLGALRISSHVSFPLEgLDLRPFLAKECTSQ--ITSYDLLSVICHHGTAGSGHYIAYCQNvINGQWY 659
           ***********999999..777888889**********************999..9**************************78999** PP
   S: 308  lfdDskVtevkeeevleetgstaYvlfYkr 337
           +fdD++Vtev+e+ v++   ++aYvlfY++
   Q: 660  EFDDQYVTEVHETVVQN---AEAYVLFYRK 686
           *****************...********98 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

RMGDSRDLCP HLDSIGEVTK EDLLLKSKGT CQSCGVAGPN LWACLQVACP YVGCGESFAD 60
HSTIHAQVKK HNLTVNLTTF RVWCYACERE VFLEQRLAAH PPGPSPKFSE QDAPLPSHPL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAATGGGGG ACTCCAGGGA CCTTTGCCCT CACCTTGACT CGATAGGGGA GGTGACCAAG 60
GAGGACTTGC TGCTCAAATC TAAGGTAAAG GGTCAGACCT TACGGGCTGA GGCCCACACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0005813--C:centrosome
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0008277--P:regulation of G-protein coupled receptor protein signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002209	Ailuropoda melanoleuca	92.58	0.00e+00	1649.00
IUUC-Apl-003351	Anas platyrhynchos	84.58	0.00e+00	1542.00
IUUC-Aca-005077	Anolis carolinensis	74.41	0.00e+00	1072.00
IUUC-Ame-011777	Astyanax mexicanus	74.08	0.00e+00	1312.00
IUUC-Bta-013063	Bos taurus	93.01	0.00e+00	1629.00
IUUC-Cja-019868	Callithrix jacchus	91.81	0.00e+00	1659.00
IUUC-Cfa-020761	Canis familiaris	93.55	0.00e+00	1684.00
IUUC-Cpo-022267	Cavia porcellus	84.73	0.00e+00	1491.00
IUUC-Csa-024251	Chlorocebus sabaeus	93.22	0.00e+00	1680.00
IUUC-Cho-024483	Choloepus hoffmanni	89.15	2.00e-113	403.00
IUUC-Dre-028061	Danio rerio	72.49	0.00e+00	1180.00
IUUC-Dno-029423	Dasypus novemcinctus	93.77	0.00e+00	1662.00
IUUC-Dor-030877	Dipodomys ordii	88.83	0.00e+00	1055.00
IUUC-Ete-032802	Echinops telfairi	80.63	4.00e-136	478.00
IUUC-Eeu-034620	Erinaceus europaeus	89.91	0.00e+00	1161.00
IUUC-Fca-036357	Felis catus	93.77	0.00e+00	1634.00
IUUC-Fal-037411	Ficedula albicollis	84.55	0.00e+00	1545.00
IUUC-Gga-041101	Gallus gallus	84.39	0.00e+00	1521.00
IUUC-Gac-041315	Gasterosteus aculeatus	72.27	0.00e+00	1283.00
IUUC-Ggo-045600	Gorilla gorilla	92.83	0.00e+00	1623.00
IUUC-Hsa-045825	Homo sapiens	93.33	0.00e+00	1635.00
IUUC-Itr-048549	Ictidomys tridecemlineatus	79.96	0.00e+00	1360.00
IUUC-Lch-050002	Latimeria chalumnae	73.16	0.00e+00	1278.00
IUUC-Loc-052574	Lepisosteus oculatus	76.50	0.00e+00	1382.00
IUUC-Laf-054428	Loxodonta africana	91.93	0.00e+00	1649.00
IUUC-Mcc-055736	Macaca mulatta	93.01	0.00e+00	1676.00
IUUC-Mga-059781	Meleagris gallopavo	83.97	0.00e+00	1524.00
IUUC-Mdo-063048	Monodelphis domestica	86.94	0.00e+00	1514.00
IUUC-Mmu-064079	Mus musculus	90.83	0.00e+00	1620.00
IUUC-Mpu-066616	Mustela putorius furo	91.49	0.00e+00	1672.00
IUUC-Mlu-067294	Myotis lucifugus	91.15	0.00e+00	1568.00
IUUC-Nle-070015	Nomascus leucogenys	93.01	0.00e+00	1602.00
IUUC-Opr-070328	Ochotona princeps	91.28	0.00e+00	1640.00
IUUC-Ont-071464	Oreochromis niloticus	73.37	0.00e+00	1279.00
IUUC-Oan-073259	Ornithorhynchus anatinus	77.29	0.00e+00	1278.00
IUUC-Ocu-074630	Oryctolagus cuniculus	89.29	0.00e+00	1556.00
IUUC-Ola-087240	Oryzias latipes	72.48	0.00e+00	1262.00
IUUC-Oga-088761	Otolemur garnettii	91.48	0.00e+00	1648.00
IUUC-Oar-089490	Ovis aries	87.32	0.00e+00	1477.00
IUUC-Ptr-091662	Pan troglodytes	93.33	0.00e+00	1634.00
IUUC-Pan-092199	Papio anubis	92.80	0.00e+00	1669.00
IUUC-Psi-093726	Pelodiscus sinensis	85.71	0.00e+00	1553.00
IUUC-Pma-094389	Petromyzon marinus	64.98	1.00e-100	359.00
IUUC-Pab-098632	Pongo abelii	93.01	0.00e+00	1623.00
IUUC-Pca-100614	Procavia capensis	83.64	0.00e+00	1248.00
IUUC-Pva-102922	Pteropus vampyrus	93.46	0.00e+00	992.00
IUUC-Rno-105215	Rattus norvegicus	90.27	0.00e+00	1616.00
IUUC-Sha-106601	Sarcophilus harrisii	84.88	0.00e+00	1489.00
IUUC-Ssc-115533	Sus scrofa	92.33	0.00e+00	1635.00
IUUC-Tgu-117364	Taeniopygia guttata	84.72	0.00e+00	1506.00
IUUC-Tru-117770	Takifugu rubripes	71.41	0.00e+00	1263.00
IUUC-Tni-120001	Tetraodon nigroviridis	72.00	0.00e+00	1235.00
IUUC-Ttr-128732	Tursiops truncatus	94.10	0.00e+00	1649.00
IUUC-Xtr-132157	Xenopus tropicalis	74.62	0.00e+00	1330.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence