• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063294
UUCD1 version UUC-MuM-01114
Ensembl Protein ID ENSMUSP00000111443.3
UniProt Accession Q9D2M8; A6X924; Q8BGH6; Q8CE99; Q8K2V7; Q9CYD7; Q9ERI8; UB2V2_MOUSE
Genbank Protein ID AAG22084.1; BAB30932.1; BAB31753.1; BAC25968.1; BAC26094.1; BAC27311.1; BAC28128.1; CAO77942.1; AAH29742.1; AAH58374.1; AAH83098.1
Protein Name Ubiquitin-conjugating enzyme E2 variant 2; Ubc-like protein MMS2
Genbank Nucleotide ID AF303828; AK017786; AK019486; AK028472; AK028742; AK031233; AK033016; CT010522; BC029742; BC058374; BC083098
Gene Name Ube2v2; Mms2; Uev2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000022674.14 ENSMUST00000115777.9 ENSMUSP00000111443.3
ENSMUSG00000022674.14 ENSMUST00000115776.1 ENSMUSP00000111442.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
PhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E2/UEV 9.40e-66 221.2 5 143
E2/UBC 3.60e-19 70.0 30 136
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E2/UEV
   S: 7    lkvvvprnfrlleeleegekglgdgtvsygldDgddilllsltgtIigpertayegrIyqlklfvgkkYPekPPtvrfsskinmaevnd 95
           + v+vprnfrlleeleeg+kg+gdgtvs+gl+D++d++l+++tg+Iigp+rt+ye+rIy+lk+++g+kYPe+PP vrf++kinm+++n+
   Q: 5    TGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNYENRIYSLKVECGSKYPEAPPSVRFVTKINMNGINN 93
           689************************************************************************************** PP
   S: 96   snGvvdpralpvLanWkreysievvlvqlkkellskenrklqqPpeGnlf 145
           s+G+vd+r++pvLa+W+++ysi+v+l++l++ ++sken+kl+qPpeG+++
   Q: 94   SSGMVDARSIPVLAKWQNSYSIKVILQELRRLMMSKENMKLPQPPEGQTY 143
           ***********************************************986 PP
   

   E2/UBC
   S: 16   gisakpvdesd..ltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.Gkv...ClsilkeeekWspalsv 98
           ++s +++d++d  lt+w  +i+Gp++t+Ye+++++l++e+ ++YP  PP+v+f+tki    ++++ G v    + +l    kW+  +s+
   Q: 30   TVSWGLEDDEDmtLTRWTGMIIGPPRTNYENRIYSLKVECGSKYPEAPPSVRFVTKINMNGINNSsGMVdarSIPVL---AKWQNSYSI 115
           456667777776689******************************************99999999899943335555...7******** PP
   S: 99   esvllsiqsll.aepnpespl 118
           + +l ++ +l+ ++ n++ p+
   Q: 116  KVILQELRRLMmSKENMKLPQ 136
           *********996667777775 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
 Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
Protein Sequence
(Fasta)
MAVSTGVKVP RNFRLLEELE EGQKGVGDGT VSWGLEDDED MTLTRWTGMI IGPPRTNYEN 60
RIYSLKVECG SKYPEAPPSV RFVTKINMNG INNSSGMVDA RSIPVLAKWQ NSYSIKVILQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063294|E2,E2/UEV|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGTGACGTTG ACGCCCTGCG TGCGGTGGTG CGTCTGGTAG CAGGAGAAGA TGGCGGTCTC 60
CACAGGTCGG TTCCTAGCCG GGTCTGCCGC GCTCCCGCTG CTTTCTGTCC GGCGGGCCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063294|E2,E2/UEV|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD
PROSITE

PS50127--UBIQUITIN_CONJUGAT_2
Pfam

PF00179--UQ_con
Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031372--C:UBC13-MMS2 complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0000729--P:DNA double-strand break processing
GO:0042275--P:error-free postreplication DNA repair
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0045739--P:positive regulation of DNA repair
GO:0010976--P:positive regulation of neuron projection development
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0051965--P:positive regulation of synapse assembly
GO:0070534--P:protein K63-linked ubiquitination
KEGG mmu:70620
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001275 Ailuropoda melanoleuca 98.57 5.00e-79 286.00
IUUC-Apl-003790 Anas platyrhynchos 97.12 1.00e-69 254.00
IUUC-Aca-004448 Anolis carolinensis 97.12 7.00e-70 255.00
IUUC-Aly-006115 Arabidopsis lyrata 54.89 3.00e-38 150.00
IUUC-Ath-006915 Arabidopsis thaliana 53.73 4.00e-38 150.00
IUUC-Ago-007810 Ashbya gossypii 50.00 1.00e-34 138.00
IUUC-Afl-008598 Aspergillus flavus 48.55 8.00e-34 135.00
IUUC-Ani-009325 Aspergillus nidulans 48.23 2.00e-35 141.00
IUUC-Aor-010051 Aspergillus oryzae 48.55 8.00e-34 135.00
IUUC-Ate-010471 Aspergillus terreus 44.93 1.00e-28 118.00
IUUC-Bgr-012010 Blumeria graminis 48.92 4.00e-33 133.00
IUUC-Bta-012471 Bos taurus 98.62 7.00e-82 295.00
IUUC-Bra-017054 Brassica rapa 53.73 9.00e-38 149.00
IUUC-Cel-018398 Caenorhabditis elegans 63.04 5.00e-47 179.00
IUUC-Cja-019506 Callithrix jacchus 97.93 1.00e-81 294.00
IUUC-Cfa-020370 Canis familiaris 98.62 7.00e-82 295.00
IUUC-Cpo-021317 Cavia porcellus 95.86 2.00e-79 286.00
IUUC-Csa-023412 Chlorocebus sabaeus 98.62 7.00e-82 295.00
IUUC-Cho-025024 Choloepus hoffmanni 97.78 2.00e-48 182.00
IUUC-Cne-026817 Cryptococcus neoformans 46.72 5.00e-37 146.00
IUUC-Dre-028062 Danio rerio 92.41 7.00e-78 281.00
IUUC-Dno-029546 Dasypus novemcinctus 98.57 4.00e-79 286.00
IUUC-Dse-031272 Dothistroma septosporum 50.72 5.00e-35 139.00
IUUC-Dme-031635 Drosophila melanogaster 67.14 1.00e-57 215.00
IUUC-Fca-035746 Felis catus 98.57 6.00e-79 285.00
IUUC-Fal-037369 Ficedula albicollis 95.86 2.00e-70 257.00
IUUC-Gmo-039696 Gadus morhua 83.33 3.00e-68 250.00
IUUC-Ggr-039839 Gaeumannomyces graminis 46.50 2.00e-30 125.00
IUUC-Gga-040634 Gallus gallus 95.86 2.00e-70 257.00
IUUC-Gac-041936 Gasterosteus aculeatus 84.03 4.00e-62 229.00
IUUC-Ggo-044696 Gorilla gorilla 98.62 7.00e-82 295.00
IUUC-Hsa-046699 Homo sapiens 98.62 7.00e-82 295.00
IUUC-Hvu-047307 Hordeum vulgare 51.43 5.00e-38 149.00
IUUC-Itr-048151 Ictidomys tridecemlineatus 98.62 7.00e-82 295.00
IUUC-Kpa-049337 Komagataella pastoris 48.89 9.00e-31 125.00
IUUC-Loc-052012 Lepisosteus oculatus 92.41 1.00e-77 281.00
IUUC-Lma-053194 Leptosphaeria maculans 50.72 1.00e-34 138.00
IUUC-Laf-053991 Loxodonta africana 97.86 1.00e-78 284.00
IUUC-Mcc-055850 Macaca mulatta 98.57 3.00e-79 286.00
IUUC-Mor-056915 Magnaporthe oryzae 37.09 9.00e-21 92.80
IUUC-Mpo-057437 Magnaporthe poae 45.86 4.00e-30 124.00
IUUC-Mla-058919 Melampsora laricipopulina 52.52 2.00e-34 137.00
IUUC-Mga-059210 Meleagris gallopavo 97.12 7.00e-70 255.00
IUUC-Mvi-060260 Microbotryum violaceum 52.55 7.00e-36 142.00
IUUC-Mmr-061751 Microcebus murinus 97.24 3.00e-80 290.00
IUUC-Mdo-062503 Monodelphis domestica 96.55 8.00e-73 265.00
IUUC-Mac-065220 Musa acuminata 51.41 2.00e-38 150.00
IUUC-Mpu-065942 Mustela putorius furo 98.62 7.00e-82 295.00
IUUC-Mlu-067702 Myotis lucifugus 98.57 6.00e-79 285.00
IUUC-Ncr-068946 Neurospora crassa 45.86 8.00e-37 145.00
IUUC-Nle-069327 Nomascus leucogenys 98.62 7.00e-82 295.00
IUUC-Opr-070697 Ochotona princeps 82.73 1.00e-61 228.00
IUUC-Ont-072098 Oreochromis niloticus 87.50 8.00e-66 241.00
IUUC-Oan-073215 Ornithorhynchus anatinus 89.12 4.00e-66 243.00
IUUC-Ocu-073859 Oryctolagus cuniculus 98.62 7.00e-82 295.00
IUUC-Oba-075005 Oryza barthii 53.73 4.00e-38 150.00
IUUC-Obr-076238 Oryza brachyantha 53.73 2.00e-38 150.00
IUUC-Ogl-077233 Oryza glaberrima 53.73 4.00e-38 150.00
IUUC-Ogu-078374 Oryza glumaepatula 53.73 4.00e-38 150.00
IUUC-Oin-079721 Oryza indica 53.73 4.00e-38 150.00
IUUC-Olo-080242 Oryza longistaminata 49.65 2.00e-39 154.00
IUUC-Ome-081761 Oryza meridionalis 53.73 2.00e-38 151.00
IUUC-Oni-082346 Oryza nivara 53.73 4.00e-38 150.00
IUUC-Opu-083148 Oryza punctata 53.73 4.00e-38 150.00
IUUC-Oru-084359 Oryza rufipogon 53.73 4.00e-38 150.00
IUUC-Osa-085664 Oryza sativa 53.73 4.00e-38 150.00
IUUC-Ola-087529 Oryzias latipes 86.11 5.00e-65 239.00
IUUC-Olu-087815 Ostreococcus lucimarinus 41.23 8.00e-21 92.40
IUUC-Oar-090010 Ovis aries 98.57 5.00e-79 285.00
IUUC-Ptr-091024 Pan troglodytes 98.57 5.00e-79 285.00
IUUC-Pan-091955 Papio anubis 98.62 7.00e-82 295.00
IUUC-Psi-093138 Pelodiscus sinensis 95.86 2.00e-70 257.00
IUUC-Pma-094142 Petromyzon marinus 81.48 4.00e-21 92.40
IUUC-Pno-095070 Phaeosphaeria nodorum 51.45 2.00e-35 141.00
IUUC-Pfo-096483 Poecilia formosa 88.19 4.00e-66 243.00
IUUC-Pab-098753 Pongo abelii 98.62 7.00e-82 295.00
IUUC-Ppe-101725 Prunus persica 55.15 9.00e-39 152.00
IUUC-Pva-102989 Pteropus vampyrus 98.62 7.00e-82 295.00
IUUC-Pgr-103617 Puccinia graminis 51.45 3.00e-32 130.00
IUUC-Ptt-104008 Puccinia triticina 43.48 2.00e-16 78.20
IUUC-Pte-104176 Pyrenophora teres 50.72 3.00e-35 140.00
IUUC-Pyt-104517 Pyrenophora triticirepentis 50.72 3.00e-35 140.00
IUUC-Rno-105839 Rattus norvegicus 99.31 1.00e-82 297.00
IUUC-Sce-106349 Saccharomyces cerevisiae 49.26 2.00e-32 131.00
IUUC-Sha-106779 Sarcophilus harrisii 96.55 6.00e-73 265.00
IUUC-Sja-107722 Schizosaccharomyces japonicus 51.82 2.00e-33 134.00
IUUC-Spo-108027 Schizosaccharomyces pombe 48.91 4.00e-32 130.00
IUUC-Sar-113406 Sorex araneus 69.29 6.00e-49 186.00
IUUC-Ssc-115259 Sus scrofa 96.53 1.00e-79 288.00
IUUC-Tgu-116732 Taeniopygia guttata 97.10 3.00e-69 253.00
IUUC-Tru-118526 Takifugu rubripes 86.23 7.00e-54 202.00
IUUC-Tni-120169 Tetraodon nigroviridis 84.83 6.00e-56 209.00
IUUC-Tca-121025 Theobroma cacao 57.46 1.00e-39 156.00
IUUC-Tre-121971 Trichoderma reesei 53.24 2.00e-37 147.00
IUUC-Tae-123682 Triticum aestivum 51.43 7.00e-38 149.00
IUUC-Tme-127171 Tuber melanosporum 47.45 7.00e-30 122.00
IUUC-Tbe-127265 Tupaia belangeri 92.14 3.00e-64 236.00
IUUC-Ttr-128959 Tursiops truncatus 97.93 1.00e-81 294.00
IUUC-Xtr-131975 Xenopus tropicalis 91.72 1.00e-77 281.00
IUUC-Xma-133222 Xiphophorus maculatus 88.19 4.00e-66 243.00
IUUC-Yli-134591 Yarrowia lipolytica 49.50 1.00e-27 114.00
IUUC-Zma-135558 Zea mays 54.48 3.00e-38 150.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved