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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105839
UUCD1 version UUC-RaN-00994
Ensembl Protein ID ENSRNOP00000062102.1
UniProt Accession Q7M767; Q8CHN0; UB2V2_RAT
Genbank Protein ID CAD56165.1; CAD56854.1; AAH87593.1
Protein Name Ubiquitin-conjugating enzyme E2 variant 2; Ubiquitin-conjugating enzyme variant MMS2
Genbank Nucleotide ID AJ515244; BN000090; BC087593
Gene Name Ube2v2; Mms2; Uev2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000001829.7 ENSRNOT00000031401.4 ENSRNOP00000062102.1
ENSRNOG00000001829.7 ENSRNOT00000088212.1 ENSRNOP00000068914.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACmiRNAMapRAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E2/UBC 1.90e-19 70.2 30 136
E2/UEV 5.50e-66 221.2 5 143
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E2/UBC
   S: 16   gisakpvdesd..ltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.Gkv...ClsilkeeekWspalsv 98
           ++s +++d++d  lt+w  +i+Gp++t+Ye+++++l++e+ ++YP  PP+v+f+tki    ++++ G v    + +l    kW+  +s+
   Q: 30   TVSWGLEDDEDmtLTRWTGMIIGPPRTNYENRIYSLKVECGSKYPEAPPSVRFVTKINMNGINNSsGMVdarSIPVL---AKWQNSYSI 115
           456667777776689******************************************99999999899943335555...7******** PP
   S: 99   esvllsiqsll.aepnpespl 118
           + vl ++ +l+ ++ n++ p+
   Q: 116  KVVLQELRRLMmSKENMKLPQ 136
           *********996667777775 PP
   

   E2/UEV
   S: 7    lkvvvprnfrlleeleegekglgdgtvsygldDgddilllsltgtIigpertayegrIyqlklfvgkkYPekPPtvrfsskinmaevnd 95
           + v+vprnfrlleeleeg+kg+gdgtvs+gl+D++d++l+++tg+Iigp+rt+ye+rIy+lk+++g+kYPe+PP vrf++kinm+++n+
   Q: 5    TGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNYENRIYSLKVECGSKYPEAPPSVRFVTKINMNGINN 93
           689************************************************************************************** PP
   S: 96   snGvvdpralpvLanWkreysievvlvqlkkellskenrklqqPpeGnlf 145
           s+G+vd+r++pvLa+W+++ysi+vvl++l++ ++sken+kl+qPpeG+++
   Q: 94   SSGMVDARSIPVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQTY 143
           ***********************************************986 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
 Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
Protein Sequence
(Fasta)
MAVSTGVKVP RNFRLLEELE EGQKGVGDGT VSWGLEDDED MTLTRWTGMI IGPPRTNYEN 60
RIYSLKVECG SKYPEAPPSV RFVTKINMNG INNSSGMVDA RSIPVLAKWQ NSYSIKVVLQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105839|E2,E2/UEV|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGTGCGGCG GTGCGTCTGG TAGAAGGAGA AGATGGCGGT GTCCACAGGT TGGTTCCTAG 60
CCCTGGTCGC CGCGTTCTCC CTGCTGGCTG TCCGGCGGGC CACGCGGGAC TGCGGGTGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105839|E2,E2/UEV|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD
PROSITE

PS50127--UBIQUITIN_CONJUGAT_2
Pfam

PF00179--UQ_con
Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031372--C:UBC13-MMS2 complex
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0000729--P:DNA double-strand break processing
GO:0042275--P:error-free postreplication DNA repair
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0045739--P:positive regulation of DNA repair
GO:0010976--P:positive regulation of neuron projection development
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0051965--P:positive regulation of synapse assembly
GO:0006301--P:postreplication repair
GO:0070534--P:protein K63-linked ubiquitination
KEGG rno:287927
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001275 Ailuropoda melanoleuca 99.29 3.00e-79 286.00
IUUC-Apl-003790 Anas platyrhynchos 97.84 7.00e-70 255.00
IUUC-Aca-004448 Anolis carolinensis 97.84 5.00e-70 256.00
IUUC-Aly-006115 Arabidopsis lyrata 54.14 5.00e-38 149.00
IUUC-Ate-010471 Aspergillus terreus 44.20 2.00e-28 117.00
IUUC-Bgr-012010 Blumeria graminis 49.64 3.00e-33 134.00
IUUC-Bta-012471 Bos taurus 99.31 5.00e-82 295.00
IUUC-Bra-017054 Brassica rapa 52.99 1.00e-37 148.00
IUUC-Cel-018398 Caenorhabditis elegans 63.77 3.00e-47 180.00
IUUC-Cja-019506 Callithrix jacchus 98.62 8.00e-82 295.00
IUUC-Cfa-020370 Canis familiaris 99.31 5.00e-82 295.00
IUUC-Cpo-021317 Cavia porcellus 96.55 1.00e-79 287.00
IUUC-Csa-023412 Chlorocebus sabaeus 99.31 5.00e-82 295.00
IUUC-Cho-025024 Choloepus hoffmanni 98.89 1.00e-48 183.00
IUUC-Cne-026817 Cryptococcus neoformans 47.45 3.00e-37 147.00
IUUC-Dre-028062 Danio rerio 93.10 5.00e-78 282.00
IUUC-Dno-029546 Dasypus novemcinctus 99.29 3.00e-79 286.00
IUUC-Dor-030185 Dipodomys ordii 92.73 2.00e-26 112.00
IUUC-Dse-031272 Dothistroma septosporum 50.00 8.00e-35 139.00
IUUC-Fca-035746 Felis catus 99.29 4.00e-79 286.00
IUUC-Fal-037369 Ficedula albicollis 96.55 2.00e-70 257.00
IUUC-Gmo-039696 Gadus morhua 84.03 2.00e-68 250.00
IUUC-Ggr-039839 Gaeumannomyces graminis 46.50 1.00e-30 125.00
IUUC-Gga-040634 Gallus gallus 96.55 2.00e-70 257.00
IUUC-Gac-041936 Gasterosteus aculeatus 83.33 6.00e-62 229.00
IUUC-Ggo-044696 Gorilla gorilla 99.31 5.00e-82 295.00
IUUC-Hsa-046699 Homo sapiens 99.31 5.00e-82 295.00
IUUC-Itr-048151 Ictidomys tridecemlineatus 99.31 5.00e-82 295.00
IUUC-Kpa-049337 Komagataella pastoris 49.63 6.00e-31 125.00
IUUC-Lpe-050874 Leersia perrieri 53.73 2.00e-38 151.00
IUUC-Loc-052012 Lepisosteus oculatus 93.10 9.00e-78 281.00
IUUC-Lma-053194 Leptosphaeria maculans 50.00 2.00e-34 137.00
IUUC-Laf-053991 Loxodonta africana 98.57 1.00e-78 285.00
IUUC-Mcc-055850 Macaca mulatta 99.29 2.00e-79 287.00
IUUC-Mor-056915 Magnaporthe oryzae 37.09 6.00e-21 93.20
IUUC-Mpo-057437 Magnaporthe poae 45.86 2.00e-30 124.00
IUUC-Mla-058919 Melampsora laricipopulina 53.24 1.00e-34 138.00
IUUC-Mga-059210 Meleagris gallopavo 97.84 5.00e-70 255.00
IUUC-Mvi-060260 Microbotryum violaceum 53.28 4.00e-36 143.00
IUUC-Mmr-061751 Microcebus murinus 97.93 2.00e-80 290.00
IUUC-Mdo-062503 Monodelphis domestica 97.24 7.00e-73 265.00
IUUC-Mmu-063294 Mus musculus 99.31 1.00e-82 297.00
IUUC-Mpu-065942 Mustela putorius furo 99.31 5.00e-82 295.00
IUUC-Mlu-067702 Myotis lucifugus 99.29 4.00e-79 286.00
IUUC-Ncr-068946 Neurospora crassa 45.86 5.00e-37 146.00
IUUC-Nle-069327 Nomascus leucogenys 99.31 5.00e-82 295.00
IUUC-Opr-070697 Ochotona princeps 83.45 9.00e-62 228.00
IUUC-Ont-072098 Oreochromis niloticus 88.19 6.00e-66 242.00
IUUC-Oan-073215 Ornithorhynchus anatinus 89.80 3.00e-66 243.00
IUUC-Ocu-073859 Oryctolagus cuniculus 99.31 5.00e-82 295.00
IUUC-Obr-076238 Oryza brachyantha 52.99 3.00e-38 150.00
IUUC-Olo-080242 Oryza longistaminata 48.94 3.00e-39 154.00
IUUC-Ola-087529 Oryzias latipes 86.81 3.00e-65 239.00
IUUC-Olu-087815 Ostreococcus lucimarinus 41.23 6.00e-21 93.20
IUUC-Oar-090010 Ovis aries 99.29 3.00e-79 286.00
IUUC-Ptr-091024 Pan troglodytes 99.29 3.00e-79 286.00
IUUC-Pan-091955 Papio anubis 99.31 5.00e-82 295.00
IUUC-Psi-093138 Pelodiscus sinensis 96.55 2.00e-70 257.00
IUUC-Pno-095070 Phaeosphaeria nodorum 50.72 2.00e-35 140.00
IUUC-Pfo-096483 Poecilia formosa 88.89 3.00e-66 243.00
IUUC-Pab-098753 Pongo abelii 99.31 5.00e-82 295.00
IUUC-Pva-102989 Pteropus vampyrus 99.31 5.00e-82 295.00
IUUC-Pgr-103617 Puccinia graminis 52.17 2.00e-32 130.00
IUUC-Ptt-104008 Puccinia triticina 44.93 1.00e-16 78.60
IUUC-Pte-104176 Pyrenophora teres 50.00 3.00e-35 140.00
IUUC-Pyt-104517 Pyrenophora triticirepentis 50.00 3.00e-35 140.00
IUUC-Sce-106349 Saccharomyces cerevisiae 49.26 2.00e-32 130.00
IUUC-Sha-106779 Sarcophilus harrisii 97.24 4.00e-73 266.00
IUUC-Sja-107722 Schizosaccharomyces japonicus 52.55 2.00e-33 134.00
IUUC-Spo-108027 Schizosaccharomyces pombe 49.64 2.00e-32 130.00
IUUC-Sar-113406 Sorex araneus 70.00 4.00e-49 186.00
IUUC-Ssc-115259 Sus scrofa 97.22 7.00e-80 288.00
IUUC-Tgu-116732 Taeniopygia guttata 97.83 2.00e-69 254.00
IUUC-Tru-118526 Takifugu rubripes 86.96 4.00e-54 202.00
IUUC-Tni-120169 Tetraodon nigroviridis 85.52 3.00e-56 209.00
IUUC-Tre-121971 Trichoderma reesei 52.52 3.00e-37 147.00
IUUC-Tme-127171 Tuber melanosporum 46.72 1.00e-29 122.00
IUUC-Tbe-127265 Tupaia belangeri 92.86 2.00e-64 237.00
IUUC-Ttr-128959 Tursiops truncatus 98.62 8.00e-82 295.00
IUUC-Xtr-131975 Xenopus tropicalis 92.41 8.00e-78 281.00
IUUC-Xma-133222 Xiphophorus maculatus 88.89 2.00e-66 244.00
IUUC-Yli-134591 Yarrowia lipolytica 50.50 7.00e-28 114.00
Created Date 25-Jun-2017

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