iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.10e-14	54.7	402	467

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggede.....k.....slveCekCrewfHpaClkls.....veeelpnsekwiCpkCrsk 54
           +vClvCge+g+++     +     +l+eC++C+e++Hp+Clk++     v++elpn+  w+CpkC+++
   Q: 402  AVCLVCGEAGKEDtveeeEgkfnlMLMECSICNEIIHPGCLKIKesegvVNDELPNC--WECPKCNHA 467
           79*********9977765156789*********************************..*******85 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

KIFWLIPPTL HNLALYEEWV LSGKQSDIFL GDRVERCQRI ELKQGYTFFI PSGWIHAVYT 60
PVDSLVFGGN ILHSFNVPMQ LRIYEIEDRT RVQPKFRYPF YYEMCWYVLE RYVYCVTQRS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGATCTTTT GGCTGATCCC CCCAACCCTG CACAACTTGG CTCTGTATGA GGAGTGGGTG 60
CTGTCTGGCA AACAGAGTGA CATCTTTCTG GGAGACCGAG TGGAACGCTG CCAAAGAATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001810--F-box_dom
IPR003347--JmjC_dom
IPR032675--L_dom-like
IPR006553--Leu-rich_rpt_Cys-con_subtyp
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51184--JMJC
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF00646--F-box
PF16866--PHD_4
PF02008--zf-CXXC

SMART

SM00367--LRR_CC
SM00249--PHD

Gene Ontology

GO:0031519--C:PcG protein complex
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0048596--P:embryonic camera-type eye morphogenesis
GO:0021592--P:fourth ventricle development
GO:0035518--P:histone H2A monoubiquitination
GO:0070544--P:histone H3-K36 demethylation
GO:0021993--P:initiation of neural tube closure
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0021555--P:midbrain-hindbrain boundary morphogenesis
GO:2000178--P:negative regulation of neural precursor cell proliferation
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030307--P:positive regulation of cell growth
GO:1902459--P:positive regulation of stem cell population maintenance
GO:0007283--P:spermatogenesis
GO:0021678--P:third ventricle development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001358	Ailuropoda melanoleuca	94.76	0.00e+00	1810.00
IUUC-Apl-003787	Anas platyrhynchos	81.98	0.00e+00	1578.00
IUUC-Aca-004247	Anolis carolinensis	76.19	0.00e+00	1400.00
IUUC-Ame-011114	Astyanax mexicanus	67.42	4.00e-127	449.00
IUUC-Bta-013531	Bos taurus	95.38	0.00e+00	1851.00
IUUC-Cja-018876	Callithrix jacchus	93.62	0.00e+00	1796.00
IUUC-Cfa-020857	Canis familiaris	95.01	0.00e+00	1842.00
IUUC-Cpo-021967	Cavia porcellus	91.39	0.00e+00	1674.00
IUUC-Csa-023210	Chlorocebus sabaeus	94.83	0.00e+00	1764.00
IUUC-Dre-028272	Danio rerio	59.38	0.00e+00	1139.00
IUUC-Dno-030034	Dasypus novemcinctus	92.24	0.00e+00	1732.00
IUUC-Dor-030736	Dipodomys ordii	85.87	0.00e+00	987.00
IUUC-Eca-034255	Equus caballus	95.92	0.00e+00	1854.00
IUUC-Eeu-035038	Erinaceus europaeus	97.36	0.00e+00	1173.00
IUUC-Fca-035786	Felis catus	94.82	0.00e+00	1899.00
IUUC-Fal-037589	Ficedula albicollis	82.30	0.00e+00	1611.00
IUUC-Gac-041304	Gasterosteus aculeatus	59.06	0.00e+00	1156.00
IUUC-Ggo-044522	Gorilla gorilla	94.83	0.00e+00	1684.00
IUUC-Hsa-045877	Homo sapiens	94.90	0.00e+00	1789.00
IUUC-Itr-049003	Ictidomys tridecemlineatus	97.09	0.00e+00	1318.00
IUUC-Lch-049950	Latimeria chalumnae	76.52	0.00e+00	1489.00
IUUC-Laf-053623	Loxodonta africana	94.16	0.00e+00	1721.00
IUUC-Mcc-054943	Macaca mulatta	94.99	0.00e+00	1784.00
IUUC-Meu-056259	Macropus eugenii	84.69	0.00e+00	1638.00
IUUC-Mga-059671	Meleagris gallopavo	83.16	0.00e+00	1638.00
IUUC-Mmr-061003	Microcebus murinus	94.72	0.00e+00	1823.00
IUUC-Mdo-062017	Monodelphis domestica	80.77	0.00e+00	658.00
IUUC-Mmu-063584	Mus musculus	96.40	0.00e+00	1832.00
IUUC-Mpu-066056	Mustela putorius furo	94.46	0.00e+00	1804.00
IUUC-Mlu-067850	Myotis lucifugus	94.27	0.00e+00	1837.00
IUUC-Nle-069837	Nomascus leucogenys	91.16	0.00e+00	1644.00
IUUC-Opr-070943	Ochotona princeps	90.82	0.00e+00	1680.00
IUUC-Ont-071663	Oreochromis niloticus	63.60	0.00e+00	1211.00
IUUC-Oan-072934	Ornithorhynchus anatinus	74.95	0.00e+00	1253.00
IUUC-Ocu-074706	Oryctolagus cuniculus	95.46	0.00e+00	1844.00
IUUC-Ola-086543	Oryzias latipes	61.22	0.00e+00	1195.00
IUUC-Oga-088671	Otolemur garnettii	79.51	0.00e+00	734.00
IUUC-Oar-089560	Ovis aries	89.46	0.00e+00	1751.00
IUUC-Ptr-090875	Pan troglodytes	94.90	0.00e+00	1817.00
IUUC-Pan-091788	Papio anubis	91.58	0.00e+00	1735.00
IUUC-Psi-093382	Pelodiscus sinensis	83.13	0.00e+00	1625.00
IUUC-Pma-094687	Petromyzon marinus	56.44	2.00e-91	330.00
IUUC-Pfo-096272	Poecilia formosa	60.34	0.00e+00	1124.00
IUUC-Pab-097907	Pongo abelii	89.70	0.00e+00	1642.00
IUUC-Pca-100628	Procavia capensis	88.34	0.00e+00	1510.00
IUUC-Pva-102956	Pteropus vampyrus	93.56	0.00e+00	1166.00
IUUC-Sha-106626	Sarcophilus harrisii	79.52	0.00e+00	1565.00
IUUC-Ssc-115918	Sus scrofa	94.22	0.00e+00	1655.00
IUUC-Tru-118758	Takifugu rubripes	69.21	6.00e-159	554.00
IUUC-Tsy-118820	Tarsius syrichta	91.49	0.00e+00	760.00
IUUC-Tbe-127654	Tupaia belangeri	79.80	0.00e+00	1313.00
IUUC-Ttr-128821	Tursiops truncatus	90.00	0.00e+00	1698.00
IUUC-Xtr-131823	Xenopus tropicalis	73.73	0.00e+00	1362.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence