iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mcc-054787

UUCD1 version

UUC-MaM-00544

Ensembl Protein ID

ENSMMUP00000033002.2

UniProt Accession

H9FSK0; F6XN59; H9FSK0_MACMU

Genbank Protein ID

AFE77609.1; AFH29037.1

Protein Name

E3 ubiquitin-protein ligase HECTD1

Genbank Nucleotide ID

JSUE03039411; JU472233

Gene Name

HECTD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000003120.3	ENSMMUT00000039940.2	ENSMMUP00000033002.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.30e-124	414.8	2152	2610

Active Site

Position(s)	Description	Evidence
2579	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysen..dketlqpnpdsglknp..................... 65
           ++d+k++levef+gEeg++l G+t+ef+al+++e+q++dlg++l+++n  d+e+++++   glk+p                     
   Q: 2152 HADRKSVLEVEFLGEEGTGL-GPTLEFYALVAAEFQRTDLGAWLCDDNfpDDESRHVDLGGGLKPPgyyvqrscglftapfpqdsde 2237
           6899****************.******************************************988********************* PP
   S: 66   ..ehlklFeflGrllgkalqdgrlldlplsksfykll.................................................. 100
             + +klF+flG++l+k++qd+rl+dlp+sk+f+kl+                                                  
   Q: 2238 leRITKLFHFLGIFLAKCIQDNRLVDLPISKPFFKLMcmgdiksnmskliyesrgdrdlhctesqseasteeghdslsvgsfeedsk 2324
           *************************************99999999999999999999999999999999999999988888888887 PP
   S: 101  ...............lgkklsledleevdpelykslkeikenaes..................................dieelgld 138
                          ++  l++ed+e v+p+++++lkeik++a +                                  +ie+lgl+
   Q: 2325 sefildppkpkppawFNGILTWEDFELVNPHRARFLKEIKDLAIKrrqilsnkglsedekntklqelvlknpsgsgpplSIEDLGLN 2411
           7777777777766666668***********************9334455555666777788899999999999************** PP
   S: 139  ltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeid 225
           ++f++s++i+g t+++ Lkp+Ge++++t++N+eeYv+l++++++++gi++q+eafr+Gfn+v+p+e+ls+F++ee+++++cG+   +
   Q: 2412 FQFCPSSRIYGFTAVD-LKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRDGFNKVFPMEKLSSFSHEEVQMILCGN---Q 2494
           *************999.******************************************************************...6 PP
   S: 226  vedlkket..ky...kggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfn 306
           ++++++e+  +y   k gyt+dsp++ +F++vl+++ss+erkafLqF+Tg+s+lP+gG+a+l+prl+v+rk da+d+++Ps+nTC++
   Q: 2495 SPSWAAEDiiNYtepKLGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKvDATDASYPSVNTCVH 2581
           666666665555555************************************************************************ PP
   S: 307  yLkLPeYsskeilkekLlyAieetkgFels 336
           yLkLPeYss+ei++e+Ll+A++e kgF+l+
   Q: 2582 YLKLPEYSSEEIMRERLLAATME-KGFHLN 2610
           ***********************.****86 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP RTFLPALCKI 60
FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK ALCNRLVVVE LNNRTSRDLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAAAGAGGCT TTTAAAAAAC CATGGCAGAT GTGGACCCAG ATACATTGCT GGAATGGCTA 60
CAGATGGGAC AGGGAGATGA AAGGGACATG CAACTAATAG CCCTTGAACA GCTATGCATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR012919--SUN_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT
PS51416--MIB_HERC2

Pfam

PF12796--Ank_2
PF00632--HECT
PF06701--MIB_HERC2
PF07738--Sad1_UNC

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0016874--F:ligase activity
GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

mcc:717177

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001987	Ailuropoda melanoleuca	99.54	0.00e+00	4685.00
IUUC-Apl-003493	Anas platyrhynchos	95.58	0.00e+00	4516.00
IUUC-Aca-004521	Anolis carolinensis	96.59	0.00e+00	2816.00
IUUC-Ame-011258	Astyanax mexicanus	91.32	0.00e+00	2390.00
IUUC-Bta-012835	Bos taurus	99.66	0.00e+00	4702.00
IUUC-Cel-018153	Caenorhabditis elegans	52.31	4.00e-169	590.00
IUUC-Cja-019174	Callithrix jacchus	98.70	0.00e+00	4613.00
IUUC-Cfa-021115	Canis familiaris	99.50	0.00e+00	4646.00
IUUC-Cpo-022382	Cavia porcellus	95.38	0.00e+00	4436.00
IUUC-Csa-023230	Chlorocebus sabaeus	100.00	0.00e+00	4705.00
IUUC-Cho-024711	Choloepus hoffmanni	96.50	0.00e+00	1652.00
IUUC-Cin-025342	Ciona intestinalis	53.48	0.00e+00	1384.00
IUUC-Csv-026031	Ciona savignyi	51.86	0.00e+00	1406.00
IUUC-Dre-027435	Danio rerio	87.10	0.00e+00	4125.00
IUUC-Dno-029954	Dasypus novemcinctus	99.46	0.00e+00	4654.00
IUUC-Dor-030734	Dipodomys ordii	98.17	0.00e+00	1504.00
IUUC-Dme-031739	Drosophila melanogaster	59.66	0.00e+00	1622.00
IUUC-Ete-033192	Echinops telfairi	90.96	0.00e+00	1184.00
IUUC-Eca-033434	Equus caballus	98.97	0.00e+00	4648.00
IUUC-Eeu-035031	Erinaceus europaeus	83.22	0.00e+00	1076.00
IUUC-Fca-035998	Felis catus	98.01	0.00e+00	4580.00
IUUC-Fal-037468	Ficedula albicollis	95.56	0.00e+00	2808.00
IUUC-Gmo-038495	Gadus morhua	90.71	0.00e+00	1367.00
IUUC-Gga-040736	Gallus gallus	97.55	0.00e+00	2822.00
IUUC-Gac-041777	Gasterosteus aculeatus	91.43	0.00e+00	2404.00
IUUC-Ggo-044677	Gorilla gorilla	95.38	0.00e+00	4418.00
IUUC-Hsa-045879	Homo sapiens	100.00	0.00e+00	4705.00
IUUC-Itr-048664	Ictidomys tridecemlineatus	99.73	0.00e+00	4697.00
IUUC-Lch-050444	Latimeria chalumnae	92.13	0.00e+00	4213.00
IUUC-Loc-051986	Lepisosteus oculatus	88.29	0.00e+00	4169.00
IUUC-Laf-054230	Loxodonta africana	98.97	0.00e+00	4600.00
IUUC-Meu-056502	Macropus eugenii	89.29	0.00e+00	1335.00
IUUC-Mga-059409	Meleagris gallopavo	91.22	0.00e+00	2078.00
IUUC-Mmr-061667	Microcebus murinus	99.08	0.00e+00	4656.00
IUUC-Mdo-061960	Monodelphis domestica	97.36	0.00e+00	4586.00
IUUC-Mmu-063941	Mus musculus	98.32	0.00e+00	4603.00
IUUC-Mpu-065939	Mustela putorius furo	99.66	0.00e+00	4695.00
IUUC-Mlu-068112	Myotis lucifugus	99.23	0.00e+00	4648.00
IUUC-Nle-069001	Nomascus leucogenys	99.92	0.00e+00	4702.00
IUUC-Opr-071222	Ochotona princeps	94.39	0.00e+00	2100.00
IUUC-Ont-072101	Oreochromis niloticus	86.46	0.00e+00	2627.00
IUUC-Oan-072814	Ornithorhynchus anatinus	97.70	0.00e+00	4589.00
IUUC-Ocu-074011	Oryctolagus cuniculus	99.73	0.00e+00	4694.00
IUUC-Ola-086412	Oryzias latipes	91.36	0.00e+00	2400.00
IUUC-Oar-089668	Ovis aries	99.73	0.00e+00	4697.00
IUUC-Ptr-090517	Pan troglodytes	99.35	0.00e+00	4649.00
IUUC-Pan-091849	Papio anubis	97.28	0.00e+00	4531.00
IUUC-Psi-093390	Pelodiscus sinensis	94.26	0.00e+00	2723.00
IUUC-Pma-094628	Petromyzon marinus	83.40	0.00e+00	1582.00
IUUC-Pfo-097075	Poecilia formosa	92.27	0.00e+00	2451.00
IUUC-Pab-098176	Pongo abelii	100.00	0.00e+00	4705.00
IUUC-Pca-101123	Procavia capensis	94.04	0.00e+00	2489.00
IUUC-Pva-103008	Pteropus vampyrus	94.91	0.00e+00	1925.00
IUUC-Rno-105885	Rattus norvegicus	98.97	0.00e+00	4658.00
IUUC-Sha-107048	Sarcophilus harrisii	95.81	0.00e+00	4500.00
IUUC-Sar-113071	Sorex araneus	94.10	0.00e+00	1277.00
IUUC-Ssc-115963	Sus scrofa	99.35	0.00e+00	4676.00
IUUC-Tgu-117167	Taeniopygia guttata	93.86	0.00e+00	2624.00
IUUC-Tru-118626	Takifugu rubripes	92.59	0.00e+00	2470.00
IUUC-Tsy-119504	Tarsius syrichta	96.50	0.00e+00	2305.00
IUUC-Tni-119877	Tetraodon nigroviridis	91.67	0.00e+00	2411.00
IUUC-Tbe-127602	Tupaia belangeri	97.41	0.00e+00	994.00
IUUC-Ttr-128394	Tursiops truncatus	98.76	0.00e+00	3157.00
IUUC-Vpa-130280	Vicugna pacos	98.65	0.00e+00	4450.00
IUUC-Xtr-131787	Xenopus tropicalis	86.65	0.00e+00	2601.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence