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Tag Content
iUUCD ID IUUC-Ont-071786
Ensembl Protein ID ENSONIP00000007098.1
UniProt Accession I3JE07; I3JE07_ORENI
Genbank Protein ID ENSONIP00000007098
Protein Name Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16
Genbank Nucleotide ID AERX01023752
Gene Name usp16; USP16
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSONIG00000005639.1 ENSONIT00000007103.1 ENSONIP00000007098.1
ENSONIG00000005639.1 ENSONIT00000007104.1 ENSONIP00000007099.1
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 2.00e-79 267.6 219 839
Active Site
Position(s) Description Evidence
228 Nucleophile ECO:0000256|HAMAP-Rule:MF_03062}
780 Proton acceptor ECO:0000256|HAMAP-Rule:MF_03062}
Domain Profile

   DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp............kepkgellkslqklfeelwkskkkavsprellkal 77
    +Gl+NlgNtC++N+v+Q Ls+++ lr+ l++ ++ek + +p ++ g+l+ ++ +l+ e+++skk++v+prel++++
   Q: 219 KGLSNLGNTCFFNAVIQNLSQTQLLRQTLNKVTEEKSLNIKPgasldlepievqLDRPGSLTLAMYHLLCEIQESKKSVVTPRELFTQV 307
    5******************************4444444444457788888888889999****************************** PP
   S: 78 kkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdn 161
    +++a +f+g++qqD+qE+l++lld+++ e +++ ++ ++++ +++++ ++ e +e++k+ k++++++F+g+++s+i+c++c++
   Q: 308 CRKAARFKGFQQQDSQELLRYLLDGMRAEEHNRISSGIMDTLKQSREGTDGElktllKEYEKNGFLKNFVDQVFGGEITSTIMCQQCRT 396
    ******************************999999999999999888888899999999999999*********************** PP
   S: 162 vssreepfldlslpvpgkeetkke................................................................. 185
    vs+ +e fldlslpv+++ +kk+
   Q: 397 VSVVTEMFLDLSLPVSDEAYRKKNqkkktsassqddssspvrtsgnddiptgagskyqqkkakkqakkqakhqkrqqklegratldslt 485
    ****************9998888799999************************************************************ PP
   S: 186 ......................................................................................... 185
   
   Q: 486 spsqaesehtdatadskdrentdnetleedsqhpaqvsvseedqkphnavqveqekeededsasdhdssvsnrftalseeqhskdstvc 574
    ***************************************************************************************** PP
   S: 186 .................................................................................slqdcLes 193
    s+q+cL +
   Q: 575 nemsnmgqeedkteeedtqlvrkmskvtlddafiedtdameqsmesedgvletkeytvinqdpelafhtmaartipekqecSVQSCLFQ 663
    ***************************************************************************************** PP
   S: 194 ftkeeelegenkyycekckkkqe...............aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts 267
    ft+ e+l+++n + c +c+k+q a k++ +++ P vL+lhLkRf +++++s k+n++v+fp Ldl+pfc+
   Q: 664 FTEVETLTQNNSLLCVTCTKRQLgnnksggskkniytdALKQILISSPPSVLTLHLKRF--QQNGYSICKVNRHVTFPFILDLAPFCAV 750
    *******************9888999999999999999*********************..88889999******************** PP
   S: 268 peekqke...kkkYeLiavvvHsGslssGHYvayvkn...................ekgkWllfdDskVtevkeeevleetgstaYvlf 334
    ++++ e + Y L+++v HsG+++sGHY+ayvk +g+W++++D++V++v+e++v++ ++aY+lf
   Q: 751 KCKNIPEghnQILYGLYGIVEHSGTMRSGHYTAYVKVrpecpqpssngltdgdaesPRGSWFHISDTSVQPVSESKVQS---CQAYLLF 836
    998876677799*************************99999999999888877766888*******************...******* PP
   S: 335 Ykr 337
    Y+r
   Q: 837 YER 839
    *98 PP
   

Organism Oreochromis niloticus
Functional Description
(View)

Functional Description



     Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
Protein Sequence
(Fasta)
MGKKRGKDKT SKEDDELDLT VPSCRHIKKG TDQTLLKKLS GNSDWTSCQD CKQEENKENI 60
NNHLPQEAEE EQETGLWMCL KCGHRGCGRN SENQHAIKHY ETPRSDPHCL VVSLDNFSVW 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Ont-071786|DUB,USP|Oreochromis niloticus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTTAAAATGG GAAAGAAGAG GGGAAAGGAC AAGACCTCCA AGGAGGATGA TGAGCTTGAC 60
CTGACAGGTA AAGAATATTT CATCATCTTT CATGTCGTGC AACAACCTGT GGAAAGTCTA 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Ont-071786|DUB,USP|Oreochromis niloticus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0016578--P:histone deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000997 Aegilops tauschii 32.50 3.00e-23 104.00
IUUC-Aml-001931 Ailuropoda melanoleuca 51.07 3.00e-114 406.00
IUUC-Atr-003015 Amborella trichopoda 27.82 2.00e-35 144.00
IUUC-Apl-004145 Anas platyrhynchos 53.44 3.00e-107 382.00
IUUC-Aca-004314 Anolis carolinensis 45.06 4.00e-177 615.00
IUUC-Aly-006422 Arabidopsis lyrata 27.14 1.00e-27 119.00
IUUC-Ame-011659 Astyanax mexicanus 55.86 1.00e-134 474.00
IUUC-Bta-013362 Bos taurus 45.76 0.00e+00 629.00
IUUC-Bdi-014624 Brachypodium distachyon 27.33 1.00e-24 108.00
IUUC-Bol-015941 Brassica oleracea 29.29 2.00e-29 124.00
IUUC-Bra-016751 Brassica rapa 28.50 7.00e-28 120.00
IUUC-Cja-019177 Callithrix jacchus 51.19 3.00e-115 409.00
IUUC-Cfa-020051 Canis familiaris 51.29 4.00e-114 405.00
IUUC-Cpo-021886 Cavia porcellus 43.92 5.00e-171 595.00
IUUC-Csa-024103 Chlorocebus sabaeus 51.90 9.00e-116 411.00
IUUC-Cho-024315 Choloepus hoffmanni 46.82 6.00e-47 182.00
IUUC-Cin-025775 Ciona intestinalis 43.97 4.00e-35 140.00
IUUC-Csv-026075 Ciona savignyi 46.43 1.00e-47 184.00
IUUC-Dre-028388 Danio rerio 54.41 0.00e+00 801.00
IUUC-Dno-029409 Dasypus novemcinctus 51.90 5.00e-116 412.00
IUUC-Dor-030443 Dipodomys ordii 44.16 7.00e-83 301.00
IUUC-Dme-031870 Drosophila melanogaster 51.97 4.00e-37 150.00
IUUC-Ete-032807 Echinops telfairi 44.28 6.00e-92 332.00
IUUC-Eca-033479 Equus caballus 51.18 4.00e-116 412.00
IUUC-Eeu-034835 Erinaceus europaeus 56.62 5.00e-68 253.00
IUUC-Fca-036320 Felis catus 51.89 7.00e-116 411.00
IUUC-Fal-037029 Ficedula albicollis 50.12 4.00e-103 369.00
IUUC-Gmo-039480 Gadus morhua 61.45 1.00e-144 506.00
IUUC-Gga-040527 Gallus gallus 52.42 7.00e-110 391.00
IUUC-Gac-042343 Gasterosteus aculeatus 70.60 0.00e+00 1082.00
IUUC-Gma-044402 Glycine max 27.98 6.00e-34 140.00
IUUC-Ggo-045598 Gorilla gorilla 51.66 2.00e-116 414.00
IUUC-Hsa-046598 Homo sapiens 51.66 8.00e-117 414.00
IUUC-Hvu-047146 Hordeum vulgare 32.83 7.00e-23 103.00
IUUC-Itr-047951 Ictidomys tridecemlineatus 52.59 2.00e-115 410.00
IUUC-Lch-050536 Latimeria chalumnae 48.69 6.00e-97 348.00
IUUC-Lpe-050703 Leersia perrieri 33.84 8.00e-23 103.00
IUUC-Loc-051814 Lepisosteus oculatus 54.12 0.00e+00 797.00
IUUC-Laf-053732 Loxodonta africana 49.77 4.00e-113 402.00
IUUC-Mcc-054661 Macaca mulatta 51.90 9.00e-116 411.00
IUUC-Meu-055967 Macropus eugenii 48.80 2.00e-90 327.00
IUUC-Mtr-057945 Medicago truncatula 31.69 1.00e-33 138.00
IUUC-Mga-059551 Meleagris gallopavo 52.11 3.00e-114 406.00
IUUC-Mmr-061747 Microcebus murinus 52.37 3.00e-112 399.00
IUUC-Mdo-062220 Monodelphis domestica 49.88 1.00e-111 397.00
IUUC-Mmu-063582 Mus musculus 49.53 1.00e-104 374.00
IUUC-Mac-064941 Musa acuminata 40.50 4.00e-32 133.00
IUUC-Mpu-066339 Mustela putorius furo 50.47 3.00e-114 406.00
IUUC-Mlu-067511 Myotis lucifugus 49.41 2.00e-113 403.00
IUUC-Nle-069252 Nomascus leucogenys 51.66 4.00e-116 412.00
IUUC-Opr-070969 Ochotona princeps 50.63 1.00e-106 380.00
IUUC-Ocu-074704 Oryctolagus cuniculus 51.12 7.00e-111 395.00
IUUC-Oba-075094 Oryza barthii 26.30 2.00e-24 108.00
IUUC-Obr-076743 Oryza brachyantha 33.84 2.00e-24 108.00
IUUC-Ogl-077739 Oryza glaberrima 26.30 9.00e-25 109.00
IUUC-Ogu-078851 Oryza glumaepatula 26.59 1.00e-24 109.00
IUUC-Oin-079402 Oryza indica 26.59 1.00e-24 108.00
IUUC-Olo-080431 Oryza longistaminata 26.59 9.00e-25 109.00
IUUC-Ome-081580 Oryza meridionalis 38.51 2.00e-23 105.00
IUUC-Oni-082644 Oryza nivara 26.59 1.00e-24 108.00
IUUC-Opu-083452 Oryza punctata 27.19 7.00e-25 109.00
IUUC-Oru-084546 Oryza rufipogon 26.59 1.00e-24 108.00
IUUC-Osa-085858 Oryza sativa 26.59 1.00e-24 109.00
IUUC-Ola-086795 Oryzias latipes 64.29 0.00e+00 944.00
IUUC-Oga-088713 Otolemur garnettii 51.42 5.00e-113 402.00
IUUC-Oar-089887 Ovis aries 45.53 4.00e-180 625.00
IUUC-Ptr-091670 Pan troglodytes 51.90 6.00e-117 415.00
IUUC-Pan-092293 Papio anubis 51.90 9.00e-116 411.00
IUUC-Psi-093101 Pelodiscus sinensis 49.28 2.00e-105 377.00
IUUC-Ppa-095622 Physcomitrella patens 28.74 3.00e-30 127.00
IUUC-Pfo-097202 Poecilia formosa 70.02 0.00e+00 1078.00
IUUC-Pop-099136 Populus trichocarpa 30.12 2.00e-36 148.00
IUUC-Pca-101069 Procavia capensis 56.31 1.00e-66 248.00
IUUC-Ppe-101794 Prunus persica 33.05 4.00e-34 140.00
IUUC-Rno-105237 Rattus norvegicus 50.00 6.00e-105 375.00
IUUC-Sha-106889 Sarcophilus harrisii 50.72 2.00e-106 380.00
IUUC-Sit-110283 Setaria italica 39.61 7.00e-25 109.00
IUUC-Sly-111491 Solanum lycopersicum 26.85 2.00e-32 134.00
IUUC-Stu-112820 Solanum tuberosum 28.57 6.00e-38 153.00
IUUC-Sar-113530 Sorex araneus 50.95 4.00e-114 405.00
IUUC-Sbi-113785 Sorghum bicolor 37.25 8.00e-22 99.80
IUUC-Ssc-116091 Sus scrofa 50.47 2.00e-114 406.00
IUUC-Tgu-117478 Taeniopygia guttata 49.17 2.00e-104 373.00
IUUC-Tru-118640 Takifugu rubripes 66.51 0.00e+00 986.00
IUUC-Tsy-119042 Tarsius syrichta 37.41 6.00e-100 358.00
IUUC-Tni-120015 Tetraodon nigroviridis 62.83 0.00e+00 962.00
IUUC-Tca-121701 Theobroma cacao 30.00 2.00e-38 154.00
IUUC-Tae-125785 Triticum aestivum 31.47 1.00e-21 99.00
IUUC-Tur-126788 Triticum urartu 31.47 9.00e-22 99.40
IUUC-Tbe-127309 Tupaia belangeri 43.80 5.00e-68 253.00
IUUC-Ttr-128271 Tursiops truncatus 51.90 1.00e-116 414.00
IUUC-Vpa-130674 Vicugna pacos 52.13 2.00e-116 413.00
IUUC-Xtr-131869 Xenopus tropicalis 48.48 5.00e-106 379.00
IUUC-Xma-134195 Xiphophorus maculatus 69.44 0.00e+00 1077.00
Created Date 25-Jun-2017

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