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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046049
Ensembl Protein ID ENSP00000261435.6
UniProt Accession Q86UW6; A0AVR3; Q9NVK2; Q9P2D4; N4BP2_HUMAN
Genbank Protein ID AAP22172.1; AAI26467.1; BAA91748.1; BAA92651.1
Protein Name NEDD4-binding protein 2; BCL-3-binding protein
Genbank Nucleotide ID AY267013; BC126466; AK001542; AB037834
Gene Name N4BP2; B3BP; KIAA1413
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000078177.13 ENST00000261435.10 ENSP00000261435.6
ENSG00000078177.13 ENST00000511480.5 ENSP00000422436.1
ENSG00000078177.13 ENST00000513269.1 ENSP00000426430.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/CUE CUE 20558726
Classification
Family E-value Score Start End
UBD/Alpha-Helix/CUE 1.40e-08 36.2 46 88
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/CUE
   S: 1    dletaleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
           d+e++++ + eiF +ld++v++ +L+++++ +e+a+++LLe+s
   Q: 46   DQEELFTSISEIFSDLDPDVVYLMLSECDFKVENAMDCLLELS 88
           689**************************************97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination.
 Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination.
Protein Sequence
(Fasta)
MPRRRKNLGG NPFRKTANPK EVVVSSVASR EEPTTTLPSM GETKVDQEEL FTSISEIFSD 60
LDPDVVYLML SECDFKVENA MDCLLELSAT DTKIEESSSQ SFVASENQVG AAESKIMEKR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046049|UBD,CUE|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTCCCCGGCC GGACGGAGAG CGGCAGTGTC TCCCCGCCGG GCGCGCTCGC CGTGTCTCCC 60
CCGCGGCCGC AGCTGCTTGC TAGCCTTGCG CGGCGCGGGA GAGCGCAGTG GCGCCGGCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046049|UBD,CUE|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0832--Ubl conjugation
Interpro

IPR003892--CUE
IPR013899--DUF1771
IPR027417--P-loop_NTPase
IPR002625--Smr_dom
IPR009060--UBA-like
PROSITE

PS51140--CUE
PS50828--SMR
Pfam

PF08590--DUF1771
PF01713--Smr
SMART

SM01162--DUF1771
SM00463--SMR
Gene Ontology

GO:0005829--C:cytosol
GO:0005524--F:ATP binding
GO:0046404--F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
GO:0004519--F:endonuclease activity
KEGG hsa:55728
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000307 Aegilops tauschii 30.77 1.00e-15 77.80
IUUC-Aml-001291 Ailuropoda melanoleuca 81.03 0.00e+00 2726.00
IUUC-Atr-002800 Amborella trichopoda 33.33 2.00e-16 80.50
IUUC-Apl-003628 Anas platyrhynchos 46.98 0.00e+00 756.00
IUUC-Aca-005334 Anolis carolinensis 43.62 0.00e+00 937.00
IUUC-Aly-006196 Arabidopsis lyrata 30.91 3.00e-13 70.10
IUUC-Ath-006720 Arabidopsis thaliana 30.91 2.00e-13 71.20
IUUC-Ago-007797 Ashbya gossypii 34.33 6.00e-11 61.20
IUUC-Acl-008358 Aspergillus clavatus 29.87 3.00e-13 70.50
IUUC-Afl-008652 Aspergillus flavus 31.82 6.00e-13 69.70
IUUC-Afu-008968 Aspergillus fumigatus 29.87 4.00e-13 70.50
IUUC-Ang-009527 Aspergillus niger 30.52 3.00e-13 70.90
IUUC-Aor-010090 Aspergillus oryzae 31.82 6.00e-13 69.70
IUUC-Ate-010565 Aspergillus terreus 30.52 4.00e-13 70.10
IUUC-Ame-011671 Astyanax mexicanus 51.85 3.00e-106 380.00
IUUC-Bgr-012080 Blumeria graminis 31.47 1.00e-12 66.60
IUUC-Bta-013181 Bos taurus 79.62 0.00e+00 2594.00
IUUC-Bci-013717 Botrytis cinerea 34.62 5.00e-13 68.20
IUUC-Bdi-014201 Brachypodium distachyon 29.49 2.00e-15 77.40
IUUC-Bol-015623 Brassica oleracea 33.13 7.00e-15 75.50
IUUC-Bra-017329 Brassica rapa 31.48 2.00e-14 73.60
IUUC-Cja-019184 Callithrix jacchus 91.03 0.00e+00 3086.00
IUUC-Cfa-021092 Canis familiaris 80.91 0.00e+00 2625.00
IUUC-Cpo-022517 Cavia porcellus 69.11 0.00e+00 1973.00
IUUC-Csa-024113 Chlorocebus sabaeus 95.60 0.00e+00 3276.00
IUUC-Cho-025097 Choloepus hoffmanni 74.17 0.00e+00 2475.00
IUUC-Cgl-026652 Colletotrichum gloeosporioides 30.87 9.00e-11 62.40
IUUC-Cme-027204 Cyanidioschyzon merolae 31.16 2.00e-12 65.90
IUUC-Dre-028125 Danio rerio 48.76 5.00e-93 337.00
IUUC-Dno-028869 Dasypus novemcinctus 76.58 0.00e+00 2511.00
IUUC-Dor-030516 Dipodomys ordii 69.86 0.00e+00 1929.00
IUUC-Dse-031379 Dothistroma septosporum 34.62 6.00e-11 60.80
IUUC-Ete-032277 Echinops telfairi 56.22 0.00e+00 788.00
IUUC-Eca-034418 Equus caballus 81.35 0.00e+00 2616.00
IUUC-Fca-035464 Felis catus 79.96 0.00e+00 2540.00
IUUC-Fal-036958 Ficedula albicollis 45.94 0.00e+00 736.00
IUUC-Fox-037804 Fusarium oxysporum 25.77 1.90e-01 30.40
IUUC-Fso-038365 Fusarium solani 26.73 4.00e-03 36.20
IUUC-Ggr-039919 Gaeumannomyces graminis 30.23 6.00e-04 38.90
IUUC-Gga-040829 Gallus gallus 43.92 0.00e+00 715.00
IUUC-Gma-043695 Glycine max 32.92 1.00e-16 81.60
IUUC-Ggo-045014 Gorilla gorilla 91.53 0.00e+00 3024.00
IUUC-Hvu-047315 Hordeum vulgare 30.13 1.00e-15 78.20
IUUC-Itr-047979 Ictidomys tridecemlineatus 81.85 0.00e+00 2095.00
IUUC-Kpa-049234 Komagataella pastoris 32.82 3.00e-09 55.50
IUUC-Lch-050089 Latimeria chalumnae 54.01 1.00e-65 245.00
IUUC-Lpe-050913 Leersia perrieri 30.00 3.00e-15 76.60
IUUC-Loc-052313 Lepisosteus oculatus 53.66 7.00e-115 409.00
IUUC-Laf-054208 Loxodonta africana 71.06 0.00e+00 1976.00
IUUC-Mcc-055097 Macaca mulatta 95.99 0.00e+00 3251.00
IUUC-Meu-056220 Macropus eugenii 48.13 2.00e-131 464.00
IUUC-Mor-057049 Magnaporthe oryzae 26.72 3.60e-02 33.10
IUUC-Mtr-057639 Medicago truncatula 33.33 1.00e-15 77.80
IUUC-Mla-058827 Melampsora laricipopulina 36.00 2.00e-12 64.70
IUUC-Mga-060071 Meleagris gallopavo 41.88 0.00e+00 1109.00
IUUC-Mmu-063261 Mus musculus 70.22 0.00e+00 2163.00
IUUC-Mac-065582 Musa acuminata 31.25 5.00e-18 85.90
IUUC-Mpu-066564 Mustela putorius furo 80.66 0.00e+00 2112.00
IUUC-Mlu-067134 Myotis lucifugus 80.90 0.00e+00 2633.00
IUUC-Nfi-068329 Neosartorya fischeri 38.46 1.00e-15 76.60
IUUC-Ncr-068888 Neurospora crassa 36.15 3.00e-13 68.60
IUUC-Nle-070076 Nomascus leucogenys 97.68 0.00e+00 3286.00
IUUC-Opr-071217 Ochotona princeps 67.94 0.00e+00 2154.00
IUUC-Ont-072331 Oreochromis niloticus 51.00 3.00e-104 374.00
IUUC-Oan-073398 Ornithorhynchus anatinus 47.88 0.00e+00 1055.00
IUUC-Ocu-074175 Oryctolagus cuniculus 76.88 0.00e+00 1862.00
IUUC-Oba-074981 Oryza barthii 29.68 6.00e-16 79.00
IUUC-Obr-076223 Oryza brachyantha 30.77 1.00e-16 81.30
IUUC-Ogl-077577 Oryza glaberrima 29.68 6.00e-16 79.00
IUUC-Ogu-078879 Oryza glumaepatula 29.38 2.00e-15 77.40
IUUC-Oin-079288 Oryza indica 29.68 7.00e-16 79.00
IUUC-Olo-080622 Oryza longistaminata 29.68 7.00e-16 79.00
IUUC-Ome-081674 Oryza meridionalis 29.38 2.00e-15 77.40
IUUC-Oni-082814 Oryza nivara 30.32 4.00e-16 79.70
IUUC-Opu-083966 Oryza punctata 29.87 3.00e-14 75.50
IUUC-Oru-084603 Oryza rufipogon 29.68 7.00e-16 79.00
IUUC-Osa-086109 Oryza sativa 29.68 7.00e-16 79.00
IUUC-Oga-089167 Otolemur garnettii 79.81 0.00e+00 2579.00
IUUC-Oar-090067 Ovis aries 79.33 0.00e+00 2624.00
IUUC-Ptr-091648 Pan troglodytes 99.60 0.00e+00 3416.00
IUUC-Pan-092074 Papio anubis 94.19 0.00e+00 3167.00
IUUC-Psi-094006 Pelodiscus sinensis 42.90 0.00e+00 1120.00
IUUC-Pma-094605 Petromyzon marinus 34.26 5.00e-104 373.00
IUUC-Pno-094845 Phaeosphaeria nodorum 36.92 3.00e-14 73.90
IUUC-Ppa-095472 Physcomitrella patens 30.62 2.00e-16 80.90
IUUC-Pfo-096653 Poecilia formosa 48.28 4.00e-104 374.00
IUUC-Pab-097841 Pongo abelii 98.02 0.00e+00 3368.00
IUUC-Pop-099018 Populus trichocarpa 33.33 4.00e-15 76.30
IUUC-Pca-100710 Procavia capensis 68.63 0.00e+00 912.00
IUUC-Ppe-101241 Prunus persica 29.49 3.00e-12 67.00
IUUC-Pva-102564 Pteropus vampyrus 75.80 0.00e+00 2456.00
IUUC-Ptt-103766 Puccinia triticina 53.33 2.60e+00 26.60
IUUC-Pte-104307 Pyrenophora teres 35.56 6.30e-01 28.90
IUUC-Rno-105882 Rattus norvegicus 70.05 0.00e+00 2170.00
IUUC-Sce-106211 Saccharomyces cerevisiae 29.76 9.00e-03 35.00
IUUC-Sha-107043 Sarcophilus harrisii 50.06 0.00e+00 1318.00
IUUC-Sja-107849 Schizosaccharomyces japonicus 31.43 9.00e-12 63.50
IUUC-Spo-108072 Schizosaccharomyces pombe 30.99 3.00e-08 53.50
IUUC-Ssl-108444 Sclerotinia sclerotiorum 32.31 8.00e-10 57.40
IUUC-Smo-108891 Selaginella moellendorffii 35.00 5.00e-20 92.40
IUUC-Sit-109705 Setaria italica 31.17 1.00e-11 64.70
IUUC-Sly-111484 Solanum lycopersicum 31.01 5.00e-16 79.30
IUUC-Stu-112625 Solanum tuberosum 31.01 3.00e-16 80.50
IUUC-Sar-113440 Sorex araneus 69.96 0.00e+00 2202.00
IUUC-Sbi-114730 Sorghum bicolor 29.03 4.00e-15 76.30
IUUC-Sre-115226 Sporisorium reilianum 30.83 4.00e-10 58.50
IUUC-Ssc-115744 Sus scrofa 79.82 0.00e+00 2140.00
IUUC-Tgu-116540 Taeniopygia guttata 44.61 0.00e+00 943.00
IUUC-Tru-118415 Takifugu rubripes 46.94 2.00e-102 368.00
IUUC-Tsy-119380 Tarsius syrichta 67.37 0.00e+00 896.00
IUUC-Tni-120411 Tetraodon nigroviridis 47.67 3.00e-101 364.00
IUUC-Tca-121821 Theobroma cacao 32.52 2.00e-13 71.20
IUUC-Tre-122107 Trichoderma reesei 36.15 6.00e-15 74.30
IUUC-Tvi-122309 Trichoderma virens 36.92 2.00e-14 72.40
IUUC-Tae-123527 Triticum aestivum 30.77 9.00e-16 78.60
IUUC-Tur-125957 Triticum urartu 31.41 1.00e-16 81.60
IUUC-Tme-126978 Tuber melanosporum 36.09 1.00e-16 79.30
IUUC-Tbe-127331 Tupaia belangeri 61.00 0.00e+00 1065.00
IUUC-Ttr-128559 Tursiops truncatus 80.79 0.00e+00 2650.00
IUUC-Uma-129434 Ustilago maydis 30.08 2.00e-09 56.20
IUUC-Vda-129975 Verticillium dahliae 34.09 4.00e-14 72.00
IUUC-Vpa-130807 Vicugna pacos 77.79 0.00e+00 2112.00
IUUC-Vvi-131687 Vitis vinifera 30.49 5.00e-13 69.70
IUUC-Xma-133915 Xiphophorus maculatus 37.58 1.00e-121 431.00
IUUC-Yli-134541 Yarrowia lipolytica 33.55 6.00e-15 74.30
IUUC-Zma-134705 Zea mays 28.85 8.00e-09 55.50
Created Date 25-Jun-2017

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