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Tag Content
UUCD2 ID IUUC-Aml-001263
UUCD1 version UUC-AiM-01040
Ensembl Protein ID ENSAMEP00000009394.1
UniProt Accession G1LQR0; G1LQR0_AILME
Genbank Protein ID ENSAMEP00000009394
Protein Name Ubiquitin carboxyl-terminal hydrolase
Genbank Nucleotide ID ACTA01146542
Gene Name BAP1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSAMEG00000008887.1 ENSAMET00000009785.1 ENSAMEP00000009385.1
ENSAMEG00000008887.1 ENSAMET00000009794.1 ENSAMEP00000009394.1
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/UCH 2.90e-170 566.3 3 736
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/UCH
   S: 6    kewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqv 94
           k+wleLesdPglftllvedfgvk++ qvee+y+L++++    q+pv+g+++lFk++e+r+s+rk++++++d++v+d+di++++ffa+q+
   Q: 3    KGWLELESDPGLFTLLVEDFGVKGV-QVEEIYDLQSKC----QGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQL 86
           89***********************.************....*********************************************** PP
   S: 95   igNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsy 183
           i+NsCat+Allsvllnc+++  dlG+tlsr+k++tk++spe+k++a+gn+++l+++hns+ar+e+r++pe+q+++++++t+eafhfvsy
   Q: 87   IPNSCATHALLSVLLNCSSV--DLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSY 173
           ********************..******************************************************************* PP
   S: 184  vningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesde....irfnllaivadrrviktlrlnvlkid......... 259
           v+i+grl+eldglk++P+d+g+++e+ee++dk+++v+  +eri+l++++e    irfnl+a+v+drr+++++rl+vlk++         
   Q: 174  VPITGRLFELDGLKVYPIDHGPWGEDEEWTDKARRVI--MERIGLATAGEpyhdIRFNLMAVVPDRRIKYEARLHVLKVNrqtvlealq 260
           *************************************..************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 261  qlirvtqpeliqthksqepqlaeeskpassksplaleasraaaasecthtdgveevagscpqapahsppskpklvvkppgsslngvppn 349
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 350  papivqrlpafldnhnyakspmqeeedlaagvgrsrvpvrppqqysddeddyeddedddvqntnsairykrkgpgkpgplsgsgdgqls 438
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 439  vlqpntinvlaeklkesqkdlsiplsiktnsgaaspavagpahxvavpthsqpsptpsnestdtaseigsafnsplrspirsanptrps 527
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 528  spvtshiskvlfgeddsllrvdcirynravrdlgpvistgllhlaedgvlsplalteggkgsspcsrpsqgsqgssspeekevvdtads 616
           ***************************************************************************************** PP
   S: 260  ....................keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetise 328
                               keLl+Llk++e+e++++ea+l++e+ekrkkfkidd+rRt+nydefic+fi++la+eg+l++lve++is+
   Q: 617  rekpglarpgeplsgekyspKELLALLKCVEAEIANYEACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISV 705
           ***************************************************************************************** PP
   S: 329  vrefgvnegrlakqrkqgrekkirplkrkrk 359
           +r++gv++grl+kqrk++r+k++rp+k+kr+
   Q: 706  RRRQGVSIGRLHKQRKPDRRKRSRPYKAKRQ 736
           *****************************97 PP
   
Organism Ailuropoda melanoleuca
Protein Sequence
(Fasta)
MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLQSKCQ GPVYGFIFLF KWIEERRSRR 60
KVSTLVDDTS VIDDDIVNNM FFAHQLIPNS CATHALLSVL LNCSSVDLGP TLSRMKDFTK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Aml-001263|DUB,UCH|Ailuropoda melanoleuca
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAATAAGG GCTGGCTGGA GCTGGAGAGC GACCCTGGTG AGGAGGGTGC TGGACGGGCC 60
GGGGTCAGAG GAGGCCGGGT GGGCCCGAAA CGCGCCCGCC TGACCACCAC CTGCTCTTTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Aml-001263|DUB,UCH|Ailuropoda melanoleuca
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR001578--Peptidase_C12_UCH
Pfam

PF01088--Peptidase_C12
PRINTS

PR00707--UBCTHYDRLASE
Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0035517--C:PR-DUB complex
GO:0003682--F:chromatin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0061519--P:macrophage homeostasis
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0071108--P:protein K48-linked deubiquitination
GO:0051726--P:regulation of cell cycle
GO:0001558--P:regulation of cell growth
GO:1900015--P:regulation of cytokine production involved in inflammatory response
GO:0010035--P:response to inorganic substance
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Apl-003405 Anas platyrhynchos 68.70 3.00e-180 624.00
IUUC-Aca-004836 Anolis carolinensis 78.91 0.00e+00 1137.00
IUUC-Ame-011946 Astyanax mexicanus 63.45 0.00e+00 880.00
IUUC-Bta-013131 Bos taurus 91.20 0.00e+00 1053.00
IUUC-Cja-019599 Callithrix jacchus 94.57 0.00e+00 1273.00
IUUC-Cfa-021003 Canis familiaris 97.42 0.00e+00 1204.00
IUUC-Cpo-022143 Cavia porcellus 93.75 0.00e+00 1248.00
IUUC-Csa-023477 Chlorocebus sabaeus 94.16 0.00e+00 1247.00
IUUC-Cho-024734 Choloepus hoffmanni 81.31 0.00e+00 714.00
IUUC-Csv-025842 Ciona savignyi 58.95 2.00e-93 335.00
IUUC-Dre-027793 Danio rerio 64.30 0.00e+00 896.00
IUUC-Dno-029253 Dasypus novemcinctus 94.10 0.00e+00 1237.00
IUUC-Dor-030891 Dipodomys ordii 87.23 0.00e+00 1156.00
IUUC-Dme-031796 Drosophila melanogaster 59.29 1.00e-91 330.00
IUUC-Ete-032646 Echinops telfairi 84.66 1.00e-166 580.00
IUUC-Eca-033805 Equus caballus 94.97 0.00e+00 1235.00
IUUC-Eeu-035216 Erinaceus europaeus 89.70 2.00e-141 496.00
IUUC-Fca-035611 Felis catus 96.83 0.00e+00 1146.00
IUUC-Fal-037186 Ficedula albicollis 78.88 0.00e+00 988.00
IUUC-Gmo-038824 Gadus morhua 70.13 1.00e-178 619.00
IUUC-Gga-040875 Gallus gallus 80.87 0.00e+00 1107.00
IUUC-Gac-042226 Gasterosteus aculeatus 66.94 0.00e+00 925.00
IUUC-Ggo-045122 Gorilla gorilla 94.16 0.00e+00 1273.00
IUUC-Hsa-045882 Homo sapiens 94.43 0.00e+00 1276.00
IUUC-Itr-048185 Ictidomys tridecemlineatus 95.11 0.00e+00 1257.00
IUUC-Lch-049960 Latimeria chalumnae 71.28 0.00e+00 988.00
IUUC-Loc-052408 Lepisosteus oculatus 74.47 0.00e+00 650.00
IUUC-Laf-054187 Loxodonta africana 94.97 0.00e+00 1228.00
IUUC-Mcc-055273 Macaca mulatta 93.61 0.00e+00 1239.00
IUUC-Meu-056267 Macropus eugenii 81.79 0.00e+00 1154.00
IUUC-Mga-059958 Meleagris gallopavo 92.88 3.00e-153 534.00
IUUC-Mmr-061280 Microcebus murinus 94.44 0.00e+00 1229.00
IUUC-Mdo-062625 Monodelphis domestica 88.18 0.00e+00 1247.00
IUUC-Mmu-063853 Mus musculus 92.66 0.00e+00 1254.00
IUUC-Mlu-067771 Myotis lucifugus 94.57 0.00e+00 1210.00
IUUC-Opr-070741 Ochotona princeps 92.93 0.00e+00 1266.00
IUUC-Ont-072172 Oreochromis niloticus 65.16 0.00e+00 929.00
IUUC-Oan-073167 Ornithorhynchus anatinus 78.94 0.00e+00 1118.00
IUUC-Ocu-074176 Oryctolagus cuniculus 94.96 0.00e+00 1216.00
IUUC-Ola-087203 Oryzias latipes 85.23 8.00e-135 473.00
IUUC-Oga-089153 Otolemur garnettii 93.83 0.00e+00 1232.00
IUUC-Oar-090008 Ovis aries 92.12 0.00e+00 1209.00
IUUC-Ptr-091234 Pan troglodytes 94.43 0.00e+00 1278.00
IUUC-Pan-092005 Papio anubis 94.97 0.00e+00 1268.00
IUUC-Psi-093995 Pelodiscus sinensis 84.46 0.00e+00 653.00
IUUC-Pma-094110 Petromyzon marinus 88.19 8.00e-65 241.00
IUUC-Pfo-097418 Poecilia formosa 64.96 0.00e+00 915.00
IUUC-Pab-098267 Pongo abelii 94.43 0.00e+00 1253.00
IUUC-Pca-101084 Procavia capensis 92.49 0.00e+00 1175.00
IUUC-Pva-102292 Pteropus vampyrus 95.02 0.00e+00 883.00
IUUC-Rno-105251 Rattus norvegicus 90.65 0.00e+00 1219.00
IUUC-Sha-107100 Sarcophilus harrisii 87.21 0.00e+00 1239.00
IUUC-Sar-113559 Sorex araneus 86.04 0.00e+00 1071.00
IUUC-Ssc-115688 Sus scrofa 94.43 0.00e+00 1260.00
IUUC-Tgu-117424 Taeniopygia guttata 79.89 0.00e+00 1112.00
IUUC-Tru-118585 Takifugu rubripes 66.98 0.00e+00 922.00
IUUC-Tsy-119299 Tarsius syrichta 83.08 0.00e+00 927.00
IUUC-Tni-120808 Tetraodon nigroviridis 65.35 0.00e+00 916.00
IUUC-Tbe-127705 Tupaia belangeri 95.43 6.00e-176 609.00
IUUC-Ttr-128225 Tursiops truncatus 94.29 0.00e+00 1209.00
IUUC-Vpa-130193 Vicugna pacos 93.66 9.00e-130 457.00
IUUC-Xtr-132449 Xenopus tropicalis 70.44 0.00e+00 934.00
Created Date 25-Jun-2017

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