iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000018395.7	ENSRNOT00000064171.2	ENSRNOP00000060806.1
ENSRNOG00000018395.7	ENSRNOT00000070819.2	ENSRNOP00000064567.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.10e-78	262.3	42	481

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkg....ellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           G++N+g tCY+ S+LQ+L+++pe+re+l++  +e+l   ++k++ +     +  +lq+lf++l+  +++a s+++l++++++++ e  +
   Q: 42   GIRNQGGTCYLSSLLQTLHFTPEFREALFSLGPEELGSLEDKDKPEakvrIIPLQLQRLFAQLLLVDQEAASTTDLTDSFGWTSDE--E 128
           9*****************************888887766554333345558899******************************98..* PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslp 175
           ++q+D+qE+ ++l+++le++l                            +++++li++l++g++ +qi+c+ec+nvs+r+e+fldl+++
   Q: 129  MRQHDVQELNRILFSALETSL--------------------------VGTSGHDLIHRLYHGTIVNQIVCKECKNVSERQEDFLDLTVA 191
           *********************..........................789*************************************** PP
   S: 176  vpgkeetkkeslqdcL.esftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp 263
           v++ +      l+d+L +++++ee ++ +n y+c +c+++++a k+ kl+klP++L++ L Rf+f+  ++ r k +++++fpl+++l+p
   Q: 192  VKNVS-----GLEDALwNMYVEEEIFDYDNLYHCGTCDRLVKAAKSAKLRKLPPFLTISLLRFNFDFVKCERYKDTSCYTFPLRINLKP 275
           *****.....9*****9************************************************************************ PP
   S: 264  fctspeekqkekkkYeLiavvvHsGslssGHYvayvkn................................................... 301
           fc++++ ++  ++ Y+L++v++H+G++ +GHY++y+k+                                                   
   Q: 276  FCEQSDMDD-MEYMYDLFSVIIHKGGCYGGHYHVYIKDvdhlgnwqcqeeisdsavnlkapqneeetddplvvlkaillqeeanqipvd 363
           ****77766.5****************************************************************************** PP
   S: 302  ...............................................................................ekgk...Wll 308
                                                                                             +   W+ 
   Q: 364  qlgqklliktgiswnkkyrkqhgplrkflrlhpqvfllstdestvslqrshfpqvpsdpqsheqiahtlaseppglrdnI--ScphWFD 450
           ********************************************************999999999999998888876541..1557*** PP
   S: 309  fdDskVtevkeeevleetg..staYvlfYkr 337
           ++DskV+++ke+++ ++ +  ++aY+lfY++
   Q: 451  INDSKVQPIKEKDIMQQFQgkESAYMLFYRK 481
           *************9998889*********97 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MFGNLFEEDY SSVSSSQYGS GKKLKTKGLE PPAPREFTKL SGIRNQGGTC YLSSLLQTLH 60
FTPEFREALF SLGPEELGSL EDKDKPEAKV RIIPLQLQRL FAQLLLVDQE AASTTDLTDS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGACGCACCC TGGGAAGTGT AGTCCGCATC TCGGGGCGGG GGGGTCACTT TCCAGAGACC 60
CGGCCTCGCC GGCATGGCGG TGCCTGTTCG GAGCGAGTTC GTTTACTCTG TGCTGTGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

rno:316599

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001216	Ailuropoda melanoleuca	77.61	0.00e+00	1744.00
IUUC-Apl-004105	Anas platyrhynchos	61.39	0.00e+00	1481.00
IUUC-Aca-004715	Anolis carolinensis	59.42	0.00e+00	1407.00
IUUC-Ame-011073	Astyanax mexicanus	46.30	0.00e+00	999.00
IUUC-Bta-012487	Bos taurus	77.20	0.00e+00	1836.00
IUUC-Cja-018937	Callithrix jacchus	79.40	0.00e+00	1913.00
IUUC-Cfa-020645	Canis familiaris	72.91	0.00e+00	1132.00
IUUC-Cpo-022160	Cavia porcellus	77.20	0.00e+00	1838.00
IUUC-Csa-023078	Chlorocebus sabaeus	78.09	0.00e+00	1917.00
IUUC-Cho-025013	Choloepus hoffmanni	63.36	0.00e+00	777.00
IUUC-Csv-026193	Ciona savignyi	54.55	5.00e-58	217.00
IUUC-Dre-027416	Danio rerio	48.44	0.00e+00	1131.00
IUUC-Dno-029639	Dasypus novemcinctus	75.65	0.00e+00	1560.00
IUUC-Dor-030624	Dipodomys ordii	89.04	1.00e-151	531.00
IUUC-Ete-032626	Echinops telfairi	60.41	0.00e+00	706.00
IUUC-Eca-034208	Equus caballus	78.66	0.00e+00	1900.00
IUUC-Eeu-035340	Erinaceus europaeus	45.00	4.00e-82	300.00
IUUC-Fca-035886	Felis catus	69.44	0.00e+00	722.00
IUUC-Fal-036925	Ficedula albicollis	61.86	0.00e+00	1389.00
IUUC-Gmo-038597	Gadus morhua	45.79	0.00e+00	901.00
IUUC-Gga-041171	Gallus gallus	61.09	0.00e+00	1451.00
IUUC-Gac-041362	Gasterosteus aculeatus	45.98	0.00e+00	959.00
IUUC-Ggo-045069	Gorilla gorilla	77.22	0.00e+00	1735.00
IUUC-Hsa-046715	Homo sapiens	78.74	0.00e+00	1898.00
IUUC-Itr-049006	Ictidomys tridecemlineatus	78.69	0.00e+00	1860.00
IUUC-Lch-050182	Latimeria chalumnae	50.59	0.00e+00	1094.00
IUUC-Loc-052705	Lepisosteus oculatus	53.00	0.00e+00	1241.00
IUUC-Laf-054132	Loxodonta africana	77.04	0.00e+00	1878.00
IUUC-Mcc-055734	Macaca mulatta	78.42	0.00e+00	1916.00
IUUC-Meu-056135	Macropus eugenii	85.71	2.00e-113	403.00
IUUC-Mga-060092	Meleagris gallopavo	60.59	0.00e+00	1418.00
IUUC-Mmr-061546	Microcebus murinus	74.90	0.00e+00	1811.00
IUUC-Mdo-061935	Monodelphis domestica	60.10	0.00e+00	1432.00
IUUC-Mmu-063630	Mus musculus	92.55	0.00e+00	2300.00
IUUC-Mpu-066579	Mustela putorius furo	75.51	0.00e+00	1857.00
IUUC-Mlu-068034	Myotis lucifugus	77.53	0.00e+00	1819.00
IUUC-Nle-069082	Nomascus leucogenys	76.09	0.00e+00	1566.00
IUUC-Opr-070953	Ochotona princeps	67.56	0.00e+00	909.00
IUUC-Ont-072435	Oreochromis niloticus	46.91	0.00e+00	1086.00
IUUC-Oan-073339	Ornithorhynchus anatinus	63.64	0.00e+00	1503.00
IUUC-Ocu-073760	Oryctolagus cuniculus	76.05	0.00e+00	1820.00
IUUC-Ola-087015	Oryzias latipes	46.07	0.00e+00	910.00
IUUC-Oga-088960	Otolemur garnettii	78.09	0.00e+00	1885.00
IUUC-Oar-089853	Ovis aries	77.72	0.00e+00	1873.00
IUUC-Ptr-091093	Pan troglodytes	78.74	0.00e+00	1897.00
IUUC-Pan-091962	Papio anubis	77.87	0.00e+00	1903.00
IUUC-Psi-093691	Pelodiscus sinensis	63.44	0.00e+00	1533.00
IUUC-Pma-094428	Petromyzon marinus	64.39	8.00e-89	320.00
IUUC-Pfo-096983	Poecilia formosa	47.62	0.00e+00	1007.00
IUUC-Pab-097860	Pongo abelii	78.00	0.00e+00	1767.00
IUUC-Pca-100514	Procavia capensis	64.15	5.00e-176	612.00
IUUC-Pva-102771	Pteropus vampyrus	76.97	0.00e+00	1746.00
IUUC-Sha-107376	Sarcophilus harrisii	61.67	0.00e+00	1419.00
IUUC-Ssc-115819	Sus scrofa	72.51	0.00e+00	1271.00
IUUC-Tgu-117262	Taeniopygia guttata	60.91	0.00e+00	1461.00
IUUC-Tru-117601	Takifugu rubripes	47.31	0.00e+00	1071.00
IUUC-Tsy-118996	Tarsius syrichta	68.86	0.00e+00	1483.00
IUUC-Tni-120682	Tetraodon nigroviridis	43.24	0.00e+00	841.00
IUUC-Tbe-127616	Tupaia belangeri	60.45	0.00e+00	1150.00
IUUC-Ttr-129075	Tursiops truncatus	75.53	0.00e+00	1761.00
IUUC-Vpa-130108	Vicugna pacos	77.11	0.00e+00	1672.00
IUUC-Xtr-132623	Xenopus tropicalis	51.89	0.00e+00	1160.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence