iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108169

Ensembl Protein ID

SPAC22G7.04.1:pep

UniProt Accession

Q09798; PAN2_SCHPO

Genbank Protein ID

CAA91128.2

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

CU329670

Gene Name

pan2; ubp13; SPAC22G7.04

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPAC22G7.04	SPAC22G7.04.1	SPAC22G7.04.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
Mentha
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.00e-12	44.4	480	813

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 8    NtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkk.........avsprellkalkkeaeefsgyeqq 90
              Y+NSvLQ Ls +p++ ++  ++         p +  ++ll++l  lf+ l +s+ +         a+s +++ ++l+ +   +s     
   Q: 480  TNSYCNSVLQLLSYVPSFSKAAISHSLG------PCDLMECLLCELGFLFAMLKESTGRncqatnflrAFSNSSFAQSLGIVFDDYSDGTFP 565
           566*********************3333......456789***********99866666233334444666666666666666666666666 PP
   S: 91   Da...qEflaflldqleeelkkeknkpkeeeeeedkselsdeaeek.kkkknkslisdlFqgqlksqikclecdnvssree.pfldlslpvp 177
           D+   q f++f+l ++++                      d +++k  ++   s++ + F +   ++ +c  c+ +s++ + + + + l+ p
   Q: 566  DSfviQKFTKFMLTEISRIA--------------------DYEDKKdGTSFPVSFLLKSFCIPEMQTYRCGICGITSQKIKsSLYIIDLHYP 637
           64444677777777776666....................2233330444555999999999999************66650556679**** PP
   S: 178  gkeetkkeslqdcLesftkee.elegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts. 267
           +++ ++ +s+++++++   +   l      +ce c ++q    +  +++lP++L ++ +    ++e ++     +k  +p++L l++++ + 
   Q: 638  SQQLESILSFEWLFKMSLDRRvDLP---PGWCEYCLAHQPFLLRSFIRSLPDCLFINTQVK--HHEHWKL--WARKNWLPKKLHLRRVNDTm 722
           **************77665541555...69**************************98877..3343443..55555666666666655554 PP
   S: 268  .........peekqkekkkYeLiavvvHsG.slssGHYvayvkn.........ekgkWllfdDskVtevkeeevleetg...........s 328
                     +++q++   Y L ++++    + ++ H+v+ ++          ++++W+ f+D  V+ev+eee l+ +g           +
   Q: 723  qcvsqkisnLDKDQQSLSVYVLRGIIYEIRqNGEEPHFVSTIRVsdntssdnpDDNRWYIFNDFLVKEVTEEEALTVHGpwkipiivyyeK 813
           444455555333444599*********9998999**********7777777666777*****************99777774444444440 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein pab1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.

Protein Sequence
(Fasta)

MDAWKEITKT TENDGVSTCS LSSIAFDPYS ELVWTGHKNG QIKSSFGPSL TSYTQFIGHE 60
GPVHQVLPQE RGVFSLSSKS LRLSNRKGTI RWRYQDSDCI DYRAMFYQSR NNPEVVIGGY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCAACACTTC AACTCCTAGA GAAAGAGGTT ATAGTCAACT GTTTGAAATG AGAGATGGAT 60
GCGTGGAAAG AAGTAATTAT TTTTATAATA TTCCATTATA AATTTTAACA AATTAGATTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening

KEGG

spo:SPAC22G7.04

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	31.72	3.00e-142	497.00
IUUC-Apl-003500	Anas platyrhynchos	31.28	2.00e-123	435.00
IUUC-Aca-004930	Anolis carolinensis	31.37	1.00e-142	498.00
IUUC-Acl-008214	Aspergillus clavatus	35.79	0.00e+00	671.00
IUUC-Afu-009112	Aspergillus fumigatus	35.92	0.00e+00	647.00
IUUC-Ang-009531	Aspergillus niger	36.04	0.00e+00	647.00
IUUC-Ame-011259	Astyanax mexicanus	46.50	1.00e-74	272.00
IUUC-Bta-012371	Bos taurus	31.69	2.00e-143	501.00
IUUC-Bci-013684	Botrytis cinerea	36.15	0.00e+00	647.00
IUUC-Cja-019297	Callithrix jacchus	31.87	3.00e-144	504.00
IUUC-Cfa-020489	Canis familiaris	31.51	2.00e-142	498.00
IUUC-Cpo-022392	Cavia porcellus	31.75	2.00e-143	501.00
IUUC-Csa-023220	Chlorocebus sabaeus	31.78	6.00e-143	499.00
IUUC-Csv-025841	Ciona savignyi	45.12	5.00e-65	241.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	37.62	0.00e+00	714.00
IUUC-Cne-026932	Cryptococcus neoformans	34.05	2.00e-161	561.00
IUUC-Dre-028482	Danio rerio	44.57	2.00e-75	275.00
IUUC-Dno-029398	Dasypus novemcinctus	31.77	2.00e-143	501.00
IUUC-Dor-030307	Dipodomys ordii	33.00	2.00e-91	328.00
IUUC-Dme-032111	Drosophila melanogaster	40.17	1.00e-71	263.00
IUUC-Eca-033985	Equus caballus	31.69	5.00e-143	500.00
IUUC-Eeu-034928	Erinaceus europaeus	28.75	5.00e-29	121.00
IUUC-Fca-035587	Felis catus	31.97	1.00e-144	505.00
IUUC-Fal-037587	Ficedula albicollis	31.54	1.00e-141	495.00
IUUC-Fso-038133	Fusarium solani	36.84	6.00e-110	390.00
IUUC-Gmo-039076	Gadus morhua	47.06	3.00e-73	268.00
IUUC-Ggr-039957	Gaeumannomyces graminis	36.47	0.00e+00	655.00
IUUC-Gga-040948	Gallus gallus	31.89	4.00e-137	480.00
IUUC-Gac-042396	Gasterosteus aculeatus	46.20	5.00e-73	267.00
IUUC-Ggo-045412	Gorilla gorilla	31.78	7.00e-143	499.00
IUUC-Hsa-046076	Homo sapiens	31.78	6.00e-143	499.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	30.46	5.00e-122	430.00
IUUC-Kpa-049178	Komagataella pastoris	31.99	2.00e-151	528.00
IUUC-Lch-050279	Latimeria chalumnae	29.66	9.00e-120	423.00
IUUC-Loc-052872	Lepisosteus oculatus	46.18	3.00e-74	271.00
IUUC-Lma-052986	Leptosphaeria maculans	38.41	0.00e+00	715.00
IUUC-Laf-054181	Loxodonta africana	32.23	2.00e-140	491.00
IUUC-Mcc-054812	Macaca mulatta	31.83	3.00e-143	501.00
IUUC-Meu-056325	Macropus eugenii	32.72	3.00e-144	504.00
IUUC-Mor-057246	Magnaporthe oryzae	34.61	9.00e-174	602.00
IUUC-Mpo-057464	Magnaporthe poae	35.74	0.00e+00	662.00
IUUC-Mla-058911	Melampsora laricipopulina	46.87	4.00e-79	288.00
IUUC-Mga-059335	Meleagris gallopavo	32.29	3.00e-134	471.00
IUUC-Mvi-060461	Microbotryum violaceum	34.72	1.00e-172	598.00
IUUC-Mmr-060636	Microcebus murinus	31.62	3.00e-142	497.00
IUUC-Mmu-063503	Mus musculus	32.41	8.00e-146	509.00
IUUC-Mpu-066670	Mustela putorius furo	31.80	2.00e-143	501.00
IUUC-Mlu-068119	Myotis lucifugus	31.48	5.00e-145	506.00
IUUC-Nfi-068398	Neosartorya fischeri	36.44	0.00e+00	674.00
IUUC-Ncr-068927	Neurospora crassa	32.67	3.00e-160	557.00
IUUC-Nle-069651	Nomascus leucogenys	34.90	1.00e-101	362.00
IUUC-Opr-070614	Ochotona princeps	31.58	3.00e-141	494.00
IUUC-Ont-072433	Oreochromis niloticus	46.79	2.00e-76	279.00
IUUC-Oan-073283	Ornithorhynchus anatinus	30.66	4.00e-114	404.00
IUUC-Ocu-074401	Oryctolagus cuniculus	31.64	5.00e-142	497.00
IUUC-Ola-087522	Oryzias latipes	35.39	4.00e-110	390.00
IUUC-Oga-088226	Otolemur garnettii	42.70	2.00e-75	275.00
IUUC-Oar-089241	Ovis aries	32.06	5.00e-143	500.00
IUUC-Pan-092297	Papio anubis	32.88	1.00e-136	478.00
IUUC-Psi-094043	Pelodiscus sinensis	30.94	2.00e-126	445.00
IUUC-Pma-094394	Petromyzon marinus	42.69	2.00e-72	265.00
IUUC-Pno-095053	Phaeosphaeria nodorum	38.36	0.00e+00	653.00
IUUC-Ppa-095188	Physcomitrella patens	28.77	4.00e-67	248.00
IUUC-Pfo-097517	Poecilia formosa	32.49	4.00e-143	500.00
IUUC-Pca-100471	Procavia capensis	31.86	2.00e-140	491.00
IUUC-Pva-102805	Pteropus vampyrus	34.56	2.00e-94	339.00
IUUC-Pte-104021	Pyrenophora teres	38.31	0.00e+00	708.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	38.50	0.00e+00	709.00
IUUC-Rno-105471	Rattus norvegicus	32.55	2.00e-146	511.00
IUUC-Sce-106235	Saccharomyces cerevisiae	29.40	3.00e-115	407.00
IUUC-Sha-106883	Sarcophilus harrisii	31.95	1.00e-135	476.00
IUUC-Sar-113323	Sorex araneus	32.63	5.00e-112	397.00
IUUC-Sre-115075	Sporisorium reilianum	40.76	3.00e-68	251.00
IUUC-Ssc-116363	Sus scrofa	43.93	8.00e-76	277.00
IUUC-Tru-118427	Takifugu rubripes	45.87	3.00e-74	271.00
IUUC-Tni-120218	Tetraodon nigroviridis	45.67	1.00e-76	280.00
IUUC-Tre-122177	Trichoderma reesei	35.85	0.00e+00	696.00
IUUC-Tme-127176	Tuber melanosporum	38.91	0.00e+00	689.00
IUUC-Tbe-127641	Tupaia belangeri	25.30	7.00e-24	104.00
IUUC-Ttr-128888	Tursiops truncatus	35.20	4.00e-106	377.00
IUUC-Uma-129361	Ustilago maydis	39.77	1.00e-67	250.00
IUUC-Xtr-132811	Xenopus tropicalis	30.96	1.00e-137	482.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence