iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033568

UUCD1 version

UUC-EqC-01070

Ensembl Protein ID

ENSECAP00000004375.1

UniProt Accession

F7AWD8; F7AWD8_HORSE

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP13

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000004152.1	ENSECAT00000006202.1	ENSECAP00000004375.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.40e-57	194.8	280	804
UBD/Alpha-Helix/UBA	6.10e-20	70.9	674	711

Active Site

Position(s)	Description	Evidence
289	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
767	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel......................wkskkka 67
           tGlkNlgN+CY+ Sv+Q++++ipe+++++  + ++ ++ + p +p++++ ++++kl + l                       k +++ 
   Q: 280  TGLKNLGNSCYLSSVMQAIFSIPEFQRAYVGNLPRIFDYS-PLDPTQDFNTQMTKLGHGLlsgqyskppvkselieqvmkeeHKPQQNG 367
           7******************************788777765.79*****************8888888888888877765543388888* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikc 156
           +spr++++ ++k ++efs+++qqDaqEf+ +l++ +e++                               +++  sd+F++ ++++i+c
   Q: 368  ISPRMFKAFVSKSHPEFSSNRQQDAQEFFLHLVNLVERNR-----------------------------IGSENPSDVFRFLVEERIQC 427
           *************************************998.............................688899************** PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeae 218
            + ++v  +e   + ++lpv ++  t+k                             ++ cL++f+++e++++   ++++  ++k+  +
   Q: 428  CQTRKVRYTERVDYLMQLPVAMEAATNKDeliayeltrreaeanrrplpevvrakiPFSACLQAFSEPENVDD---FWSSALQAKSAGV 513
           ******9999999999999999998887799****************************************97...************* PP
   S: 219  kklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts........................................ 267
           k+ ++ ++Pe+L++++k+f+f  + ++++k++ ++++p+ Ld+++  ++                                        
   Q: 514  KTSRFASFPEYLVVQIKKFTFGLD-WVPKKFDVSIDMPDLLDINHLRARglqpgeeelpdisppivipddskdrlmnqfidpsdidess 601
           *********************997.*******************999889999999999999999998888888888888888888877 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 602  vmqlaemgfpleacrkavyftgnmgaevafnwiivhmeepdfaepltmpgyggaasagasvfgatgldnqppeeivaiitsmgfhrnqa 690
           77777777777777777777777777777777777777777777777777777777777777777776666666666666666666666 PP
   S: 268  ...........peekqke...........................................kkkYeLiavvvHsG.slssGHYvayvkn 301
                      +     +                                           +  YeL+a ++H+G s+ sGHYv+++k+
   Q: 691  iqalratnnnlE-----RaldwifshpefeedsdfviemennananiiseakpegprvkdgSGMYELFAFISHMGtSTMSGHYVCHIKK 774
           666665555550.....055555555555555555566666666677888888888888889*************************** PP
   S: 302  ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
            +g+W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 775  -EGRWVIYNDHKVCAS--ERPPK---DLGYMYFYRR 804
           .9***********999..78888...99******98 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e++++ +++MGF r++a+qaLra+nnnle+A+++++++
   Q: 674  EEIVAIITSMGFHRNQAIQALRATNNNLERALDWIFSH 711
           899*********************************97 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

NSEGGLYVCM NTFLAFGREH VERHFRKTGQ SVYMHLKRHV REKVRGASGG ALPKRRNSKI 60
FLDLDTDDDL NSDDYEYEDE AKLVIFPDHY EIALPNIEEL PALVTIACDA VLSSKSPYRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATTCTGAAG GTGGACTCTA TGTATGCATG AATACATTTT TGGCCTTTGG AAGGGAACAT 60
GTTGAAAGAC ATTTTCGAAA AACTGGACAG AGTGTGTACA TGCACCTGAA GAGACATGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904454--F:ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:1904378--P:maintenance of unfolded protein involved in ERAD pathway
GO:0035523--P:protein K29-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001356	Ailuropoda melanoleuca	98.88	0.00e+00	1512.00
IUUC-Atr-002580	Amborella trichopoda	42.18	2.00e-178	619.00
IUUC-Apl-003712	Anas platyrhynchos	83.85	0.00e+00	1358.00
IUUC-Aca-004634	Anolis carolinensis	84.69	0.00e+00	1333.00
IUUC-Ame-011470	Astyanax mexicanus	74.15	0.00e+00	1220.00
IUUC-Bta-013349	Bos taurus	98.39	0.00e+00	1543.00
IUUC-Cja-019021	Callithrix jacchus	97.52	0.00e+00	1495.00
IUUC-Cfa-020614	Canis familiaris	99.26	0.00e+00	1516.00
IUUC-Cpo-022484	Cavia porcellus	98.64	0.00e+00	1514.00
IUUC-Csa-024078	Chlorocebus sabaeus	98.88	0.00e+00	1510.00
IUUC-Cho-024522	Choloepus hoffmanni	81.41	0.00e+00	1183.00
IUUC-Dre-027651	Danio rerio	74.91	0.00e+00	1287.00
IUUC-Dno-028975	Dasypus novemcinctus	98.27	0.00e+00	1507.00
IUUC-Dor-030130	Dipodomys ordii	73.36	0.00e+00	1050.00
IUUC-Ete-032251	Echinops telfairi	82.65	0.00e+00	1283.00
IUUC-Eeu-034612	Erinaceus europaeus	79.93	0.00e+00	1155.00
IUUC-Fca-036280	Felis catus	99.38	0.00e+00	1519.00
IUUC-Fal-036610	Ficedula albicollis	84.77	0.00e+00	1337.00
IUUC-Gmo-038906	Gadus morhua	72.64	0.00e+00	1189.00
IUUC-Gga-041215	Gallus gallus	84.09	0.00e+00	1355.00
IUUC-Gac-042441	Gasterosteus aculeatus	71.99	0.00e+00	1204.00
IUUC-Ggo-044446	Gorilla gorilla	98.64	0.00e+00	1512.00
IUUC-Hsa-046546	Homo sapiens	98.88	0.00e+00	1512.00
IUUC-Itr-048147	Ictidomys tridecemlineatus	91.93	0.00e+00	1434.00
IUUC-Lch-050425	Latimeria chalumnae	78.05	0.00e+00	1295.00
IUUC-Loc-052072	Lepisosteus oculatus	77.41	0.00e+00	1240.00
IUUC-Laf-053909	Loxodonta africana	96.30	0.00e+00	1493.00
IUUC-Mcc-054686	Macaca mulatta	98.88	0.00e+00	1512.00
IUUC-Meu-056361	Macropus eugenii	80.59	0.00e+00	1247.00
IUUC-Mga-059972	Meleagris gallopavo	79.23	0.00e+00	1298.00
IUUC-Mmr-060916	Microcebus murinus	97.89	0.00e+00	1503.00
IUUC-Mdo-062302	Monodelphis domestica	89.37	0.00e+00	1442.00
IUUC-Mmu-063639	Mus musculus	96.16	0.00e+00	1531.00
IUUC-Mpu-066533	Mustela putorius furo	99.26	0.00e+00	1517.00
IUUC-Mlu-067786	Myotis lucifugus	92.26	0.00e+00	1427.00
IUUC-Nle-069997	Nomascus leucogenys	98.75	0.00e+00	1498.00
IUUC-Ont-071859	Oreochromis niloticus	72.45	0.00e+00	1208.00
IUUC-Oan-072959	Ornithorhynchus anatinus	88.70	5.00e-129	452.00
IUUC-Ocu-074265	Oryctolagus cuniculus	98.64	0.00e+00	1511.00
IUUC-Ola-087344	Oryzias latipes	71.51	0.00e+00	1214.00
IUUC-Oga-088734	Otolemur garnettii	98.27	0.00e+00	1502.00
IUUC-Oar-089636	Ovis aries	98.39	0.00e+00	1581.00
IUUC-Ptr-090982	Pan troglodytes	98.88	0.00e+00	1515.00
IUUC-Pan-091991	Papio anubis	99.01	0.00e+00	1513.00
IUUC-Psi-093509	Pelodiscus sinensis	87.53	0.00e+00	1387.00
IUUC-Pfo-096029	Poecilia formosa	74.21	0.00e+00	1259.00
IUUC-Pab-098672	Pongo abelii	94.30	0.00e+00	1412.00
IUUC-Pca-100860	Procavia capensis	74.07	0.00e+00	1041.00
IUUC-Pva-102545	Pteropus vampyrus	90.71	0.00e+00	1379.00
IUUC-Rno-105210	Rattus norvegicus	95.29	0.00e+00	1508.00
IUUC-Sar-113733	Sorex araneus	96.53	0.00e+00	775.00
IUUC-Tgu-116591	Taeniopygia guttata	85.31	0.00e+00	1354.00
IUUC-Tru-118627	Takifugu rubripes	71.02	0.00e+00	1224.00
IUUC-Tsy-119278	Tarsius syrichta	89.84	0.00e+00	1357.00
IUUC-Tni-120804	Tetraodon nigroviridis	73.94	0.00e+00	1249.00
IUUC-Tbe-127699	Tupaia belangeri	79.36	0.00e+00	878.00
IUUC-Ttr-128295	Tursiops truncatus	89.60	0.00e+00	1363.00
IUUC-Vpa-130170	Vicugna pacos	87.48	0.00e+00	1340.00
IUUC-Xtr-132809	Xenopus tropicalis	74.29	0.00e+00	1202.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence