iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pfo-096029

Ensembl Protein ID

ENSPFOP00000014948.2

UniProt Accession

A0A087YA95; A0A087YA95_POEFO

Genbank Protein ID

ENSPFOP00000014948

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AYCK01005068

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPFOG00000014734.2	ENSPFOT00000014970.2	ENSPFOP00000014948.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.40e-54	184.8	319	859
UBD/Alpha-Helix/UBA	1.70e-19	69.9	717	754

Active Site

Position(s)	Description	Evidence
328	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
822	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel.........................w.ks 63
           tG+kNlgN+CY+  vLQ+L++ip++++++   + +++ + +p +p+++++++++kl + l                         +  +
   Q: 319  TGIKNLGNSCYLSTVLQVLFSIPDFQRMYVG-NLQRIFDYSPLDPTQDFATQMAKLGHGLlsgqyskppmkselieqvmkeehkvLnGH 406
           7*****************************9.777777778999999999999999999977777777777777777666655542477 PP
   S: 64   kkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlks 152
           +++ +spr+l++ +++ ++efs+++qqDa+Ef+ +l++ +e++                               +++  sd F++ +++
   Q: 407  QQRGISPRMLKALVSRGHPEFSSNRQQDAHEFFLHLINLVERNS-----------------------------AGSENPSDSFRFLVEE 466
           777**************************************999.............................6788899********* PP
   S: 153  qikclecdnvs..sreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekck 212
           +++c + ++v   +r +  ++l+ p++  +++  e                            ++ cL++ft++e++ +   ++++  +
   Q: 467  RVQCCQSRRVRyaQRVDYCIQLPAPIEAATNR--EellayeakrkeaeentrappepvrariPFTACLQAFTEPENVPD---FWSSALQ 550
           ****8888888444555555555555555544..3569***************************************97...******* PP
   S: 213  kkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts.................................. 267
           +k+  +k+ ++ ++Pe+L++++k+f+f  + ++++k++  +++p+ Ldls+  ++                                  
   Q: 551  AKSAGVKTSRFASFPEYLVVQIKKFTFGVD-WVPKKLDLAIDVPDFLDLSRLRATglqageeelpdlmppivlpedtrdnsmsstdspe 638
           ***************************776.*******************988888999999999999999999888888888888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 639  idegavmqlaemgfpleacrkavyytgnmgpemafnwiiahmeepdfaepltlpsmmdplpstsdspmgatpldnlppeesiailtsmg 727
           88888888888888888888888888888888888888877777777777777777777777777777777777777777777777777 PP
   S: 268  ..............................peekqke..........................................kkkYeLiavv 284
                                         +     e                                          + +YeL+a++
   Q: 728  fprnhsiralkatnnnleraldwifthpeeE-----EsdglsdmadtepndnsfsnmnshsdstlspdretssprvkdgPGRYELFAII 811
           7666666666666666666666666665540.....0455666666666666666777777777888888888889999********** PP
   S: 285  vHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           +H+G s+ sGHYv+++k+ +g+W+ ++D+kV  +  e+  +   + +Y++fY+r
   Q: 812  SHMGaSTMSGHYVCHIKK-EGRWVIYNDHKVCLS--ERPPK---DLGYIYFYRR 859
           ******************.9***********988..78888...89******98 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e+ ++ l++MGF+r++ ++aL a+nnnle+A+++++++
   Q: 717  EESIAILTSMGFPRNHSIRALKATNNNLERALDWIFTH 754
           789*********************************98 PP

Organism

Poecilia formosa

Protein Sequence
(Fasta)

MAADLGELLV PFMPTIRVPK TGDRVYKSEC AFSFDSPESE GGLYVCMNTF LGFGREHVER 60
HYRKTGQSVY MHLKRHVKEK TTGAAGGAIP RRRNGKVFLD LELNRDFNGE DYEYEDEAKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTCAACAGC AGCGCTGTAA TTTCTGCGCA GGTCCATGCT TATGGGGGAA AAAACCCGCA 60
CAAACAACAA CAAAAGAGCA GCTCTTTACC CTCGATGCCC TTACCCTCAG ACTCCGAGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001356	Ailuropoda melanoleuca	73.49	0.00e+00	1257.00
IUUC-Apl-003712	Anas platyrhynchos	74.40	0.00e+00	1239.00
IUUC-Aca-004634	Anolis carolinensis	74.86	0.00e+00	1289.00
IUUC-Ame-011470	Astyanax mexicanus	85.30	0.00e+00	1484.00
IUUC-Bta-013349	Bos taurus	74.28	0.00e+00	1274.00
IUUC-Cja-019021	Callithrix jacchus	73.67	0.00e+00	1254.00
IUUC-Cfa-020614	Canis familiaris	73.49	0.00e+00	1254.00
IUUC-Cpo-022484	Cavia porcellus	72.51	0.00e+00	1192.00
IUUC-Csa-024078	Chlorocebus sabaeus	73.55	0.00e+00	1258.00
IUUC-Cho-024522	Choloepus hoffmanni	61.21	0.00e+00	930.00
IUUC-Dre-027651	Danio rerio	85.19	0.00e+00	1536.00
IUUC-Dno-028975	Dasypus novemcinctus	73.50	0.00e+00	1254.00
IUUC-Dor-030130	Dipodomys ordii	54.85	0.00e+00	819.00
IUUC-Ete-032251	Echinops telfairi	62.95	0.00e+00	989.00
IUUC-Eca-033568	Equus caballus	73.45	0.00e+00	1197.00
IUUC-Fca-036280	Felis catus	73.27	0.00e+00	1191.00
IUUC-Fal-036610	Ficedula albicollis	74.33	0.00e+00	1214.00
IUUC-Gmo-038906	Gadus morhua	83.95	0.00e+00	1476.00
IUUC-Gga-041215	Gallus gallus	74.48	0.00e+00	1294.00
IUUC-Gac-042441	Gasterosteus aculeatus	88.58	0.00e+00	1577.00
IUUC-Ggo-044446	Gorilla gorilla	73.78	0.00e+00	1263.00
IUUC-Hsa-046546	Homo sapiens	73.55	0.00e+00	1258.00
IUUC-Itr-048147	Ictidomys tridecemlineatus	68.28	0.00e+00	1145.00
IUUC-Lch-050425	Latimeria chalumnae	73.27	0.00e+00	1319.00
IUUC-Loc-052072	Lepisosteus oculatus	78.50	0.00e+00	1364.00
IUUC-Laf-053909	Loxodonta africana	72.65	0.00e+00	1242.00
IUUC-Mcc-054686	Macaca mulatta	73.43	0.00e+00	1258.00
IUUC-Meu-056361	Macropus eugenii	74.84	0.00e+00	969.00
IUUC-Mga-059972	Meleagris gallopavo	70.13	0.00e+00	1186.00
IUUC-Mmr-060916	Microcebus murinus	73.55	0.00e+00	1258.00
IUUC-Mdo-062302	Monodelphis domestica	75.41	0.00e+00	1336.00
IUUC-Mmu-063639	Mus musculus	73.43	0.00e+00	1256.00
IUUC-Mac-065634	Musa acuminata	39.80	4.00e-174	605.00
IUUC-Mpu-066533	Mustela putorius furo	73.37	0.00e+00	1254.00
IUUC-Mlu-067786	Myotis lucifugus	69.35	0.00e+00	1181.00
IUUC-Nle-069997	Nomascus leucogenys	73.19	0.00e+00	1186.00
IUUC-Ont-071859	Oreochromis niloticus	89.92	0.00e+00	1620.00
IUUC-Oan-072959	Ornithorhynchus anatinus	78.84	3.00e-114	404.00
IUUC-Ocu-074265	Oryctolagus cuniculus	73.09	0.00e+00	1252.00
IUUC-Ola-087344	Oryzias latipes	88.34	0.00e+00	1616.00
IUUC-Oga-088734	Otolemur garnettii	73.33	0.00e+00	1239.00
IUUC-Oar-089636	Ovis aries	74.21	0.00e+00	1239.00
IUUC-Ptr-090982	Pan troglodytes	73.67	0.00e+00	1262.00
IUUC-Pan-091991	Papio anubis	73.55	0.00e+00	1259.00
IUUC-Psi-093509	Pelodiscus sinensis	74.51	0.00e+00	1311.00
IUUC-Pab-098672	Pongo abelii	70.07	0.00e+00	1173.00
IUUC-Pva-102545	Pteropus vampyrus	73.78	0.00e+00	1061.00
IUUC-Rno-105210	Rattus norvegicus	73.19	0.00e+00	1241.00
IUUC-Sar-113733	Sorex araneus	76.77	0.00e+00	633.00
IUUC-Tgu-116591	Taeniopygia guttata	75.20	0.00e+00	1300.00
IUUC-Tru-118627	Takifugu rubripes	89.24	0.00e+00	1640.00
IUUC-Tsy-119278	Tarsius syrichta	66.55	0.00e+00	1071.00
IUUC-Tni-120804	Tetraodon nigroviridis	91.46	0.00e+00	1659.00
IUUC-Tbe-127699	Tupaia belangeri	61.56	0.00e+00	686.00
IUUC-Ttr-128295	Tursiops truncatus	67.09	0.00e+00	1136.00
IUUC-Vpa-130170	Vicugna pacos	65.38	0.00e+00	1021.00
IUUC-Xtr-132809	Xenopus tropicalis	69.13	0.00e+00	1228.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence