iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132809

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AAMC01001929

Gene Name

usp13

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000007265.3	ENSXETT00000015787.3	ENSXETP00000015787.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.50e-51	173.1	335	861
UBD/Alpha-Helix/UBA	1.70e-13	50.4	729	766

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel......................wkskkka 67
           tG+kNlgN+ Y+  v+Q++++ipe+++++   +  ++ + +p +p+++++++++kl + l                       k + k 
   Q: 335  TGIKNLGNSSYLTTVMQVIFSIPEFQRAYVG-NLTRIFDYAPLDPTQDFSTQMAKLGHGLlsgqfskppmkselieqvmkeeHKPQPKG 422
           7******************************.6666777789******************8888888888888887765543378888* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikc 156
           +++r++++ ++k + efs+++qqDa+Ef+ ++++ +e++                               + +  sd+F++ ++++++c
   Q: 423  INTRMFKALMSKGHTEFSSNRQQDAEEFFLHFINLVERNS-----------------------------IGAENPSDVFRFLVEERTQC 482
           *************************************999.............................678899************** PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeae 218
            + ++v  +e   + ++lpvp+++ t+ke                            ++ cL++ft++e++ +   ++++  ++k+  +
   Q: 483  CQSRKVRYTERVDYIMQLPVPMETATNKEeliaydlkrreaesakrpppelvrakiPFSACLQAFTEPENVPD---FWSSALQAKSAGV 568
           ************************99999******************************************97...************* PP
   S: 219  kklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts........................................ 267
           k+ ++ ++Pe+L++++k+f+f  + ++++k++ ++++p+ Ld+++  ++                                        
   Q: 569  KTSRFASFPEYLVVQIKKFTFGLD-WVPKKLDVSIDMPDLLDINHLRATglksgeeelpdiappiiipddpngrmaesllsgsgsnvns 656
           *********************997.*******************987777888888888888888888888888888777777777777 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 657  sfkgaqplnlpfgkkeakllrymermvekfgfkfsvrlsveidfaepliipgcgtvtstsshgqnallnqppeeivalicsmgfprnha 745
           77777777777777777777777777777777777777777777777777766666666666666666666555555555555555555 PP
   S: 268  .....peekqke...................................................kkkYeLiavvvHsG.slssGHYvayv 299
                      +                                                   + +YeL+++++H G s+ sGHYv+++
   Q: 746  lqalrA-----TnnnleraldwmfshpeseegadnvsgcvdtennpngiitdseqegprikdgNGRYELFGIISHAGtSTMSGHYVCHI 829
           555550.....0555555566666666666666667777777777778888888888899999************************** PP
   S: 300  knekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           k+ +g+W+ ++D+kV+++  e+  +   + +Y++fY+r
   Q: 830  KK-EGRWVIYNDHKVSAS--ERPPK---ELGYIYFYHR 861
           **.9*************9..67777...79******97 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e++++ +++MGF+r++alqaLra+nnnle+A+++ +++
   Q: 729  EEIVALICSMGFPRNHALQALRATNNNLERALDWMFSH 766
           8999*******************************987 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

LPPSGAILGR PRSSRNGKMA EDLGELLVPY MPTIRVPKSG DRVYKTECAF SYDSPESDGG 60
LYVCMSTFLG FGREHVERHY RKTGQSVYMH LKRHIRLKAT GASGGAFPKR INGRLFLDLE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGCCCCCTA GCGGCGCAAT TCTCGGGAGG CCAAATGCGC AGATTGGAAA TCACATGGGC 60
AGTGTATGAG GGTAGTACTG GCAGTATAGA AAGCCTAGAT CGCTGATATT CAACTTTTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001356	Ailuropoda melanoleuca	73.75	0.00e+00	1247.00
IUUC-Apl-003712	Anas platyrhynchos	74.11	0.00e+00	1191.00
IUUC-Aca-004634	Anolis carolinensis	74.97	0.00e+00	1242.00
IUUC-Ame-011470	Astyanax mexicanus	69.97	0.00e+00	1181.00
IUUC-Bta-013349	Bos taurus	74.01	0.00e+00	1259.00
IUUC-Cja-019021	Callithrix jacchus	72.91	0.00e+00	1225.00
IUUC-Cfa-020614	Canis familiaris	73.87	0.00e+00	1245.00
IUUC-Cpo-022484	Cavia porcellus	73.16	0.00e+00	1166.00
IUUC-Csa-024078	Chlorocebus sabaeus	73.75	0.00e+00	1246.00
IUUC-Cho-024522	Choloepus hoffmanni	61.01	0.00e+00	897.00
IUUC-Cme-027335	Cyanidioschyzon merolae	27.56	4.00e-45	176.00
IUUC-Dre-027651	Danio rerio	69.07	0.00e+00	1229.00
IUUC-Dno-028975	Dasypus novemcinctus	73.46	0.00e+00	1235.00
IUUC-Dor-030130	Dipodomys ordii	64.08	0.00e+00	725.00
IUUC-Ete-032251	Echinops telfairi	61.06	0.00e+00	944.00
IUUC-Eca-033568	Equus caballus	73.89	0.00e+00	1170.00
IUUC-Eeu-034612	Erinaceus europaeus	71.53	0.00e+00	847.00
IUUC-Fca-036280	Felis catus	74.01	0.00e+00	1174.00
IUUC-Fal-036610	Ficedula albicollis	74.41	0.00e+00	1172.00
IUUC-Gmo-038906	Gadus morhua	67.78	0.00e+00	1169.00
IUUC-Gga-041215	Gallus gallus	74.73	0.00e+00	1250.00
IUUC-Gac-042441	Gasterosteus aculeatus	69.00	0.00e+00	1203.00
IUUC-Ggo-044446	Gorilla gorilla	73.75	0.00e+00	1246.00
IUUC-Hsa-046546	Homo sapiens	73.64	0.00e+00	1244.00
IUUC-Itr-048147	Ictidomys tridecemlineatus	68.62	0.00e+00	1112.00
IUUC-Lch-050425	Latimeria chalumnae	71.56	0.00e+00	1228.00
IUUC-Loc-052072	Lepisosteus oculatus	70.86	0.00e+00	1178.00
IUUC-Laf-053909	Loxodonta africana	72.57	0.00e+00	1224.00
IUUC-Mcc-054686	Macaca mulatta	73.75	0.00e+00	1247.00
IUUC-Meu-056361	Macropus eugenii	78.71	0.00e+00	1011.00
IUUC-Mga-059972	Meleagris gallopavo	71.00	0.00e+00	1137.00
IUUC-Mmr-060916	Microcebus murinus	73.46	0.00e+00	1243.00
IUUC-Mdo-062302	Monodelphis domestica	75.09	0.00e+00	1294.00
IUUC-Mmu-063639	Mus musculus	74.14	0.00e+00	1242.00
IUUC-Mpu-066533	Mustela putorius furo	73.87	0.00e+00	1247.00
IUUC-Mlu-067786	Myotis lucifugus	71.56	0.00e+00	1194.00
IUUC-Nle-069997	Nomascus leucogenys	73.62	0.00e+00	1157.00
IUUC-Ont-071859	Oreochromis niloticus	67.39	0.00e+00	1182.00
IUUC-Oan-072959	Ornithorhynchus anatinus	79.92	2.00e-120	424.00
IUUC-Ocu-074265	Oryctolagus cuniculus	73.40	0.00e+00	1233.00
IUUC-Ola-087344	Oryzias latipes	67.86	0.00e+00	1198.00
IUUC-Oga-088734	Otolemur garnettii	74.10	0.00e+00	1220.00
IUUC-Oar-089636	Ovis aries	74.04	0.00e+00	1186.00
IUUC-Ptr-090982	Pan troglodytes	73.64	0.00e+00	1246.00
IUUC-Pan-091991	Papio anubis	73.87	0.00e+00	1247.00
IUUC-Psi-093509	Pelodiscus sinensis	76.46	0.00e+00	1285.00
IUUC-Pfo-096029	Poecilia formosa	69.83	0.00e+00	1227.00
IUUC-Pab-098672	Pongo abelii	70.03	0.00e+00	1157.00
IUUC-Pca-100860	Procavia capensis	71.75	0.00e+00	735.00
IUUC-Pva-102545	Pteropus vampyrus	72.27	0.00e+00	1037.00
IUUC-Rno-105210	Rattus norvegicus	74.02	0.00e+00	1228.00
IUUC-Sha-106805	Sarcophilus harrisii	79.35	0.00e+00	697.00
IUUC-Sar-113733	Sorex araneus	77.67	0.00e+00	655.00
IUUC-Tgu-116591	Taeniopygia guttata	75.18	0.00e+00	1259.00
IUUC-Tru-118627	Takifugu rubripes	66.78	0.00e+00	1194.00
IUUC-Tsy-119278	Tarsius syrichta	66.58	0.00e+00	1046.00
IUUC-Tni-120804	Tetraodon nigroviridis	69.24	0.00e+00	1227.00
IUUC-Ttr-128295	Tursiops truncatus	68.26	0.00e+00	1126.00
IUUC-Vpa-130170	Vicugna pacos	65.44	0.00e+00	1011.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence