iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cfa-020225

UUCD1 version

UUC-CaF-00743

Ensembl Protein ID

ENSCAFP00000022857.3

UniProt Accession

F1PR93; I6LJ38; F1PR93_CANLF

Genbank Protein ID

ACB55038.1

Protein Name

WD repeat domain 1

Genbank Nucleotide ID

AAEX03002498

Gene Name

WDR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000015524.3	ENSCAFT00000024636.3	ENSCAFP00000022857.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.40e-40	135.1	233	263
UBD/Beta-Prp	1.90e-61	208.1	56	279

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           H ++++++++ +d t+l+s+s+D+t k+WD+
   Q: 233  HDGGIYAISWsPDsTHLLSASGDKTSKIWDV 263
           99*********999****************7 PP

UBD/Beta-Prp

   S: 8    hhksvitcvkfspdksllatgsrdgtikvwdvttgkllrsl..sgheaevtavkfspdgkilvtgseD..rtikvwdlstgkcvhtlkg 92
           +h +++ + k++p++ ++a+g  +g++++wd+t++  l ++  +   ++++++ + +d+k ++ ++e   ++  v+  ++g+ v  ++g
   Q: 56   EHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYeyQPFAGKIKDIAWTEDSKRIAVVGEGreKFGAVFLWDSGSSVGEITG 144
           455566668*************************998777742334567***********99999999887777777789********* PP
   S: 93   hedsvlslsfspsg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl..tgg 178
           h++ + s+++ +s+ ++l++Gs+d+ +  ++ +  +    t   h+++vncv+++pdgn ++++s+D+++ ++d ktg+ +  l   ++
   Q: 145  HNKVINSVDIKQSRpYRLATGSDDNCAAFFEGPPFKFKF-TIGDHNRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALggDKA 232
           ************999*****************9999998.99******************************************99667 PP
   S: 179  htdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnv 225
           h++ +y +s+++++++l+s+s d+t k+wd+  +++v+t++  ++  
   Q: 233  HDGGIYAISWSPDSTHLLSASGDKTSKIWDVNVNSVVNTFTMGSTVL 279
           ***************************************98765444 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MPYEIKKVFA SLPQVERGVS KILGGDPKGN NFLYTNGKCV ILRNIDNPAL ADIYTEHAHQ 60
VVVAKYAPSG FYIASGDVSG KLRIWDTTQK EHLLKYEYQP FAGKIKDIAW TEDSKRIAVV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTGGCTTTC CCTGGAAGTT TTGAGCTGGG AGTTCAGGCC CACCGAGGAG ATCCCCAAAG 60
TTTCCGCTGC CGTCGGATTT TTTAGGGGAA GGGCGATTCC TACACCCAGG TTCTTAAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR011048--Haem_d1
IPR011045--N2O_reductase_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0042643--C:actomyosin, actin portion
GO:0005911--C:cell-cell junction
GO:0030864--C:cortical actin cytoskeleton
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0043209--C:myelin sheath
GO:0051015--F:actin filament binding
GO:0030042--P:actin filament depolymerization
GO:0030043--P:actin filament fragmentation
GO:0043297--P:apical junction assembly
GO:0030865--P:cortical cytoskeleton organization
GO:0042247--P:establishment of planar polarity of follicular epithelium
GO:0040011--P:locomotion
GO:0045199--P:maintenance of epithelial cell apical/basal polarity
GO:0002446--P:neutrophil mediated immunity
GO:1990266--P:neutrophil migration
GO:0030220--P:platelet formation
GO:0030836--P:positive regulation of actin filament depolymerization
GO:0008360--P:regulation of cell shape
GO:0060307--P:regulation of ventricular cardiac muscle cell membrane repolarization
GO:0045214--P:sarcomere organization

KEGG

cfa:611070

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000457	Aegilops tauschii	35.20	2.00e-82	299.00
IUUC-Aml-002368	Ailuropoda melanoleuca	97.50	0.00e+00	1193.00
IUUC-Atr-003160	Amborella trichopoda	36.81	6.00e-114	404.00
IUUC-Apl-004012	Anas platyrhynchos	88.61	0.00e+00	1088.00
IUUC-Aca-004707	Anolis carolinensis	83.66	0.00e+00	1058.00
IUUC-Aly-006465	Arabidopsis lyrata	36.91	7.00e-111	394.00
IUUC-Ath-006740	Arabidopsis thaliana	36.75	4.00e-110	392.00
IUUC-Ago-007920	Ashbya gossypii	28.75	6.00e-75	275.00
IUUC-Acl-008262	Aspergillus clavatus	36.26	4.00e-108	385.00
IUUC-Afl-008471	Aspergillus flavus	33.05	3.00e-79	290.00
IUUC-Afu-008989	Aspergillus fumigatus	38.42	1.00e-97	350.00
IUUC-Ani-009167	Aspergillus nidulans	38.03	5.00e-117	415.00
IUUC-Ang-009595	Aspergillus niger	37.67	2.00e-104	373.00
IUUC-Aor-009908	Aspergillus oryzae	36.64	3.00e-103	369.00
IUUC-Ate-010580	Aspergillus terreus	37.85	6.00e-110	392.00
IUUC-Ame-011269	Astyanax mexicanus	60.75	6.00e-135	474.00
IUUC-Bgr-011996	Blumeria graminis	35.12	1.00e-109	390.00
IUUC-Bta-013278	Bos taurus	95.87	0.00e+00	1213.00
IUUC-Bci-013925	Botrytis cinerea	35.93	3.00e-109	389.00
IUUC-Bdi-014659	Brachypodium distachyon	35.80	7.00e-105	374.00
IUUC-Bol-016043	Brassica oleracea	35.46	3.00e-107	382.00
IUUC-Bra-017139	Brassica rapa	36.16	2.00e-108	386.00
IUUC-Cel-018417	Caenorhabditis elegans	40.89	3.00e-124	439.00
IUUC-Cja-019952	Callithrix jacchus	95.87	0.00e+00	1169.00
IUUC-Cpo-021900	Cavia porcellus	94.01	0.00e+00	1168.00
IUUC-Csa-023028	Chlorocebus sabaeus	96.86	0.00e+00	1176.00
IUUC-Cho-025030	Choloepus hoffmanni	68.17	0.00e+00	755.00
IUUC-Cin-025152	Ciona intestinalis	56.03	3.00e-81	294.00
IUUC-Csv-025986	Ciona savignyi	37.85	4.00e-94	338.00
IUUC-Cgl-026597	Colletotrichum gloeosporioides	38.11	3.00e-112	399.00
IUUC-Cne-026814	Cryptococcus neoformans	34.46	5.00e-98	352.00
IUUC-Dre-027498	Danio rerio	81.03	2.00e-96	343.00
IUUC-Dno-029383	Dasypus novemcinctus	94.88	0.00e+00	1151.00
IUUC-Dor-030633	Dipodomys ordii	93.94	0.00e+00	1088.00
IUUC-Dse-031526	Dothistroma septosporum	38.39	3.00e-117	416.00
IUUC-Dme-031597	Drosophila melanogaster	47.93	3.00e-168	585.00
IUUC-Ete-032780	Echinops telfairi	84.10	0.00e+00	1044.00
IUUC-Eca-034306	Equus caballus	95.67	0.00e+00	1160.00
IUUC-Eeu-034531	Erinaceus europaeus	74.45	3.00e-136	478.00
IUUC-Fca-036301	Felis catus	96.67	0.00e+00	1213.00
IUUC-Fal-037361	Ficedula albicollis	88.26	0.00e+00	1134.00
IUUC-Fox-037924	Fusarium oxysporum	35.14	5.00e-102	365.00
IUUC-Fso-038199	Fusarium solani	34.96	7.00e-99	354.00
IUUC-Gmo-039238	Gadus morhua	72.65	0.00e+00	901.00
IUUC-Ggr-039830	Gaeumannomyces graminis	36.67	4.00e-97	348.00
IUUC-Gga-040235	Gallus gallus	89.27	0.00e+00	1112.00
IUUC-Gac-042363	Gasterosteus aculeatus	72.32	0.00e+00	934.00
IUUC-Gma-044189	Glycine max	36.99	8.00e-113	400.00
IUUC-Ggo-044632	Gorilla gorilla	94.40	0.00e+00	1140.00
IUUC-Hsa-045792	Homo sapiens	96.37	0.00e+00	1193.00
IUUC-Hvu-047517	Hordeum vulgare	35.02	8.00e-109	387.00
IUUC-Itr-048076	Ictidomys tridecemlineatus	96.17	0.00e+00	1177.00
IUUC-Kpa-049183	Komagataella pastoris	32.57	5.00e-85	308.00
IUUC-Lch-050428	Latimeria chalumnae	76.77	0.00e+00	1006.00
IUUC-Lpe-051306	Leersia perrieri	36.11	5.00e-110	391.00
IUUC-Loc-052096	Lepisosteus oculatus	72.08	0.00e+00	903.00
IUUC-Lma-053313	Leptosphaeria maculans	38.95	3.00e-117	418.00
IUUC-Laf-054060	Loxodonta africana	93.07	0.00e+00	1145.00
IUUC-Mcc-055619	Macaca mulatta	94.76	0.00e+00	1148.00
IUUC-Meu-056689	Macropus eugenii	78.39	0.00e+00	634.00
IUUC-Mor-056940	Magnaporthe oryzae	35.01	8.00e-98	351.00
IUUC-Mpo-057557	Magnaporthe poae	28.59	7.00e-59	221.00
IUUC-Mtr-057922	Medicago truncatula	35.68	8.00e-110	390.00
IUUC-Mla-059103	Melampsora laricipopulina	33.80	3.00e-78	286.00
IUUC-Mga-060150	Meleagris gallopavo	88.91	0.00e+00	1100.00
IUUC-Mvi-060448	Microbotryum violaceum	31.67	2.00e-75	276.00
IUUC-Mmr-061226	Microcebus murinus	94.55	0.00e+00	1161.00
IUUC-Mdo-062674	Monodelphis domestica	92.24	0.00e+00	1152.00
IUUC-Mmu-064170	Mus musculus	95.21	0.00e+00	1185.00
IUUC-Mac-065124	Musa acuminata	37.48	6.00e-113	401.00
IUUC-Mpu-066001	Mustela putorius furo	93.64	0.00e+00	1180.00
IUUC-Mlu-067253	Myotis lucifugus	95.51	0.00e+00	1186.00
IUUC-Nfi-068550	Neosartorya fischeri	38.45	6.00e-113	401.00
IUUC-Ncr-068948	Neurospora crassa	36.82	1.00e-116	414.00
IUUC-Nle-070115	Nomascus leucogenys	92.70	0.00e+00	1075.00
IUUC-Opr-070254	Ochotona princeps	93.17	0.00e+00	1106.00
IUUC-Ont-071666	Oreochromis niloticus	75.58	0.00e+00	965.00
IUUC-Oan-073594	Ornithorhynchus anatinus	92.49	1.00e-168	585.00
IUUC-Ocu-074824	Oryctolagus cuniculus	94.06	0.00e+00	1135.00
IUUC-Oba-075010	Oryza barthii	36.50	7.00e-111	394.00
IUUC-Obr-076364	Oryza brachyantha	36.87	7.00e-112	397.00
IUUC-Ogl-077019	Oryza glaberrima	36.50	7.00e-111	394.00
IUUC-Ogu-078496	Oryza glumaepatula	36.50	7.00e-111	394.00
IUUC-Oin-080116	Oryza indica	36.66	2.00e-111	396.00
IUUC-Olo-080290	Oryza longistaminata	36.50	1.00e-110	393.00
IUUC-Ome-081969	Oryza meridionalis	36.50	1.00e-110	394.00
IUUC-Oni-082075	Oryza nivara	36.50	7.00e-111	394.00
IUUC-Opu-083959	Oryza punctata	36.54	6.00e-111	394.00
IUUC-Oru-084711	Oryza rufipogon	36.50	7.00e-111	394.00
IUUC-Osa-085958	Oryza sativa	36.66	2.00e-111	396.00
IUUC-Ola-086968	Oryzias latipes	76.73	0.00e+00	977.00
IUUC-Oga-089108	Otolemur garnettii	95.09	0.00e+00	1210.00
IUUC-Oar-089986	Ovis aries	90.33	0.00e+00	1123.00
IUUC-Ptr-091281	Pan troglodytes	96.50	0.00e+00	1183.00
IUUC-Pan-092585	Papio anubis	97.03	0.00e+00	1179.00
IUUC-Psi-093811	Pelodiscus sinensis	86.88	0.00e+00	1120.00
IUUC-Pma-094542	Petromyzon marinus	70.02	0.00e+00	891.00
IUUC-Pno-095086	Phaeosphaeria nodorum	37.62	1.00e-110	394.00
IUUC-Ppa-095876	Physcomitrella patens	36.44	1.00e-111	397.00
IUUC-Pfo-096973	Poecilia formosa	75.41	0.00e+00	995.00
IUUC-Pab-098391	Pongo abelii	96.53	0.00e+00	1176.00
IUUC-Pop-098850	Populus trichocarpa	36.87	2.00e-112	399.00
IUUC-Pca-100257	Procavia capensis	59.93	4.00e-91	328.00
IUUC-Ppe-101578	Prunus persica	37.42	7.00e-114	404.00
IUUC-Pva-102872	Pteropus vampyrus	90.61	0.00e+00	1139.00
IUUC-Pgr-103593	Puccinia graminis	32.67	6.00e-80	291.00
IUUC-Pte-104365	Pyrenophora teres	39.16	1.00e-112	400.00
IUUC-Pyt-104689	Pyrenophora triticirepentis	38.83	3.00e-115	409.00
IUUC-Rno-105737	Rattus norvegicus	95.71	0.00e+00	1215.00
IUUC-Sce-106383	Saccharomyces cerevisiae	29.84	5.00e-71	262.00
IUUC-Sha-107084	Sarcophilus harrisii	89.84	0.00e+00	1013.00
IUUC-Sja-107688	Schizosaccharomyces japonicus	35.47	3.00e-111	395.00
IUUC-Spo-108309	Schizosaccharomyces pombe	33.33	2.00e-96	346.00
IUUC-Ssl-108408	Sclerotinia sclerotiorum	35.28	2.00e-107	383.00
IUUC-Smo-109255	Selaginella moellendorffii	34.75	1.00e-99	357.00
IUUC-Sit-109962	Setaria italica	37.48	7.00e-113	401.00
IUUC-Sly-110897	Solanum lycopersicum	37.81	1.00e-114	407.00
IUUC-Stu-111971	Solanum tuberosum	37.81	4.00e-114	405.00
IUUC-Sar-113415	Sorex araneus	72.69	7.00e-110	391.00
IUUC-Sbi-114857	Sorghum bicolor	36.93	1.00e-110	393.00
IUUC-Sre-114900	Sporisorium reilianum	33.60	4.00e-91	328.00
IUUC-Tgu-117256	Taeniopygia guttata	88.04	0.00e+00	1126.00
IUUC-Tru-117871	Takifugu rubripes	70.91	0.00e+00	898.00
IUUC-Tsy-119172	Tarsius syrichta	96.67	1.00e-138	486.00
IUUC-Tni-120339	Tetraodon nigroviridis	70.46	0.00e+00	928.00
IUUC-Tca-121609	Theobroma cacao	37.01	4.00e-112	399.00
IUUC-Tre-122076	Trichoderma reesei	35.96	6.00e-96	344.00
IUUC-Tvi-122528	Trichoderma virens	34.80	1.00e-97	350.00
IUUC-Tae-124549	Triticum aestivum	35.62	1.00e-109	390.00
IUUC-Tur-126845	Triticum urartu	35.17	2.00e-81	296.00
IUUC-Tme-127217	Tuber melanosporum	35.47	9.00e-106	377.00
IUUC-Tbe-127526	Tupaia belangeri	92.57	0.00e+00	1153.00
IUUC-Ttr-128898	Tursiops truncatus	87.81	0.00e+00	1098.00
IUUC-Uma-129631	Ustilago maydis	31.97	2.00e-94	339.00
IUUC-Vda-129732	Verticillium dahliae	35.09	1.00e-93	337.00
IUUC-Vvi-131217	Vitis vinifera	37.89	2.00e-112	399.00
IUUC-Xtr-132860	Xenopus tropicalis	73.91	0.00e+00	944.00
IUUC-Xma-133830	Xiphophorus maculatus	75.41	0.00e+00	996.00
IUUC-Yli-134335	Yarrowia lipolytica	33.33	2.00e-77	283.00
IUUC-Zma-135907	Zea mays	36.93	2.00e-111	396.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence