iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000102879.15	ENST00000561815.5	ENSP00000456756.1
ENSG00000102879.15	ENST00000219150.9	ENSP00000219150.5
ENSG00000102879.15	ENST00000565497.5	ENSP00000456457.1
ENSG00000102879.15	ENST00000570244.5	ENSP00000457332.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
miRNAMap	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Variation
ClinVar	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.70e-20	72.8	79	115

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWDlrtgv 34
           gHt++v ++a+   +d+ ++sGs D+t++vW++ +g 
   Q: 79   GHTAPVLDIAWcphNDNVIASGSEDCTVMVWEIPDGG 115
           8***********9877****************98886 PP

Organism

Homo sapiens

Functional Description
(View)

May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.

Protein Sequence
(Fasta)

MSRQVVRSSK FRHVFGQPAK ADQCYEDVRV SQTTWDSGFC AVNPKFVALI CEASGGGAFL 60
VLPLGKTGRV DKNAPTVCGH TAPVLDIAWC PHNDNVIASG SEDCTVMVWE IPDGGLMLPL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTGCTGCCT CCAGAAGCCT CTCTGAATCC AAGGGTGGGA ACTATTCCTC CTTGCCCTCG 60
AGCCTTCGCC AAAGCCAGGG CTTGGAGCGG CCGTGGGCTC CTCCTCCTTC CCCCAGGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0009--Actin-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR029508--CORO1A
IPR015505--Coronin
IPR015048--DUF1899
IPR015049--Trimer_CC
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08953--DUF1899
PF08954--Trimer_CC
PF00400--WD40

SMART

SM01166--DUF1899
SM00320--WD40

Gene Ontology

GO:0005884--C:actin filament
GO:0030424--C:axon
GO:0005911--C:cell-cell junction
GO:0030864--C:cortical actin cytoskeleton
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0070062--C:extracellular exosome
GO:0001772--C:immunological synapse
GO:0030027--C:lamellipodium
GO:0016020--C:membrane
GO:0001891--C:phagocytic cup
GO:0045335--C:phagocytic vesicle
GO:0030670--C:phagocytic vesicle membrane
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0003779--F:actin binding
GO:0051015--F:actin filament binding
GO:0003785--F:actin monomer binding
GO:0008092--F:cytoskeletal protein binding
GO:0032036--F:myosin heavy chain binding
GO:0043548--F:phosphatidylinositol 3-kinase binding
GO:0008022--F:protein C-terminus binding
GO:0042803--F:protein homodimerization activity
GO:0003723--F:RNA binding
GO:0030036--P:actin cytoskeleton organization
GO:0007015--P:actin filament organization
GO:0006816--P:calcium ion transport
GO:0031589--P:cell-substrate adhesion
GO:0071353--P:cellular response to interleukin-4
GO:0061502--P:early endosome to recycling endosome transport
GO:0048873--P:homeostasis of number of cells within a tissue
GO:0045087--P:innate immune response
GO:0030595--P:leukocyte chemotaxis
GO:0006928--P:movement of cell or subcellular component
GO:0043320--P:natural killer cell degranulation
GO:0051126--P:negative regulation of actin nucleation
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0031339--P:negative regulation of vesicle fusion
GO:0038180--P:nerve growth factor signaling pathway
GO:0006909--P:phagocytosis
GO:0001845--P:phagolysosome assembly
GO:0050918--P:positive chemotaxis
GO:0030335--P:positive regulation of cell migration
GO:0042102--P:positive regulation of T cell proliferation
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0008360--P:regulation of cell shape
GO:0051279--P:regulation of release of sequestered calcium ion into cytosol
GO:0043029--P:T cell homeostasis
GO:0032796--P:uropod organization

KEGG

hsa:11151

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002012	Ailuropoda melanoleuca	96.31	0.00e+00	919.00
IUUC-Aca-005048	Anolis carolinensis	66.39	0.00e+00	673.00
IUUC-Ame-011101	Astyanax mexicanus	68.86	0.00e+00	684.00
IUUC-Bta-013168	Bos taurus	95.44	0.00e+00	916.00
IUUC-Cja-019660	Callithrix jacchus	98.05	0.00e+00	936.00
IUUC-Cfa-020938	Canis familiaris	97.18	0.00e+00	927.00
IUUC-Cpo-022056	Cavia porcellus	95.01	0.00e+00	915.00
IUUC-Csa-023193	Chlorocebus sabaeus	99.13	0.00e+00	942.00
IUUC-Cne-026773	Cryptococcus neoformans	38.70	4.00e-86	312.00
IUUC-Dre-028167	Danio rerio	68.42	0.00e+00	674.00
IUUC-Dno-029363	Dasypus novemcinctus	96.53	0.00e+00	921.00
IUUC-Dor-030426	Dipodomys ordii	95.66	0.00e+00	914.00
IUUC-Eca-034229	Equus caballus	96.53	0.00e+00	922.00
IUUC-Eeu-034499	Erinaceus europaeus	94.32	0.00e+00	788.00
IUUC-Fca-036472	Felis catus	95.44	0.00e+00	914.00
IUUC-Gmo-039519	Gadus morhua	66.30	0.00e+00	655.00
IUUC-Ggo-045162	Gorilla gorilla	100.00	0.00e+00	951.00
IUUC-Itr-048911	Ictidomys tridecemlineatus	96.31	0.00e+00	925.00
IUUC-Lch-050582	Latimeria chalumnae	66.74	0.00e+00	689.00
IUUC-Laf-053427	Loxodonta africana	96.53	0.00e+00	915.00
IUUC-Mcc-055750	Macaca mulatta	99.06	0.00e+00	875.00
IUUC-Meu-056083	Macropus eugenii	88.07	0.00e+00	848.00
IUUC-Mmr-060858	Microcebus murinus	97.18	0.00e+00	929.00
IUUC-Mdo-062469	Monodelphis domestica	89.96	0.00e+00	856.00
IUUC-Mmu-063583	Mus musculus	94.58	0.00e+00	910.00
IUUC-Mpu-066451	Mustela putorius furo	96.15	0.00e+00	886.00
IUUC-Mlu-066978	Myotis lucifugus	95.44	0.00e+00	915.00
IUUC-Nle-069815	Nomascus leucogenys	99.35	0.00e+00	943.00
IUUC-Opr-070911	Ochotona princeps	93.28	0.00e+00	890.00
IUUC-Ont-072391	Oreochromis niloticus	68.40	0.00e+00	682.00
IUUC-Ocu-074429	Oryctolagus cuniculus	85.03	0.00e+00	783.00
IUUC-Oga-089072	Otolemur garnettii	94.82	0.00e+00	908.00
IUUC-Oar-089676	Ovis aries	95.66	0.00e+00	919.00
IUUC-Ptr-091647	Pan troglodytes	99.78	0.00e+00	949.00
IUUC-Pan-092672	Papio anubis	99.13	0.00e+00	942.00
IUUC-Pab-098348	Pongo abelii	94.14	0.00e+00	877.00
IUUC-Pva-102668	Pteropus vampyrus	95.44	0.00e+00	914.00
IUUC-Rno-105604	Rattus norvegicus	93.93	0.00e+00	902.00
IUUC-Sha-107210	Sarcophilus harrisii	89.37	0.00e+00	873.00
IUUC-Sar-113292	Sorex araneus	95.95	0.00e+00	736.00
IUUC-Sre-114911	Sporisorium reilianum	39.37	2.00e-79	290.00
IUUC-Tme-126924	Tuber melanosporum	41.85	2.00e-93	336.00
IUUC-Tbe-128025	Tupaia belangeri	94.42	5.00e-150	523.00
IUUC-Ttr-128689	Tursiops truncatus	95.66	0.00e+00	917.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence