iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033900

UUCD1 version

UUC-EqC-00117

Ensembl Protein ID

ENSECAP00000003427.1

UniProt Accession

F6RJK1; F6RJK1_HORSE

Protein Name

Uncharacterized protein

Gene Name

CBL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000003448.1	ENSECAT00000004914.1	ENSECAP00000003427.1
ENSECAG00000003448.1	ENSECAT00000005112.1	ENSECAP00000003581.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.20e-07	31.4	317	356

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e  kd +++ pCgH+++++Cl  w    + +s  + CP Cr
   Q: 317  CKICAENDKD-VKIEPCGHLMCTSCLTSW----Q-ESEGQGCPFCR 356
           99********.******************....5.555555****8 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

QVVRLCQNPK LALKNSPPYI LDLLPDTYQH LRTILSRYEG KMETLGENEY FRVFMENLMK 60
KTKQTISLFK EGKERMYEEN SQPRRNLTKL SLIFSHMLAE LKGIFPSGLF QGDTFRITKA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGTGGTGC GGTTGTGTCA GAACCCAAAG CTGGCGCTAA AGAATAGCCC ACCTTATATC 60
TTAGACCTGC TGCCAGATAC CTACCAGCAT CTCCGTACTA TCTTGTCAAG ATATGAGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR015940--UBA
IPR009060--UBA-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS50030--UBA
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3
PF00627--UBA

SMART

SM00184--RING
SM00165--UBA

Gene Ontology

GO:0005829--C:cytosol
GO:0016600--C:flotillin complex
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005509--F:calcium ion binding
GO:0030971--F:receptor tyrosine kinase binding
GO:0017124--F:SH3 domain binding
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0043066--P:negative regulation of apoptotic process
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0048260--P:positive regulation of receptor-mediated endocytosis
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006508--P:proteolysis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002357	Ailuropoda melanoleuca	93.78	0.00e+00	1502.00
IUUC-Apl-004041	Anas platyrhynchos	85.66	0.00e+00	1391.00
IUUC-Aca-004899	Anolis carolinensis	82.35	0.00e+00	1270.00
IUUC-Ame-010746	Astyanax mexicanus	57.37	2.00e-174	605.00
IUUC-Bta-012759	Bos taurus	94.04	0.00e+00	1511.00
IUUC-Cja-019207	Callithrix jacchus	93.54	0.00e+00	1491.00
IUUC-Cfa-020897	Canis familiaris	93.68	0.00e+00	1484.00
IUUC-Cpo-021453	Cavia porcellus	92.74	0.00e+00	1518.00
IUUC-Csa-023136	Chlorocebus sabaeus	93.31	0.00e+00	1483.00
IUUC-Cho-024282	Choloepus hoffmanni	84.99	0.00e+00	1218.00
IUUC-Csv-025938	Ciona savignyi	69.74	8.00e-167	579.00
IUUC-Dre-027644	Danio rerio	68.04	0.00e+00	986.00
IUUC-Dno-030025	Dasypus novemcinctus	94.50	0.00e+00	1486.00
IUUC-Ete-033118	Echinops telfairi	80.20	0.00e+00	797.00
IUUC-Eeu-035142	Erinaceus europaeus	87.97	0.00e+00	947.00
IUUC-Fca-035455	Felis catus	94.04	0.00e+00	1476.00
IUUC-Fal-037182	Ficedula albicollis	97.09	0.00e+00	874.00
IUUC-Gmo-038698	Gadus morhua	87.29	0.00e+00	841.00
IUUC-Gga-040438	Gallus gallus	85.66	0.00e+00	1379.00
IUUC-Gac-042166	Gasterosteus aculeatus	78.08	0.00e+00	833.00
IUUC-Ggo-045618	Gorilla gorilla	94.37	0.00e+00	1503.00
IUUC-Hsa-046177	Homo sapiens	93.54	0.00e+00	1490.00
IUUC-Itr-048795	Ictidomys tridecemlineatus	96.29	0.00e+00	989.00
IUUC-Lch-050095	Latimeria chalumnae	74.48	0.00e+00	1126.00
IUUC-Loc-052570	Lepisosteus oculatus	71.05	0.00e+00	1077.00
IUUC-Laf-054008	Loxodonta africana	91.43	0.00e+00	1464.00
IUUC-Mcc-054676	Macaca mulatta	93.19	0.00e+00	1481.00
IUUC-Mga-059239	Meleagris gallopavo	84.97	0.00e+00	1377.00
IUUC-Mmr-060907	Microcebus murinus	91.25	0.00e+00	1447.00
IUUC-Mdo-062595	Monodelphis domestica	89.61	0.00e+00	1417.00
IUUC-Mmu-063725	Mus musculus	93.09	0.00e+00	1523.00
IUUC-Mpu-066771	Mustela putorius furo	92.61	0.00e+00	1487.00
IUUC-Mlu-067206	Myotis lucifugus	77.34	0.00e+00	1100.00
IUUC-Nle-069285	Nomascus leucogenys	91.11	0.00e+00	1391.00
IUUC-Opr-071026	Ochotona princeps	92.61	0.00e+00	1471.00
IUUC-Ont-071954	Oreochromis niloticus	68.80	0.00e+00	999.00
IUUC-Ocu-074657	Oryctolagus cuniculus	93.19	0.00e+00	1464.00
IUUC-Ola-087165	Oryzias latipes	67.19	0.00e+00	1006.00
IUUC-Oga-088198	Otolemur garnettii	81.37	0.00e+00	1244.00
IUUC-Oar-090258	Ovis aries	94.26	0.00e+00	1509.00
IUUC-Ptr-090710	Pan troglodytes	93.54	0.00e+00	1490.00
IUUC-Pan-092785	Papio anubis	93.19	0.00e+00	1480.00
IUUC-Psi-093431	Pelodiscus sinensis	75.96	0.00e+00	715.00
IUUC-Pfo-096990	Poecilia formosa	90.02	0.00e+00	786.00
IUUC-Pab-098526	Pongo abelii	94.01	0.00e+00	1487.00
IUUC-Pca-100984	Procavia capensis	76.97	1.00e-156	546.00
IUUC-Pva-102352	Pteropus vampyrus	98.79	0.00e+00	845.00
IUUC-Rno-105876	Rattus norvegicus	92.26	0.00e+00	1496.00
IUUC-Sha-107588	Sarcophilus harrisii	87.53	0.00e+00	1234.00
IUUC-Sar-112959	Sorex araneus	88.95	0.00e+00	1416.00
IUUC-Ssc-115261	Sus scrofa	94.61	0.00e+00	1503.00
IUUC-Tgu-116580	Taeniopygia guttata	82.89	0.00e+00	1298.00
IUUC-Tru-118731	Takifugu rubripes	67.04	0.00e+00	985.00
IUUC-Tsy-118982	Tarsius syrichta	85.78	0.00e+00	1023.00
IUUC-Tni-120725	Tetraodon nigroviridis	67.82	0.00e+00	998.00
IUUC-Tbe-128018	Tupaia belangeri	96.08	0.00e+00	1143.00
IUUC-Ttr-128927	Tursiops truncatus	94.96	0.00e+00	1530.00
IUUC-Vpa-130369	Vicugna pacos	93.66	0.00e+00	1461.00
IUUC-Xtr-132474	Xenopus tropicalis	74.30	0.00e+00	1107.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence