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Tag Content
iUUCD ID IUUC-Bta-012922
Ensembl Protein ID ENSBTAP00000002506.3
UniProt Accession Q29RK4; RD23B_BOVIN
Genbank Protein ID AAI14134.1
Protein Name UV excision repair protein RAD23 homolog B
Genbank Nucleotide ID BC114133
Gene Name RAD23B
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000001926.3 ENSBTAT00000002506.3 ENSBTAP00000002506.3
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/Alpha-Helix/UBA 2.60e-19 68.9 190 227
ULD/UDP/UBQ/UBQ_PIM 1.40e-26 92.3 1 78
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLld 40
    +e ++ ++++MG++re+++ aLra++nn+++AveyLl
   Q: 190 YENMVTEIMSMGYEREQVIAALRASFNNPDRAVEYLLM 227
    5789********************************95 PP
   


   ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesg...vppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkksk 75
    m +t+ktl++++f++++++d+tv +lKeki++e+g +p++ qkLIyaGkiL+Ddt L+e++i+++++v+++v+k+k
   Q: 1 MLVTLKTLQQQTFKIDIDPDETVRALKEKIESEKGkdaFPVAGQKLIYAGKILNDDTALKEYKIDEKNFVVVMVTKPK 78
    789************************************************************************997 PP
   

Organism Bos taurus
Functional Description
(View)

Functional Description



     The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1 (By similarity).
The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1 (By similarity).
Protein Sequence
(Fasta)
MLVTLKTLQQ QTFKIDIDPD ETVRALKEKI ESEKGKDAFP VAGQKLIYAG KILNDDTALK 60
EYKIDEKNFV VVMVTKPKAV TTPAPATTQQ SNSAATTTVS SSTAPAVTQA PAPAPASAPT 120
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Protein Fasta Sequence



>IUUC-Bta-012922|UBD,UBA;ULD,UBQ_PIM|Bos taurus
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Nucleotide Sequence
(Fasta)
AGGGCGCGTC TCGGCGAGTC ACGATGATGG CGGCCACCAG CCTGTGGTGA GCTAGCGGAT 60
TCTCTGCTGC TTTCGCAGAG CCCCTCGCGC TTCCGACAGA CCCACTGGCT GGTAACCGGG 120
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Nucleotide Fasta Sequence



>IUUC-Bta-012922|UBD,UBA;ULD,UBQ_PIM|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR004806--Rad23
IPR006636--STI1_HS-bd
IPR015940--UBA
IPR009060--UBA-like
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR015360--XPC-bd

PROSITE

PS50030--UBA
PS50053--UBIQUITIN_2

Pfam

PF00627--UBA
PF00240--ubiquitin
PF09280--XPC-binding

PRINTS

PR01839--RAD23PROTEIN

SMART

SM00727--STI1
SM00165--UBA
SM00213--UBQ

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0000502--C:proteasome complex
GO:0071942--C:XPC complex
GO:0003684--F:damaged DNA binding
GO:0000715--P:nucleotide-excision repair, DNA damage recognition
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0032434--P:regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0007283--P:spermatogenesis

KEGG bta:530189
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000770 Aegilops tauschii 35.74 8.00e-32 131.00
IUUC-Aml-001195 Ailuropoda melanoleuca 96.19 4.00e-89 321.00
IUUC-Atr-003116 Amborella trichopoda 37.90 2.00e-31 129.00
IUUC-Apl-003371 Anas platyrhynchos 85.29 7.00e-89 320.00
IUUC-Aca-004599 Anolis carolinensis 73.94 6.00e-125 440.00
IUUC-Aly-006159 Arabidopsis lyrata 33.95 1.00e-54 206.00
IUUC-Afu-008877 Aspergillus fumigatus 45.52 1.00e-18 87.40
IUUC-Ate-010458 Aspergillus terreus 40.73 1.00e-30 127.00
IUUC-Bci-013933 Botrytis cinerea 36.09 2.00e-21 96.70
IUUC-Bdi-014253 Brachypodium distachyon 35.74 7.00e-34 137.00
IUUC-Bol-015354 Brassica oleracea 36.40 3.00e-37 149.00
IUUC-Bra-017582 Brassica rapa 36.03 5.00e-37 148.00
IUUC-Cja-018772 Callithrix jacchus 92.18 2.00e-138 485.00
IUUC-Cfa-020683 Canis familiaris 84.07 3.00e-129 454.00
IUUC-Cpo-022145 Cavia porcellus 87.04 2.00e-126 445.00
IUUC-Cre-022810 Chlamydomonas reinhardtii 37.96 4.00e-30 125.00
IUUC-Csa-023714 Chlorocebus sabaeus 92.67 6.00e-147 513.00
IUUC-Cho-024814 Choloepus hoffmanni 59.41 3.00e-90 325.00
IUUC-Cin-025741 Ciona intestinalis 40.55 2.00e-33 135.00
IUUC-Csv-025823 Ciona savignyi 39.42 2.00e-41 162.00
IUUC-Cne-027056 Cryptococcus neoformans 48.68 3.00e-15 75.90
IUUC-Dre-028369 Danio rerio 71.60 6.00e-82 297.00
IUUC-Dno-029543 Dasypus novemcinctus 88.26 4.00e-136 477.00
IUUC-Dse-031336 Dothistroma septosporum 48.84 2.00e-17 83.20
IUUC-Ete-032583 Echinops telfairi 81.28 5.00e-65 241.00
IUUC-Eca-034243 Equus caballus 99.57 3.00e-99 355.00
IUUC-Eeu-034721 Erinaceus europaeus 89.57 3.00e-70 258.00
IUUC-Fca-035679 Felis catus 94.36 2.00e-137 481.00
IUUC-Fal-037148 Ficedula albicollis 73.28 3.00e-111 395.00
IUUC-Fox-037960 Fusarium oxysporum 43.28 7.00e-16 78.20
IUUC-Gmo-039080 Gadus morhua 62.50 1.00e-60 226.00
IUUC-Ggr-040116 Gaeumannomyces graminis 44.78 3.00e-16 79.30
IUUC-Gga-040544 Gallus gallus 73.40 9.00e-115 406.00
IUUC-Gma-043937 Glycine max 35.74 7.00e-39 154.00
IUUC-Ggo-045125 Gorilla gorilla 98.31 1.00e-95 343.00
IUUC-Hsa-046519 Homo sapiens 98.31 1.00e-95 343.00
IUUC-Hvu-047832 Hordeum vulgare 36.14 5.00e-34 138.00
IUUC-Itr-048295 Ictidomys tridecemlineatus 90.22 1.00e-126 446.00
IUUC-Kpa-049314 Komagataella pastoris 36.67 6.00e-31 127.00
IUUC-Lch-050553 Latimeria chalumnae 65.66 1.00e-91 330.00
IUUC-Lpe-050801 Leersia perrieri 35.10 5.00e-34 138.00
IUUC-Loc-051748 Lepisosteus oculatus 74.89 2.00e-75 276.00
IUUC-Lma-053328 Leptosphaeria maculans 47.37 4.00e-13 65.50
IUUC-Laf-054293 Loxodonta africana 93.54 8.00e-122 430.00
IUUC-Mcc-055600 Macaca mulatta 96.99 2.00e-101 362.00
IUUC-Meu-056082 Macropus eugenii 66.18 4.00e-68 251.00
IUUC-Mor-057287 Magnaporthe oryzae 50.00 9.00e-16 77.80
IUUC-Mpo-057609 Magnaporthe poae 44.96 1.00e-15 76.60
IUUC-Mla-058961 Melampsora laricipopulina 47.37 8.00e-26 111.00
IUUC-Mga-060060 Meleagris gallopavo 49.02 2.00e-15 76.30
IUUC-Mvi-060220 Microbotryum violaceum 43.61 2.00e-21 96.70
IUUC-Mmr-061159 Microcebus murinus 95.80 2.00e-94 338.00
IUUC-Mdo-061967 Monodelphis domestica 83.01 9.00e-119 419.00
IUUC-Mmu-063258 Mus musculus 85.82 2.00e-137 482.00
IUUC-Mac-064468 Musa acuminata 34.66 2.00e-49 189.00
IUUC-Mpu-066389 Mustela putorius furo 96.61 2.00e-89 322.00
IUUC-Mlu-067999 Myotis lucifugus 90.98 1.00e-123 436.00
IUUC-Nfi-068390 Neosartorya fischeri 45.52 1.00e-18 87.40
IUUC-Ncr-068685 Neurospora crassa 44.78 3.00e-24 106.00
IUUC-Nle-069655 Nomascus leucogenys 92.67 4.00e-141 494.00
IUUC-Opr-070234 Ochotona princeps 87.65 8.00e-29 120.00
IUUC-Ont-072484 Oreochromis niloticus 57.73 1.00e-104 373.00
IUUC-Oan-073258 Ornithorhynchus anatinus 90.61 7.00e-52 196.00
IUUC-Ocu-074831 Oryctolagus cuniculus 82.20 3.00e-130 457.00
IUUC-Ola-086540 Oryzias latipes 64.37 3.00e-64 238.00
IUUC-Olu-087843 Ostreococcus lucimarinus 41.92 2.00e-38 152.00
IUUC-Oga-088023 Otolemur garnettii 87.17 2.00e-136 478.00
IUUC-Oar-089964 Ovis aries 97.15 4.00e-123 434.00
IUUC-Ptr-091165 Pan troglodytes 98.31 2.00e-95 342.00
IUUC-Pan-092009 Papio anubis 91.99 6.00e-140 490.00
IUUC-Psi-093477 Pelodiscus sinensis 83.70 6.00e-82 297.00
IUUC-Ppa-095654 Physcomitrella patens 38.06 4.00e-36 145.00
IUUC-Pfo-097385 Poecilia formosa 59.86 3.00e-102 365.00
IUUC-Pab-097868 Pongo abelii 98.31 7.00e-95 340.00
IUUC-Pca-100652 Procavia capensis 95.50 5.00e-70 258.00
IUUC-Pva-102137 Pteropus vampyrus 99.58 6.00e-101 360.00
IUUC-Ptt-103717 Puccinia triticina 45.86 4.00e-25 108.00
IUUC-Pte-104303 Pyrenophora teres 50.00 5.00e-20 92.00
IUUC-Pyt-104580 Pyrenophora triticirepentis 50.00 6.00e-20 91.70
IUUC-Rno-104844 Rattus norvegicus 87.47 1.00e-139 489.00
IUUC-Sce-106214 Saccharomyces cerevisiae 32.84 7.00e-13 68.20
IUUC-Sha-107073 Sarcophilus harrisii 83.85 1.00e-107 382.00
IUUC-Spo-108298 Schizosaccharomyces pombe 41.87 3.00e-38 152.00
IUUC-Ssl-108382 Sclerotinia sclerotiorum 43.75 3.00e-17 82.40
IUUC-Sar-112925 Sorex araneus 88.72 2.00e-87 316.00
IUUC-Sbi-113871 Sorghum bicolor 34.40 7.00e-33 134.00
IUUC-Sre-114894 Sporisorium reilianum 51.61 3.00e-11 62.80
IUUC-Ssc-116329 Sus scrofa 95.59 3.00e-140 491.00
IUUC-Tgu-116918 Taeniopygia guttata 76.59 4.00e-123 434.00
IUUC-Tsy-118836 Tarsius syrichta 98.53 9.00e-49 187.00
IUUC-Tvi-122617 Trichoderma virens 52.56 9.00e-18 84.30
IUUC-Tae-124646 Triticum aestivum 35.74 2.00e-32 133.00
IUUC-Tur-126610 Triticum urartu 35.74 2.00e-32 134.00
IUUC-Tbe-127493 Tupaia belangeri 79.63 2.00e-69 256.00
IUUC-Ttr-128464 Tursiops truncatus 97.74 4.00e-105 374.00
IUUC-Uma-129484 Ustilago maydis 47.54 9.00e-12 64.70
IUUC-Vpa-130357 Vicugna pacos 90.83 6.00e-89 320.00
IUUC-Vvi-130842 Vitis vinifera 37.30 1.00e-37 150.00
IUUC-Xtr-132679 Xenopus tropicalis 80.50 8.00e-67 247.00
IUUC-Xma-133503 Xiphophorus maculatus 53.95 8.00e-103 367.00
IUUC-Yli-134615 Yarrowia lipolytica 43.26 3.00e-38 152.00
IUUC-Zma-135929 Zea mays 32.70 7.00e-51 194.00
Created Date 25-Jun-2017

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