iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-098605

UUCD1 version

UUC-PoA-00930

Ensembl Protein ID

ENSPPYP00000008101.2

UniProt Accession

Q5R9G1; DCNL3_PONAB

Genbank Protein ID

CAH90180.1; CAH91599.1

Protein Name

DCN1-like protein 3; DCUN1 domain-containing protein 3; Defective in cullin neddylation protein 1-like protein 3

Genbank Nucleotide ID

CR857932; CR859427

Gene Name

DCUN1D3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000007164.2	ENSPPYT00000008436.2	ENSPPYP00000008101.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/DCUN1	9.80e-85	283.5	87	278

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/DCUN1

   S: 2    skkkleelferYkdpqedligieglekfcedlgvdpediavLvlawkleaatlcefsreefldgltalgcdsieklqeklktleselkd 90
           s ++leelf+rYkd++ed+i++eg+e+fc+dl+vdp++++vL+lawk++aat+c+f+r+ef+dg++a+++dsi+++++++++l +e+k+
   Q: 87   SLQRLEELFRRYKDEREDAILEEGMERFCNDLCVDPTEFRVLLLAWKFQAATMCKFTRKEFFDGCKAISADSIDGICARFPSLLTEAKQ 175
           679************************************************************************************** PP
   S: 91   eqkfkdiYrfafnfakd..kgqksldldtaialwkLllaerefklldawlkfLeee..kkksiskDtWnllLefskviakdlsnYdeeg 175
           e+kfkd+Yrf+f+f++d  +gq+sl++++aialwkL+++++++++ld+wl+fL+e+  ++k+is+DtWn++L+f++vi +dlsnY+e++
   Q: 176  EDKFKDLYRFTFQFGLDseEGQRSLHREIAIALWKLVFTQNNPPVLDQWLNFLTENpsGIKGISRDTWNMFLNFTQVIGPDLSNYSEDE 264
           ***************998899**********************************9889****************************** PP
   S: 176  aWPvliDefveylk 189
           aWP+l+D+fve+++
   Q: 265  AWPSLFDTFVEWEM 278
           ************85 PP

Organism

Pongo abelii

Functional Description
(View)

Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane.

Protein Sequence
(Fasta)

MGQCVTKCKN PSSTLGSKNG DRDPSNKSHS RRGAGHREEQ VPPCGKPGGD ILVNGTKKAE 60
AATEACQLPT SSGDAGRESK SNAEESSLQR LEELFRRYKD EREDAILEEG MERFCNDLCV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGTTGGCAA GACAGATTTC GTCTGGAATA TTTCTGTCAA ACTGCAGTCT TTGATGCATT 60
CTACATATGA ATCAGCCTCT TTGAAATCTA TGTTACCTTA AGAATTTTAG GAATTTCCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0519--Myristate
KW-1185--Reference proteome

Interpro

IPR014764--DCN-prot
IPR005176--PONY_dom

PROSITE

PS51229--DCUN1

Pfam

PF03556--Cullin_binding

Gene Ontology

GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0030308--P:negative regulation of cell growth
GO:0043065--P:positive regulation of apoptotic process
GO:0010332--P:response to gamma radiation
GO:0010225--P:response to UV-C

KEGG

pon:100172877

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001689	Ailuropoda melanoleuca	97.37	1.00e-166	578.00
IUUC-Apl-003497	Anas platyrhynchos	82.24	4.00e-143	500.00
IUUC-Aca-004961	Anolis carolinensis	80.26	4.00e-146	510.00
IUUC-Ani-009241	Aspergillus nidulans	34.98	3.00e-23	102.00
IUUC-Aor-009902	Aspergillus oryzae	33.83	2.00e-11	60.80
IUUC-Ame-011413	Astyanax mexicanus	63.60	3.00e-100	357.00
IUUC-Bta-013338	Bos taurus	97.37	2.00e-167	580.00
IUUC-Cja-019458	Callithrix jacchus	99.67	7.00e-172	595.00
IUUC-Cfa-020160	Canis familiaris	97.70	3.00e-167	580.00
IUUC-Cpo-021835	Cavia porcellus	98.36	2.00e-159	554.00
IUUC-Csa-023328	Chlorocebus sabaeus	100.00	2.00e-172	597.00
IUUC-Cho-024888	Choloepus hoffmanni	95.70	3.00e-165	573.00
IUUC-Cin-025134	Ciona intestinalis	52.24	4.00e-60	224.00
IUUC-Csv-025904	Ciona savignyi	50.41	2.00e-32	130.00
IUUC-Dre-027780	Danio rerio	64.39	2.00e-97	348.00
IUUC-Dno-028866	Dasypus novemcinctus	97.37	7.00e-166	575.00
IUUC-Dor-030387	Dipodomys ordii	97.70	5.00e-168	583.00
IUUC-Dme-032081	Drosophila melanogaster	45.61	2.00e-48	186.00
IUUC-Eca-033857	Equus caballus	97.37	8.00e-168	582.00
IUUC-Eeu-034825	Erinaceus europaeus	89.47	5.00e-151	526.00
IUUC-Fca-036130	Felis catus	98.03	2.00e-168	584.00
IUUC-Fal-037296	Ficedula albicollis	82.24	8.00e-142	496.00
IUUC-Gmo-039626	Gadus morhua	64.41	3.00e-98	350.00
IUUC-Ggr-039959	Gaeumannomyces graminis	26.64	3.00e-15	76.60
IUUC-Gga-040741	Gallus gallus	81.58	8.00e-140	489.00
IUUC-Gac-042271	Gasterosteus aculeatus	66.91	2.00e-92	332.00
IUUC-Ggo-044727	Gorilla gorilla	100.00	2.00e-172	597.00
IUUC-Hsa-046288	Homo sapiens	99.67	5.00e-172	596.00
IUUC-Itr-049054	Ictidomys tridecemlineatus	98.68	2.00e-179	620.00
IUUC-Lch-050289	Latimeria chalumnae	77.89	1.00e-132	466.00
IUUC-Loc-052455	Lepisosteus oculatus	71.94	2.00e-108	384.00
IUUC-Laf-054369	Loxodonta africana	95.72	3.00e-158	550.00
IUUC-Mcc-055413	Macaca mulatta	79.87	4.00e-124	437.00
IUUC-Meu-056535	Macropus eugenii	86.84	1.00e-152	532.00
IUUC-Mga-059290	Meleagris gallopavo	82.24	8.00e-142	496.00
IUUC-Mmr-060689	Microcebus murinus	99.34	3.00e-171	593.00
IUUC-Mdo-062128	Monodelphis domestica	87.17	1.00e-147	515.00
IUUC-Mmu-064396	Mus musculus	98.03	4.00e-178	616.00
IUUC-Mpu-065926	Mustela putorius furo	97.37	1.00e-166	578.00
IUUC-Mlu-067044	Myotis lucifugus	95.39	4.00e-173	600.00
IUUC-Nle-069346	Nomascus leucogenys	100.00	2.00e-172	597.00
IUUC-Opr-070682	Ochotona princeps	98.68	6.00e-158	549.00
IUUC-Ont-071772	Oreochromis niloticus	68.10	5.00e-101	360.00
IUUC-Oan-072765	Ornithorhynchus anatinus	83.88	4.00e-145	506.00
IUUC-Ocu-074272	Oryctolagus cuniculus	92.74	1.00e-119	421.00
IUUC-Ola-087561	Oryzias latipes	69.10	2.00e-107	381.00
IUUC-Oga-088440	Otolemur garnettii	79.05	1.00e-125	442.00
IUUC-Oar-089403	Ovis aries	97.70	3.00e-168	583.00
IUUC-Ptr-091384	Pan troglodytes	100.00	2.00e-172	597.00
IUUC-Pan-092650	Papio anubis	100.00	2.00e-172	597.00
IUUC-Psi-093806	Pelodiscus sinensis	82.89	9.00e-135	472.00
IUUC-Pma-094196	Petromyzon marinus	51.57	9.00e-88	316.00
IUUC-Pfo-096584	Poecilia formosa	69.64	5.00e-105	374.00
IUUC-Pca-100933	Procavia capensis	79.61	2.00e-116	411.00
IUUC-Pva-102172	Pteropus vampyrus	92.83	8.00e-162	562.00
IUUC-Rno-105406	Rattus norvegicus	98.36	6.00e-179	619.00
IUUC-Sha-106531	Sarcophilus harrisii	86.51	5.00e-153	533.00
IUUC-Sar-113051	Sorex araneus	77.30	8.00e-118	416.00
IUUC-Ssc-115555	Sus scrofa	97.70	3.00e-168	583.00
IUUC-Tgu-117178	Taeniopygia guttata	82.57	1.00e-143	501.00
IUUC-Tru-117876	Takifugu rubripes	67.13	3.00e-105	374.00
IUUC-Tsy-118790	Tarsius syrichta	97.05	7.00e-137	479.00
IUUC-Tni-119673	Tetraodon nigroviridis	66.23	3.00e-107	380.00
IUUC-Tbe-127429	Tupaia belangeri	99.01	3.00e-171	593.00
IUUC-Ttr-128467	Tursiops truncatus	98.03	6.00e-169	585.00
IUUC-Vpa-130376	Vicugna pacos	68.00	5.00e-97	347.00
IUUC-Xtr-132134	Xenopus tropicalis	78.91	7.00e-123	432.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence