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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-106102
Ensembl Protein ID ENSRNOP00000049322.4
UniProt Accession Q9WU70; Q9WU71; Q9Z152; STXB5_RAT
Genbank Protein ID AAD04756.1; AAD27818.1; AAD27819.1
Protein Name Syntaxin-binding protein 5; Lethal(2) giant larvae protein homolog 3; Tomosyn-1
Genbank Nucleotide ID U92072; AF118889; AF118890
Gene Name Stxbp5; Llgl3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000013351.8 ENSRNOT00000049699.6 ENSRNOP00000049322.4
ENSRNOG00000013351.8 ENSRNOT00000040559.5 ENSRNOP00000044738.3
ENSRNOG00000013351.8 ENSRNOT00000044778.4 ENSRNOP00000039502.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
TRANSFACRAID2
Protein-protein Interaction
IIDMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.60e-13 50.7 240 272
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 5    svtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
            ++++a+ ++ + ++++  Dgt+ +W++r+ ++
   Q: 240  AIHSVAWhHEgKQFICSHSDGTLTIWNVRSPTK 272
           69*****977799***************99776 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane (By similarity). Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Competes with STXBP1 for STX1 binding.
 Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane (By similarity). Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Competes with STXBP1 for STX1 binding.
Protein Sequence
(Fasta)
MRKFNIRKVL DGLTAGSSSA SQQQQQQQHP PGNREPEIQE TLQSEHFQLC KTVRHGFPYQ 60
PSALAFDPVQ KILAVGTQTG ALRLFGRPGV ECYCQHDSGA AVIQLQFLIN EGALVSALAD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-106102|E3,WD_repeat|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCCGGGCGGC TGCGCTGAGC AGAGGCCGAG CCCGGGACGC GCCGAGGGAC TGCGGGGCTG 60
CGGGTCATGG ATGCGGCGGC AGCGGCGCGG GACGGCGGGA GCCCGGCCGC GACCAGGTGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-106102|E3,WD_repeat|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0903--Direct protein sequencing
KW-0268--Exocytosis
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0770--Synapse
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR000664--Lethal2_giant
IPR013905--Lgl_C_dom
IPR013577--LLGL2
IPR001388--Synaptobrevin
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50892--V_SNARE
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF08596--Lgl_C
PF08366--LLGL
PF00400--WD40
PRINTS

PR00962--LETHAL2GIANT
SMART

SM00320--WD40
Gene Ontology

GO:0030054--C:cell junction
GO:0030659--C:cytoplasmic vesicle membrane
GO:0005829--C:cytosol
GO:0016021--C:integral component of membrane
GO:0005886--C:plasma membrane
GO:0030141--C:secretory granule
GO:0008021--C:synaptic vesicle
GO:0005096--F:GTPase activator activity
GO:0017137--F:Rab GTPase binding
GO:0017075--F:syntaxin-1 binding
GO:0006887--P:exocytosis
GO:0045921--P:positive regulation of exocytosis
GO:0015031--P:protein transport
GO:0030193--P:regulation of blood coagulation
GO:0010468--P:regulation of gene expression
GO:0050708--P:regulation of protein secretion
KEGG rno:81022
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000919 Aegilops tauschii 21.47 1.00e-18 89.40
IUUC-Aml-001923 Ailuropoda melanoleuca 96.27 0.00e+00 2120.00
IUUC-Atr-002583 Amborella trichopoda 22.12 2.00e-18 88.20
IUUC-Aca-004796 Anolis carolinensis 88.99 0.00e+00 2004.00
IUUC-Aly-005770 Arabidopsis lyrata 23.38 6.00e-22 100.00
IUUC-Ath-007643 Arabidopsis thaliana 22.85 3.00e-20 94.40
IUUC-Ago-007756 Ashbya gossypii 23.39 7.00e-19 89.70
IUUC-Acl-008044 Aspergillus clavatus 20.52 1.00e-11 65.90
IUUC-Afl-008612 Aspergillus flavus 22.27 2.00e-13 71.60
IUUC-Afu-008901 Aspergillus fumigatus 22.24 5.00e-13 70.50
IUUC-Ani-009223 Aspergillus nidulans 21.40 1.00e-14 75.50
IUUC-Ang-009861 Aspergillus niger 22.31 2.00e-14 74.70
IUUC-Aor-010078 Aspergillus oryzae 22.27 2.00e-13 71.60
IUUC-Ate-010462 Aspergillus terreus 21.41 1.00e-14 75.90
IUUC-Ame-010663 Astyanax mexicanus 78.38 0.00e+00 1754.00
IUUC-Bgr-012214 Blumeria graminis 22.76 4.00e-08 53.90
IUUC-Bta-013413 Bos taurus 96.18 0.00e+00 2146.00
IUUC-Bci-013698 Botrytis cinerea 21.74 4.00e-14 73.90
IUUC-Bdi-015011 Brachypodium distachyon 20.88 2.00e-16 81.60
IUUC-Bol-015788 Brassica oleracea 23.57 3.00e-21 97.80
IUUC-Bra-017845 Brassica rapa 23.76 8.00e-22 99.80
IUUC-Cel-018519 Caenorhabditis elegans 38.88 6.00e-138 485.00
IUUC-Cja-018984 Callithrix jacchus 96.79 0.00e+00 2120.00
IUUC-Cfa-021212 Canis familiaris 96.35 0.00e+00 2114.00
IUUC-Cpo-021336 Cavia porcellus 92.70 0.00e+00 1865.00
IUUC-Csa-023249 Chlorocebus sabaeus 94.01 0.00e+00 2027.00
IUUC-Cin-025731 Ciona intestinalis 57.72 6.00e-88 317.00
IUUC-Csv-026036 Ciona savignyi 39.30 0.00e+00 709.00
IUUC-Cgl-026432 Colletotrichum gloeosporioides 23.47 3.00e-12 67.80
IUUC-Dre-027886 Danio rerio 78.79 0.00e+00 1751.00
IUUC-Dno-029866 Dasypus novemcinctus 88.20 0.00e+00 1939.00
IUUC-Dor-031024 Dipodomys ordii 89.65 0.00e+00 1882.00
IUUC-Dse-031263 Dothistroma septosporum 23.85 7.00e-12 66.60
IUUC-Dme-031607 Drosophila melanogaster 47.69 0.00e+00 657.00
IUUC-Ete-032893 Echinops telfairi 95.77 0.00e+00 1542.00
IUUC-Eeu-034491 Erinaceus europaeus 80.78 0.00e+00 1111.00
IUUC-Fca-036249 Felis catus 96.00 0.00e+00 2082.00
IUUC-Fal-036761 Ficedula albicollis 91.75 0.00e+00 2026.00
IUUC-Fox-037853 Fusarium oxysporum 22.92 2.00e-17 85.10
IUUC-Fso-038327 Fusarium solani 23.28 6.00e-16 80.10
IUUC-Gmo-039272 Gadus morhua 73.39 0.00e+00 1698.00
IUUC-Ggr-039723 Gaeumannomyces graminis 21.77 2.00e-15 78.20
IUUC-Gga-040415 Gallus gallus 89.93 0.00e+00 1974.00
IUUC-Gac-041699 Gasterosteus aculeatus 76.10 0.00e+00 1701.00
IUUC-Gma-043398 Glycine max 31.09 1.00e-18 89.00
IUUC-Ggo-045391 Gorilla gorilla 96.96 0.00e+00 2092.00
IUUC-Hsa-045903 Homo sapiens 96.88 0.00e+00 2088.00
IUUC-Hvu-047650 Hordeum vulgare 21.51 5.00e-18 86.70
IUUC-Itr-048722 Ictidomys tridecemlineatus 86.02 0.00e+00 1739.00
IUUC-Lpe-051115 Leersia perrieri 21.79 7.00e-18 86.70
IUUC-Loc-052677 Lepisosteus oculatus 79.45 0.00e+00 1834.00
IUUC-Lma-053029 Leptosphaeria maculans 22.86 4.00e-16 80.50
IUUC-Mcc-055526 Macaca mulatta 96.88 0.00e+00 2087.00
IUUC-Mor-057129 Magnaporthe oryzae 22.13 6.00e-15 76.60
IUUC-Mpo-057585 Magnaporthe poae 22.40 7.00e-16 79.70
IUUC-Mtr-057936 Medicago truncatula 24.68 2.00e-19 91.30
IUUC-Mla-058927 Melampsora laricipopulina 21.31 2.00e-06 48.90
IUUC-Mga-059965 Meleagris gallopavo 91.67 0.00e+00 1892.00
IUUC-Mvi-060348 Microbotryum violaceum 23.23 4.00e-11 64.30
IUUC-Mmr-061246 Microcebus murinus 96.79 0.00e+00 2087.00
IUUC-Mdo-062626 Monodelphis domestica 93.86 0.00e+00 2067.00
IUUC-Mmu-063848 Mus musculus 98.26 0.00e+00 2152.00
IUUC-Mac-065436 Musa acuminata 29.41 2.00e-12 68.60
IUUC-Mpu-066690 Mustela putorius furo 93.28 0.00e+00 1752.00
IUUC-Mlu-067504 Myotis lucifugus 88.84 0.00e+00 1969.00
IUUC-Nfi-068318 Neosartorya fischeri 22.24 4.00e-13 70.50
IUUC-Ncr-068624 Neurospora crassa 22.73 1.00e-17 85.50
IUUC-Nle-069640 Nomascus leucogenys 96.70 0.00e+00 2083.00
IUUC-Opr-070681 Ochotona princeps 80.75 0.00e+00 1039.00
IUUC-Ont-071645 Oreochromis niloticus 77.16 0.00e+00 1721.00
IUUC-Oan-073020 Ornithorhynchus anatinus 91.55 0.00e+00 1689.00
IUUC-Ocu-074803 Oryctolagus cuniculus 96.66 0.00e+00 2095.00
IUUC-Oba-075180 Oryza barthii 21.48 4.00e-19 90.90
IUUC-Obr-076139 Oryza brachyantha 21.48 3.00e-17 84.30
IUUC-Ogl-077142 Oryza glaberrima 21.48 4.00e-19 90.90
IUUC-Ogu-079037 Oryza glumaepatula 21.08 5.00e-18 87.40
IUUC-Oin-079192 Oryza indica 21.02 1.00e-17 85.50
IUUC-Olo-080693 Oryza longistaminata 22.30 3.00e-15 77.80
IUUC-Ome-081753 Oryza meridionalis 25.93 3.00e-08 54.30
IUUC-Oni-082885 Oryza nivara 21.59 1.00e-18 89.40
IUUC-Oru-084893 Oryza rufipogon 21.96 4.00e-16 80.50
IUUC-Osa-085916 Oryza sativa 21.42 1.00e-17 85.90
IUUC-Ola-087197 Oryzias latipes 72.58 0.00e+00 1515.00
IUUC-Oga-088333 Otolemur garnettii 92.33 0.00e+00 1999.00
IUUC-Oar-090222 Ovis aries 95.67 0.00e+00 2107.00
IUUC-Ptr-091012 Pan troglodytes 96.96 0.00e+00 2092.00
IUUC-Pan-091748 Papio anubis 95.84 0.00e+00 2075.00
IUUC-Psi-093405 Pelodiscus sinensis 89.29 0.00e+00 2007.00
IUUC-Pno-095147 Phaeosphaeria nodorum 22.53 1.00e-09 58.90
IUUC-Pfo-096143 Poecilia formosa 78.27 0.00e+00 1772.00
IUUC-Pab-098201 Pongo abelii 93.40 0.00e+00 1982.00
IUUC-Pop-099380 Populus trichocarpa 27.24 3.00e-17 84.30
IUUC-Pca-100605 Procavia capensis 90.22 0.00e+00 1544.00
IUUC-Ppe-101373 Prunus persica 27.78 2.00e-21 98.20
IUUC-Pva-102580 Pteropus vampyrus 90.89 0.00e+00 1946.00
IUUC-Pte-104412 Pyrenophora teres 22.54 3.00e-15 77.80
IUUC-Pyt-104770 Pyrenophora triticirepentis 22.74 1.00e-15 79.00
IUUC-Sce-106140 Saccharomyces cerevisiae 23.44 3.00e-11 64.30
IUUC-Sit-110386 Setaria italica 22.90 9.00e-20 92.80
IUUC-Sly-111338 Solanum lycopersicum 25.81 9.00e-20 90.90
IUUC-Stu-112417 Solanum tuberosum 26.38 5.00e-21 95.50
IUUC-Sar-113111 Sorex araneus 87.56 0.00e+00 1785.00
IUUC-Sbi-114175 Sorghum bicolor 21.89 3.00e-19 90.90
IUUC-Sre-115050 Sporisorium reilianum 22.54 3.00e-13 71.60
IUUC-Ssc-115307 Sus scrofa 93.32 0.00e+00 2055.00
IUUC-Tgu-116507 Taeniopygia guttata 91.75 0.00e+00 2033.00
IUUC-Tru-118038 Takifugu rubripes 72.32 0.00e+00 1635.00
IUUC-Tsy-119133 Tarsius syrichta 90.27 0.00e+00 1932.00
IUUC-Tni-120014 Tetraodon nigroviridis 75.75 0.00e+00 1710.00
IUUC-Tca-121778 Theobroma cacao 21.61 3.00e-19 90.90
IUUC-Tre-122192 Trichoderma reesei 24.22 2.00e-17 84.70
IUUC-Tvi-122424 Trichoderma virens 23.56 5.00e-18 86.70
IUUC-Tae-125643 Triticum aestivum 20.88 8.00e-20 92.80
IUUC-Tur-126560 Triticum urartu 20.83 1.00e-15 79.00
IUUC-Tbe-127510 Tupaia belangeri 91.35 0.00e+00 1321.00
IUUC-Ttr-128804 Tursiops truncatus 84.82 0.00e+00 1830.00
IUUC-Uma-129388 Ustilago maydis 22.57 3.00e-13 71.60
IUUC-Vda-129843 Verticillium dahliae 19.67 5.00e-13 70.10
IUUC-Vpa-130694 Vicugna pacos 87.76 0.00e+00 1866.00
IUUC-Vvi-131379 Vitis vinifera 23.58 2.00e-20 95.50
IUUC-Xtr-132160 Xenopus tropicalis 88.01 0.00e+00 1821.00
IUUC-Xma-133008 Xiphophorus maculatus 77.96 0.00e+00 1768.00
IUUC-Yli-134491 Yarrowia lipolytica 22.48 2.00e-16 81.60
IUUC-Zma-135923 Zea mays 23.21 8.00e-23 103.00
Created Date 25-Jun-2017

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