iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-088692

Ensembl Protein ID

ENSOGAP00000015340.2

UniProt Accession

H0XGW8; H0XGW8_OTOGA

Genbank Protein ID

ENSOGAP00000015340

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03083455

Gene Name

TRIM24

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000017126.2	ENSOGAT00000017130.2	ENSOGAP00000015340.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.30e-09	38.1	825	869

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           ++C+vC++gge    l++CekC ++fH  C+ ++  +++p+ e wiC+ Cr
   Q: 825  DWCAVCQNGGE----LLCCEKCPKVFHLSCHVPT-LTNFPSGE-WICTFCR 869
           79*********....*******************.*******8.******8 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MEVAVEKTAA PAASAAAAGG PSAAPSGENE AESRQGPDSE RGSETARLNL LDTCAVCHQN 60
IQSRAPKLLP CLHSFCQRCL PAPQRYLMLP APMLGSAETP PPVPAPGSPV SGSSPFATQV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGGTGG CGGTGGAGAA GACGGCGGCG CCCGCGGCTT CGGCGGCGGC CGCCGGGGGG 60
CCCTCGGCCG CGCCGAGCGG GGAGAACGAG GCCGAGAGTC GGCAGGGCCC GGACTCGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0103--Bromodomain
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003649--Bbox_C
IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR030934--Intein_C
IPR019786--Zinc_finger_PHD-type_CS
IPR000315--Znf_B-box
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS50818--INTEIN_C_TER
PS50119--ZF_BBOX
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00439--Bromodomain
PF00628--PHD
PF00643--zf-B_box

PRINTS

PR00503--BROMODOMAIN

SMART

SM00502--BBC
SM00336--BBOX
SM00297--BROMO
SM00249--PHD
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005719--C:nuclear euchromatin
GO:0005654--C:nucleoplasm
GO:0005726--C:perichromatin fibrils
GO:0003682--F:chromatin binding
GO:0034056--F:estrogen response element binding
GO:0004672--F:protein kinase activity
GO:0043565--F:sequence-specific DNA binding
GO:0003713--F:transcription coactivator activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0055074--P:calcium ion homeostasis
GO:0071391--P:cellular response to estrogen stimulus
GO:0008285--P:negative regulation of cell proliferation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0046777--P:protein autophosphorylation
GO:0030163--P:protein catabolic process
GO:0042981--P:regulation of apoptotic process
GO:0031647--P:regulation of protein stability
GO:1901796--P:regulation of signal transduction by p53 class mediator
GO:0070562--P:regulation of vitamin D receptor signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001838	Ailuropoda melanoleuca	95.91	0.00e+00	1686.00
IUUC-Apl-003697	Anas platyrhynchos	80.26	0.00e+00	1334.00
IUUC-Bta-013282	Bos taurus	95.41	0.00e+00	1720.00
IUUC-Cja-018920	Callithrix jacchus	94.85	0.00e+00	1764.00
IUUC-Cfa-020984	Canis familiaris	96.18	0.00e+00	1735.00
IUUC-Cpo-022035	Cavia porcellus	95.26	0.00e+00	1638.00
IUUC-Csa-024208	Chlorocebus sabaeus	97.06	0.00e+00	1769.00
IUUC-Cho-024413	Choloepus hoffmanni	65.02	1.00e-162	566.00
IUUC-Dno-029145	Dasypus novemcinctus	96.23	0.00e+00	1648.00
IUUC-Dor-030396	Dipodomys ordii	93.13	0.00e+00	1250.00
IUUC-Ete-032414	Echinops telfairi	86.67	0.00e+00	912.00
IUUC-Eca-033489	Equus caballus	96.56	0.00e+00	1593.00
IUUC-Eeu-034654	Erinaceus europaeus	93.39	0.00e+00	768.00
IUUC-Fca-035844	Felis catus	92.70	0.00e+00	1467.00
IUUC-Fal-036735	Ficedula albicollis	79.57	0.00e+00	1342.00
IUUC-Gga-041124	Gallus gallus	78.24	0.00e+00	1386.00
IUUC-Ggo-044542	Gorilla gorilla	97.16	0.00e+00	1770.00
IUUC-Hsa-046785	Homo sapiens	97.06	0.00e+00	1766.00
IUUC-Itr-048262	Ictidomys tridecemlineatus	96.18	0.00e+00	1687.00
IUUC-Laf-054279	Loxodonta africana	92.72	0.00e+00	1702.00
IUUC-Mcc-055668	Macaca mulatta	97.06	0.00e+00	1770.00
IUUC-Meu-056195	Macropus eugenii	76.81	0.00e+00	815.00
IUUC-Mga-059272	Meleagris gallopavo	79.83	0.00e+00	1305.00
IUUC-Mmr-060936	Microcebus murinus	97.71	0.00e+00	1778.00
IUUC-Mdo-062848	Monodelphis domestica	88.00	0.00e+00	1606.00
IUUC-Mmu-063598	Mus musculus	91.07	0.00e+00	1679.00
IUUC-Mpu-066272	Mustela putorius furo	96.15	0.00e+00	1605.00
IUUC-Mlu-067958	Myotis lucifugus	94.09	0.00e+00	1582.00
IUUC-Nle-069375	Nomascus leucogenys	97.16	0.00e+00	1770.00
IUUC-Opr-070836	Ochotona princeps	81.86	0.00e+00	667.00
IUUC-Oan-073393	Ornithorhynchus anatinus	79.47	0.00e+00	1027.00
IUUC-Ocu-074873	Oryctolagus cuniculus	93.90	0.00e+00	1586.00
IUUC-Oar-090160	Ovis aries	95.80	0.00e+00	1580.00
IUUC-Ptr-090756	Pan troglodytes	97.06	0.00e+00	1766.00
IUUC-Pan-091719	Papio anubis	96.96	0.00e+00	1765.00
IUUC-Psi-093433	Pelodiscus sinensis	81.77	0.00e+00	1384.00
IUUC-Pab-098599	Pongo abelii	95.79	0.00e+00	1741.00
IUUC-Pca-100540	Procavia capensis	87.64	0.00e+00	962.00
IUUC-Pva-102478	Pteropus vampyrus	89.32	0.00e+00	1555.00
IUUC-Rno-105478	Rattus norvegicus	77.46	0.00e+00	650.00
IUUC-Sha-106740	Sarcophilus harrisii	84.23	0.00e+00	1389.00
IUUC-Sar-113615	Sorex araneus	94.16	0.00e+00	1390.00
IUUC-Tgu-117368	Taeniopygia guttata	77.01	0.00e+00	1408.00
IUUC-Tsy-118904	Tarsius syrichta	97.09	0.00e+00	1628.00
IUUC-Tbe-127354	Tupaia belangeri	82.22	0.00e+00	724.00
IUUC-Ttr-128983	Tursiops truncatus	92.01	0.00e+00	1182.00
IUUC-Vpa-130420	Vicugna pacos	94.29	0.00e+00	1562.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence