iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ssc-115609

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

CU570846

Gene Name

ERCC8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000016934.2	ENSSSCT00000018442.2	ENSSSCP00000017943.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.90e-29	100.7	98	130
UBD/Beta-Prp	4.60e-47	160.9	98	371

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sd.tllvsGsdDgtikvWDlr 31
           H+ sv  +++  +d +++ s+s D+t+kvWD+ 
   Q: 98   HKYSVETVQWypHDtGMFTSSSFDKTLKVWDTN 130
           8999*******9778****************75 PP

UBD/Beta-Prp

   S: 9    hksvitcvkf.spdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk...ilvtgseDrtikvwdlstgkcvhtlkgh 93
           hk  +  v++   d+ +++++s d+t+kvwd+ t ++ + + + e++v++  +sp +    + + g +   +++ dl++g+c h+l+gh
   Q: 98   HKYSVETVQWyPHDTGMFTSSSFDKTLKVWDTNTLQT-ADVFNFEETVYSHHMSPVATkhcLVAVGTKGPKVQLCDLKSGSCSHILQGH 185
           66677779995666778888999***********777.7777888899999999988888799999999******************** PP
   S: 94   edsvlslsfsp.sgdklvsGshdrtirvwdletgq.clee..............tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl 166
            +++l++s+sp + + l+++s+d+ +++wd++  + cl +               ++ h+g vn++++ +dg  l + ++D+ +rlW++
   Q: 186  RQEILAVSWSPrYEYILATASADSKAKLWDVRRASgCLITldqhngkksqavesANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNS 274
           ***********888*****************9876366669*******************************999************99 PP
   S: 167  ktgk.llrtltgghtdsvyslsfdsng...kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW.. 249
           ++g+  l    + h+ds + l+f+ +    +e+v + + +t+ ++ + +ge +  l+gh + v +  f +n + l+sgs D  i  W  
   Q: 275  SNGEnTLVNYGKVHNDSRKGLKFTVSCgcsTEFVFVPYGSTIAVYTIYSGEQITMLKGHYKSVDCCVFQSNFQELYSGSRDCNILAWvp 363
           6654144555667*********99876788********************************************************966 PP
   S: 250  .......d 250
                  d
   Q: 364  slyesvpD 371
           66655553 PP

Organism

Sus scrofa

Protein Sequence
(Fasta)

MLGFLSARQA GLEDPLRLRR AESTRRVLGL ELNKDRDVER IHGSGVNTLD IEPVEGRYML 60
SGGSDGVIVL YDLENASRQP YYTCKAVCSV GRNHPDVHKY SVETVQWYPH DTGMFTSSSF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCCGAGTTC TGTCATGGCG GCGTCCAGCT CTCCACCTGG GGTAAAAGGA AGGGATGCTA 60
GGGTTTTTGT CGGCGCGACA AGCGGGTTTG GAGGACCCTC TTCGCCTACG GAGAGCGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0016363--C:nuclear matrix
GO:0000109--C:nucleotide-excision repair complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0006979--P:response to oxidative stress
GO:0009411--P:response to UV
GO:0010165--P:response to X-ray
GO:0006283--P:transcription-coupled nucleotide-excision repair

KEGG

ssc:100524405

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001170	Aegilops tauschii	31.06	2.00e-37	151.00
IUUC-Aml-002201	Ailuropoda melanoleuca	94.95	0.00e+00	791.00
IUUC-Atr-002784	Amborella trichopoda	37.45	8.00e-41	160.00
IUUC-Apl-003202	Anas platyrhynchos	81.58	0.00e+00	664.00
IUUC-Aca-004708	Anolis carolinensis	82.47	2.00e-178	618.00
IUUC-Aly-006144	Arabidopsis lyrata	29.63	9.00e-45	174.00
IUUC-Ath-006673	Arabidopsis thaliana	41.15	8.00e-46	177.00
IUUC-Acl-008195	Aspergillus clavatus	38.26	2.00e-42	166.00
IUUC-Afl-008406	Aspergillus flavus	37.30	1.00e-38	153.00
IUUC-Afu-008759	Aspergillus fumigatus	35.47	4.00e-39	155.00
IUUC-Ani-009380	Aspergillus nidulans	35.10	8.00e-41	160.00
IUUC-Ang-009820	Aspergillus niger	36.29	7.00e-38	150.00
IUUC-Aor-010092	Aspergillus oryzae	37.88	1.00e-43	170.00
IUUC-Ate-010491	Aspergillus terreus	36.59	9.00e-44	171.00
IUUC-Bta-012825	Bos taurus	95.97	0.00e+00	795.00
IUUC-Bci-013856	Botrytis cinerea	32.68	3.00e-53	202.00
IUUC-Bdi-014899	Brachypodium distachyon	34.86	4.00e-65	242.00
IUUC-Bol-015337	Brassica oleracea	38.79	2.00e-44	173.00
IUUC-Bra-018089	Brassica rapa	38.36	5.00e-45	174.00
IUUC-Cja-018725	Callithrix jacchus	93.94	0.00e+00	786.00
IUUC-Cfa-021162	Canis familiaris	95.71	0.00e+00	793.00
IUUC-Cpo-022190	Cavia porcellus	92.93	0.00e+00	783.00
IUUC-Cre-022960	Chlamydomonas reinhardtii	37.62	4.00e-40	159.00
IUUC-Csa-023610	Chlorocebus sabaeus	94.44	0.00e+00	794.00
IUUC-Cho-024689	Choloepus hoffmanni	93.24	0.00e+00	721.00
IUUC-Cin-025324	Ciona intestinalis	38.52	9.00e-80	290.00
IUUC-Csv-026059	Ciona savignyi	37.62	3.00e-73	268.00
IUUC-Cgl-026384	Colletotrichum gloeosporioides	35.44	7.00e-41	161.00
IUUC-Cme-027182	Cyanidioschyzon merolae	28.66	2.00e-13	70.50
IUUC-Dre-028696	Danio rerio	72.50	2.00e-176	611.00
IUUC-Dno-029102	Dasypus novemcinctus	94.95	0.00e+00	793.00
IUUC-Dor-030361	Dipodomys ordii	76.52	5.00e-178	616.00
IUUC-Dse-031167	Dothistroma septosporum	30.31	4.00e-44	172.00
IUUC-Ete-032856	Echinops telfairi	76.52	2.00e-178	618.00
IUUC-Eca-033611	Equus caballus	96.15	0.00e+00	685.00
IUUC-Eeu-034583	Erinaceus europaeus	71.97	1.00e-163	568.00
IUUC-Fca-036481	Felis catus	95.71	0.00e+00	794.00
IUUC-Fal-037327	Ficedula albicollis	78.82	3.00e-166	577.00
IUUC-Fox-037684	Fusarium oxysporum	34.12	3.00e-44	172.00
IUUC-Fso-038306	Fusarium solani	34.31	7.00e-55	207.00
IUUC-Gmo-039043	Gadus morhua	69.70	5.00e-167	580.00
IUUC-Ggr-039783	Gaeumannomyces graminis	31.32	2.00e-39	156.00
IUUC-Gga-041085	Gallus gallus	87.36	0.00e+00	646.00
IUUC-Gac-042328	Gasterosteus aculeatus	68.58	3.00e-160	557.00
IUUC-Gma-043004	Glycine max	33.18	5.00e-57	214.00
IUUC-Ggo-045627	Gorilla gorilla	86.07	0.00e+00	711.00
IUUC-Hsa-046028	Homo sapiens	94.44	0.00e+00	794.00
IUUC-Hvu-047678	Hordeum vulgare	31.95	6.00e-35	140.00
IUUC-Itr-048648	Ictidomys tridecemlineatus	94.70	0.00e+00	794.00
IUUC-Kpa-049386	Komagataella pastoris	29.63	1.00e-44	173.00
IUUC-Lch-050590	Latimeria chalumnae	79.89	2.00e-162	564.00
IUUC-Lpe-051725	Leersia perrieri	34.53	5.00e-37	148.00
IUUC-Loc-051788	Lepisosteus oculatus	75.77	4.00e-180	623.00
IUUC-Lma-053082	Leptosphaeria maculans	35.01	3.00e-54	205.00
IUUC-Laf-053809	Loxodonta africana	94.46	0.00e+00	795.00
IUUC-Mcc-054998	Macaca mulatta	94.66	7.00e-163	565.00
IUUC-Meu-055929	Macropus eugenii	78.14	0.00e+00	635.00
IUUC-Mor-057003	Magnaporthe oryzae	33.63	6.00e-48	184.00
IUUC-Mtr-057921	Medicago truncatula	31.54	2.00e-56	213.00
IUUC-Mga-059449	Meleagris gallopavo	66.47	1.00e-127	448.00
IUUC-Mmr-061609	Microcebus murinus	90.79	0.00e+00	734.00
IUUC-Mdo-062564	Monodelphis domestica	86.40	0.00e+00	725.00
IUUC-Mmu-063904	Mus musculus	90.18	0.00e+00	754.00
IUUC-Mac-064716	Musa acuminata	38.84	1.00e-41	163.00
IUUC-Mpu-066617	Mustela putorius furo	95.45	0.00e+00	797.00
IUUC-Mlu-067054	Myotis lucifugus	91.92	0.00e+00	771.00
IUUC-Nfi-068467	Neosartorya fischeri	36.11	2.00e-33	136.00
IUUC-Nle-069731	Nomascus leucogenys	94.44	0.00e+00	794.00
IUUC-Opr-070297	Ochotona princeps	68.20	2.00e-88	319.00
IUUC-Ont-072558	Oreochromis niloticus	71.32	2.00e-166	578.00
IUUC-Oan-072864	Ornithorhynchus anatinus	91.23	4.00e-28	115.00
IUUC-Ocu-074415	Oryctolagus cuniculus	94.70	0.00e+00	795.00
IUUC-Oba-075759	Oryza barthii	30.17	1.00e-43	171.00
IUUC-Obr-076387	Oryza brachyantha	29.95	5.00e-47	181.00
IUUC-Ogl-077924	Oryza glaberrima	40.60	6.00e-18	83.60
IUUC-Ogu-078186	Oryza glumaepatula	35.23	3.00e-63	235.00
IUUC-Oin-079389	Oryza indica	34.56	6.00e-47	181.00
IUUC-Olo-080916	Oryza longistaminata	28.43	9.00e-17	79.30
IUUC-Ome-081471	Oryza meridionalis	41.05	1.00e-40	160.00
IUUC-Oni-082449	Oryza nivara	41.58	1.00e-40	160.00
IUUC-Opu-083210	Oryza punctata	29.95	1.00e-53	203.00
IUUC-Oru-085159	Oryza rufipogon	42.11	1.00e-43	170.00
IUUC-Osa-085926	Oryza sativa	42.57	2.00e-33	134.00
IUUC-Ola-087084	Oryzias latipes	69.37	2.00e-168	585.00
IUUC-Olu-087853	Ostreococcus lucimarinus	29.55	3.00e-40	158.00
IUUC-Oga-089008	Otolemur garnettii	92.73	0.00e+00	779.00
IUUC-Oar-089259	Ovis aries	95.97	0.00e+00	796.00
IUUC-Ptr-091112	Pan troglodytes	93.64	0.00e+00	783.00
IUUC-Pan-092303	Papio anubis	92.97	3.00e-70	256.00
IUUC-Psi-093050	Pelodiscus sinensis	83.67	0.00e+00	701.00
IUUC-Pma-094259	Petromyzon marinus	58.17	1.00e-131	462.00
IUUC-Pno-094798	Phaeosphaeria nodorum	31.99	1.00e-51	196.00
IUUC-Ppa-095477	Physcomitrella patens	31.09	2.00e-55	209.00
IUUC-Pfo-096855	Poecilia formosa	68.91	6.00e-165	573.00
IUUC-Pab-098096	Pongo abelii	93.69	0.00e+00	787.00
IUUC-Pop-098800	Populus trichocarpa	27.54	2.00e-47	183.00
IUUC-Pca-100187	Procavia capensis	94.17	5.00e-116	410.00
IUUC-Ppe-101759	Prunus persica	38.22	1.00e-44	173.00
IUUC-Pva-102438	Pteropus vampyrus	80.49	2.00e-94	338.00
IUUC-Pte-104197	Pyrenophora teres	32.77	7.00e-49	187.00
IUUC-Pyt-104421	Pyrenophora triticirepentis	33.62	4.00e-49	188.00
IUUC-Rno-106087	Rattus norvegicus	90.68	0.00e+00	758.00
IUUC-Sce-106276	Saccharomyces cerevisiae	27.32	7.00e-13	68.60
IUUC-Sha-106831	Sarcophilus harrisii	83.17	0.00e+00	689.00
IUUC-Sja-107681	Schizosaccharomyces japonicus	32.66	3.00e-57	215.00
IUUC-Spo-108294	Schizosaccharomyces pombe	36.55	2.00e-64	239.00
IUUC-Ssl-108613	Sclerotinia sclerotiorum	33.24	2.00e-52	199.00
IUUC-Smo-109008	Selaginella moellendorffii	40.15	8.00e-75	273.00
IUUC-Sit-110300	Setaria italica	31.18	7.00e-54	204.00
IUUC-Sly-111441	Solanum lycopersicum	30.82	1.00e-48	186.00
IUUC-Stu-111995	Solanum tuberosum	30.66	3.00e-48	185.00
IUUC-Sar-113196	Sorex araneus	83.65	9.00e-129	452.00
IUUC-Sbi-113790	Sorghum bicolor	31.72	2.00e-54	206.00
IUUC-Tgu-116927	Taeniopygia guttata	79.95	0.00e+00	664.00
IUUC-Tru-118164	Takifugu rubripes	70.22	1.00e-172	598.00
IUUC-Tsy-119151	Tarsius syrichta	88.89	0.00e+00	739.00
IUUC-Tni-120896	Tetraodon nigroviridis	69.15	3.00e-162	564.00
IUUC-Tca-121592	Theobroma cacao	29.82	2.00e-49	189.00
IUUC-Tre-122023	Trichoderma reesei	35.15	4.00e-50	192.00
IUUC-Tvi-122507	Trichoderma virens	36.99	3.00e-52	199.00
IUUC-Tae-125730	Triticum aestivum	34.37	2.00e-60	225.00
IUUC-Tur-126092	Triticum urartu	31.31	1.00e-35	143.00
IUUC-Tbe-127422	Tupaia belangeri	71.35	7.00e-152	529.00
IUUC-Ttr-129097	Tursiops truncatus	92.68	0.00e+00	776.00
IUUC-Vda-130014	Verticillium dahliae	35.74	1.00e-49	190.00
IUUC-Vpa-130782	Vicugna pacos	95.97	0.00e+00	801.00
IUUC-Vvi-131494	Vitis vinifera	37.28	6.00e-45	174.00
IUUC-Xtr-132165	Xenopus tropicalis	78.38	2.00e-180	624.00
IUUC-Xma-133205	Xiphophorus maculatus	69.58	1.00e-168	585.00
IUUC-Yli-134614	Yarrowia lipolytica	33.85	8.00e-58	217.00
IUUC-Zma-135861	Zea mays	35.19	2.00e-60	226.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence