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Tag Content
UUCD2 ID IUUC-Bta-012413
UUCD1 version UUC-BoT-00055
Ensembl Protein ID ENSBTAP00000026289.4
UniProt Accession A5PKG6; UBE4A_BOVIN
Genbank Protein ID AAI42481.1
Protein Name Ubiquitin conjugation factor E4 A; RING-type E3 ubiquitin transferase E4 A
Genbank Nucleotide ID BC142480
Gene Name UBE4A
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000019725.4 ENSBTAT00000026289.4 ENSBTAP00000026289.4
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/U-box 2.40e-22 78.9 988 1059
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 2    vpeeflCpIslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawceens 73
            ++efl+pI+ +lM+dPvvlp s++t+drs+I+++l s+++ +P++r+plt +++ Pn++l++ iq+w++e++
   Q: 988  ACDEFLDPIMSTLMSDPVVLPsSRVTVDRSTIARHLLSDQT-DPFNRSPLTMDQIRPNTELKEKIQRWLAERK 1059
           579******************9******************9.***************************9976 PP
   
Organism Bos taurus
Functional Description
(View)

Functional Description


     Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.
 Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.
Protein Sequence
(Fasta)
MTDQENNNNI SSNPFAALFG SLADAKQFAA IQKEQLKQQS DELPASPDDS DNSVSESLDE 60
FDYSVAEISR SFRSQQEICE QLNINHMIQR IFLITLDNSD PSLKSGNGIP SRCVYLEEMA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Bta-012413|E3,U-box|Bos taurus
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Nucleotide Sequence
(Fasta)
CTGAGACTCT GTCGTGTCGT CGCTGCTGGC CTTTCAGGCT CTGGTAAGAG AGGGTATAGC 60
TGGAGGGGAG GGGATCGTTG AGTCTGCAGT GGGACTTTTT TTTTCTCCTA GTCGGATACC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Bta-012413|E3,U-box|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR019474--Ub_conjug_fac_E4_core
IPR003613--Ubox_domain
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51698--U_BOX
Pfam

PF04564--U-box
PF10408--Ufd2P_core
SMART

SM00504--Ubox
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0000209--P:protein polyubiquitination
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG bta:517544
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001281 Ailuropoda melanoleuca 97.11 0.00e+00 2075.00
IUUC-Apl-003514 Anas platyrhynchos 88.54 0.00e+00 1881.00
IUUC-Aca-005167 Anolis carolinensis 84.48 0.00e+00 1749.00
IUUC-Ame-010905 Astyanax mexicanus 67.35 0.00e+00 711.00
IUUC-Cja-019715 Callithrix jacchus 96.09 0.00e+00 2077.00
IUUC-Cfa-021185 Canis familiaris 97.47 0.00e+00 2126.00
IUUC-Cpo-021516 Cavia porcellus 96.72 0.00e+00 2083.00
IUUC-Csa-023765 Chlorocebus sabaeus 97.00 0.00e+00 2061.00
IUUC-Cho-024614 Choloepus hoffmanni 97.96 0.00e+00 861.00
IUUC-Cin-025532 Ciona intestinalis 36.62 4.00e-164 572.00
IUUC-Csv-025834 Ciona savignyi 50.97 6.00e-48 182.00
IUUC-Dre-028223 Danio rerio 76.47 0.00e+00 1602.00
IUUC-Dno-029785 Dasypus novemcinctus 96.63 0.00e+00 2085.00
IUUC-Dor-030421 Dipodomys ordii 92.09 0.00e+00 1951.00
IUUC-Dme-031715 Drosophila melanogaster 35.03 7.00e-135 474.00
IUUC-Ete-032767 Echinops telfairi 92.96 0.00e+00 1295.00
IUUC-Eca-033587 Equus caballus 97.56 0.00e+00 2104.00
IUUC-Fca-035622 Felis catus 97.02 0.00e+00 2130.00
IUUC-Fal-037262 Ficedula albicollis 86.67 0.00e+00 1882.00
IUUC-Gmo-038686 Gadus morhua 72.61 0.00e+00 1575.00
IUUC-Gga-041222 Gallus gallus 87.77 0.00e+00 1933.00
IUUC-Gac-042637 Gasterosteus aculeatus 73.44 0.00e+00 1562.00
IUUC-Ggo-044685 Gorilla gorilla 96.37 0.00e+00 2082.00
IUUC-Hsa-046176 Homo sapiens 96.91 0.00e+00 2088.00
IUUC-Itr-048469 Ictidomys tridecemlineatus 97.96 0.00e+00 1064.00
IUUC-Lch-049630 Latimeria chalumnae 80.63 0.00e+00 1738.00
IUUC-Loc-052727 Lepisosteus oculatus 76.00 0.00e+00 1637.00
IUUC-Laf-054041 Loxodonta africana 94.11 0.00e+00 2068.00
IUUC-Mcc-055099 Macaca mulatta 95.83 0.00e+00 2080.00
IUUC-Meu-055991 Macropus eugenii 89.59 0.00e+00 1934.00
IUUC-Mga-059596 Meleagris gallopavo 87.68 0.00e+00 1766.00
IUUC-Mmr-061244 Microcebus murinus 95.18 0.00e+00 1716.00
IUUC-Mdo-062335 Monodelphis domestica 89.90 0.00e+00 1913.00
IUUC-Mmu-063572 Mus musculus 93.83 0.00e+00 2051.00
IUUC-Mpu-066444 Mustela putorius furo 93.18 0.00e+00 2025.00
IUUC-Mlu-068232 Myotis lucifugus 95.60 0.00e+00 2071.00
IUUC-Nle-070036 Nomascus leucogenys 96.28 0.00e+00 2079.00
IUUC-Opr-070503 Ochotona princeps 89.83 0.00e+00 1336.00
IUUC-Ont-072389 Oreochromis niloticus 75.37 0.00e+00 1598.00
IUUC-Oan-073114 Ornithorhynchus anatinus 87.27 0.00e+00 1706.00
IUUC-Ocu-074370 Oryctolagus cuniculus 95.57 0.00e+00 1814.00
IUUC-Ola-086562 Oryzias latipes 72.76 0.00e+00 1578.00
IUUC-Oga-088146 Otolemur garnettii 95.86 0.00e+00 2060.00
IUUC-Oar-089190 Ovis aries 98.59 0.00e+00 2094.00
IUUC-Ptr-090592 Pan troglodytes 96.09 0.00e+00 2079.00
IUUC-Pan-092271 Papio anubis 97.00 0.00e+00 2090.00
IUUC-Psi-093730 Pelodiscus sinensis 85.41 0.00e+00 1886.00
IUUC-Pma-094120 Petromyzon marinus 76.72 5.00e-132 463.00
IUUC-Pfo-097077 Poecilia formosa 72.28 0.00e+00 1544.00
IUUC-Pab-098069 Pongo abelii 96.09 0.00e+00 2042.00
IUUC-Pca-100762 Procavia capensis 92.83 0.00e+00 1939.00
IUUC-Pva-103149 Pteropus vampyrus 96.37 0.00e+00 2082.00
IUUC-Rno-105342 Rattus norvegicus 93.37 0.00e+00 2042.00
IUUC-Sha-106555 Sarcophilus harrisii 90.74 0.00e+00 1959.00
IUUC-Sly-110848 Solanum lycopersicum 39.41 1.00e-76 280.00
IUUC-Sar-113131 Sorex araneus 90.03 0.00e+00 1183.00
IUUC-Ssc-115841 Sus scrofa 97.84 0.00e+00 2113.00
IUUC-Tgu-116823 Taeniopygia guttata 85.75 0.00e+00 1855.00
IUUC-Tru-118249 Takifugu rubripes 72.63 0.00e+00 1561.00
IUUC-Tsy-119112 Tarsius syrichta 97.35 0.00e+00 738.00
IUUC-Tni-119848 Tetraodon nigroviridis 73.32 0.00e+00 1544.00
IUUC-Tbe-127889 Tupaia belangeri 82.42 0.00e+00 846.00
IUUC-Ttr-129300 Tursiops truncatus 88.61 0.00e+00 1180.00
IUUC-Vpa-130215 Vicugna pacos 97.21 0.00e+00 2096.00
IUUC-Xtr-132107 Xenopus tropicalis 80.02 0.00e+00 1687.00
Created Date 25-Jun-2017

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