iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Kpa-049178

Ensembl Protein ID

CAY67507

UniProt Accession

C4QW84; C4QW84_KOMPG

Genbank Protein ID

CAY67507.1

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

FN392319

Gene Name

PAN2; PAS_chr1-1_0143

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
PAS_chr1-1_0143	CAY67507	CAY67507

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.50e-13	47.9	534	858

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.............gyeq 89
           Gl+ +  + Y+NS+LQ   + p + ++   +  e+      + ++++ll++l  lf  ++k + ++++p+++ k+l+k+ e  +              ++ 
   Q: 534  GLESHVQSAYCNSLLQLYRFAPLMFNYAVGSLAEE------SVDNNSLLTELGFLFDMMVKASGQHIAPSNFQKMLSKIPEASRildiynngynrdeHSQR 628
           888899999*******9999999999988833333......345679*******************************99986677777653322211111 PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeet.kkeslqd 189
              q f +fll++++ +                         ++ k+  + + ++++++ ++ + +   c+ ++  + + ++l +  p+ ++   +++l++
   Q: 629  VLIQSFNNFLLERISLDE-----------------------MNQAKSNAPHIFNTIMGIPVECEFIGVGCGLRKIGNTTLYSLDVRHPKTNNVvLNKKLNH 706
           122444444444444444.......................3567788899***********************999999999999987665414457777 PP
   S: 190  cLesftkeeeleg.enkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkv.efpleLdlspfctspeekqkekkkYeLiavvvHsG 288
           ++  + +    ++ + ++ c++c++        ++k lP++L+l+L   + + ++ + +k n    ef  +++  + c ++ ++  ++ kYeL++ v    
   Q: 707  SIIPYIELALSRNlSVNMACDNCNETHAFDTLYTVKDLPPILSLNLELTNQELSELKASKTNWLAsEFYASMNKGRICLKSITTGFRHLKYELLGYVAQVT 807
           776666544332213359*******************************55444444444443321344445555799988888888************** PP
   S: 289  .slssGHYvayvknekgkWllfdDskVtevkeeevleetg..staYvlfYk 336
            + ++   v++vk  k++W+lf+D  V +++e+evl+ +   +++ +++Yk
   Q: 808  dKEGNSNLVTFVKVGKDEWFLFNDFLVMPISEHEVLNLNYwwKKPVIVIYK 858
           9999********************************966577777777776 PP

Organism

Komagataella pastoris

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein PAB1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.

Protein Sequence
(Fasta)

MEGWNEINRV PCMRPSFRIS DPTRQSVPSA LLFDDSHDLT WIGSEDGFVK SLADQMLTPY 60
TSFRCHSSKV LQLLNNKRGI LSLSENSIKL TSRTGLCRMN LHDISVNHSR SMAYTSNTEN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAAGGAT GGAACGAAAT CAATCGAGTT CCATGCATGA GGCCTTCTTT TAGGATTTCT 60
GATCCAACCC GGCAAAGTGT CCCTTCTGCT TTACTTTTTG ACGACTCCCA TGACCTGACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening

KEGG

ppa:PAS_chr1-1_0143

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	40.48	2.00e-66	245.00
IUUC-Apl-003500	Anas platyrhynchos	39.43	1.00e-51	196.00
IUUC-Aca-004930	Anolis carolinensis	38.99	5.00e-64	237.00
IUUC-Acl-008214	Aspergillus clavatus	33.01	4.00e-172	596.00
IUUC-Afu-009112	Aspergillus fumigatus	33.19	3.00e-165	573.00
IUUC-Ang-009531	Aspergillus niger	32.93	4.00e-166	576.00
IUUC-Ame-011259	Astyanax mexicanus	41.02	2.00e-66	245.00
IUUC-Bta-012371	Bos taurus	40.48	2.00e-66	245.00
IUUC-Bci-013684	Botrytis cinerea	32.24	1.00e-159	555.00
IUUC-Cja-019297	Callithrix jacchus	40.48	2.00e-66	245.00
IUUC-Cfa-020489	Canis familiaris	31.67	2.00e-85	309.00
IUUC-Cpo-022392	Cavia porcellus	31.48	9.00e-86	310.00
IUUC-Csa-023220	Chlorocebus sabaeus	40.48	2.00e-66	245.00
IUUC-Csv-025841	Ciona savignyi	36.64	2.00e-58	218.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	33.13	2.00e-172	597.00
IUUC-Cne-026932	Cryptococcus neoformans	30.40	3.00e-136	477.00
IUUC-Dre-028482	Danio rerio	40.90	1.00e-66	246.00
IUUC-Dno-029398	Dasypus novemcinctus	31.58	5.00e-85	307.00
IUUC-Dor-030307	Dipodomys ordii	36.01	1.00e-53	202.00
IUUC-Dme-032111	Drosophila melanogaster	36.16	4.00e-59	221.00
IUUC-Eca-033985	Equus caballus	40.48	2.00e-66	245.00
IUUC-Eeu-034928	Erinaceus europaeus	24.36	4.00e-21	95.10
IUUC-Fca-035587	Felis catus	40.48	2.00e-66	246.00
IUUC-Fal-037587	Ficedula albicollis	40.18	2.00e-65	242.00
IUUC-Fso-038133	Fusarium solani	34.21	1.00e-93	335.00
IUUC-Gmo-039076	Gadus morhua	39.47	7.00e-63	234.00
IUUC-Ggr-039957	Gaeumannomyces graminis	31.20	5.00e-154	536.00
IUUC-Gga-040948	Gallus gallus	39.88	2.00e-65	242.00
IUUC-Gac-042396	Gasterosteus aculeatus	41.12	9.00e-66	243.00
IUUC-Ggo-045412	Gorilla gorilla	40.48	2.00e-66	245.00
IUUC-Hsa-046076	Homo sapiens	40.48	3.00e-66	245.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	37.80	2.00e-56	212.00
IUUC-Lch-050279	Latimeria chalumnae	40.48	3.00e-67	248.00
IUUC-Loc-052872	Lepisosteus oculatus	40.72	2.00e-65	242.00
IUUC-Lma-052986	Leptosphaeria maculans	34.57	9.00e-177	612.00
IUUC-Laf-054181	Loxodonta africana	40.82	3.00e-67	248.00
IUUC-Mcc-054812	Macaca mulatta	40.48	2.00e-66	245.00
IUUC-Meu-056325	Macropus eugenii	30.41	3.00e-83	301.00
IUUC-Mor-057246	Magnaporthe oryzae	32.04	4.00e-148	516.00
IUUC-Mpo-057464	Magnaporthe poae	31.23	8.00e-160	555.00
IUUC-Mla-058911	Melampsora laricipopulina	34.40	4.00e-95	340.00
IUUC-Mga-059335	Meleagris gallopavo	40.84	1.00e-63	236.00
IUUC-Mvi-060461	Microbotryum violaceum	30.26	9.00e-133	466.00
IUUC-Mmr-060636	Microcebus murinus	40.48	2.00e-66	245.00
IUUC-Mmu-063503	Mus musculus	31.68	9.00e-86	310.00
IUUC-Mpu-066670	Mustela putorius furo	40.48	2.00e-66	245.00
IUUC-Mlu-068119	Myotis lucifugus	39.88	9.00e-67	246.00
IUUC-Nfi-068398	Neosartorya fischeri	33.19	2.00e-171	594.00
IUUC-Ncr-068927	Neurospora crassa	30.42	7.00e-137	479.00
IUUC-Nle-069651	Nomascus leucogenys	40.52	7.00e-67	247.00
IUUC-Opr-070614	Ochotona princeps	40.48	3.00e-66	245.00
IUUC-Ont-072433	Oreochromis niloticus	31.15	3.00e-88	318.00
IUUC-Oan-073283	Ornithorhynchus anatinus	37.43	5.00e-61	227.00
IUUC-Ocu-074401	Oryctolagus cuniculus	40.48	2.00e-66	245.00
IUUC-Ola-087522	Oryzias latipes	41.07	1.00e-66	246.00
IUUC-Oga-088226	Otolemur garnettii	40.48	2.00e-66	245.00
IUUC-Oar-089241	Ovis aries	40.48	3.00e-67	248.00
IUUC-Pan-092297	Papio anubis	40.48	3.00e-66	244.00
IUUC-Psi-094043	Pelodiscus sinensis	38.01	2.00e-56	213.00
IUUC-Pma-094394	Petromyzon marinus	40.48	1.00e-65	243.00
IUUC-Pno-095053	Phaeosphaeria nodorum	35.31	2.00e-168	584.00
IUUC-Ppa-095188	Physcomitrella patens	37.54	7.00e-52	197.00
IUUC-Pfo-097517	Poecilia formosa	41.37	8.00e-68	250.00
IUUC-Pca-100471	Procavia capensis	31.53	3.00e-86	311.00
IUUC-Pva-102805	Pteropus vampyrus	31.29	9.00e-72	263.00
IUUC-Pte-104021	Pyrenophora teres	34.02	1.00e-178	618.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	34.11	2.00e-177	614.00
IUUC-Rno-105471	Rattus norvegicus	40.18	1.00e-65	243.00
IUUC-Sce-106235	Saccharomyces cerevisiae	37.18	0.00e+00	650.00
IUUC-Sha-106883	Sarcophilus harrisii	39.58	6.00e-65	240.00
IUUC-Spo-108169	Schizosaccharomyces pombe	32.08	5.00e-150	523.00
IUUC-Sar-113323	Sorex araneus	32.34	5.00e-86	310.00
IUUC-Sre-115075	Sporisorium reilianum	40.59	8.00e-60	224.00
IUUC-Ssc-116363	Sus scrofa	40.48	3.00e-67	248.00
IUUC-Tru-118427	Takifugu rubripes	41.07	2.00e-66	246.00
IUUC-Tni-120218	Tetraodon nigroviridis	41.37	3.00e-67	248.00
IUUC-Tre-122177	Trichoderma reesei	33.16	4.00e-177	613.00
IUUC-Tme-127176	Tuber melanosporum	34.74	8.00e-176	608.00
IUUC-Tbe-127641	Tupaia belangeri	25.11	2.00e-14	72.80
IUUC-Ttr-128888	Tursiops truncatus	39.88	6.00e-62	230.00
IUUC-Uma-129361	Ustilago maydis	40.83	1.00e-60	226.00
IUUC-Xtr-132811	Xenopus tropicalis	39.29	4.00e-65	241.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence