iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sre-115075

Ensembl Protein ID

CBQ69014

UniProt Accession

E6ZP57; E6ZP57_SPORE

Genbank Protein ID

CBQ69014.1

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

FQ311434

Gene Name

PAN2; sr15474

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
sr15474	CBQ69014	CBQ69014

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.10e-11	40.1	621	1135

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaee..fsgyeqqDaqEfla. 97
           Gl+ +    Y NS LQ+L+ +p++re  + +   ++++e      ++ll++   lf+ l + k  + + +++l+a+++ ++   +  +e +D+   ++ 
   Q: 621  GLETHIQNSYANSYLQALHYLPPFRETAKAHILYNCPRE------NCLLCEAGFLFRMLEDAKGANCQASNFLRAFGNSHKAetLGLMEREDSLAKVSs 713
           777777788*********************888899876......599999999999999999999999999999988777632446777776655440 PP
   S: 98   ........flldqleeelkk......eknkpkeeeeeedkselsde..................................................aee 132
                   ++ +ql ++l++       ++ ++++                                                               + 
   Q: 714  nsgvskneIMCSQLVQTLNRfvldctATEAQTSQ-----------AgvssnsasaraspagappglgpplssnrgggvssgagrriagdlasptspLPP 801
           0011111144444444444455444322222222...........1222234455568999******************************99988777 PP
   S: 133  kkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke....slqdcLesftkeeelegenkyycekckkkqe...aekklklk 224
           +     +s + +lF   + ++++c +c+++ssr +p l++ l  p++  ++++    ++ ++L++   +e  +   +  c+ c+        + +   +
   Q: 802  DSAAAFDSSVAKLFALNTVTKTVCIHCGRESSRSNPLLSVDLIYPRRPMSNESappsDFASVLRASLLREVQN---RAPCRACQFTAMfrtRRVMPATS 897
           7888899**********************************99997666666622226666666555555554...57888887555422144555789 PP
   S: 225  klPevLilhLkRfsfseeqksrekinkkvefple.Ldlspfctspeekqke................................................ 274
           +lP+vL+++       e+ +     n+k + p+  +  ++ +  p ++q++                                                
   Q: 898  ELPRVLSVNAAIQAP-EHLHYWLDANQKGNKPQPhMGPARPTG-PMQQQQQqppygnngkmgymgmpprgagagvptgpradsnaeakrtylppriaig 994
           9*****999776622.222222334444444433233332222.3333333467778888888888888888888888888888899999999999999 PP
   S: 275  ...........................kkkYeLiavvvHsG.slssGHYvayvkn............................................ 301
                                      + +Y+L ++vv      ++ H +a+v+                                             
   Q: 995  vygddvrvvpvwaaedvervkaslggqPAIYKLRSMVVQISaDKEQPHLCAVVRVpeaeastlggssadaaataattpkmahsaaggvaapsstkksar 1093
           999999999999999999999999999**********99999******************************************999999999888877 PP
   S: 302  ...ekgk...WllfdDskVtevkeeevleetg..staYvlfYkr 337
              +  +   W+lf+D  V+ v+e+e l +++  + + vl+++r
   Q: 1094 akaS--QlgpWYLFNDFLVRNVSEAEALGFQNtwKMPSVLMWER 1135
           6441..2557****************999887777777777766 PP

Organism

Sporisorium reilianum

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein PAB1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.

Protein Sequence
(Fasta)

MADWSEHAHY GNANGPMGLP PAVTALAFDP YSELLWQGTS FGTVSSLYSS QLSRYTSYAA 60
HGLPTRPSPA KGILADERHI FSVGDNGIKC SHRRGLAKWT TLTHDIGTNA MNLVSMCASP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCGACT GGAGCGAGCA TGCCCACTAT GGCAACGCCA ACGGGCCCAT GGGCCTCCCG 60
CCCGCCGTCA CCGCGCTCGC ATTCGATCCC TACAGCGAGC TCCTCTGGCA GGGCACCTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR011047--Quinoprotein_ADH-like_supfam
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	31.47	9.00e-107	380.00
IUUC-Apl-003500	Anas platyrhynchos	32.40	6.00e-66	244.00
IUUC-Aca-004930	Anolis carolinensis	32.18	7.00e-106	377.00
IUUC-Acl-008214	Aspergillus clavatus	42.61	7.00e-74	270.00
IUUC-Afu-009112	Aspergillus fumigatus	41.76	7.00e-73	267.00
IUUC-Ang-009531	Aspergillus niger	41.18	1.00e-71	263.00
IUUC-Ame-011259	Astyanax mexicanus	40.76	1.00e-68	253.00
IUUC-Bta-012371	Bos taurus	31.35	2.00e-105	375.00
IUUC-Bci-013684	Botrytis cinerea	39.81	5.00e-63	234.00
IUUC-Cja-019297	Callithrix jacchus	31.35	8.00e-106	377.00
IUUC-Cfa-020489	Canis familiaris	31.24	2.00e-104	372.00
IUUC-Cpo-022392	Cavia porcellus	31.08	8.00e-105	373.00
IUUC-Csa-023220	Chlorocebus sabaeus	31.59	1.00e-106	379.00
IUUC-Csv-025841	Ciona savignyi	40.92	3.00e-61	228.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	43.71	2.00e-74	273.00
IUUC-Cne-026932	Cryptococcus neoformans	43.19	2.00e-86	312.00
IUUC-Dre-028482	Danio rerio	40.94	4.00e-69	255.00
IUUC-Dno-029398	Dasypus novemcinctus	31.82	5.00e-106	377.00
IUUC-Dor-030307	Dipodomys ordii	31.23	4.00e-89	321.00
IUUC-Dme-032111	Drosophila melanogaster	30.16	2.00e-95	342.00
IUUC-Eca-033985	Equus caballus	31.35	5.00e-105	374.00
IUUC-Eeu-034928	Erinaceus europaeus	24.77	1.00e-27	117.00
IUUC-Fca-035587	Felis catus	31.47	7.00e-106	377.00
IUUC-Fal-037587	Ficedula albicollis	31.72	9.00e-72	263.00
IUUC-Fso-038133	Fusarium solani	43.40	2.00e-77	282.00
IUUC-Gmo-039076	Gadus morhua	40.06	4.00e-67	248.00
IUUC-Ggr-039957	Gaeumannomyces graminis	35.76	2.00e-65	242.00
IUUC-Gga-040948	Gallus gallus	31.94	1.00e-102	366.00
IUUC-Gac-042396	Gasterosteus aculeatus	40.35	6.00e-68	251.00
IUUC-Ggo-045412	Gorilla gorilla	31.70	1.00e-106	379.00
IUUC-Hsa-046076	Homo sapiens	31.70	2.00e-106	379.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	29.63	9.00e-91	327.00
IUUC-Kpa-049178	Komagataella pastoris	40.59	6.00e-66	244.00
IUUC-Lch-050279	Latimeria chalumnae	40.46	2.00e-67	249.00
IUUC-Loc-052872	Lepisosteus oculatus	41.62	1.00e-66	247.00
IUUC-Lma-052986	Leptosphaeria maculans	41.53	2.00e-68	252.00
IUUC-Laf-054181	Loxodonta africana	31.44	6.00e-107	380.00
IUUC-Mcc-054812	Macaca mulatta	31.47	3.00e-105	375.00
IUUC-Meu-056325	Macropus eugenii	31.91	8.00e-108	383.00
IUUC-Mor-057246	Magnaporthe oryzae	38.59	1.00e-53	204.00
IUUC-Mpo-057464	Magnaporthe poae	36.16	3.00e-72	265.00
IUUC-Mla-058911	Melampsora laricipopulina	42.37	9.00e-87	313.00
IUUC-Mga-059335	Meleagris gallopavo	42.17	1.00e-64	240.00
IUUC-Mvi-060461	Microbotryum violaceum	40.66	1.00e-161	562.00
IUUC-Mmr-060636	Microcebus murinus	31.47	2.00e-105	375.00
IUUC-Mmu-063503	Mus musculus	31.56	1.00e-106	379.00
IUUC-Mpu-066670	Mustela putorius furo	31.24	8.00e-105	373.00
IUUC-Mlu-068119	Myotis lucifugus	30.76	3.00e-103	368.00
IUUC-Nfi-068398	Neosartorya fischeri	41.76	1.00e-72	266.00
IUUC-Ncr-068927	Neurospora crassa	42.35	1.00e-70	260.00
IUUC-Nle-069651	Nomascus leucogenys	29.64	9.00e-98	350.00
IUUC-Opr-070614	Ochotona princeps	31.55	1.00e-104	372.00
IUUC-Ont-072433	Oreochromis niloticus	40.94	1.00e-69	256.00
IUUC-Oan-073283	Ornithorhynchus anatinus	37.30	2.00e-62	232.00
IUUC-Ocu-074401	Oryctolagus cuniculus	31.45	4.00e-104	371.00
IUUC-Ola-087522	Oryzias latipes	40.35	5.00e-69	254.00
IUUC-Oga-088226	Otolemur garnettii	30.99	7.00e-104	370.00
IUUC-Oar-089241	Ovis aries	31.46	2.00e-108	385.00
IUUC-Pan-092297	Papio anubis	31.47	2.00e-105	375.00
IUUC-Psi-094043	Pelodiscus sinensis	29.97	2.00e-62	232.00
IUUC-Pma-094394	Petromyzon marinus	32.25	9.00e-109	386.00
IUUC-Pno-095053	Phaeosphaeria nodorum	40.98	7.00e-68	250.00
IUUC-Ppa-095188	Physcomitrella patens	34.42	2.00e-60	226.00
IUUC-Pfo-097517	Poecilia formosa	32.39	2.00e-79	289.00
IUUC-Pca-100471	Procavia capensis	31.23	3.00e-107	381.00
IUUC-Pva-102805	Pteropus vampyrus	29.94	2.00e-89	322.00
IUUC-Pte-104021	Pyrenophora teres	40.70	2.00e-68	252.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	40.70	2.00e-68	252.00
IUUC-Rno-105471	Rattus norvegicus	31.31	1.00e-105	376.00
IUUC-Sce-106235	Saccharomyces cerevisiae	38.82	1.00e-60	226.00
IUUC-Sha-106883	Sarcophilus harrisii	31.76	3.00e-104	371.00
IUUC-Spo-108169	Schizosaccharomyces pombe	37.39	3.00e-83	301.00
IUUC-Sar-113323	Sorex araneus	32.28	1.00e-106	379.00
IUUC-Ssc-116363	Sus scrofa	31.48	2.00e-105	375.00
IUUC-Tru-118427	Takifugu rubripes	41.23	4.00e-69	255.00
IUUC-Tni-120218	Tetraodon nigroviridis	41.23	5.00e-70	258.00
IUUC-Tre-122177	Trichoderma reesei	38.90	3.00e-75	275.00
IUUC-Tme-127176	Tuber melanosporum	42.65	2.00e-72	266.00
IUUC-Tbe-127641	Tupaia belangeri	30.00	7.00e-22	98.20
IUUC-Ttr-128888	Tursiops truncatus	31.08	5.00e-102	364.00
IUUC-Uma-129361	Ustilago maydis	78.30	0.00e+00	2122.00
IUUC-Xtr-132811	Xenopus tropicalis	41.04	1.00e-68	253.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence